Project name: 2510-4.pdb

Chain sequence(s)	H: EVQLQQSGAELARPGASVKMSCKASGYTFTSYTIHWLKQRPGQGLEWIGYINPSSGYTNYNQKFKDKATLTADKSSSTAYMQLSSLTSEDSAVYFCARGTTAFAYWGQGTLVTVSS; L: DIKMTQSPSSLSASLGERVSLTCRASQEISGYLSWLQQKPDGTIKRLIYAASTLDSGVPKRFSGSRSGSDYSLTISSLESEDFADYYCLQYASYPLTFGAGTKLELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:02)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:21)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:23)

• Minimal score value: -3.1279
• Maximal score value: 1.3628
• Average score: -0.5952
• Total score value: -132.7351

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9881
2	V	H	-0.8762
3	Q	H	-1.5228
4	L	H	0.0000
5	Q	H	-2.0397
6	Q	H	-1.3412
7	S	H	-0.8628
8	G	H	-0.5012
9	A	H	0.3830
11	E	H	0.0527
12	L	H	0.8786
13	A	H	-0.6033
14	R	H	-1.9361
15	P	H	-1.6983
16	G	H	-1.2424
17	A	H	-1.0447
18	S	H	-1.0654
19	V	H	0.0000
20	K	H	-1.3264
21	M	H	0.0000
22	S	H	-0.7079
23	C	H	0.0000
24	K	H	-1.4714
25	A	H	0.0000
26	S	H	-1.1375
27	G	H	-1.1120
28	Y	H	-0.4226
29	T	H	-0.0605
30	F	H	0.0000
35	T	H	-0.5710
36	S	H	-0.1058
37	Y	H	0.2083
38	T	H	0.0847
39	I	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	L	H	0.0000
43	K	H	0.0000
44	Q	H	-0.5649
45	R	H	-1.0714
46	P	H	-0.7748
47	G	H	-1.1533
48	Q	H	-1.4499
49	G	H	-0.9052
50	L	H	0.0000
51	E	H	-0.8981
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	Y	H	0.0000
56	I	H	0.0000
57	N	H	-0.0871
58	P	H	0.0000
59	S	H	-0.5364
62	S	H	-0.2401
63	G	H	-0.1407
64	Y	H	0.9161
65	T	H	0.3433
66	N	H	-0.1266
67	Y	H	-0.9950
68	N	H	-1.7681
69	Q	H	-2.7033
70	K	H	-3.0540
71	F	H	0.0000
72	K	H	-3.1279
74	D	H	-3.0565
75	K	H	-2.1001
76	A	H	0.0000
77	T	H	-0.8709
78	L	H	0.0000
79	T	H	-0.2998
80	A	H	-0.7061
81	D	H	-1.4508
82	K	H	-1.8424
83	S	H	-1.0904
84	S	H	-0.9035
85	S	H	-1.0230
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.2636
89	M	H	0.0000
90	Q	H	-0.9981
91	L	H	0.0000
92	S	H	-1.0483
93	S	H	-1.0654
94	L	H	0.0000
95	T	H	-1.2600
96	S	H	-1.2947
97	E	H	-1.6728
98	D	H	0.0000
99	S	H	-0.2981
100	A	H	0.0000
101	V	H	0.6418
102	Y	H	0.0000
103	F	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	G	H	0.0000
108	T	H	-0.0321
109	T	H	0.2623
114	A	H	0.0000
115	F	H	0.0000
116	A	H	0.2103
117	Y	H	0.4081
118	W	H	-0.2414
119	G	H	0.0000
120	Q	H	-1.5809
121	G	H	0.0000
122	T	H	0.0000
123	L	H	1.3628
124	V	H	0.0000
125	T	H	0.1856
126	V	H	0.0000
127	S	H	-0.7086
128	S	H	-0.8580
1	D	L	-2.2032
2	I	L	0.0000
3	K	L	-2.6938
4	M	L	0.0000
5	T	L	-1.2866
6	Q	L	0.0000
7	S	L	-0.5696
8	P	L	-0.4460
9	S	L	-0.6117
10	S	L	-1.0083
11	L	L	-0.6178
12	S	L	-0.9973
13	A	L	0.0000
14	S	L	-0.9245
15	L	L	-0.5052
16	G	L	-1.3056
17	E	L	-1.9200
18	R	L	-2.3487
19	V	L	0.0000
20	S	L	-0.6224
21	L	L	0.0000
22	T	L	-0.8330
23	C	L	0.0000
24	R	L	-2.9141
25	A	L	0.0000
26	S	L	-2.4470
27	Q	L	-2.8244
28	E	L	-2.3595
29	I	L	0.0000
36	S	L	-0.5790
37	G	L	-0.0383
38	Y	L	1.0921
39	L	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	L	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.5181
46	P	L	-1.3757
47	D	L	-2.2565
48	G	L	-1.5247
49	T	L	-1.2376
50	I	L	0.0000
51	K	L	-0.8308
52	R	L	-0.4337
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.6034
56	A	L	0.4211
57	A	L	0.0000
65	S	L	-0.2652
66	T	L	0.0130
67	L	L	-0.3243
68	D	L	-0.5797
69	S	L	-0.5211
70	G	L	-0.8446
71	V	L	0.0000
72	P	L	-1.1230
74	K	L	-1.9125
75	R	L	-1.5098
76	F	L	0.0000
77	S	L	-0.6454
78	G	L	-0.4748
79	S	L	-1.0009
80	R	L	-1.8189
83	S	L	-1.3641
84	G	L	-1.4673
85	S	L	-2.0037
86	D	L	-1.9295
87	Y	L	0.0000
88	S	L	-0.8791
89	L	L	0.0000
90	T	L	-0.6363
91	I	L	0.0000
92	S	L	-1.5738
93	S	L	-1.5611
94	L	L	0.0000
95	E	L	-1.9882
96	S	L	-1.4116
97	E	L	-1.9072
98	D	L	0.0000
99	F	L	-1.0661
100	A	L	0.0000
101	D	L	-1.1753
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	L	L	0.0000
106	Q	L	0.0000
107	Y	L	0.7841
108	A	L	0.4444
109	S	L	0.4271
114	Y	L	0.7176
115	P	L	-0.1940
116	L	L	0.0000
117	T	L	-0.5119
118	F	L	-0.2354
119	G	L	0.0000
120	A	L	-0.5189
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.6414
124	L	L	0.0000
125	E	L	-1.6845
126	L	L	0.0017
127	K	L	-1.2749