Project name: clone58

Chain sequence(s)	H: EVQLLESGGGLVQPGGSLRLSCTASGFTFSNHAMSWVRRAPGKGLAWVSVTNNRGVMTHLLDSVKGRFIASRDNSKNTLYLEMRSLRADDTAVYYCSTAYSGWYDYWGRGTLVTVSS; L: EIVMTQSPVTLSVSPGERVTLSCRASQTVESSLAWYSQKAGQAPRLLIYDASTRATGVSARFSGSGFGTEFTLTISSQQSEDFEVYYCQQYNDWPWTFGQGTKVELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:12)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:13)

• Minimal score value: -2.6599
• Maximal score value: 1.6605
• Average score: -0.5188
• Total score value: -116.2018

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.8763
2	V	H	-0.7226
3	Q	H	-0.6820
4	L	H	0.0000
5	L	H	0.1150
6	E	H	-0.3655
7	S	H	-0.5826
8	G	H	-0.7134
9	G	H	0.1303
11	G	H	0.8431
12	L	H	1.4251
13	V	H	-0.0162
14	Q	H	-1.3184
15	P	H	-1.3970
16	G	H	-1.4548
17	G	H	-1.2676
18	S	H	-1.3769
19	L	H	-0.9926
20	R	H	-1.8269
21	L	H	0.0000
22	S	H	-0.5315
23	C	H	0.0000
24	T	H	-0.4113
25	A	H	0.0000
26	S	H	-0.7610
27	G	H	-0.9489
28	F	H	-0.5571
29	T	H	-0.6050
30	F	H	0.0000
35	S	H	-1.7533
36	N	H	-1.8310
37	H	H	-1.0074
38	A	H	-0.7209
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	R	H	-0.5511
45	A	H	-0.9665
46	P	H	-1.0298
47	G	H	-1.4623
48	K	H	-2.2609
49	G	H	-1.3189
50	L	H	0.0000
51	A	H	-0.2957
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	V	H	0.0000
56	T	H	0.0000
57	N	H	-0.9725
58	N	H	-1.7774
59	R	H	-1.9754
62	G	H	-0.4806
63	V	H	1.2246
64	M	H	0.6719
65	T	H	0.2034
66	H	H	-0.5571
67	L	H	-0.6978
68	L	H	-0.8714
69	D	H	-2.3341
70	S	H	-1.5539
71	V	H	0.0000
72	K	H	-2.2781
74	G	H	-1.4984
75	R	H	-1.3661
76	F	H	0.0000
77	I	H	-0.0234
78	A	H	0.0000
79	S	H	-0.0281
80	R	H	-1.3450
81	D	H	-1.7951
82	N	H	-2.3086
83	S	H	-1.6665
84	K	H	-2.4450
85	N	H	-1.8240
86	T	H	0.0000
87	L	H	0.0000
88	Y	H	-0.3975
89	L	H	0.0000
90	E	H	-1.1365
91	M	H	0.0000
92	R	H	-1.5637
93	S	H	-1.3580
94	L	H	0.0000
95	R	H	-2.0043
96	A	H	-1.5208
97	D	H	-2.0711
98	D	H	0.0000
99	T	H	-0.3090
100	A	H	0.0000
101	V	H	0.6615
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	S	H	0.0000
106	T	H	0.0000
107	A	H	0.0000
108	Y	H	0.9783
109	S	H	0.2851
113	G	H	0.0000
114	W	H	0.0000
115	Y	H	0.0000
116	D	H	0.1600
117	Y	H	0.3088
118	W	H	-0.2016
119	G	H	0.0000
120	R	H	-1.9928
121	G	H	-0.7877
122	T	H	0.0000
123	L	H	1.6605
124	V	H	0.0000
125	T	H	0.3953
126	V	H	0.0000
127	S	H	-0.5082
128	S	H	-0.5984
1	E	L	-1.5251
2	I	L	0.0000
3	V	L	0.7116
4	M	L	0.0000
5	T	L	-0.5029
6	Q	L	0.0000
7	S	L	-0.1571
8	P	L	0.4908
9	V	L	1.3283
10	T	L	0.3859
11	L	L	0.2000
12	S	L	-0.3744
13	V	L	0.0000
14	S	L	-1.2187
15	P	L	-1.3799
16	G	L	-1.6332
17	E	L	-2.4648
18	R	L	-2.6599
19	V	L	0.0000
20	T	L	-0.4871
21	L	L	0.0000
22	S	L	-0.8045
23	C	L	0.0000
24	R	L	-2.4156
25	A	L	0.0000
26	S	L	-1.0631
27	Q	L	-1.7885
28	T	L	-1.2337
29	V	L	0.0000
36	E	L	-0.9844
37	S	L	-0.3595
38	S	L	-0.5902
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	S	L	0.0000
44	Q	L	0.0000
45	K	L	-1.5514
46	A	L	-0.8503
47	G	L	-1.4456
48	Q	L	-2.1762
49	A	L	-1.4760
50	P	L	0.0000
51	R	L	-0.9032
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.3355
56	D	L	-0.7906
57	A	L	0.0000
65	S	L	-0.5408
66	T	L	-0.6929
67	R	L	-0.9519
68	A	L	0.0000
69	T	L	-0.4566
70	G	L	-0.5092
71	V	L	-0.3587
72	S	L	-0.3178
74	A	L	-0.3347
75	R	L	-0.7751
76	F	L	0.0000
77	S	L	-0.4956
78	G	L	-0.5558
79	S	L	-0.4159
80	G	L	-0.4581
83	F	L	0.5923
84	G	L	0.0000
85	T	L	-1.6493
86	E	L	-2.4223
87	F	L	0.0000
88	T	L	-0.6655
89	L	L	0.0000
90	T	L	-0.6041
91	I	L	0.0000
92	S	L	-1.4652
93	S	L	-1.6450
94	Q	L	0.0000
95	Q	L	-1.3731
96	S	L	-0.8456
97	E	L	-1.4271
98	D	L	0.0000
99	F	L	-0.3172
100	E	L	0.0000
101	V	L	-0.1506
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	-0.4128
108	N	L	-1.1566
109	D	L	-0.8013
114	W	L	0.1056
115	P	L	-0.3830
116	W	L	0.0000
117	T	L	0.0276
118	F	L	0.2938
119	G	L	0.0000
120	Q	L	-0.5729
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.6173
124	V	L	0.0000
125	E	L	-0.2266
126	L	L	0.4385
127	K	L	-1.2156