| Chain sequence(s) |
A: GPLPGNPEPPPRSTSEYVTPTDLLYYAETDLLTETGHPTKDIVVDGKVLVPKVSAYQWKVFKLKLPDPNKLPLPSEDFIDPETEILIWQLEAYRIGVGGPLGVGEYGHPNWNRLGNVTNPTAYQHGGPDDTQNYSFTPKRLQMYIIGDQPPIGKYTAPAEPAPGLPPGATPPTKEVTTIIQHGDMADIGFGAKDFKALYPRKNEVPDIIRDTTTKVPDIDGMKAEPYGDRMFDYDRYESSYDKETYVLDGPDPNPLPSSPPPSLLYTPPPPSSPYAVLPSRNYFTIPDRGEITEEDLLFNKPRFLEKTEGLNNGVLWHNQLYITILDNSRAEIEEIKTQLSTPEINVYNPENYLTSKRYTEEYQISLILRLCKIPLTPEILEELRRRDPRILVDANLPFIPPVERPDPLAGLKFKEIDLTNKLSSDLEKSPLGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2089 | |
| 2 | P | A | 0.1104 | |
| 3 | L | A | 0.8553 | |
| 4 | P | A | -0.2604 | |
| 5 | G | A | -1.1606 | |
| 6 | N | A | -1.9779 | |
| 7 | P | A | -2.0415 | |
| 8 | E | A | -2.5562 | |
| 9 | P | A | -1.6377 | |
| 10 | P | A | -1.1597 | |
| 11 | P | A | -1.0160 | |
| 12 | R | A | -1.4164 | |
| 13 | S | A | -1.0081 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.4563 | |
| 16 | E | A | -2.0969 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6405 | |
| 20 | P | A | -0.7974 | |
| 21 | T | A | -0.9605 | |
| 22 | D | A | -1.6764 | |
| 23 | L | A | -0.5514 | |
| 24 | L | A | -0.3017 | |
| 25 | Y | A | -0.1666 | |
| 26 | Y | A | -0.6547 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.1478 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3676 | |
| 31 | L | A | 0.3175 | |
| 32 | L | A | 0.0237 | |
| 33 | T | A | -0.2393 | |
| 34 | E | A | -0.4232 | |
| 35 | T | A | -0.3934 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.3931 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.4627 | |
| 40 | K | A | -2.1780 | |
| 41 | D | A | -0.7365 | |
| 42 | I | A | 1.3345 | |
| 43 | V | A | 2.2269 | |
| 44 | V | A | 1.4375 | |
| 45 | D | A | -1.0369 | |
| 46 | G | A | -0.5965 | |
| 47 | K | A | -0.2358 | |
| 48 | V | A | 1.9633 | |
| 49 | L | A | 2.4845 | |
| 50 | V | A | 1.1613 | |
| 51 | P | A | -0.0702 | |
| 52 | K | A | -1.0867 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -2.0146 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -3.0342 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.5021 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.7948 | |
| 70 | K | A | -1.9744 | |
| 71 | L | A | -0.8418 | |
| 72 | P | A | -0.6040 | |
| 73 | L | A | -0.4541 | |
| 74 | P | A | -0.5533 | |
| 75 | S | A | -1.4071 | |
| 76 | E | A | -2.7093 | |
| 77 | D | A | -2.7238 | |
| 78 | F | A | -1.3075 | |
| 79 | I | A | -1.6564 | |
| 80 | D | A | -2.5011 | |
| 81 | P | A | -2.0541 | |
| 82 | E | A | -2.2430 | |
| 83 | T | A | -1.5362 | |
| 84 | E | A | -1.4707 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | -0.3905 | |
| 90 | L | A | 0.0000 | |
| 91 | E | A | -0.7068 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | R | A | -1.1186 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -0.8156 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.6162 | |
| 99 | G | A | -0.9187 | |
| 100 | P | A | -0.4811 | |
| 101 | L | A | -0.1762 | |
| 102 | G | A | -0.2807 | |
| 103 | V | A | -0.3309 | |
| 104 | G | A | 0.0000 | |
| 105 | E | A | -1.3071 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.1082 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.9103 | |
| 110 | N | A | -2.8085 | |
| 111 | W | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -0.8516 | |
| 114 | L | A | -0.8322 | |
| 115 | G | A | 0.0000 | |
| 116 | N | A | -0.4191 | |
| 117 | V | A | -0.0460 | |
| 118 | T | A | -0.7035 | |
| 119 | N | A | -1.4202 | |
| 120 | P | A | -0.7575 | |
| 121 | T | A | -0.4196 | |
| 122 | A | A | -0.1321 | |
| 123 | Y | A | 0.5554 | |
| 124 | Q | A | -0.0429 | |
| 125 | H | A | -0.3176 | |
| 126 | G | A | -1.1668 | |
| 127 | G | A | -1.5079 | |
| 128 | P | A | -1.4960 | |
| 129 | D | A | -2.6837 | |
| 130 | D | A | -2.2338 | |
| 131 | T | A | -2.3463 | |
| 132 | Q | A | -2.7300 | |
| 133 | N | A | -2.3890 | |
| 134 | Y | A | -1.3165 | |
| 135 | S | A | -0.9243 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | M | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | Q | A | -0.3839 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | 0.1559 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.6628 | |
| 155 | Y | A | -1.0238 | |
| 156 | T | A | -1.4709 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -1.3613 | |
| 159 | A | A | -1.8588 | |
| 160 | E | A | -2.2696 | |
| 161 | P | A | -1.1731 | |
| 162 | A | A | -0.5507 | |
| 163 | P | A | -0.5195 | |
| 164 | G | A | -0.2471 | |
| 165 | L | A | 0.3151 | |
| 166 | P | A | -0.1924 | |
| 167 | P | A | -0.4612 | |
| 168 | G | A | -0.6009 | |
| 169 | A | A | -0.3450 | |
| 170 | T | A | -0.3385 | |
| 171 | P | A | -0.6275 | |
| 172 | P | A | -1.1003 | |
| 173 | T | A | -1.7374 | |
| 174 | K | A | -2.7799 | |
| 175 | E | A | -2.6595 | |
| 176 | V | A | -1.2742 | |
| 177 | T | A | -0.5533 | |
| 178 | T | A | -0.0948 | |
| 179 | I | A | 0.0377 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.8241 | |
| 182 | H | A | -1.1878 | |
| 183 | G | A | -0.7879 | |
| 184 | D | A | -0.6848 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.1827 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2960 | |
| 190 | F | A | 0.0104 | |
| 191 | G | A | -0.1885 | |
| 192 | A | A | -0.5016 | |
| 193 | K | A | -1.0291 | |
| 194 | D | A | -1.2258 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -2.8689 | |
| 197 | A | A | -1.3565 | |
| 198 | L | A | -0.7410 | |
| 199 | Y | A | -1.4706 | |
| 200 | P | A | -1.7452 | |
| 201 | R | A | -2.4679 | |
| 202 | K | A | -2.5281 | |
| 203 | N | A | -1.9210 | |
| 204 | E | A | -1.3120 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.8305 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -2.5003 | |
| 211 | D | A | -3.0194 | |
| 212 | T | A | -1.7876 | |
| 213 | T | A | -1.1589 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.1940 | |
| 217 | P | A | -0.1380 | |
| 218 | D | A | -0.8164 | |
| 219 | I | A | -1.0921 | |
| 220 | D | A | -2.3283 | |
| 221 | G | A | -1.5568 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.5146 | |
| 224 | A | A | -1.3807 | |
| 225 | E | A | -1.2158 | |
| 226 | P | A | -0.7288 | |
| 227 | Y | A | -0.6082 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.5648 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.9216 | |
| 234 | Y | A | -0.5388 | |
| 235 | D | A | -1.2707 | |
| 236 | R | A | -2.0229 | |
| 237 | Y | A | -1.0655 | |
| 238 | E | A | -1.3639 | |
| 239 | S | A | -0.6192 | |
| 240 | S | A | -0.5717 | |
| 241 | Y | A | -0.4092 | |
| 242 | D | A | -1.8844 | |
| 243 | K | A | -1.7729 | |
| 244 | E | A | -1.4578 | |
| 245 | T | A | -0.5824 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | -0.0992 | |
| 249 | D | A | -1.0710 | |
| 250 | G | A | -0.6927 | |
| 251 | P | A | -1.0685 | |
| 252 | D | A | -1.4707 | |
| 253 | P | A | -1.3255 | |
| 254 | N | A | -1.7324 | |
| 255 | P | A | -0.9284 | |
| 256 | L | A | 0.1488 | |
| 257 | P | A | -0.2145 | |
| 258 | S | A | -0.3407 | |
| 259 | S | A | -0.2015 | |
| 260 | P | A | 0.3582 | |
| 261 | P | A | 0.1773 | |
| 262 | P | A | 0.3984 | |
| 263 | S | A | 0.6492 | |
| 264 | L | A | 1.7195 | |
| 265 | L | A | 2.2282 | |
| 266 | Y | A | 1.7724 | |
| 267 | T | A | 0.6493 | |
| 268 | P | A | 0.4996 | |
| 269 | P | A | 0.3632 | |
| 270 | P | A | -0.2061 | |
| 271 | P | A | -0.1261 | |
| 272 | S | A | -0.3278 | |
| 273 | S | A | 0.2145 | |
| 274 | P | A | 0.5410 | |
| 275 | Y | A | 1.5376 | |
| 276 | A | A | 1.2075 | |
| 277 | V | A | 2.2198 | |
| 278 | L | A | 1.6730 | |
| 279 | P | A | 0.3066 | |
| 280 | S | A | -0.4153 | |
| 281 | R | A | -0.8373 | |
| 282 | N | A | -0.4360 | |
| 283 | Y | A | 1.0056 | |
| 284 | F | A | 0.7027 | |
| 285 | T | A | -0.2045 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.1742 | |
| 289 | R | A | -0.9946 | |
| 290 | G | A | -1.2033 | |
| 291 | E | A | -1.7256 | |
| 292 | I | A | -1.3412 | |
| 293 | T | A | -1.9215 | |
| 294 | E | A | -2.7516 | |
| 295 | E | A | -2.9728 | |
| 296 | D | A | -2.1593 | |
| 297 | L | A | -1.4304 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6146 | |
| 301 | K | A | -1.7782 | |
| 302 | P | A | -1.2143 | |
| 303 | R | A | -0.9772 | |
| 304 | F | A | -0.5610 | |
| 305 | L | A | -1.2411 | |
| 306 | E | A | -2.5669 | |
| 307 | K | A | -3.0106 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.5023 | |
| 310 | G | A | -1.5017 | |
| 311 | L | A | -0.7383 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.2451 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9403 | |
| 319 | N | A | -1.0580 | |
| 320 | Q | A | -1.2527 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.5121 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.1674 | |
| 333 | I | A | -1.9724 | |
| 334 | E | A | -2.7124 | |
| 335 | E | A | -2.5445 | |
| 336 | I | A | -0.5260 | |
| 337 | K | A | -1.1607 | |
| 338 | T | A | -0.1973 | |
| 339 | Q | A | -0.5487 | |
| 340 | L | A | 0.9288 | |
| 341 | S | A | -0.0021 | |
| 342 | T | A | -0.1929 | |
| 343 | P | A | -0.4141 | |
| 344 | E | A | -0.5701 | |
| 345 | I | A | 1.2155 | |
| 346 | N | A | 0.3203 | |
| 347 | V | A | 1.6348 | |
| 348 | Y | A | 1.2392 | |
| 349 | N | A | -0.5938 | |
| 350 | P | A | -0.6390 | |
| 351 | E | A | -1.3959 | |
| 352 | N | A | -0.7036 | |
| 353 | Y | A | 0.3540 | |
| 354 | L | A | 0.9627 | |
| 355 | T | A | -0.3723 | |
| 356 | S | A | -0.8168 | |
| 357 | K | A | -1.9444 | |
| 358 | R | A | -1.6392 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.8799 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.5651 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.8603 | |
| 365 | I | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | R | A | -0.5804 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.5725 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.8394 | |
| 376 | L | A | -0.9033 | |
| 377 | T | A | -0.9406 | |
| 378 | P | A | -1.5048 | |
| 379 | E | A | -2.4379 | |
| 380 | I | A | 0.0000 | |
| 381 | L | A | -1.8327 | |
| 382 | E | A | -3.1295 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | R | A | -2.8841 | |
| 386 | R | A | -2.1969 | |
| 387 | R | A | -1.6225 | |
| 388 | D | A | -1.2239 | |
| 389 | P | A | -1.5489 | |
| 390 | R | A | -1.3968 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.8671 | |
| 394 | D | A | -1.5937 | |
| 395 | A | A | -1.2862 | |
| 396 | N | A | -1.3964 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.1149 | |
| 399 | F | A | 1.4848 | |
| 400 | I | A | 0.9278 | |
| 401 | P | A | 0.3451 | |
| 402 | P | A | -0.2292 | |
| 403 | V | A | 0.2474 | |
| 404 | E | A | -1.8629 | |
| 405 | R | A | -2.0340 | |
| 406 | P | A | -1.6768 | |
| 407 | D | A | -1.8946 | |
| 408 | P | A | -0.9344 | |
| 409 | L | A | -0.5582 | |
| 410 | A | A | -0.7241 | |
| 411 | G | A | -0.7590 | |
| 412 | L | A | -0.5903 | |
| 413 | K | A | -2.0340 | |
| 414 | F | A | -1.5955 | |
| 415 | K | A | -2.1576 | |
| 416 | E | A | -3.1179 | |
| 417 | I | A | -2.4608 | |
| 418 | D | A | -3.3005 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.9485 | |
| 421 | N | A | -2.2860 | |
| 422 | K | A | -2.2685 | |
| 423 | L | A | -0.8437 | |
| 424 | S | A | -1.0657 | |
| 425 | S | A | -0.7591 | |
| 426 | D | A | -1.9063 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.2161 | |
| 429 | K | A | -3.0778 | |
| 430 | S | A | 0.0000 | |
| 431 | P | A | -1.4967 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.7351 | |
| 435 | E | A | -1.9835 | |
| 436 | Y | A | -1.1615 | |
| 437 | L | A | -0.7733 | |
| 438 | N | A | -2.0567 | |
| 439 | R | A | -2.3182 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine