Project name: b4c6e53778a2fdb

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASDFSLTTYGVHWVRQAPGKGLEWLGVIWSGGSTDYNAAFISRLTISKDNSKNTVYLQMNSLRAEDTAVYYCARDYGSTYVDAIDYWGQGTLVTVSS; L: DIVLTQSPDSLAVSLGERATINCRASESVESYGNRYMTWYQQKPGQPPKLLIYRAANLQSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSNEDPWTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:03)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:05)

• Minimal score value: -2.918
• Maximal score value: 1.6987
• Average score: -0.5651
• Total score value: -130.5435

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.5290
2	V	H	-1.7076
3	Q	H	-1.6473
4	L	H	0.0000
5	V	H	0.6391
6	E	H	0.0000
7	S	H	-0.1849
8	G	H	-0.4441
9	G	H	0.2363
11	G	H	0.8287
12	L	H	1.3742
13	V	H	-0.0557
14	Q	H	-1.3431
15	P	H	-1.6240
16	G	H	-1.4621
17	G	H	-1.2189
18	S	H	-1.1421
19	L	H	-0.6259
20	R	H	-1.2823
21	L	H	0.0000
22	S	H	-0.2710
23	C	H	0.0000
24	A	H	-0.1686
25	A	H	-0.7148
26	S	H	-1.5277
27	D	H	-2.5303
28	F	H	0.0000
29	S	H	-0.9149
30	L	H	0.0000
35	T	H	-0.8721
36	T	H	-0.2839
37	Y	H	0.0812
38	G	H	0.0000
39	V	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6057
45	A	H	-1.0102
46	P	H	-0.9923
47	G	H	-1.4467
48	K	H	-2.3152
49	G	H	-1.4339
50	L	H	0.0000
51	E	H	-0.9651
52	W	H	0.0000
53	L	H	0.0000
54	G	H	0.0000
55	V	H	0.0000
56	I	H	0.0000
57	W	H	-0.1930
58	S	H	-0.3062
59	G	H	-0.5787
63	G	H	-0.7577
64	S	H	-0.6077
65	T	H	-0.6206
66	D	H	-0.7344
67	Y	H	0.0789
68	N	H	-0.2409
69	A	H	0.1475
70	A	H	0.4783
71	F	H	0.0000
72	I	H	1.6987
74	S	H	0.5105
75	R	H	-0.1288
76	L	H	0.0000
77	T	H	-0.1639
78	I	H	0.0000
79	S	H	-0.5121
80	K	H	-1.1407
81	D	H	-1.7751
82	N	H	-2.2949
83	S	H	-1.8562
84	K	H	-2.4750
85	N	H	-1.9663
86	T	H	-1.0398
87	V	H	0.0000
88	Y	H	-0.3838
89	L	H	0.0000
90	Q	H	-0.9147
91	M	H	0.0000
92	N	H	-1.3065
93	S	H	-1.3117
94	L	H	0.0000
95	R	H	-2.3875
96	A	H	-1.7185
97	E	H	-2.2784
98	D	H	0.0000
99	T	H	-0.3248
100	A	H	0.0000
101	V	H	0.8688
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	D	H	0.0000
108	Y	H	0.3554
109	G	H	-0.0313
110	S	H	0.0512
111	T	H	0.2809
112A	Y	H	0.8772
112	V	H	0.3994
113	D	H	0.0000
114	A	H	0.0000
115	I	H	0.0000
116	D	H	-0.1480
117	Y	H	0.0382
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.0654
121	G	H	-0.1709
122	T	H	0.5621
123	L	H	1.5685
124	V	H	0.0000
125	T	H	0.3395
126	V	H	0.0000
127	S	H	-0.5382
128	S	H	-0.5608
1	D	L	-2.2195
2	I	L	0.0000
3	V	L	0.7107
4	L	L	0.0000
5	T	L	-0.9558
6	Q	L	0.0000
7	S	L	-1.5051
8	P	L	-1.3846
9	D	L	-2.3745
10	S	L	-1.5098
11	L	L	-0.8974
12	A	L	-0.7385
13	V	L	-1.0228
14	S	L	-0.9940
15	L	L	-0.0137
16	G	L	-1.1522
17	E	L	-2.5859
18	R	L	-2.5032
19	A	L	0.0000
20	T	L	-0.8641
21	I	L	0.0000
22	N	L	-1.8060
23	C	L	0.0000
24	R	L	-2.4688
25	A	L	0.0000
26	S	L	-0.9987
27	E	L	-1.6562
28	S	L	-1.5024
29	V	L	0.0000
30	E	L	-1.2245
31	S	L	-0.2284
34	Y	L	0.8673
35	G	L	-0.2881
36	N	L	-0.5478
37	R	L	-1.0385
38	Y	L	0.0000
39	M	L	0.0000
40	T	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.1361
46	P	L	-0.8013
47	G	L	-1.2780
48	Q	L	-1.7688
49	P	L	-1.1690
50	P	L	0.0000
51	K	L	-1.1324
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1925
56	R	L	-0.3159
57	A	L	0.0000
65	A	L	-0.3230
66	N	L	-0.3141
67	L	L	-0.0671
68	Q	L	-0.4488
69	S	L	-0.4615
70	G	L	-0.7467
71	V	L	0.0000
72	P	L	-1.0870
74	D	L	-1.9450
75	R	L	-1.4044
76	F	L	0.0000
77	S	L	-0.6077
78	G	L	-0.3251
79	S	L	-0.8140
80	G	L	-1.2090
83	S	L	-1.2573
84	G	L	-1.4276
85	T	L	-1.8011
86	D	L	-2.2612
87	F	L	0.0000
88	T	L	-1.0459
89	L	L	0.0000
90	T	L	0.0000
91	I	L	0.0000
92	S	L	-1.6690
93	S	L	-1.6169
94	L	L	0.0000
95	Q	L	-1.0885
96	A	L	-0.9013
97	E	L	-1.7841
98	D	L	0.0000
99	V	L	-0.6058
100	A	L	0.0000
101	V	L	-0.5182
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	0.0000
108	N	L	-1.4476
109	E	L	-2.9180
114	D	L	-2.8928
115	P	L	-2.0728
116	W	L	0.0000
117	T	L	-0.5889
118	F	L	0.1359
119	G	L	0.0000
120	Q	L	-1.3899
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.4989
124	V	L	0.0000
125	E	L	-1.1207
126	I	L	-0.7663
127	K	L	-1.5044