| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGAEAAAKEAAAKEAAAKEAAAKALEAEAAAKEAAAKEAAAKEAAAKAFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:28)
[INFO] Main: Simulation completed successfully. (00:02:30)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.4477 | |
| 2 | S | A | -0.1372 | |
| 3 | R | A | -1.6832 | |
| 4 | P | A | -1.0739 | |
| 5 | G | A | -0.9570 | |
| 6 | L | A | -0.5053 | |
| 7 | P | A | -0.2270 | |
| 8 | V | A | 0.2128 | |
| 9 | E | A | 0.0249 | |
| 10 | Y | A | 0.7864 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.8089 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.6111 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -1.0043 | |
| 17 | S | A | -0.7053 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3689 | |
| 20 | R | A | -2.0318 | |
| 21 | D | A | -2.7583 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.4241 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.8338 | |
| 29 | G | A | -1.0094 | |
| 30 | G | A | -1.6969 | |
| 31 | N | A | -2.3176 | |
| 32 | N | A | -2.1811 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.1172 | |
| 43 | R | A | -2.4955 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.3320 | |
| 46 | D | A | -2.7818 | |
| 47 | D | A | -1.6571 | |
| 48 | Y | A | -0.1691 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.9389 | |
| 54 | N | A | -0.1245 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.0213 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.4045 | |
| 60 | W | A | -0.1268 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | 0.0972 | |
| 63 | Q | A | -1.0004 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.1140 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | -1.6038 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.4071 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.6133 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.8886 | |
| 84 | S | A | 0.0588 | |
| 85 | P | A | -0.1806 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.4527 | |
| 88 | G | A | -1.2016 | |
| 89 | K | A | -1.9142 | |
| 90 | A | A | -0.8132 | |
| 91 | G | A | -0.5079 | |
| 92 | C | A | 0.1190 | |
| 93 | Q | A | -0.5042 | |
| 94 | T | A | -0.4480 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.8541 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.5888 | |
| 99 | T | A | -0.5154 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3788 | |
| 103 | S | A | -0.5376 | |
| 104 | E | A | -0.6995 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.4703 | |
| 108 | W | A | -0.8570 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.2545 | |
| 111 | A | A | -0.8627 | |
| 112 | N | A | -1.2902 | |
| 113 | R | A | -1.5609 | |
| 114 | A | A | -1.5248 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.1810 | |
| 117 | P | A | -0.9209 | |
| 118 | T | A | -0.7117 | |
| 119 | G | A | -0.4148 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | -0.1196 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.1994 | |
| 139 | H | A | -0.4634 | |
| 140 | P | A | -0.9259 | |
| 141 | Q | A | -1.2663 | |
| 142 | Q | A | -0.7165 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.2368 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.0715 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | -0.9723 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.2319 | |
| 157 | Q | A | -1.4052 | |
| 158 | G | A | -0.5128 | |
| 159 | M | A | 0.5284 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | 0.0190 | |
| 162 | S | A | 0.4292 | |
| 163 | L | A | 0.9364 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.0538 | |
| 166 | L | A | 0.7294 | |
| 167 | A | A | -0.3068 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.2709 | |
| 170 | D | A | -1.9097 | |
| 171 | A | A | -1.5218 | |
| 172 | G | A | 0.0000 | |
| 173 | G | A | -1.5914 | |
| 174 | Y | A | 0.0000 | |
| 175 | K | A | -1.6991 | |
| 176 | A | A | 0.0000 | |
| 177 | A | A | -0.7436 | |
| 178 | D | A | -0.6300 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | -0.4377 | |
| 182 | P | A | -0.6277 | |
| 183 | S | A | -0.8709 | |
| 184 | S | A | -0.7473 | |
| 185 | D | A | -0.9111 | |
| 186 | P | A | -0.9734 | |
| 187 | A | A | -0.6688 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -1.9153 | |
| 190 | R | A | -1.2819 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.3763 | |
| 195 | Q | A | -1.8606 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -1.0295 | |
| 199 | K | A | -1.2603 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.1698 | |
| 202 | A | A | -0.8718 | |
| 203 | N | A | -1.3374 | |
| 204 | N | A | -1.7296 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.6820 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.7527 | |
| 214 | G | A | -0.3524 | |
| 215 | T | A | -0.6777 | |
| 216 | P | A | -0.9502 | |
| 217 | N | A | -1.2066 | |
| 218 | E | A | -1.8370 | |
| 219 | L | A | -0.6100 | |
| 220 | G | A | -0.8481 | |
| 221 | G | A | -0.5791 | |
| 222 | A | A | -0.3133 | |
| 223 | N | A | 0.2345 | |
| 224 | I | A | 1.9371 | |
| 225 | P | A | 1.0648 | |
| 226 | A | A | 0.0000 | |
| 227 | E | A | 0.5115 | |
| 228 | F | A | 1.8928 | |
| 229 | L | A | 1.1034 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.6449 | |
| 232 | F | A | 0.3956 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.5418 | |
| 235 | S | A | -0.5073 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.3694 | |
| 239 | K | A | -1.6951 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.4074 | |
| 242 | D | A | -2.4557 | |
| 243 | A | A | -1.6863 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.1791 | |
| 246 | A | A | -1.2103 | |
| 247 | A | A | -0.9189 | |
| 248 | G | A | -1.0622 | |
| 249 | G | A | -1.6172 | |
| 250 | H | A | -1.6291 | |
| 251 | N | A | -1.2146 | |
| 252 | A | A | -0.5067 | |
| 253 | V | A | 0.3243 | |
| 254 | F | A | 0.6117 | |
| 255 | N | A | 0.1274 | |
| 256 | F | A | 0.2100 | |
| 257 | P | A | -0.2413 | |
| 258 | P | A | -0.5488 | |
| 259 | N | A | -0.8356 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.3406 | |
| 263 | S | A | -0.5134 | |
| 264 | W | A | -0.4410 | |
| 265 | E | A | -1.1932 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.4379 | |
| 270 | Q | A | -0.5710 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.9172 | |
| 273 | A | A | -0.6245 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0677 | |
| 276 | G | A | -1.1081 | |
| 277 | D | A | -0.8822 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -0.9953 | |
| 280 | S | A | -0.8299 | |
| 281 | S | A | -0.5387 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | -0.8707 | |
| 284 | A | A | -0.9743 | |
| 285 | G | A | -1.5631 | |
| 286 | A | A | -1.4889 | |
| 287 | E | A | -2.9478 | |
| 288 | A | A | -2.2561 | |
| 289 | A | A | -1.6903 | |
| 290 | A | A | -2.1375 | |
| 291 | K | A | -3.4308 | |
| 292 | E | A | -3.5100 | |
| 293 | A | A | -2.5593 | |
| 294 | A | A | -2.2248 | |
| 295 | A | A | -2.5571 | |
| 296 | K | A | -3.6228 | |
| 297 | E | A | -3.6715 | |
| 298 | A | A | -2.5191 | |
| 299 | A | A | -2.1737 | |
| 300 | A | A | -2.5107 | |
| 301 | K | A | -3.4038 | |
| 302 | E | A | -3.3806 | |
| 303 | A | A | -1.9953 | |
| 304 | A | A | -1.3981 | |
| 305 | A | A | -1.8851 | |
| 306 | K | A | -2.6942 | |
| 307 | A | A | -1.4164 | |
| 308 | L | A | -0.3775 | |
| 309 | E | A | -2.2916 | |
| 310 | A | A | -1.9699 | |
| 311 | E | A | -2.6119 | |
| 312 | A | A | -2.1743 | |
| 313 | A | A | -1.8320 | |
| 314 | A | A | -2.1270 | |
| 315 | K | A | -3.5324 | |
| 316 | E | A | -3.4676 | |
| 317 | A | A | -2.5194 | |
| 318 | A | A | -2.1877 | |
| 319 | A | A | -2.5063 | |
| 320 | K | A | -3.5964 | |
| 321 | E | A | -3.6509 | |
| 322 | A | A | -2.5151 | |
| 323 | A | A | -2.1835 | |
| 324 | A | A | -2.5082 | |
| 325 | K | A | -3.4108 | |
| 326 | E | A | -3.2043 | |
| 327 | A | A | -1.7716 | |
| 328 | A | A | -1.0680 | |
| 329 | A | A | -0.8641 | |
| 330 | K | A | -1.2621 | |
| 331 | A | A | 0.1872 | |
| 332 | F | A | 1.2700 | |
| 333 | A | A | 0.2982 | |
| 334 | V | A | 1.0943 | |
| 335 | T | A | 0.3035 | |
| 336 | N | A | -0.4071 | |
| 337 | D | A | -0.8870 | |
| 338 | G | A | -0.0312 | |
| 339 | V | A | 1.7750 | |
| 340 | I | A | 2.2136 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine