Project name: b95aeb02f85af7e

Chain sequence(s)	H: VQLVESGGGVVQPGRSLRLSCAASGFTFSNYGMHWVRQAPGKGLDWVAVISYDGSDKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRGTPLAGDYYFDYWGQGTLVTVSS; L: QSALTQPPSASGSPGQSVTISCTGTSSDVGGYNYVSWYQQHPGKAPKLIIYEVTNRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYAGSNNWVFGGGTK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:53)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:55)

• Minimal score value: -2.9733
• Maximal score value: 1.775
• Average score: -0.6303
• Total score value: -143.6977

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	V	H	0.8937
3	Q	H	-0.4159
4	L	H	0.0000
5	V	H	0.0464
6	E	H	0.0000
7	S	H	-0.3265
8	G	H	-0.5158
9	G	H	0.3229
11	G	H	0.9468
12	V	H	1.7750
13	V	H	-0.0169
14	Q	H	-1.2185
15	P	H	-1.8330
16	G	H	-2.0683
17	R	H	-2.6051
18	S	H	-1.5836
19	L	H	-0.7462
20	R	H	-1.0868
21	L	H	0.0000
22	S	H	-0.3174
23	C	H	0.0000
24	A	H	-0.4524
25	A	H	0.0000
26	S	H	-0.2873
27	G	H	-0.1041
28	F	H	0.0837
29	T	H	-0.2008
30	F	H	0.0000
35	S	H	-1.1357
36	N	H	-0.8747
37	Y	H	-0.3296
38	G	H	0.0000
39	M	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5567
45	A	H	-0.9964
46	P	H	-0.8073
47	G	H	-1.4790
48	K	H	-2.2248
49	G	H	-1.3997
50	L	H	0.0000
51	D	H	-0.7332
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	V	H	0.0000
56	I	H	0.0000
57	S	H	-0.7169
58	Y	H	-0.5388
59	D	H	-2.0082
62	G	H	-1.5153
63	S	H	-1.3011
64	D	H	-1.5719
65	K	H	-1.1308
66	Y	H	-0.5595
67	Y	H	-0.8371
68	A	H	0.0000
69	D	H	-2.4987
70	S	H	-1.8097
71	V	H	0.0000
72	K	H	-2.0511
74	G	H	-1.4820
75	R	H	-1.2483
76	F	H	0.0000
77	T	H	-0.6590
78	I	H	0.0000
79	S	H	-0.7220
80	R	H	-1.0315
81	D	H	-1.6037
82	N	H	-1.8118
83	S	H	-1.4912
84	K	H	-2.2978
85	N	H	-1.6407
86	T	H	-1.0100
87	L	H	0.0000
88	Y	H	-0.2816
89	L	H	0.0000
90	Q	H	-0.7093
91	M	H	0.0000
92	N	H	-1.6041
93	S	H	-1.6806
94	L	H	0.0000
95	R	H	-2.4157
96	A	H	-1.6175
97	E	H	-2.2350
98	D	H	0.0000
99	T	H	-0.3178
100	A	H	0.0000
101	V	H	0.7947
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	K	H	0.0000
107	D	H	0.0000
108	R	H	-1.3822
109	G	H	-0.5853
110	T	H	-0.1623
111	P	H	0.2814
111A	L	H	1.4565
112B	A	H	0.4031
112A	G	H	0.1014
112	D	H	-0.5410
113	Y	H	-0.1228
114	Y	H	0.0000
115	F	H	0.0000
116	D	H	-0.3491
117	Y	H	0.4885
118	W	H	-0.0085
119	G	H	0.0000
120	Q	H	-1.4748
121	G	H	-0.3872
122	T	H	0.4584
123	L	H	1.6999
124	V	H	0.0000
125	T	H	0.5010
126	V	H	0.0000
127	S	H	-0.4648
128	S	H	-0.4708
1	Q	L	-1.6006
2	S	L	-0.8232
3	A	L	-0.5842
4	L	L	0.0000
5	T	L	-0.3663
6	Q	L	-0.6583
7	P	L	-0.7190
8	P	L	-1.0083
9	S	L	-1.1767
11	A	L	-0.8261
12	S	L	-1.0966
13	G	L	-1.1012
14	S	L	-1.0883
15	P	L	-1.3003
16	G	L	-1.5053
17	Q	L	-1.8634
18	S	L	-1.0624
19	V	L	-0.3857
20	T	L	-0.1458
21	I	L	0.0000
22	S	L	-0.2619
23	C	L	0.0000
24	T	L	-0.5421
25	G	L	-0.6005
26	T	L	-0.6653
27	S	L	-0.7938
28	S	L	-0.5528
29	D	L	0.0000
30	V	L	0.0000
31	G	L	-1.2126
35	G	L	-0.9133
36	Y	L	-0.5962
37	N	L	-1.3163
38	Y	L	-0.4266
39	V	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	H	L	-1.9215
46	P	L	-1.4734
47	G	L	-1.6239
48	K	L	-2.4751
49	A	L	-1.4339
50	P	L	0.0000
51	K	L	-0.9656
52	L	L	0.0000
53	I	L	0.0000
54	I	L	0.0000
55	Y	L	-0.9880
56	E	L	-1.1885
57	V	L	0.0000
65	T	L	-1.1829
66	N	L	-1.6681
67	R	L	-1.8298
68	P	L	-0.9940
69	S	L	-0.7488
70	G	L	-0.8561
71	V	L	-0.9751
72	P	L	-1.2940
74	D	L	-2.2101
75	R	L	-1.3921
76	F	L	0.0000
77	S	L	-1.0114
78	G	L	0.0000
79	S	L	-0.8816
80	K	L	-1.2436
83	S	L	-0.9369
84	G	L	-1.1832
85	N	L	-1.2890
86	T	L	-0.8719
87	A	L	0.0000
88	S	L	-0.3796
89	L	L	0.0000
90	T	L	-0.1987
91	V	L	0.0000
92	S	L	-1.1711
93	G	L	-1.3930
94	L	L	-1.6683
95	Q	L	-2.0702
96	A	L	-1.8127
97	E	L	-2.6579
98	D	L	0.0000
99	E	L	-2.9733
100	A	L	-2.1313
101	D	L	-1.4586
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	S	L	0.0000
106	S	L	0.0000
107	Y	L	-0.1173
108	A	L	-0.2227
109	G	L	-0.3414
113	S	L	-0.3496
114	N	L	-0.5444
115	N	L	-0.5082
116	W	L	0.0000
117	V	L	0.0000
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-1.1133
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-2.3447