| Chain sequence(s) |
A: GPLPLNPGPKLKSTDEFVEPTDLLYYAETDLITEVGNPTKDIVVNGKVLIPKVSAYQWKVFLLTLPDPNTLPLPSEDFVDPSTEILIWRLLAYRIHKFGPLGKGTYGHPNFNALGDVDNPTEYVVEGEDDTQNLSWTPKRLQEYIIGDLPPIGKYTAKAAPEPGLPPGAPPPTKTVSTIIEHGDMADIGFGAKDFKALEPRKNEVPDIILNTTTKVVDYDGMKAEPTGRRMFDSNRYESSSNSKNLVLSGEDLFPLPAAPPPSPLYTKPPPTSPFWKLPPYRYFTLPDAGEISEDDLIFNKPIWLTETPGLNNGILWNNRLYITVLDNSRSEIETIQTQIATPEKNVYNPDYYVTSKRYKEEYKIELIVQLCRIPLTPEVLAYLESVDPRILVNANLPDIPKVERKDPYEGKKFINIDLTDKLSSDLSSSDLGRAYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2009 | |
| 2 | P | A | 0.4318 | |
| 3 | L | A | 1.3834 | |
| 4 | P | A | 0.6667 | |
| 5 | L | A | 1.0270 | |
| 6 | N | A | -0.6561 | |
| 7 | P | A | -1.0538 | |
| 8 | G | A | -1.1052 | |
| 9 | P | A | -1.6230 | |
| 10 | K | A | -1.4684 | |
| 11 | L | A | 0.1464 | |
| 12 | K | A | -0.9614 | |
| 13 | S | A | -1.1984 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -3.1675 | |
| 16 | E | A | -2.9738 | |
| 17 | F | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.2244 | |
| 20 | P | A | -1.6327 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6125 | |
| 23 | L | A | -0.4448 | |
| 24 | L | A | -0.2553 | |
| 25 | Y | A | -0.3103 | |
| 26 | Y | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.3490 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.5823 | |
| 31 | L | A | 0.4633 | |
| 32 | I | A | 0.3085 | |
| 33 | T | A | 0.0689 | |
| 34 | E | A | -0.1324 | |
| 35 | V | A | 0.1954 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -1.7036 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.6277 | |
| 40 | K | A | -1.9264 | |
| 41 | D | A | -0.6542 | |
| 42 | I | A | 1.3887 | |
| 43 | V | A | 2.3342 | |
| 44 | V | A | 1.6089 | |
| 45 | N | A | -0.5848 | |
| 46 | G | A | -0.4002 | |
| 47 | K | A | -0.0823 | |
| 48 | V | A | 2.1165 | |
| 49 | L | A | 2.7170 | |
| 50 | I | A | 1.6685 | |
| 51 | P | A | 0.3606 | |
| 52 | K | A | -0.9303 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.0960 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.7489 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.9841 | |
| 70 | T | A | -0.4368 | |
| 71 | L | A | 0.0061 | |
| 72 | P | A | -0.2194 | |
| 73 | L | A | -0.2921 | |
| 74 | P | A | -0.6174 | |
| 75 | S | A | -1.5099 | |
| 76 | E | A | -2.8256 | |
| 77 | D | A | -2.8708 | |
| 78 | F | A | -1.5310 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -2.2281 | |
| 81 | P | A | -1.4802 | |
| 82 | S | A | -1.0406 | |
| 83 | T | A | -0.7721 | |
| 84 | E | A | -0.9677 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3400 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.0000 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | R | A | -0.8165 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.4628 | |
| 97 | K | A | 0.0000 | |
| 98 | F | A | 0.3984 | |
| 99 | G | A | -0.5306 | |
| 100 | P | A | -0.4460 | |
| 101 | L | A | -0.4343 | |
| 102 | G | A | -1.1421 | |
| 103 | K | A | -1.4864 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5499 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.8848 | |
| 108 | H | A | -1.6917 | |
| 109 | P | A | -1.9255 | |
| 110 | N | A | -2.8638 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | -0.3177 | |
| 115 | G | A | -0.7059 | |
| 116 | D | A | -1.6863 | |
| 117 | V | A | -1.1999 | |
| 118 | D | A | -2.6172 | |
| 119 | N | A | -2.6576 | |
| 120 | P | A | -1.8093 | |
| 121 | T | A | -1.5658 | |
| 122 | E | A | -1.6269 | |
| 123 | Y | A | 0.3408 | |
| 124 | V | A | 0.4593 | |
| 125 | V | A | 1.0404 | |
| 126 | E | A | -1.0384 | |
| 127 | G | A | -1.9948 | |
| 128 | E | A | -3.1948 | |
| 129 | D | A | -3.4277 | |
| 130 | D | A | -2.1657 | |
| 131 | T | A | -2.3190 | |
| 132 | Q | A | -2.6205 | |
| 133 | N | A | -2.3971 | |
| 134 | L | A | -1.2703 | |
| 135 | S | A | -0.7072 | |
| 136 | W | A | 0.0000 | |
| 137 | T | A | -0.5288 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | L | A | 0.1011 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | 0.1237 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.3635 | |
| 155 | Y | A | -0.5311 | |
| 156 | T | A | -1.0895 | |
| 157 | A | A | -1.6329 | |
| 158 | K | A | -2.2231 | |
| 159 | A | A | -1.5919 | |
| 160 | A | A | -1.1228 | |
| 161 | P | A | -1.3529 | |
| 162 | E | A | -1.9790 | |
| 163 | P | A | -1.1918 | |
| 164 | G | A | -0.6960 | |
| 165 | L | A | -0.1179 | |
| 166 | P | A | -0.1368 | |
| 167 | P | A | -0.3785 | |
| 168 | G | A | -0.7045 | |
| 169 | A | A | 0.0257 | |
| 170 | P | A | -0.4170 | |
| 171 | P | A | -1.0104 | |
| 172 | P | A | -1.2592 | |
| 173 | T | A | -1.5459 | |
| 174 | K | A | -2.0862 | |
| 175 | T | A | -1.1257 | |
| 176 | V | A | -0.6515 | |
| 177 | S | A | -0.3490 | |
| 178 | T | A | -0.0444 | |
| 179 | I | A | -0.2356 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.1380 | |
| 182 | H | A | -1.0182 | |
| 183 | G | A | -0.7227 | |
| 184 | D | A | -0.7382 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2190 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.4463 | |
| 190 | F | A | -0.1427 | |
| 191 | G | A | -0.2901 | |
| 192 | A | A | -0.3310 | |
| 193 | K | A | -1.0963 | |
| 194 | D | A | -1.4158 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -2.9984 | |
| 197 | A | A | -1.5624 | |
| 198 | L | A | -1.5125 | |
| 199 | E | A | -2.0226 | |
| 200 | P | A | -2.2382 | |
| 201 | R | A | -3.0515 | |
| 202 | K | A | -3.4428 | |
| 203 | N | A | -2.3519 | |
| 204 | E | A | -1.4280 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.6033 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.7252 | |
| 211 | N | A | -2.3757 | |
| 212 | T | A | -1.2997 | |
| 213 | T | A | -0.9267 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.1183 | |
| 217 | V | A | 0.0000 | |
| 218 | D | A | -0.9227 | |
| 219 | Y | A | -1.3803 | |
| 220 | D | A | -2.4882 | |
| 221 | G | A | -1.7364 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.6259 | |
| 224 | A | A | -1.6189 | |
| 225 | E | A | -1.4148 | |
| 226 | P | A | -0.5728 | |
| 227 | T | A | -0.2184 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.4564 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.7099 | |
| 234 | S | A | -0.8681 | |
| 235 | N | A | -1.3244 | |
| 236 | R | A | -1.6676 | |
| 237 | Y | A | -0.7908 | |
| 238 | E | A | -0.8536 | |
| 239 | S | A | -0.6895 | |
| 240 | S | A | -1.1064 | |
| 241 | S | A | -1.3920 | |
| 242 | N | A | -1.8476 | |
| 243 | S | A | -1.4937 | |
| 244 | K | A | -1.9007 | |
| 245 | N | A | -1.2911 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | 0.0240 | |
| 249 | S | A | -0.5867 | |
| 250 | G | A | -1.1877 | |
| 251 | E | A | -1.7819 | |
| 252 | D | A | -0.4786 | |
| 253 | L | A | 0.6349 | |
| 254 | F | A | 1.7979 | |
| 255 | P | A | 0.6445 | |
| 256 | L | A | 1.2687 | |
| 257 | P | A | 0.5038 | |
| 258 | A | A | -0.0115 | |
| 259 | A | A | -0.0403 | |
| 260 | P | A | -0.5849 | |
| 261 | P | A | -0.5208 | |
| 262 | P | A | -0.3997 | |
| 263 | S | A | 0.0048 | |
| 264 | P | A | 0.3822 | |
| 265 | L | A | 1.4779 | |
| 266 | Y | A | 0.7309 | |
| 267 | T | A | -0.1058 | |
| 268 | K | A | -0.3637 | |
| 269 | P | A | -0.1691 | |
| 270 | P | A | -0.2374 | |
| 271 | P | A | -0.3919 | |
| 272 | T | A | -0.0136 | |
| 273 | S | A | 0.0855 | |
| 274 | P | A | 0.3767 | |
| 275 | F | A | 1.2222 | |
| 276 | W | A | 0.2199 | |
| 277 | K | A | -0.5519 | |
| 278 | L | A | 0.6096 | |
| 279 | P | A | 0.6422 | |
| 280 | P | A | 0.1239 | |
| 281 | Y | A | 0.8430 | |
| 282 | R | A | 0.3624 | |
| 283 | Y | A | 1.4421 | |
| 284 | F | A | 0.7572 | |
| 285 | T | A | -0.3775 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.2909 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -1.4416 | |
| 291 | E | A | -1.9363 | |
| 292 | I | A | -1.4750 | |
| 293 | S | A | -1.9422 | |
| 294 | E | A | -2.7243 | |
| 295 | D | A | -2.9076 | |
| 296 | D | A | -1.8830 | |
| 297 | L | A | -1.3321 | |
| 298 | I | A | -1.0513 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1718 | |
| 301 | K | A | -1.5652 | |
| 302 | P | A | -0.8544 | |
| 303 | I | A | 0.0546 | |
| 304 | W | A | 0.1426 | |
| 305 | L | A | -0.2580 | |
| 306 | T | A | -0.7566 | |
| 307 | E | A | -2.0233 | |
| 308 | T | A | 0.0000 | |
| 309 | P | A | -1.0091 | |
| 310 | G | A | -0.8120 | |
| 311 | L | A | -0.4086 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | N | A | -0.6152 | |
| 319 | N | A | -0.6499 | |
| 320 | R | A | -0.6331 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.7775 | |
| 331 | S | A | 0.0000 | |
| 332 | E | A | -2.6593 | |
| 333 | I | A | -2.2984 | |
| 334 | E | A | -2.7583 | |
| 335 | T | A | -1.7241 | |
| 336 | I | A | -0.6283 | |
| 337 | Q | A | -0.6928 | |
| 338 | T | A | 0.1295 | |
| 339 | Q | A | -0.1814 | |
| 340 | I | A | 1.5426 | |
| 341 | A | A | 0.3836 | |
| 342 | T | A | -0.6090 | |
| 343 | P | A | -1.2377 | |
| 344 | E | A | -2.3601 | |
| 345 | K | A | -2.5686 | |
| 346 | N | A | -1.5485 | |
| 347 | V | A | 0.3586 | |
| 348 | Y | A | 0.7651 | |
| 349 | N | A | -0.3235 | |
| 350 | P | A | -0.4930 | |
| 351 | D | A | -1.1455 | |
| 352 | Y | A | -0.2485 | |
| 353 | Y | A | 0.5554 | |
| 354 | V | A | 1.1501 | |
| 355 | T | A | -0.0615 | |
| 356 | S | A | -1.0459 | |
| 357 | K | A | -2.5204 | |
| 358 | R | A | -2.5204 | |
| 359 | Y | A | 0.0000 | |
| 360 | K | A | -1.4795 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | 0.0390 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.5276 | |
| 365 | I | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3742 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -1.0918 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7688 | |
| 376 | L | A | -0.3060 | |
| 377 | T | A | -0.6046 | |
| 378 | P | A | -0.9516 | |
| 379 | E | A | -1.8065 | |
| 380 | V | A | 0.0000 | |
| 381 | L | A | -0.4024 | |
| 382 | A | A | -0.8414 | |
| 383 | Y | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -0.8435 | |
| 386 | S | A | -0.4286 | |
| 387 | V | A | 0.0038 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -0.5063 | |
| 390 | R | A | -1.3059 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.4939 | |
| 394 | N | A | -1.9285 | |
| 395 | A | A | -1.2036 | |
| 396 | N | A | -2.0932 | |
| 397 | L | A | -1.4580 | |
| 398 | P | A | -1.5001 | |
| 399 | D | A | -2.1243 | |
| 400 | I | A | -1.0862 | |
| 401 | P | A | -1.1358 | |
| 402 | K | A | -2.0265 | |
| 403 | V | A | -0.4012 | |
| 404 | E | A | -2.5040 | |
| 405 | R | A | -2.7012 | |
| 406 | K | A | -3.0734 | |
| 407 | D | A | -2.5169 | |
| 408 | P | A | -1.7509 | |
| 409 | Y | A | -1.8526 | |
| 410 | E | A | -3.0665 | |
| 411 | G | A | -2.2287 | |
| 412 | K | A | -2.4988 | |
| 413 | K | A | -2.6849 | |
| 414 | F | A | -1.2279 | |
| 415 | I | A | -0.7802 | |
| 416 | N | A | -1.6295 | |
| 417 | I | A | -1.4487 | |
| 418 | D | A | -2.7036 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8167 | |
| 421 | D | A | -2.6666 | |
| 422 | K | A | -2.6538 | |
| 423 | L | A | -1.1992 | |
| 424 | S | A | -1.1219 | |
| 425 | S | A | -0.7348 | |
| 426 | D | A | -1.7133 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.2688 | |
| 429 | S | A | -1.3673 | |
| 430 | S | A | 0.0000 | |
| 431 | D | A | -2.1739 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.0726 | |
| 435 | A | A | -1.3400 | |
| 436 | Y | A | -0.5753 | |
| 437 | L | A | -0.0117 | |
| 438 | N | A | -1.6835 | |
| 439 | R | A | -2.0610 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine