| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTAPLHEGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRCGPDGVPLPSAPPPSPLYTPPPPSSPYAVLPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPLPNVYDPACFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9415 | |
| 2 | L | A | 1.9642 | |
| 3 | P | A | 0.6564 | |
| 4 | P | A | 0.3605 | |
| 5 | T | A | 0.1168 | |
| 6 | T | A | 0.1333 | |
| 7 | P | A | 0.1610 | |
| 8 | V | A | 1.2356 | |
| 9 | A | A | 0.0806 | |
| 10 | K | A | -1.0326 | |
| 11 | V | A | -0.1813 | |
| 12 | Q | A | -1.4165 | |
| 13 | S | A | -1.5552 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.3956 | |
| 16 | E | A | -2.4283 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4659 | |
| 20 | P | A | 0.1103 | |
| 21 | T | A | 0.1106 | |
| 22 | S | A | -0.1703 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1009 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2776 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8715 | |
| 31 | R | A | -2.6563 | |
| 32 | L | A | -0.7748 | |
| 33 | L | A | 1.1748 | |
| 34 | T | A | 1.3786 | |
| 35 | V | A | 1.8598 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2062 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6101 | |
| 40 | K | A | -1.6405 | |
| 41 | D | A | -0.9464 | |
| 42 | I | A | 0.8018 | |
| 43 | V | A | 0.9967 | |
| 44 | K | A | -1.1924 | |
| 45 | N | A | -1.9347 | |
| 46 | G | A | -1.2430 | |
| 47 | K | A | -0.9938 | |
| 48 | V | A | 1.3987 | |
| 49 | V | A | 2.0051 | |
| 50 | V | A | 1.2385 | |
| 51 | P | A | 0.4235 | |
| 52 | K | A | -0.6453 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1944 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4135 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2772 | |
| 70 | K | A | -1.7958 | |
| 71 | F | A | -0.6428 | |
| 72 | A | A | -0.5691 | |
| 73 | L | A | -0.8643 | |
| 74 | P | A | -1.2773 | |
| 75 | Q | A | -2.4944 | |
| 76 | K | A | -3.0991 | |
| 77 | D | A | -2.9807 | |
| 78 | F | A | -1.6530 | |
| 79 | Y | A | -1.8706 | |
| 80 | D | A | -2.6739 | |
| 81 | P | A | -2.3037 | |
| 82 | E | A | -3.0469 | |
| 83 | K | A | -3.3919 | |
| 84 | E | A | -2.4560 | |
| 85 | R | A | -1.2924 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6379 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9513 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3198 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6733 | |
| 99 | G | A | -0.5273 | |
| 100 | P | A | -0.3693 | |
| 101 | L | A | 0.1141 | |
| 102 | G | A | -0.1139 | |
| 103 | K | A | -0.4540 | |
| 104 | G | A | -0.3668 | |
| 105 | T | A | -0.4176 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | 0.1408 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4173 | |
| 110 | L | A | 0.3057 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0375 | |
| 113 | K | A | -0.3807 | |
| 114 | L | A | -1.0190 | |
| 115 | G | A | -0.8651 | |
| 116 | D | A | -1.1674 | |
| 117 | T | A | -0.8481 | |
| 118 | E | A | -1.7991 | |
| 119 | N | A | -1.9444 | |
| 120 | P | A | -1.3071 | |
| 121 | T | A | -0.6408 | |
| 122 | A | A | -0.3604 | |
| 123 | P | A | -0.0349 | |
| 124 | L | A | -0.3835 | |
| 125 | H | A | -1.4969 | |
| 126 | E | A | -2.1983 | |
| 127 | G | A | -1.9487 | |
| 128 | A | A | -1.4743 | |
| 129 | D | A | -2.3802 | |
| 130 | D | A | -1.9463 | |
| 131 | R | A | -1.0383 | |
| 132 | V | A | 0.2593 | |
| 133 | A | A | 0.4435 | |
| 134 | F | A | 0.2782 | |
| 135 | S | A | -0.0769 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.4390 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5569 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2003 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1397 | |
| 157 | D | A | 0.3192 | |
| 158 | I | A | 0.8485 | |
| 159 | A | A | 0.1253 | |
| 160 | E | A | -1.4744 | |
| 161 | P | A | -0.2246 | |
| 162 | C | A | 0.1892 | |
| 163 | P | A | -0.1692 | |
| 164 | G | A | -0.0761 | |
| 165 | L | A | 0.5936 | |
| 166 | P | A | -0.1126 | |
| 167 | P | A | -0.3387 | |
| 168 | G | A | -0.4211 | |
| 169 | A | A | 0.2942 | |
| 170 | C | A | 1.1009 | |
| 171 | P | A | 0.5595 | |
| 172 | P | A | 0.8544 | |
| 173 | I | A | 2.0573 | |
| 174 | Q | A | 0.8698 | |
| 175 | L | A | 1.4635 | |
| 176 | V | A | 0.8606 | |
| 177 | N | A | -0.2921 | |
| 178 | S | A | 0.0225 | |
| 179 | V | A | 0.4193 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3859 | |
| 182 | D | A | 0.0707 | |
| 183 | G | A | -0.1545 | |
| 184 | D | A | -0.5347 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1094 | |
| 190 | F | A | 0.0593 | |
| 191 | G | A | -0.1062 | |
| 192 | N | A | -0.2632 | |
| 193 | M | A | -0.1230 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3698 | |
| 197 | E | A | -2.5867 | |
| 198 | L | A | -1.1995 | |
| 199 | Q | A | -2.5338 | |
| 200 | Q | A | -3.2986 | |
| 201 | D | A | -3.5694 | |
| 202 | R | A | -3.3271 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2160 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3357 | |
| 211 | S | A | -1.8763 | |
| 212 | T | A | -1.4370 | |
| 213 | R | A | -2.0787 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1530 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3286 | |
| 220 | L | A | 0.5874 | |
| 221 | K | A | -1.1399 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8233 | |
| 224 | N | A | -1.5859 | |
| 225 | E | A | -1.2424 | |
| 226 | A | A | -0.6088 | |
| 227 | Y | A | -0.3652 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6596 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0734 | |
| 234 | F | A | 0.2555 | |
| 235 | G | A | -0.8061 | |
| 236 | R | A | -2.5788 | |
| 237 | R | A | -2.8160 | |
| 238 | E | A | -2.1389 | |
| 239 | Q | A | -0.1988 | |
| 240 | V | A | 1.4150 | |
| 241 | Y | A | 1.1934 | |
| 242 | A | A | 0.3332 | |
| 243 | R | A | -0.6985 | |
| 244 | H | A | -0.7234 | |
| 245 | F | A | 0.0248 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.6221 | |
| 249 | C | A | -1.1449 | |
| 250 | G | A | -1.0081 | |
| 251 | P | A | -0.6566 | |
| 252 | D | A | -0.3201 | |
| 253 | G | A | 0.0652 | |
| 254 | V | A | 1.3175 | |
| 255 | P | A | 0.4132 | |
| 256 | L | A | 0.9007 | |
| 257 | P | A | 0.3308 | |
| 258 | S | A | -0.0872 | |
| 259 | A | A | -0.1374 | |
| 260 | P | A | -0.5816 | |
| 261 | P | A | -0.4441 | |
| 262 | P | A | -0.3222 | |
| 263 | S | A | 0.0585 | |
| 264 | P | A | 0.3958 | |
| 265 | L | A | 1.4865 | |
| 266 | Y | A | 0.8144 | |
| 267 | T | A | 0.0525 | |
| 268 | P | A | 0.1623 | |
| 269 | P | A | 0.1487 | |
| 270 | P | A | -0.4112 | |
| 271 | P | A | -0.1697 | |
| 272 | S | A | -0.3595 | |
| 273 | S | A | 0.1281 | |
| 274 | P | A | 0.3611 | |
| 275 | Y | A | 1.3850 | |
| 276 | A | A | 1.1136 | |
| 277 | V | A | 2.1893 | |
| 278 | L | A | 1.5147 | |
| 279 | P | A | 0.3265 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.0629 | |
| 282 | D | A | -0.5925 | |
| 283 | Y | A | 0.8278 | |
| 284 | F | A | 0.6665 | |
| 285 | G | A | 0.2773 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9535 | |
| 291 | L | A | 1.6332 | |
| 292 | V | A | 0.6712 | |
| 293 | S | A | -0.1507 | |
| 294 | S | A | -0.9525 | |
| 295 | D | A | -1.8426 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0936 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6198 | |
| 301 | R | A | -1.8388 | |
| 302 | P | A | -0.9711 | |
| 303 | F | A | -0.1834 | |
| 304 | W | A | -0.5577 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0803 | |
| 307 | R | A | -2.8275 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.3755 | |
| 310 | G | A | -1.2213 | |
| 311 | N | A | -1.2720 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8235 | |
| 319 | N | A | -0.9457 | |
| 320 | E | A | -1.0480 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.2840 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0089 | |
| 333 | N | A | 0.5994 | |
| 334 | F | A | 1.7785 | |
| 335 | T | A | 0.8805 | |
| 336 | I | A | 0.4372 | |
| 337 | S | A | -0.9750 | |
| 338 | Q | A | -1.7800 | |
| 339 | Q | A | -1.2579 | |
| 340 | L | A | 0.6360 | |
| 341 | C | A | 0.4256 | |
| 342 | T | A | 0.2072 | |
| 343 | P | A | -0.1009 | |
| 344 | L | A | 0.5340 | |
| 345 | P | A | 0.2479 | |
| 346 | N | A | -0.1776 | |
| 347 | V | A | 1.6071 | |
| 348 | Y | A | 1.5411 | |
| 349 | D | A | 0.2281 | |
| 350 | P | A | -0.2691 | |
| 351 | A | A | -0.0784 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7262 | |
| 354 | K | A | -1.8056 | |
| 355 | N | A | -1.7998 | |
| 356 | Y | A | -0.0891 | |
| 357 | L | A | 0.6651 | |
| 358 | R | A | 1.0163 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4107 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0569 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9621 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6741 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3034 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3128 | |
| 376 | L | A | -1.7104 | |
| 377 | D | A | -1.9948 | |
| 378 | P | A | -1.0394 | |
| 379 | G | A | -1.0123 | |
| 380 | V | A | -0.9307 | |
| 381 | L | A | -0.5246 | |
| 382 | A | A | -0.6491 | |
| 383 | H | A | -0.8056 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3957 | |
| 386 | T | A | -0.5434 | |
| 387 | M | A | -0.2919 | |
| 388 | N | A | -0.8567 | |
| 389 | P | A | -1.2373 | |
| 390 | T | A | -1.4416 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4447 | |
| 393 | E | A | -2.7828 | |
| 394 | N | A | -2.3892 | |
| 395 | W | A | -1.3916 | |
| 396 | N | A | -1.1583 | |
| 397 | L | A | -0.2463 | |
| 398 | G | A | 0.5028 | |
| 399 | F | A | 2.4061 | |
| 400 | V | A | 1.8123 | |
| 401 | P | A | 0.0350 | |
| 402 | P | A | -1.8083 | |
| 403 | K | A | -3.3203 | |
| 404 | E | A | -3.7709 | |
| 405 | R | A | -3.8984 | |
| 406 | E | A | -3.7855 | |
| 407 | D | A | -2.8736 | |
| 408 | P | A | -1.7665 | |
| 409 | Y | A | -0.9862 | |
| 410 | K | A | -2.1240 | |
| 411 | G | A | -0.6384 | |
| 412 | L | A | 0.6741 | |
| 413 | I | A | 1.5772 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4283 | |
| 416 | E | A | -1.7671 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9686 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0452 | |
| 421 | E | A | -2.7547 | |
| 422 | R | A | -2.5793 | |
| 423 | F | A | -1.2554 | |
| 424 | S | A | -1.4627 | |
| 425 | Q | A | -1.9117 | |
| 426 | D | A | -2.9750 | |
| 427 | L | A | -2.1580 | |
| 428 | D | A | -3.0199 | |
| 429 | Q | A | -2.7578 | |
| 430 | F | A | -1.6099 | |
| 431 | A | A | -1.1212 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2167 | |
| 435 | K | A | -1.0461 | |
| 436 | F | A | -0.0753 | |
| 437 | L | A | 0.8094 | |
| 438 | Y | A | 0.6493 | |
| 439 | Q | A | -0.3752 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine