| Chain sequence(s) |
A: GPPPANPAPELRSTDEYVEPTDLLYYAETDLLTETGDPTKDIIEDGKVKVKKVSAYQWKVFKLTLPDPNELPLPSPDAVDPATEILIWRLRAFEIKRFGKLGTGSYGHANFNKLGDVTNPTAPVHDSADVTVNYSFTPKRKQEYIIGDKPPIGKYTAPAAPAPGLPPGALPPTETVTDIIEHGDMADIGFGAKDFKALEPEKNNVPDIILNTSTKVVDYDGMKAEPWGDRMFTYDRYESSYDKETLVRAGPDLIPPPASPPPSPLYVPPPPSSPTATRPPTDTFTIPDRGEIKESDLLFNKPIFLEKAEGLNNGILWHNQLYITVLDNTRDEIETIETKKSTPETNVYDPSNYETSRRYSEEYQLSLIVQLCRVPLTPETLAELERRDPSILVRARLPEIPPREEPDPYAGKKFIEIDLTSKLSTDLSKTPLGRKYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.7017 | |
| 2 | P | A | -0.6616 | |
| 3 | P | A | -0.8180 | |
| 4 | P | A | -0.8812 | |
| 5 | A | A | -0.8429 | |
| 6 | N | A | -1.5021 | |
| 7 | P | A | -1.2371 | |
| 8 | A | A | -0.9279 | |
| 9 | P | A | -1.3128 | |
| 10 | E | A | -1.8717 | |
| 11 | L | A | -0.7583 | |
| 12 | R | A | -1.3891 | |
| 13 | S | A | -1.3834 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -3.1742 | |
| 16 | E | A | -2.9879 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.2903 | |
| 20 | P | A | -1.6213 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6368 | |
| 23 | L | A | -0.4999 | |
| 24 | L | A | -0.1502 | |
| 25 | Y | A | -0.0657 | |
| 26 | Y | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.8747 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2514 | |
| 31 | L | A | 0.3309 | |
| 32 | L | A | 0.1526 | |
| 33 | T | A | -0.2164 | |
| 34 | E | A | -0.8039 | |
| 35 | T | A | -0.9813 | |
| 36 | G | A | 0.0000 | |
| 37 | D | A | 0.0000 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.6678 | |
| 40 | K | A | -2.1553 | |
| 41 | D | A | -1.9923 | |
| 42 | I | A | -0.3648 | |
| 43 | I | A | -0.1340 | |
| 44 | E | A | -2.0283 | |
| 45 | D | A | -2.7937 | |
| 46 | G | A | -1.9076 | |
| 47 | K | A | -2.2596 | |
| 48 | V | A | -0.9119 | |
| 49 | K | A | -1.8135 | |
| 50 | V | A | -1.2887 | |
| 51 | K | A | -2.1863 | |
| 52 | K | A | -2.1672 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1726 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.2039 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -2.0733 | |
| 70 | E | A | -2.1594 | |
| 71 | L | A | -0.9179 | |
| 72 | P | A | -0.5685 | |
| 73 | L | A | -0.4165 | |
| 74 | P | A | -0.3999 | |
| 75 | S | A | -0.8355 | |
| 76 | P | A | -1.2982 | |
| 77 | D | A | -2.1599 | |
| 78 | A | A | -1.1801 | |
| 79 | V | A | -1.3492 | |
| 80 | D | A | -1.8183 | |
| 81 | P | A | -1.4046 | |
| 82 | A | A | -0.5361 | |
| 83 | T | A | -0.5923 | |
| 84 | E | A | -0.8958 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.4923 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | E | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | K | A | -0.5819 | |
| 97 | R | A | 0.0000 | |
| 98 | F | A | 0.0680 | |
| 99 | G | A | -1.0009 | |
| 100 | K | A | -1.5655 | |
| 101 | L | A | -0.7863 | |
| 102 | G | A | -0.4912 | |
| 103 | T | A | -0.5127 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.2206 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.8469 | |
| 108 | H | A | -1.3867 | |
| 109 | A | A | -1.2998 | |
| 110 | N | A | -2.2112 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | K | A | -0.8240 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0765 | |
| 116 | D | A | -0.1350 | |
| 117 | V | A | 0.5012 | |
| 118 | T | A | -0.5106 | |
| 119 | N | A | -0.7775 | |
| 120 | P | A | -0.3240 | |
| 121 | T | A | -0.2097 | |
| 122 | A | A | -0.0688 | |
| 123 | P | A | -0.0894 | |
| 124 | V | A | 0.6087 | |
| 125 | H | A | -1.1782 | |
| 126 | D | A | -2.0670 | |
| 127 | S | A | -1.6534 | |
| 128 | A | A | -1.4030 | |
| 129 | D | A | -2.3633 | |
| 130 | V | A | 0.0000 | |
| 131 | T | A | -1.4007 | |
| 132 | V | A | -1.1657 | |
| 133 | N | A | -1.5611 | |
| 134 | Y | A | -0.8051 | |
| 135 | S | A | -0.4899 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.4553 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | K | A | -0.5541 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | -0.1884 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.5650 | |
| 155 | Y | A | -0.5874 | |
| 156 | T | A | -0.7259 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.4325 | |
| 159 | A | A | -0.5771 | |
| 160 | A | A | -0.3368 | |
| 161 | P | A | -0.0606 | |
| 162 | A | A | -0.1187 | |
| 163 | P | A | -0.3173 | |
| 164 | G | A | -0.3135 | |
| 165 | L | A | 0.4257 | |
| 166 | P | A | -0.0547 | |
| 167 | P | A | -0.2676 | |
| 168 | G | A | -0.1460 | |
| 169 | A | A | 0.5366 | |
| 170 | L | A | 1.3728 | |
| 171 | P | A | 0.4179 | |
| 172 | P | A | -0.0803 | |
| 173 | T | A | -0.6758 | |
| 174 | E | A | -1.4246 | |
| 175 | T | A | -0.8471 | |
| 176 | V | A | -0.4462 | |
| 177 | T | A | -0.4872 | |
| 178 | D | A | -0.5823 | |
| 179 | I | A | -0.5599 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.0887 | |
| 182 | H | A | -0.9240 | |
| 183 | G | A | -0.6946 | |
| 184 | D | A | -0.7272 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2089 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2713 | |
| 190 | F | A | 0.0152 | |
| 191 | G | A | -0.2565 | |
| 192 | A | A | -0.3688 | |
| 193 | K | A | -0.8044 | |
| 194 | D | A | -1.1799 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -2.7053 | |
| 197 | A | A | -1.2402 | |
| 198 | L | A | -1.0789 | |
| 199 | E | A | -2.0785 | |
| 200 | P | A | -2.2099 | |
| 201 | E | A | -2.8450 | |
| 202 | K | A | -3.5200 | |
| 203 | N | A | -2.2331 | |
| 204 | N | A | -1.4546 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.7689 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.8886 | |
| 211 | N | A | -2.4618 | |
| 212 | T | A | -1.4018 | |
| 213 | S | A | -1.0474 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.0574 | |
| 217 | V | A | 0.0000 | |
| 218 | D | A | -1.0553 | |
| 219 | Y | A | -1.4049 | |
| 220 | D | A | -2.5072 | |
| 221 | G | A | -1.7293 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.9031 | |
| 224 | A | A | -1.5692 | |
| 225 | E | A | -1.3021 | |
| 226 | P | A | -0.5108 | |
| 227 | W | A | -0.4235 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.6636 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -1.0074 | |
| 234 | Y | A | -0.8374 | |
| 235 | D | A | -1.5396 | |
| 236 | R | A | -2.3244 | |
| 237 | Y | A | -1.4520 | |
| 238 | E | A | -1.8274 | |
| 239 | S | A | -0.7678 | |
| 240 | S | A | -0.8662 | |
| 241 | Y | A | -0.5700 | |
| 242 | D | A | -2.2072 | |
| 243 | K | A | -2.5176 | |
| 244 | E | A | -1.7096 | |
| 245 | T | A | -0.8798 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.7296 | |
| 249 | A | A | -0.9413 | |
| 250 | G | A | -0.5347 | |
| 251 | P | A | -0.2734 | |
| 252 | D | A | 0.0615 | |
| 253 | L | A | 1.4537 | |
| 254 | I | A | 1.5283 | |
| 255 | P | A | 0.3224 | |
| 256 | P | A | 0.1941 | |
| 257 | P | A | -0.2071 | |
| 258 | A | A | -0.3029 | |
| 259 | S | A | -0.5021 | |
| 260 | P | A | -0.6568 | |
| 261 | P | A | -0.6507 | |
| 262 | P | A | 0.0429 | |
| 263 | S | A | 0.5861 | |
| 264 | P | A | 0.7519 | |
| 265 | L | A | 1.9750 | |
| 266 | Y | A | 1.7604 | |
| 267 | V | A | 1.9342 | |
| 268 | P | A | 0.4329 | |
| 269 | P | A | -0.0354 | |
| 270 | P | A | -0.3796 | |
| 271 | P | A | -0.5964 | |
| 272 | S | A | -0.5141 | |
| 273 | S | A | -0.4946 | |
| 274 | P | A | -0.4692 | |
| 275 | T | A | -0.4781 | |
| 276 | A | A | -0.4963 | |
| 277 | T | A | -0.4150 | |
| 278 | R | A | -0.5713 | |
| 279 | P | A | -0.4791 | |
| 280 | P | A | -0.3810 | |
| 281 | T | A | 0.0161 | |
| 282 | D | A | -0.2926 | |
| 283 | T | A | -0.0296 | |
| 284 | F | A | -0.1750 | |
| 285 | T | A | -0.6738 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.2844 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.3751 | |
| 291 | E | A | -2.3240 | |
| 292 | I | A | -1.8534 | |
| 293 | K | A | -3.0129 | |
| 294 | E | A | -2.8533 | |
| 295 | S | A | -1.7710 | |
| 296 | D | A | -1.6538 | |
| 297 | L | A | -1.2676 | |
| 298 | L | A | -0.9613 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3491 | |
| 301 | K | A | -1.7259 | |
| 302 | P | A | -0.9210 | |
| 303 | I | A | -0.0654 | |
| 304 | F | A | -0.4168 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.1537 | |
| 307 | K | A | -2.9538 | |
| 308 | A | A | 0.0000 | |
| 309 | E | A | -2.4579 | |
| 310 | G | A | -1.5332 | |
| 311 | L | A | -0.7798 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.5179 | |
| 319 | N | A | 0.0000 | |
| 320 | Q | A | -0.5967 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | D | A | 0.0000 | |
| 332 | E | A | -1.4828 | |
| 333 | I | A | -1.4402 | |
| 334 | E | A | -2.4915 | |
| 335 | T | A | -1.6408 | |
| 336 | I | A | -1.3406 | |
| 337 | E | A | -2.8312 | |
| 338 | T | A | -2.5725 | |
| 339 | K | A | -3.3974 | |
| 340 | K | A | -3.1999 | |
| 341 | S | A | -2.0054 | |
| 342 | T | A | -1.3389 | |
| 343 | P | A | -1.4338 | |
| 344 | E | A | -1.9528 | |
| 345 | T | A | -0.9140 | |
| 346 | N | A | -0.6312 | |
| 347 | V | A | 1.2534 | |
| 348 | Y | A | 1.3559 | |
| 349 | D | A | -0.1073 | |
| 350 | P | A | -0.6520 | |
| 351 | S | A | -1.2098 | |
| 352 | N | A | -1.8675 | |
| 353 | Y | A | -2.3592 | |
| 354 | E | A | -2.9085 | |
| 355 | T | A | -1.7540 | |
| 356 | S | A | -1.6178 | |
| 357 | R | A | -1.9783 | |
| 358 | R | A | -2.3304 | |
| 359 | Y | A | 0.0000 | |
| 360 | S | A | -1.0287 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.2357 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.3832 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3921 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -1.2818 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -0.7590 | |
| 376 | L | A | -0.2400 | |
| 377 | T | A | -0.5923 | |
| 378 | P | A | -0.9479 | |
| 379 | E | A | -1.9044 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.6615 | |
| 382 | A | A | -1.1106 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -1.9780 | |
| 386 | R | A | -1.4788 | |
| 387 | R | A | 0.0000 | |
| 388 | D | A | -1.0647 | |
| 389 | P | A | -1.1248 | |
| 390 | S | A | -1.3209 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.9905 | |
| 394 | R | A | -2.1499 | |
| 395 | A | A | -1.4330 | |
| 396 | R | A | -2.6651 | |
| 397 | L | A | -1.5043 | |
| 398 | P | A | -1.4355 | |
| 399 | E | A | -2.0328 | |
| 400 | I | A | -1.3958 | |
| 401 | P | A | -1.5824 | |
| 402 | P | A | -2.4135 | |
| 403 | R | A | -3.4716 | |
| 404 | E | A | -3.6580 | |
| 405 | E | A | -3.1877 | |
| 406 | P | A | -2.1474 | |
| 407 | D | A | -2.0213 | |
| 408 | P | A | -1.1396 | |
| 409 | Y | A | -0.9609 | |
| 410 | A | A | -1.0659 | |
| 411 | G | A | -1.2674 | |
| 412 | K | A | -1.7480 | |
| 413 | K | A | -2.3307 | |
| 414 | F | A | -1.3288 | |
| 415 | I | A | -1.0680 | |
| 416 | E | A | -2.2674 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.3750 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -0.8640 | |
| 421 | S | A | -0.8007 | |
| 422 | K | A | -1.0261 | |
| 423 | L | A | -0.2673 | |
| 424 | S | A | -0.5108 | |
| 425 | T | A | -0.3597 | |
| 426 | D | A | -1.1634 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.6962 | |
| 429 | K | A | -2.2685 | |
| 430 | T | A | -1.6521 | |
| 431 | P | A | -1.3375 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.4371 | |
| 435 | K | A | -2.2339 | |
| 436 | Y | A | -1.0692 | |
| 437 | L | A | -0.4562 | |
| 438 | N | A | -2.1721 | |
| 439 | R | A | -2.3450 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine