Project name: b09b73f751487be

Chain sequence(s)	H: QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSA; L: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:00)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:01)

• Minimal score value: -3.0954
• Maximal score value: 2.0609
• Average score: -0.4788
• Total score value: -108.6794

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.2593
2	V	H	-0.5411
3	Q	H	-1.2741
4	L	H	0.0000
5	Q	H	-1.5233
6	Q	H	-1.0043
7	P	H	-0.7499
8	G	H	-0.6702
9	A	H	-0.0917
11	E	H	0.0685
12	L	H	0.9450
13	V	H	0.0000
14	K	H	-1.5539
15	P	H	-1.1121
16	G	H	-1.1051
17	A	H	-0.8880
18	S	H	-0.9200
19	V	H	-0.6159
20	K	H	-1.1383
21	M	H	0.0000
22	S	H	-0.6369
23	C	H	0.0000
24	K	H	-1.4525
25	A	H	0.0000
26	S	H	-0.9180
27	G	H	-0.7747
28	Y	H	-0.2111
29	T	H	-0.1607
30	F	H	0.0000
35	T	H	-0.6501
36	S	H	-0.1838
37	Y	H	0.3831
38	N	H	-0.3195
39	M	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	K	H	0.0000
44	Q	H	-0.3456
45	T	H	0.0000
46	P	H	-0.6835
47	G	H	-1.2046
48	R	H	-1.1680
49	G	H	-0.8241
50	L	H	0.0000
51	E	H	-0.6194
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	A	H	0.0000
56	I	H	0.0000
57	Y	H	-0.6572
58	P	H	0.0000
59	G	H	-1.2665
62	N	H	-2.0384
63	G	H	-1.9273
64	D	H	-2.2490
65	T	H	-1.0726
66	S	H	-0.9414
67	Y	H	-1.2908
68	N	H	-2.0393
69	Q	H	-2.9077
70	K	H	-2.9136
71	F	H	0.0000
72	K	H	-2.9053
74	G	H	-1.9091
75	K	H	-1.6092
76	A	H	0.0000
77	T	H	-0.7588
78	L	H	0.0000
79	T	H	-0.5799
80	A	H	-0.8048
81	D	H	-1.3818
82	K	H	-1.9076
83	S	H	-1.0583
84	S	H	-0.9150
85	S	H	-1.0485
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.2900
89	M	H	0.0000
90	Q	H	-0.9591
91	L	H	0.0000
92	S	H	-0.7390
93	S	H	-0.8214
94	L	H	0.0000
95	T	H	-1.2002
96	S	H	-1.1755
97	E	H	-1.9886
98	D	H	0.0000
99	S	H	-0.5124
100	A	H	0.0000
101	V	H	0.2007
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	S	H	0.0000
108	T	H	0.0000
109	Y	H	2.0609
110	Y	H	1.7970
111	G	H	0.3367
112A	G	H	0.3339
112	D	H	0.0000
113	W	H	1.4316
114	Y	H	0.8730
115	F	H	0.0000
116	N	H	0.0204
117	V	H	-0.0889
118	W	H	0.0000
119	G	H	0.0000
120	A	H	-0.3937
121	G	H	0.0000
122	T	H	0.0000
123	T	H	0.0920
124	V	H	0.0000
125	T	H	0.1820
126	V	H	-0.5042
127	S	H	-0.3845
128	A	H	-0.4672
1	Q	L	-1.0766
2	I	L	0.1260
3	V	L	1.1026
4	L	L	0.0000
5	S	L	-0.5763
6	Q	L	-0.5054
7	S	L	-0.4088
8	P	L	0.1681
9	A	L	0.3855
10	I	L	1.1919
11	L	L	0.5131
12	S	L	-0.3080
13	A	L	0.0000
14	S	L	-1.7173
15	P	L	-1.8491
16	G	L	-2.1277
17	E	L	-2.6418
18	K	L	-2.8473
19	V	L	0.0000
20	T	L	-0.5304
21	M	L	0.0000
22	T	L	-0.6258
23	C	L	0.0000
24	R	L	-1.6672
25	A	L	0.0000
26	S	L	-0.2498
27	S	L	-0.4172
28	S	L	-0.6281
29	V	L	0.0000
37	S	L	-0.1986
38	Y	L	0.2070
39	I	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	F	L	0.0000
43	Q	L	0.0000
44	Q	L	-0.7155
45	K	L	-1.0357
46	P	L	-0.7062
47	G	L	-0.6883
48	S	L	-0.6339
49	S	L	-0.3825
50	P	L	0.0000
51	K	L	-0.7676
52	P	L	-0.3553
53	W	L	0.0000
54	I	L	0.0000
55	Y	L	0.1513
56	A	L	0.0970
57	T	L	-0.2657
65	S	L	-0.4981
66	N	L	-0.7248
67	L	L	0.1655
68	A	L	-0.3382
69	S	L	-0.4804
70	G	L	-0.2900
71	V	L	0.0000
72	P	L	0.6036
74	V	L	1.4071
75	R	L	-0.2938
76	F	L	0.0000
77	S	L	-0.0757
78	G	L	-0.4409
79	S	L	-0.5755
80	G	L	-0.7934
83	S	L	-0.7002
84	G	L	-0.6999
85	T	L	-0.9211
86	S	L	-1.0732
87	Y	L	0.0000
88	S	L	-0.5580
89	L	L	0.0000
90	T	L	-0.7826
91	I	L	0.0000
92	S	L	-1.8423
93	R	L	-3.0954
94	V	L	0.0000
95	E	L	-2.5683
96	A	L	-1.6462
97	E	L	-2.0806
98	D	L	0.0000
99	A	L	-1.0118
100	A	L	0.0000
101	T	L	-0.4507
102	Y	L	0.0000
103	Y	L	-0.2384
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	W	L	-0.0055
108	T	L	-0.2624
109	S	L	-0.8827
114	N	L	-1.7136
115	P	L	-1.5071
116	P	L	0.0000
117	T	L	-0.0656
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.6498
121	G	L	-0.3521
122	T	L	0.0000
123	K	L	-0.5533
124	L	L	0.0000
125	E	L	-0.4782
126	I	L	-0.9862
127	K	L	-1.6543