| Chain sequence(s) |
A: HPATSSKVEVPSEAGQKELLRKGSLKSDFQDGAPLNGSSQRLPQTIIIGVRKGGTRALLEMLSLHPGIAAAESEVHFFDWEDHYGNGLEWYLSQMPYSFPHQLTVEKTPAYFTSSKVPERVYNMNPSIRLLLILRDPSERVLSDYTQVFYNHVQKHKPYPSIEEFLIKDGELNVEYKAINRSLYYFHMQNWLQYFPLDHIHIVDGDQLIRDPFPEIEKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELVGRTFDWH
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:59)
[INFO] Main: Simulation completed successfully. (00:05:01)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | H | A | -1.1073 | |
| 2 | P | A | -0.7485 | |
| 3 | A | A | -0.4268 | |
| 4 | T | A | -0.6075 | |
| 5 | S | A | -0.8346 | |
| 6 | S | A | -1.2639 | |
| 7 | K | A | -1.7880 | |
| 8 | V | A | -0.5372 | |
| 9 | E | A | -1.0426 | |
| 10 | V | A | 0.4893 | |
| 11 | P | A | -0.4122 | |
| 12 | S | A | -1.3520 | |
| 13 | E | A | -2.6075 | |
| 14 | A | A | -2.2226 | |
| 15 | G | A | -2.1418 | |
| 16 | Q | A | -2.7632 | |
| 17 | K | A | -3.7131 | |
| 18 | E | A | -3.8662 | |
| 19 | L | A | -2.6373 | |
| 20 | L | A | -2.6982 | |
| 21 | R | A | -3.8653 | |
| 22 | K | A | -3.3688 | |
| 23 | G | A | -2.2461 | |
| 24 | S | A | -1.2905 | |
| 25 | L | A | -0.0114 | |
| 26 | K | A | -1.3572 | |
| 27 | S | A | -1.1670 | |
| 28 | D | A | -1.7952 | |
| 29 | F | A | -0.3853 | |
| 30 | Q | A | -1.7736 | |
| 31 | D | A | -2.2713 | |
| 32 | G | A | -1.1527 | |
| 33 | A | A | -0.7816 | |
| 34 | P | A | -0.0606 | |
| 35 | L | A | 0.7029 | |
| 36 | N | A | -0.5349 | |
| 37 | G | A | -0.3902 | |
| 38 | S | A | 0.0000 | |
| 39 | S | A | 0.1680 | |
| 40 | Q | A | 0.1132 | |
| 41 | R | A | -0.0568 | |
| 42 | L | A | -0.0836 | |
| 43 | P | A | 0.0000 | |
| 44 | Q | A | -0.5418 | |
| 45 | T | A | 0.0000 | |
| 46 | I | A | 0.0000 | |
| 47 | I | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | V | A | 0.0000 | |
| 51 | R | A | -1.0001 | |
| 52 | K | A | -1.0750 | |
| 53 | G | A | 0.0000 | |
| 54 | G | A | -0.6042 | |
| 55 | T | A | 0.0000 | |
| 56 | R | A | -1.1987 | |
| 57 | A | A | 0.0000 | |
| 58 | L | A | 0.0000 | |
| 59 | L | A | 0.0000 | |
| 60 | E | A | -0.7272 | |
| 61 | M | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | S | A | -0.1586 | |
| 64 | L | A | -0.6647 | |
| 65 | H | A | 0.0000 | |
| 66 | P | A | -0.5729 | |
| 67 | G | A | -0.4576 | |
| 68 | I | A | 0.0000 | |
| 69 | A | A | -0.0277 | |
| 70 | A | A | -0.3808 | |
| 71 | A | A | 0.0000 | |
| 72 | E | A | -2.2456 | |
| 73 | S | A | -1.7173 | |
| 74 | E | A | -1.7519 | |
| 75 | V | A | 0.0000 | |
| 76 | H | A | -0.7481 | |
| 77 | F | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | D | A | -0.7255 | |
| 80 | W | A | -0.8341 | |
| 81 | E | A | -2.5615 | |
| 82 | D | A | -2.7927 | |
| 83 | H | A | -1.6814 | |
| 84 | Y | A | -1.3495 | |
| 85 | G | A | -1.9597 | |
| 86 | N | A | -2.3356 | |
| 87 | G | A | 0.0000 | |
| 88 | L | A | 0.0000 | |
| 89 | E | A | -2.0997 | |
| 90 | W | A | -1.0163 | |
| 91 | Y | A | 0.0000 | |
| 92 | L | A | -0.3372 | |
| 93 | S | A | -0.5472 | |
| 94 | Q | A | -0.9585 | |
| 95 | M | A | 0.0000 | |
| 96 | P | A | 0.1577 | |
| 97 | Y | A | 0.9419 | |
| 98 | S | A | 0.0000 | |
| 99 | F | A | 0.2268 | |
| 100 | P | A | -0.3914 | |
| 101 | H | A | -0.9130 | |
| 102 | Q | A | -0.3048 | |
| 103 | L | A | -0.0633 | |
| 104 | T | A | 0.0000 | |
| 105 | V | A | 0.0000 | |
| 106 | E | A | 0.0000 | |
| 107 | K | A | 0.0000 | |
| 108 | T | A | 0.0000 | |
| 109 | P | A | 0.0000 | |
| 110 | A | A | -0.3650 | |
| 111 | Y | A | 0.0000 | |
| 112 | F | A | 0.0000 | |
| 113 | T | A | -0.3914 | |
| 114 | S | A | -0.4479 | |
| 115 | S | A | -0.8210 | |
| 116 | K | A | -1.3172 | |
| 117 | V | A | 0.0000 | |
| 118 | P | A | 0.0000 | |
| 119 | E | A | -1.9962 | |
| 120 | R | A | -1.2395 | |
| 121 | V | A | 0.0000 | |
| 122 | Y | A | 0.0000 | |
| 123 | N | A | -0.8602 | |
| 124 | M | A | 0.0000 | |
| 125 | N | A | -0.8890 | |
| 126 | P | A | -0.4702 | |
| 127 | S | A | -0.6436 | |
| 128 | I | A | 0.0000 | |
| 129 | R | A | -1.1537 | |
| 130 | L | A | 0.0000 | |
| 131 | L | A | 0.0000 | |
| 132 | L | A | 0.0000 | |
| 133 | I | A | 0.0000 | |
| 134 | L | A | 0.0000 | |
| 135 | R | A | -0.7885 | |
| 136 | D | A | 0.0000 | |
| 137 | P | A | 0.0000 | |
| 138 | S | A | 0.0000 | |
| 139 | E | A | -0.8381 | |
| 140 | R | A | 0.0000 | |
| 141 | V | A | 0.0000 | |
| 142 | L | A | 0.0000 | |
| 143 | S | A | -0.6094 | |
| 144 | D | A | 0.0000 | |
| 145 | Y | A | 0.0000 | |
| 146 | T | A | 0.0000 | |
| 147 | Q | A | -0.2248 | |
| 148 | V | A | 0.8053 | |
| 149 | F | A | 0.8202 | |
| 150 | Y | A | 0.0405 | |
| 151 | N | A | -1.0017 | |
| 152 | H | A | -1.1687 | |
| 153 | V | A | -0.3588 | |
| 154 | Q | A | -1.9829 | |
| 155 | K | A | -3.0138 | |
| 156 | H | A | -2.5607 | |
| 157 | K | A | -2.5738 | |
| 158 | P | A | -1.0304 | |
| 159 | Y | A | -0.1675 | |
| 160 | P | A | -0.5649 | |
| 161 | S | A | -0.8791 | |
| 162 | I | A | 0.0000 | |
| 163 | E | A | -2.0043 | |
| 164 | E | A | -2.3413 | |
| 165 | F | A | -1.3523 | |
| 166 | L | A | 0.0000 | |
| 167 | I | A | -1.8683 | |
| 168 | K | A | -3.3314 | |
| 169 | D | A | -3.1824 | |
| 170 | G | A | -2.5147 | |
| 171 | E | A | -2.8307 | |
| 172 | L | A | 0.0000 | |
| 173 | N | A | -1.7080 | |
| 174 | V | A | -0.3395 | |
| 175 | E | A | -1.9927 | |
| 176 | Y | A | 0.0000 | |
| 177 | K | A | -2.2820 | |
| 178 | A | A | 0.0000 | |
| 179 | I | A | 0.0000 | |
| 180 | N | A | -1.3937 | |
| 181 | R | A | -1.0892 | |
| 182 | S | A | 0.0000 | |
| 183 | L | A | 0.0000 | |
| 184 | Y | A | 0.0000 | |
| 185 | Y | A | -0.0125 | |
| 186 | F | A | 0.9458 | |
| 187 | H | A | 0.1404 | |
| 188 | M | A | 0.0000 | |
| 189 | Q | A | -0.2817 | |
| 190 | N | A | -1.0335 | |
| 191 | W | A | 0.0000 | |
| 192 | L | A | -0.4102 | |
| 193 | Q | A | -1.4576 | |
| 194 | Y | A | -0.7435 | |
| 195 | F | A | 0.0000 | |
| 196 | P | A | -0.7545 | |
| 197 | L | A | -0.5174 | |
| 198 | D | A | -1.7753 | |
| 199 | H | A | -1.2011 | |
| 200 | I | A | 0.0000 | |
| 201 | H | A | -0.7864 | |
| 202 | I | A | 0.0000 | |
| 203 | V | A | 0.0000 | |
| 204 | D | A | -0.6643 | |
| 205 | G | A | 0.0000 | |
| 206 | D | A | -1.3983 | |
| 207 | Q | A | -1.8828 | |
| 208 | L | A | 0.0000 | |
| 209 | I | A | -0.9901 | |
| 210 | R | A | -2.2338 | |
| 211 | D | A | -1.9880 | |
| 212 | P | A | 0.0000 | |
| 213 | F | A | -0.8347 | |
| 214 | P | A | -0.9686 | |
| 215 | E | A | 0.0000 | |
| 216 | I | A | 0.0000 | |
| 217 | E | A | -1.9690 | |
| 218 | K | A | -2.6501 | |
| 219 | V | A | 0.0000 | |
| 220 | E | A | 0.0000 | |
| 221 | R | A | -2.9753 | |
| 222 | F | A | -2.0287 | |
| 223 | L | A | 0.0000 | |
| 224 | K | A | -2.4303 | |
| 225 | L | A | -1.5064 | |
| 226 | S | A | -1.3791 | |
| 227 | P | A | -1.8212 | |
| 228 | Q | A | -1.6381 | |
| 229 | I | A | 0.0000 | |
| 230 | N | A | -1.1771 | |
| 231 | A | A | -0.6503 | |
| 232 | S | A | -0.7704 | |
| 233 | N | A | -1.6021 | |
| 234 | F | A | 0.0000 | |
| 235 | Y | A | 0.1104 | |
| 236 | F | A | 0.6151 | |
| 237 | N | A | -0.5738 | |
| 238 | K | A | -1.8080 | |
| 239 | T | A | -1.3199 | |
| 240 | K | A | -1.8998 | |
| 241 | G | A | -1.3183 | |
| 242 | F | A | 0.0000 | |
| 243 | Y | A | -0.1532 | |
| 244 | C | A | 0.0000 | |
| 245 | L | A | 0.0000 | |
| 246 | R | A | -3.1652 | |
| 247 | D | A | -3.0989 | |
| 248 | S | A | -2.0011 | |
| 249 | G | A | -2.5577 | |
| 250 | R | A | -3.8522 | |
| 251 | D | A | -3.7147 | |
| 252 | R | A | -2.8907 | |
| 253 | C | A | -1.4195 | |
| 254 | L | A | 0.0000 | |
| 255 | H | A | -2.2878 | |
| 256 | E | A | -2.8277 | |
| 257 | S | A | -1.9063 | |
| 258 | K | A | -2.0867 | |
| 259 | G | A | -1.7650 | |
| 260 | R | A | -1.6853 | |
| 261 | A | A | -0.8356 | |
| 262 | H | A | -0.9286 | |
| 263 | P | A | -0.8335 | |
| 264 | Q | A | -1.3678 | |
| 265 | V | A | -1.2766 | |
| 266 | D | A | -1.9360 | |
| 267 | P | A | -1.8936 | |
| 268 | K | A | -2.5863 | |
| 269 | L | A | 0.0000 | |
| 270 | L | A | -1.9341 | |
| 271 | N | A | -2.8510 | |
| 272 | K | A | -2.5430 | |
| 273 | L | A | 0.0000 | |
| 274 | H | A | -2.4819 | |
| 275 | E | A | -3.0903 | |
| 276 | Y | A | -1.4473 | |
| 277 | F | A | 0.0000 | |
| 278 | H | A | -3.0976 | |
| 279 | E | A | -3.2395 | |
| 280 | P | A | -1.7536 | |
| 281 | N | A | 0.0000 | |
| 282 | K | A | -3.1811 | |
| 283 | K | A | -2.3137 | |
| 284 | F | A | 0.0000 | |
| 285 | F | A | -1.8121 | |
| 286 | E | A | -2.4260 | |
| 287 | L | A | -0.9201 | |
| 288 | V | A | -0.7590 | |
| 289 | G | A | -1.2445 | |
| 290 | R | A | -1.4510 | |
| 291 | T | A | -1.3839 | |
| 292 | F | A | 0.0000 | |
| 293 | D | A | -2.1124 | |
| 294 | W | A | -1.5183 | |
| 295 | H | A | -2.0560 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine