Project name: Ganitumab

Chain sequence(s)	H: QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCARWTGRTDAFDIWGQGTMVTVSS; L: DVVMTQSPLSLPVTPGEPASISCRSSQSLLHSNGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWPLTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:03)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:05)

• Minimal score value: -3.0564
• Maximal score value: 0.9509
• Average score: -0.6119
• Total score value: -141.3432

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.5201
2	V	H	-1.2178
3	Q	H	-1.6800
4	L	H	0.0000
5	Q	H	-1.4529
6	E	H	0.0000
7	S	H	-0.6690
8	G	H	-0.5247
9	P	H	-0.1801
11	G	H	0.1399
12	L	H	0.5606
13	V	H	0.0000
14	K	H	-1.7018
15	P	H	-1.0585
16	S	H	-0.8935
17	G	H	-0.9505
18	T	H	-0.9022
19	L	H	0.0000
20	S	H	-0.8175
21	L	H	0.0000
22	T	H	-0.5683
23	C	H	0.0000
24	A	H	-1.0443
25	V	H	0.0000
26	S	H	-1.1502
27	G	H	-1.2385
28	G	H	-0.9470
29	S	H	-1.0533
30	I	H	0.0000
31	S	H	-0.8940
35	S	H	-0.3571
36	S	H	-0.6096
37	N	H	0.0000
38	W	H	-0.0475
39	W	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.7534
45	P	H	-0.8177
46	P	H	-0.9247
47	G	H	-1.4563
48	K	H	-2.3386
49	G	H	-1.4743
50	L	H	0.0000
51	E	H	-0.8766
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	E	H	0.0000
56	I	H	0.0000
57	Y	H	-0.1010
58	H	H	-0.7921
59	S	H	-0.6801
63	G	H	-0.6568
64	S	H	-0.4131
65	T	H	-0.1979
66	N	H	-0.1350
67	Y	H	-0.3184
68	N	H	-0.7650
69	P	H	-0.9717
70	S	H	-0.8380
71	L	H	0.0000
72	K	H	-2.0010
74	S	H	-1.2932
75	R	H	-1.3207
76	V	H	0.0000
77	T	H	-0.9058
78	I	H	0.0000
79	S	H	-0.6661
80	V	H	-1.1330
81	D	H	-2.2606
82	K	H	-2.9097
83	S	H	-2.1718
84	K	H	-2.7656
85	N	H	-2.2608
86	Q	H	-1.7754
87	F	H	0.0000
88	S	H	-0.5505
89	L	H	0.0000
90	K	H	-1.3446
91	L	H	0.0000
92	S	H	-0.7941
93	S	H	-0.7513
94	V	H	0.0000
95	T	H	-0.4496
96	A	H	-0.2411
97	A	H	0.0603
98	D	H	0.0000
99	T	H	0.1967
100	A	H	0.0000
101	V	H	0.3052
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.4174
107	W	H	0.0000
108	T	H	-0.9581
109	G	H	-1.3693
110	R	H	-2.1064
112	T	H	-1.1407
113	D	H	0.0000
114	A	H	0.0000
115	F	H	0.0000
116	D	H	-0.8408
117	I	H	-0.7154
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.7829
121	G	H	-0.7976
122	T	H	-0.2520
123	M	H	0.5657
124	V	H	0.0000
125	T	H	0.1726
126	V	H	0.0000
127	S	H	-0.5728
128	S	H	-0.7540
1	D	L	-1.3755
2	V	L	0.0000
3	V	L	0.6900
4	M	L	0.0000
5	T	L	-0.4755
6	Q	L	0.0000
7	S	L	-0.2258
8	P	L	0.2557
9	L	L	0.9509
10	S	L	-0.0170
11	L	L	-0.3323
12	P	L	-1.0043
13	V	L	0.0000
14	T	L	-1.5333
15	P	L	-1.6458
16	G	L	-1.9340
17	E	L	-2.3825
18	P	L	-2.0980
19	A	L	0.0000
20	S	L	-0.7208
21	I	L	0.0000
22	S	L	-0.8441
23	C	L	0.0000
24	R	L	-2.2427
25	S	L	0.0000
26	S	L	-0.9440
27	Q	L	-1.5718
28	S	L	-1.0692
29	L	L	0.0000
30	L	L	0.1101
31	H	L	-0.7783
32	S	L	-0.9965
34	N	L	-1.4261
35	G	L	-0.6977
36	Y	L	0.3285
37	N	L	0.1720
38	Y	L	0.2890
39	L	L	0.0000
40	D	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	L	L	0.0000
44	Q	L	-0.8425
45	K	L	-1.3582
46	P	L	-1.1174
47	G	L	-1.4337
48	Q	L	-2.0192
49	S	L	-1.2841
50	P	L	0.0000
51	Q	L	-0.8556
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.2154
56	L	L	0.0000
57	G	L	0.0000
65	S	L	-0.5804
66	N	L	-0.9224
67	R	L	-1.6086
68	A	L	-0.9148
69	S	L	-0.7954
70	G	L	-0.8876
71	V	L	-0.9604
72	P	L	-1.3081
74	D	L	-2.1974
75	R	L	-2.0799
76	F	L	0.0000
77	S	L	-1.2675
78	G	L	0.0000
79	S	L	-0.7326
80	G	L	-0.9369
83	S	L	-0.5816
84	G	L	-0.7030
85	T	L	-1.4605
86	D	L	-1.9388
87	F	L	0.0000
88	T	L	-0.9867
89	L	L	0.0000
90	K	L	-1.4586
91	I	L	0.0000
92	S	L	-2.2145
93	R	L	-3.0564
94	V	L	0.0000
95	E	L	-2.3413
96	A	L	-1.4555
97	E	L	-2.0232
98	D	L	0.0000
99	V	L	-0.7138
100	G	L	0.0000
101	V	L	-0.2015
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	M	L	0.0000
106	Q	L	0.0000
107	G	L	0.1404
108	T	L	0.0055
109	H	L	-0.3164
114	W	L	0.4597
115	P	L	-0.0680
116	L	L	0.0000
117	T	L	-0.0218
118	F	L	0.0720
119	G	L	0.0000
120	Q	L	-0.8581
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.7688
124	V	L	0.0000
125	E	L	-1.1796
126	I	L	-0.9221
127	K	L	-1.6231