Project name: b449002446935bf

Chain sequence(s)	H: QVQLQESGPGLVKPSETLSLTCAVSGHSISHDHAWSWVRQPPGEGLEWIGFISYSGITNYNPSLQGRVTISRDNSKNTLYLQMNSLRAEDTAVYYCARSLARTTAMDYWGEGTLVTVSS; L: DIQMTQSPSSLSASVGDSVTITCQASTDISSHLNWYQQKPGKAPELLIYYGSHLLSGVPSRFSGSGSGTDFTFTISSLEAEDAATYYCGQGNRLPYTFGQGTKVEIE
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:05)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:07)

• Minimal score value: -2.8133
• Maximal score value: 1.8225
• Average score: -0.677
• Total score value: -152.9997

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.5288
2	V	H	0.0000
3	Q	H	-1.6046
4	L	H	0.0000
5	Q	H	-1.8320
6	E	H	0.0000
7	S	H	-0.6326
8	G	H	-0.4803
9	P	H	-0.1383
11	G	H	0.1996
12	L	H	0.6174
13	V	H	0.0000
14	K	H	-1.6384
15	P	H	-1.6898
16	S	H	-1.4414
17	E	H	-1.6699
18	T	H	-1.2641
19	L	H	0.0000
20	S	H	-0.7210
21	L	H	0.0000
22	T	H	-0.4272
23	C	H	0.0000
24	A	H	-0.9188
25	V	H	0.0000
26	S	H	-1.3507
27	G	H	-1.2684
28	H	H	-1.1905
29	S	H	-1.2748
30	I	H	0.0000
31	S	H	-1.3060
35	H	H	-1.4795
36	D	H	-1.0119
37	H	H	-0.7166
38	A	H	0.0000
39	W	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.7297
45	P	H	-1.1887
46	P	H	-0.9457
47	G	H	-1.5252
48	E	H	-2.4741
49	G	H	-1.6447
50	L	H	0.0000
51	E	H	-0.8588
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	F	H	0.3554
56	I	H	0.0000
57	S	H	0.1586
58	Y	H	-0.1176
59	S	H	0.1798
63	G	H	0.6394
64	I	H	1.8225
65	T	H	0.7684
66	N	H	-0.0026
67	Y	H	-0.4748
68	N	H	-0.7665
69	P	H	-1.1163
70	S	H	-0.8112
71	L	H	0.0000
72	Q	H	-1.7167
74	G	H	-1.3316
75	R	H	-1.2833
76	V	H	0.0000
77	T	H	-0.6600
78	I	H	0.0000
79	S	H	-0.2805
80	R	H	-1.1407
81	D	H	-1.7960
82	N	H	-2.4035
83	S	H	-1.9066
84	K	H	-2.4918
85	N	H	-1.9689
86	T	H	0.0000
87	L	H	0.0000
88	Y	H	-0.1158
89	L	H	0.0000
90	Q	H	-0.8698
91	M	H	0.0000
92	N	H	-1.2639
93	S	H	-1.3069
94	L	H	0.0000
95	R	H	-2.3543
96	A	H	-1.6868
97	E	H	-2.2498
98	D	H	0.0000
99	T	H	-0.6102
100	A	H	0.0000
101	V	H	0.2909
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.1192
107	S	H	0.0000
108	L	H	-0.3052
109	A	H	-0.8270
110	R	H	-2.0909
112	T	H	-1.2884
113	T	H	-0.4456
114	A	H	0.0000
115	M	H	0.0000
116	D	H	-0.1630
117	Y	H	-0.3062
118	W	H	-0.9524
119	G	H	0.0000
120	E	H	-2.4609
121	G	H	-1.2284
122	T	H	-0.3706
123	L	H	0.5726
124	V	H	0.0000
125	T	H	-0.0823
126	V	H	0.0000
127	S	H	-0.6063
128	S	H	-0.5835
1	D	L	-2.3921
2	I	L	0.0000
3	Q	L	-2.0461
4	M	L	0.0000
5	T	L	-1.2976
6	Q	L	0.0000
7	S	L	-0.6378
8	P	L	-0.6725
9	S	L	-0.9664
10	S	L	-1.1946
11	L	L	-0.9971
12	S	L	-1.3369
13	A	L	-0.9334
14	S	L	-0.7275
15	V	L	0.3630
16	G	L	-0.4432
17	D	L	-1.1843
18	S	L	-0.8599
19	V	L	0.0000
20	T	L	-0.2664
21	I	L	0.0000
22	T	L	-0.7399
23	C	L	0.0000
24	Q	L	-2.2536
25	A	L	0.0000
26	S	L	-1.7133
27	T	L	-2.0398
28	D	L	-2.6139
29	I	L	0.0000
36	S	L	-1.1044
37	S	L	-0.8294
38	H	L	-1.0178
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-1.5381
45	K	L	-1.8758
46	P	L	-1.2176
47	G	L	-1.7468
48	K	L	-2.8133
49	A	L	-1.9172
50	P	L	0.0000
51	E	L	-1.9667
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.3481
56	Y	L	0.1203
57	G	L	0.0000
65	S	L	-0.3808
66	H	L	-0.2974
67	L	L	0.3140
68	L	L	0.1151
69	S	L	-0.1947
70	G	L	-0.3648
71	V	L	-0.2246
72	P	L	-0.2622
74	S	L	-0.3782
75	R	L	-0.6472
76	F	L	0.0000
77	S	L	-0.3731
78	G	L	-0.3025
79	S	L	-0.7685
80	G	L	-1.1097
83	S	L	-1.3269
84	G	L	-1.6495
85	T	L	-1.9884
86	D	L	-2.5013
87	F	L	0.0000
88	T	L	-0.7419
89	F	L	0.0000
90	T	L	-0.3004
91	I	L	0.0000
92	S	L	-0.9182
93	S	L	-0.8698
94	L	L	0.0000
95	E	L	-1.3254
96	A	L	-1.2184
97	E	L	-1.9241
98	D	L	0.0000
99	A	L	-1.5085
100	A	L	0.0000
101	T	L	-1.2701
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	G	L	0.0000
106	Q	L	0.0000
107	G	L	0.0000
108	N	L	-1.9665
109	R	L	-2.6172
114	L	L	-1.0336
115	P	L	-1.0077
116	Y	L	-0.7745
117	T	L	-0.9793
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.9302
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-2.1187
124	V	L	0.0000
125	E	L	-2.3796
126	I	L	-1.5584
127	E	L	-1.8006