| Chain sequence(s) |
A: GGFGNQGGFGNNRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG
C: GGFGNQGGFGNNRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG B: GGFGNQGGFGNNRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG E: GGFGNQGGFGNNRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG D: GGFGNQGGFGNNRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG input PDB |
| Selected Chain(s) | A,C,B,E,D |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:27)
[INFO] Main: Simulation completed successfully. (00:01:30)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 281 | G | A | -1.2257 | |
| 282 | G | A | -0.9819 | |
| 283 | F | A | 0.0000 | |
| 284 | G | A | -1.0410 | |
| 285 | N | A | 0.0000 | |
| 286 | Q | A | -1.7365 | |
| 287 | G | A | 0.0000 | |
| 288 | G | A | -0.9254 | |
| 289 | F | A | 0.0000 | |
| 290 | G | A | -1.5260 | |
| 291 | N | A | 0.0000 | |
| 292 | N | A | 0.0000 | |
| 293 | R | A | -3.9966 | |
| 294 | G | A | -2.8096 | |
| 295 | G | A | -1.9102 | |
| 296 | G | A | 0.0000 | |
| 297 | A | A | 0.1294 | |
| 298 | G | A | 0.6599 | |
| 299 | L | A | 1.4055 | |
| 300 | G | A | 0.0000 | |
| 301 | N | A | 0.0000 | |
| 302 | N | A | 0.0000 | |
| 303 | Q | A | 0.0000 | |
| 304 | G | A | 0.0000 | |
| 305 | S | A | 0.0000 | |
| 306 | N | A | 0.0000 | |
| 307 | M | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | G | A | 0.0000 | |
| 310 | G | A | 0.0000 | |
| 311 | M | A | 0.0000 | |
| 312 | N | A | 0.0000 | |
| 313 | F | A | 1.5385 | |
| 314 | G | A | 0.9748 | |
| 315 | A | A | 0.4751 | |
| 316 | F | A | 0.0000 | |
| 317 | S | A | -0.3041 | |
| 318 | I | A | 0.0000 | |
| 319 | N | A | -1.1392 | |
| 320 | P | A | 0.0000 | |
| 321 | A | A | -0.0741 | |
| 322 | M | A | 0.0000 | |
| 323 | M | A | 0.6974 | |
| 324 | A | A | 0.0000 | |
| 325 | A | A | 0.1181 | |
| 326 | A | A | -0.2002 | |
| 327 | Q | A | -0.4606 | |
| 328 | A | A | 0.0000 | |
| 329 | A | A | 0.0000 | |
| 330 | L | A | 0.0000 | |
| 331 | Q | A | 0.0000 | |
| 332 | S | A | 0.0000 | |
| 333 | S | A | 0.0000 | |
| 334 | W | A | 0.0000 | |
| 335 | G | A | 0.0000 | |
| 336 | M | A | 0.0000 | |
| 337 | M | A | 0.0000 | |
| 338 | G | A | 0.0000 | |
| 339 | M | A | 0.0000 | |
| 340 | L | A | 0.0000 | |
| 341 | A | A | 0.0000 | |
| 342 | S | A | 0.0000 | |
| 343 | Q | A | 0.0000 | |
| 344 | Q | A | -1.4750 | |
| 345 | N | A | 0.0000 | |
| 346 | Q | A | -2.0245 | |
| 347 | S | A | -1.5400 | |
| 348 | G | A | -1.2170 | |
| 349 | P | A | 0.0000 | |
| 350 | S | A | -1.0234 | |
| 351 | G | A | -1.0933 | |
| 281 | G | B | -1.3396 | |
| 282 | G | B | -1.0628 | |
| 283 | F | B | -0.3056 | |
| 284 | G | B | -1.1026 | |
| 285 | N | B | 0.0000 | |
| 286 | Q | B | -1.7777 | |
| 287 | G | B | 0.0000 | |
| 288 | G | B | -0.8640 | |
| 289 | F | B | 0.0000 | |
| 290 | G | B | -1.3236 | |
| 291 | N | B | 0.0000 | |
| 292 | N | B | 0.0000 | |
| 293 | R | B | -3.8563 | |
| 294 | G | B | -2.5639 | |
| 295 | G | B | -1.6156 | |
| 296 | G | B | 0.0000 | |
| 297 | A | B | 0.1936 | |
| 298 | G | B | 0.6447 | |
| 299 | L | B | 1.2836 | |
| 300 | G | B | 0.0000 | |
| 301 | N | B | 0.0000 | |
| 302 | N | B | 0.0000 | |
| 303 | Q | B | 0.0000 | |
| 304 | G | B | 0.0000 | |
| 305 | S | B | -0.1028 | |
| 306 | N | B | 0.0000 | |
| 307 | M | B | 0.0000 | |
| 308 | G | B | 0.0000 | |
| 309 | G | B | 0.0000 | |
| 310 | G | B | 0.0000 | |
| 311 | M | B | 0.0000 | |
| 312 | N | B | 0.0000 | |
| 313 | F | B | 2.0559 | |
| 314 | G | B | 1.0446 | |
| 315 | A | B | 0.4226 | |
| 316 | F | B | 0.0000 | |
| 317 | S | B | -0.4071 | |
| 318 | I | B | 0.0000 | |
| 319 | N | B | -1.2733 | |
| 320 | P | B | 0.0000 | |
| 321 | A | B | -0.0993 | |
| 322 | M | B | 0.0000 | |
| 323 | M | B | 0.6322 | |
| 324 | A | B | 0.0000 | |
| 325 | A | B | 0.0987 | |
| 326 | A | B | -0.1602 | |
| 327 | Q | B | -0.5862 | |
| 328 | A | B | 0.0000 | |
| 329 | A | B | 0.0000 | |
| 330 | L | B | 0.0000 | |
| 331 | Q | B | 0.0000 | |
| 332 | S | B | 0.0000 | |
| 333 | S | B | 0.0000 | |
| 334 | W | B | 0.0000 | |
| 335 | G | B | 0.0000 | |
| 336 | M | B | 0.0000 | |
| 337 | M | B | 0.0000 | |
| 338 | G | B | 0.0000 | |
| 339 | M | B | 0.0000 | |
| 340 | L | B | 0.0000 | |
| 341 | A | B | 0.0000 | |
| 342 | S | B | 0.0000 | |
| 343 | Q | B | 0.0000 | |
| 344 | Q | B | -0.9880 | |
| 345 | N | B | 0.0000 | |
| 346 | Q | B | -1.7417 | |
| 347 | S | B | 0.0000 | |
| 348 | G | B | -1.0514 | |
| 349 | P | B | 0.0000 | |
| 350 | S | B | -0.9243 | |
| 351 | G | B | -1.1132 | |
| 281 | G | C | -1.0313 | |
| 282 | G | C | -0.7667 | |
| 283 | F | C | -0.1910 | |
| 284 | G | C | -0.7787 | |
| 285 | N | C | -1.2017 | |
| 286 | Q | C | -1.8731 | |
| 287 | G | C | -1.1557 | |
| 288 | G | C | -0.9033 | |
| 289 | F | C | -0.3462 | |
| 290 | G | C | -1.1743 | |
| 291 | N | C | -1.5558 | |
| 292 | N | C | -2.5720 | |
| 293 | R | C | -3.3467 | |
| 294 | G | C | -2.6261 | |
| 295 | G | C | -1.6853 | |
| 296 | G | C | -1.4575 | |
| 297 | A | C | -0.0829 | |
| 298 | G | C | 0.5359 | |
| 299 | L | C | 1.5505 | |
| 300 | G | C | 0.0000 | |
| 301 | N | C | -0.1742 | |
| 302 | N | C | -0.7790 | |
| 303 | Q | C | -0.5663 | |
| 304 | G | C | 0.0000 | |
| 305 | S | C | 0.0084 | |
| 306 | N | C | -0.1268 | |
| 307 | M | C | 0.2196 | |
| 308 | G | C | -0.0875 | |
| 309 | G | C | -0.4596 | |
| 310 | G | C | -0.5310 | |
| 311 | M | C | 0.2772 | |
| 312 | N | C | 0.3568 | |
| 313 | F | C | 1.9107 | |
| 314 | G | C | 0.8762 | |
| 315 | A | C | 0.5303 | |
| 316 | F | C | 0.5184 | |
| 317 | S | C | -0.1250 | |
| 318 | I | C | -0.4116 | |
| 319 | N | C | -1.2917 | |
| 320 | P | C | -0.6194 | |
| 321 | A | C | 0.0298 | |
| 322 | M | C | 0.7445 | |
| 323 | M | C | 0.8492 | |
| 324 | A | C | 0.4536 | |
| 325 | A | C | 0.1468 | |
| 326 | A | C | -0.1639 | |
| 327 | Q | C | -0.5318 | |
| 328 | A | C | 0.0229 | |
| 329 | A | C | 0.1581 | |
| 330 | L | C | 0.0060 | |
| 331 | Q | C | -0.6801 | |
| 332 | S | C | -0.0588 | |
| 333 | S | C | 0.1063 | |
| 334 | W | C | 0.3594 | |
| 335 | G | C | 0.0000 | |
| 336 | M | C | 0.3917 | |
| 337 | M | C | 0.3868 | |
| 338 | G | C | 0.2927 | |
| 339 | M | C | 0.4289 | |
| 340 | L | C | 0.1451 | |
| 341 | A | C | 0.0478 | |
| 342 | S | C | -0.4037 | |
| 343 | Q | C | -1.2162 | |
| 344 | Q | C | -2.1325 | |
| 345 | N | C | -2.2153 | |
| 346 | Q | C | -2.3411 | |
| 347 | S | C | -1.4382 | |
| 348 | G | C | -1.2892 | |
| 349 | P | C | -0.8118 | |
| 350 | S | C | -0.9064 | |
| 351 | G | C | -0.8961 | |
| 281 | G | D | -1.1580 | |
| 282 | G | D | -0.7895 | |
| 283 | F | D | 0.0000 | |
| 284 | G | D | -1.0057 | |
| 285 | N | D | 0.0000 | |
| 286 | Q | D | -1.6768 | |
| 287 | G | D | 0.0000 | |
| 288 | G | D | -0.9158 | |
| 289 | F | D | 0.0000 | |
| 290 | G | D | -1.5355 | |
| 291 | N | D | 0.0000 | |
| 292 | N | D | 0.0000 | |
| 293 | R | D | -3.4796 | |
| 294 | G | D | -2.3809 | |
| 295 | G | D | -1.6464 | |
| 296 | G | D | 0.0000 | |
| 297 | A | D | 0.1884 | |
| 298 | G | D | 0.5090 | |
| 299 | L | D | 1.2763 | |
| 300 | G | D | 0.0000 | |
| 301 | N | D | 0.0000 | |
| 302 | N | D | 0.0000 | |
| 303 | Q | D | 0.0000 | |
| 304 | G | D | 0.0000 | |
| 305 | S | D | 0.0000 | |
| 306 | N | D | 0.0000 | |
| 307 | M | D | 0.0000 | |
| 308 | G | D | 0.0000 | |
| 309 | G | D | 0.0000 | |
| 310 | G | D | 0.0000 | |
| 311 | M | D | 0.0000 | |
| 312 | N | D | 0.0000 | |
| 313 | F | D | 2.0852 | |
| 314 | G | D | 1.3002 | |
| 315 | A | D | 0.6279 | |
| 316 | F | D | 0.0000 | |
| 317 | S | D | -0.3440 | |
| 318 | I | D | 0.0000 | |
| 319 | N | D | -1.2220 | |
| 320 | P | D | 0.0000 | |
| 321 | A | D | -0.1069 | |
| 322 | M | D | 0.0000 | |
| 323 | M | D | 0.7718 | |
| 324 | A | D | 0.0000 | |
| 325 | A | D | 0.1310 | |
| 326 | A | D | -0.3262 | |
| 327 | Q | D | 0.0000 | |
| 328 | A | D | 0.0000 | |
| 329 | A | D | 0.0000 | |
| 330 | L | D | 0.0000 | |
| 331 | Q | D | 0.0000 | |
| 332 | S | D | 0.0000 | |
| 333 | S | D | 0.0000 | |
| 334 | W | D | 0.0000 | |
| 335 | G | D | 0.0000 | |
| 336 | M | D | 0.0000 | |
| 337 | M | D | 0.0000 | |
| 338 | G | D | 0.0000 | |
| 339 | M | D | 0.0000 | |
| 340 | L | D | 0.0000 | |
| 341 | A | D | 0.0000 | |
| 342 | S | D | 0.0000 | |
| 343 | Q | D | 0.0000 | |
| 344 | Q | D | -1.1486 | |
| 345 | N | D | 0.0000 | |
| 346 | Q | D | -1.8924 | |
| 347 | S | D | 0.0000 | |
| 348 | G | D | -1.1342 | |
| 349 | P | D | 0.0000 | |
| 350 | S | D | -0.8779 | |
| 351 | G | D | -1.0318 | |
| 281 | G | E | -1.0303 | |
| 282 | G | E | -0.4943 | |
| 283 | F | E | 0.2544 | |
| 284 | G | E | -0.7298 | |
| 285 | N | E | -0.8837 | |
| 286 | Q | E | -1.7793 | |
| 287 | G | E | -1.0010 | |
| 288 | G | E | -0.9492 | |
| 289 | F | E | -0.6605 | |
| 290 | G | E | -1.4571 | |
| 291 | N | E | -1.6362 | |
| 292 | N | E | -2.1630 | |
| 293 | R | E | -3.2645 | |
| 294 | G | E | -2.1835 | |
| 295 | G | E | -1.6604 | |
| 296 | G | E | -1.0431 | |
| 297 | A | E | -0.0674 | |
| 298 | G | E | 0.2598 | |
| 299 | L | E | 1.4231 | |
| 300 | G | E | 0.0951 | |
| 301 | N | E | -0.4818 | |
| 302 | N | E | -1.4307 | |
| 303 | Q | E | -1.1616 | |
| 304 | G | E | -0.8279 | |
| 305 | S | E | -0.5203 | |
| 306 | N | E | -0.7515 | |
| 307 | M | E | 0.0000 | |
| 308 | G | E | -0.2343 | |
| 309 | G | E | -0.3378 | |
| 310 | G | E | 0.0000 | |
| 311 | M | E | 0.8929 | |
| 312 | N | E | 1.2286 | |
| 313 | F | E | 2.3428 | |
| 314 | G | E | 0.9936 | |
| 315 | A | E | 0.5916 | |
| 316 | F | E | 0.4027 | |
| 317 | S | E | -0.2165 | |
| 318 | I | E | -0.2569 | |
| 319 | N | E | -1.3161 | |
| 320 | P | E | -0.4557 | |
| 321 | A | E | 0.1433 | |
| 322 | M | E | 0.8101 | |
| 323 | M | E | 1.2591 | |
| 324 | A | E | 0.0000 | |
| 325 | A | E | 0.0567 | |
| 326 | A | E | -0.4968 | |
| 327 | Q | E | -1.1052 | |
| 328 | A | E | -0.3981 | |
| 329 | A | E | 0.0000 | |
| 330 | L | E | -0.4392 | |
| 331 | Q | E | -1.3341 | |
| 332 | S | E | -0.5534 | |
| 333 | S | E | -0.2124 | |
| 334 | W | E | 0.2486 | |
| 335 | G | E | 0.1065 | |
| 336 | M | E | 0.3412 | |
| 337 | M | E | 0.0554 | |
| 338 | G | E | -0.1856 | |
| 339 | M | E | 0.1669 | |
| 340 | L | E | -0.1530 | |
| 341 | A | E | 0.0249 | |
| 342 | S | E | -0.1104 | |
| 343 | Q | E | -0.7216 | |
| 344 | Q | E | -1.4439 | |
| 345 | N | E | -1.8942 | |
| 346 | Q | E | -2.1215 | |
| 347 | S | E | -1.5348 | |
| 348 | G | E | -1.0814 | |
| 349 | P | E | -0.6867 | |
| 350 | S | E | -0.7362 | |
| 351 | G | E | -0.9716 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine