| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTAPVHEGADDRVDFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRSGPDGHPLPADPPPSPLYVPPPPSSPTAVLPSYNYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPENNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9499 | |
| 2 | L | A | 1.9788 | |
| 3 | P | A | 0.7109 | |
| 4 | P | A | 0.1183 | |
| 5 | T | A | 0.2137 | |
| 6 | T | A | 0.1591 | |
| 7 | P | A | 0.2574 | |
| 8 | V | A | 1.2482 | |
| 9 | A | A | 0.0506 | |
| 10 | K | A | -1.1168 | |
| 11 | V | A | -0.3434 | |
| 12 | Q | A | -1.4913 | |
| 13 | S | A | -1.6339 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.6087 | |
| 16 | E | A | -2.5577 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4359 | |
| 20 | P | A | 0.0414 | |
| 21 | T | A | 0.1018 | |
| 22 | S | A | -0.1780 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.0893 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2517 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7486 | |
| 31 | R | A | -2.6790 | |
| 32 | L | A | -0.8211 | |
| 33 | L | A | 1.1009 | |
| 34 | T | A | 1.3745 | |
| 35 | V | A | 1.9173 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2242 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6370 | |
| 40 | K | A | -1.8498 | |
| 41 | D | A | -0.6986 | |
| 42 | I | A | 1.3412 | |
| 43 | V | A | 2.2980 | |
| 44 | V | A | 1.6064 | |
| 45 | N | A | -0.5748 | |
| 46 | G | A | -0.3731 | |
| 47 | K | A | -0.1163 | |
| 48 | V | A | 2.2394 | |
| 49 | L | A | 2.5636 | |
| 50 | V | A | 1.4891 | |
| 51 | P | A | 0.3849 | |
| 52 | K | A | -0.6601 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.2061 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4574 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.3311 | |
| 70 | K | A | -1.8649 | |
| 71 | F | A | -0.9087 | |
| 72 | A | A | -0.5767 | |
| 73 | L | A | -0.8384 | |
| 74 | P | A | -1.2444 | |
| 75 | Q | A | -2.4789 | |
| 76 | K | A | -3.0888 | |
| 77 | D | A | -2.9793 | |
| 78 | F | A | -1.6462 | |
| 79 | Y | A | -1.9017 | |
| 80 | D | A | -2.6825 | |
| 81 | P | A | -2.3092 | |
| 82 | E | A | -3.0178 | |
| 83 | K | A | -3.3722 | |
| 84 | E | A | -2.4331 | |
| 85 | R | A | -1.2692 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.5145 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -1.0355 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3969 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7585 | |
| 99 | G | A | -0.5907 | |
| 100 | P | A | -0.4412 | |
| 101 | L | A | -0.0630 | |
| 102 | G | A | -0.5199 | |
| 103 | K | A | -0.9105 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4933 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | -0.1977 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.4436 | |
| 110 | L | A | -0.2642 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2642 | |
| 113 | K | A | -0.3039 | |
| 114 | L | A | -0.9448 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -0.9994 | |
| 117 | T | A | -0.8787 | |
| 118 | E | A | -1.9804 | |
| 119 | N | A | -1.8929 | |
| 120 | P | A | -1.2118 | |
| 121 | T | A | -0.7142 | |
| 122 | A | A | -0.7042 | |
| 123 | P | A | -0.5323 | |
| 124 | V | A | -0.4106 | |
| 125 | H | A | -1.9469 | |
| 126 | E | A | -2.7344 | |
| 127 | G | A | -2.1632 | |
| 128 | A | A | -1.5655 | |
| 129 | D | A | -2.3634 | |
| 130 | D | A | -2.0046 | |
| 131 | R | A | -1.5400 | |
| 132 | V | A | -0.5279 | |
| 133 | D | A | -1.3907 | |
| 134 | F | A | -0.6210 | |
| 135 | S | A | -0.5257 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7917 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.1739 | |
| 140 | Q | A | -0.1610 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5464 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1935 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1169 | |
| 157 | D | A | 0.3155 | |
| 158 | L | A | 0.7419 | |
| 159 | A | A | 0.0659 | |
| 160 | E | A | -1.4793 | |
| 161 | P | A | -0.2514 | |
| 162 | C | A | 0.1856 | |
| 163 | P | A | -0.1837 | |
| 164 | G | A | -0.1136 | |
| 165 | L | A | 0.5270 | |
| 166 | P | A | -0.1637 | |
| 167 | P | A | -0.3639 | |
| 168 | G | A | -0.4365 | |
| 169 | A | A | -0.0493 | |
| 170 | C | A | 0.6302 | |
| 171 | P | A | 0.5348 | |
| 172 | P | A | 0.5972 | |
| 173 | I | A | 1.7041 | |
| 174 | Q | A | 0.6880 | |
| 175 | L | A | 1.3390 | |
| 176 | V | A | 0.8015 | |
| 177 | N | A | -0.3267 | |
| 178 | S | A | -0.0144 | |
| 179 | V | A | 0.3271 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3829 | |
| 182 | D | A | 0.2719 | |
| 183 | G | A | -0.1732 | |
| 184 | D | A | -0.5210 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4124 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.0996 | |
| 190 | F | A | 0.0817 | |
| 191 | G | A | -0.1990 | |
| 192 | N | A | -0.2382 | |
| 193 | M | A | -0.0790 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.2856 | |
| 197 | E | A | -2.4732 | |
| 198 | L | A | -1.1682 | |
| 199 | Q | A | -2.4620 | |
| 200 | Q | A | -3.2496 | |
| 201 | D | A | -3.4680 | |
| 202 | R | A | -3.2751 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2016 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3666 | |
| 211 | S | A | -1.8418 | |
| 212 | T | A | -1.3633 | |
| 213 | R | A | -1.8722 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1856 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3075 | |
| 220 | L | A | 0.5619 | |
| 221 | K | A | -1.1895 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8926 | |
| 224 | N | A | -1.6225 | |
| 225 | E | A | -1.2425 | |
| 226 | A | A | -0.7775 | |
| 227 | Y | A | -0.4012 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6116 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.0865 | |
| 234 | F | A | 0.1402 | |
| 235 | G | A | -0.7296 | |
| 236 | R | A | -2.2229 | |
| 237 | R | A | -2.5844 | |
| 238 | E | A | -1.5672 | |
| 239 | Q | A | 0.1421 | |
| 240 | V | A | 1.4998 | |
| 241 | Y | A | 0.8747 | |
| 242 | A | A | -0.0400 | |
| 243 | R | A | -1.4056 | |
| 244 | H | A | -0.9580 | |
| 245 | F | A | 0.0778 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | -0.0605 | |
| 248 | R | A | -0.7557 | |
| 249 | S | A | -1.2166 | |
| 250 | G | A | -0.9809 | |
| 251 | P | A | -1.0950 | |
| 252 | D | A | -1.3647 | |
| 253 | G | A | -1.3121 | |
| 254 | H | A | -1.2569 | |
| 255 | P | A | -0.6607 | |
| 256 | L | A | 0.1634 | |
| 257 | P | A | -0.5133 | |
| 258 | A | A | -0.5551 | |
| 259 | D | A | -2.0743 | |
| 260 | P | A | -1.5899 | |
| 261 | P | A | -0.9854 | |
| 262 | P | A | -0.3376 | |
| 263 | S | A | 0.1647 | |
| 264 | P | A | 0.5590 | |
| 265 | L | A | 1.8962 | |
| 266 | Y | A | 1.7189 | |
| 267 | V | A | 1.9135 | |
| 268 | P | A | 0.9543 | |
| 269 | P | A | 0.3196 | |
| 270 | P | A | -0.3775 | |
| 271 | P | A | -0.3624 | |
| 272 | S | A | -0.5084 | |
| 273 | S | A | -0.2186 | |
| 274 | P | A | 0.0318 | |
| 275 | T | A | 0.4134 | |
| 276 | A | A | 0.6810 | |
| 277 | V | A | 1.9383 | |
| 278 | L | A | 1.5149 | |
| 279 | P | A | 0.3423 | |
| 280 | S | A | -0.0303 | |
| 281 | Y | A | 0.0747 | |
| 282 | N | A | -0.7216 | |
| 283 | Y | A | 0.9028 | |
| 284 | F | A | 0.7419 | |
| 285 | G | A | 0.2270 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.5759 | |
| 291 | L | A | 1.5997 | |
| 292 | V | A | 0.4911 | |
| 293 | S | A | -0.2461 | |
| 294 | S | A | -0.8846 | |
| 295 | D | A | -1.9119 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | -1.1106 | |
| 298 | L | A | -1.1567 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.7476 | |
| 301 | R | A | -2.0355 | |
| 302 | P | A | -1.0330 | |
| 303 | F | A | -0.1742 | |
| 304 | W | A | -0.3596 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.1645 | |
| 307 | R | A | -2.8928 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7278 | |
| 310 | G | A | -1.3502 | |
| 311 | N | A | -1.3716 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8011 | |
| 319 | N | A | -0.8725 | |
| 320 | E | A | -1.0346 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.4299 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.2659 | |
| 333 | N | A | 0.3654 | |
| 334 | F | A | 1.4369 | |
| 335 | T | A | 0.8012 | |
| 336 | I | A | 0.4804 | |
| 337 | S | A | -0.8211 | |
| 338 | Q | A | -1.5041 | |
| 339 | Q | A | -1.0699 | |
| 340 | L | A | 0.7539 | |
| 341 | C | A | 0.3809 | |
| 342 | T | A | -0.5814 | |
| 343 | P | A | -1.0963 | |
| 344 | E | A | -2.3778 | |
| 345 | N | A | -2.1024 | |
| 346 | N | A | -1.3803 | |
| 347 | V | A | 0.7451 | |
| 348 | Y | A | 1.0574 | |
| 349 | D | A | -0.2103 | |
| 350 | P | A | -0.5133 | |
| 351 | S | A | -0.2416 | |
| 352 | C | A | 0.0408 | |
| 353 | F | A | -0.5187 | |
| 354 | K | A | -1.6968 | |
| 355 | N | A | -1.5899 | |
| 356 | Y | A | 0.1252 | |
| 357 | L | A | 0.7861 | |
| 358 | R | A | 0.9787 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.1784 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.1968 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0067 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6778 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2688 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3191 | |
| 376 | L | A | -1.7236 | |
| 377 | D | A | -2.0143 | |
| 378 | P | A | -1.0788 | |
| 379 | G | A | -1.0861 | |
| 380 | V | A | 0.0000 | |
| 381 | L | A | -0.5957 | |
| 382 | A | A | -0.6943 | |
| 383 | H | A | -0.8810 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3998 | |
| 386 | T | A | -0.5717 | |
| 387 | M | A | -0.3259 | |
| 388 | N | A | -0.8726 | |
| 389 | P | A | -1.2414 | |
| 390 | T | A | -1.4875 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4609 | |
| 393 | E | A | -2.8255 | |
| 394 | N | A | -2.1716 | |
| 395 | W | A | -1.4909 | |
| 396 | N | A | -1.3038 | |
| 397 | L | A | -0.2236 | |
| 398 | G | A | 0.5790 | |
| 399 | F | A | 2.3794 | |
| 400 | V | A | 1.7768 | |
| 401 | P | A | 0.0473 | |
| 402 | P | A | -1.8994 | |
| 403 | K | A | -3.2845 | |
| 404 | E | A | -3.8350 | |
| 405 | R | A | -4.0762 | |
| 406 | E | A | -3.8245 | |
| 407 | D | A | -2.8583 | |
| 408 | P | A | -1.7528 | |
| 409 | Y | A | -0.9848 | |
| 410 | K | A | -2.1035 | |
| 411 | G | A | -0.6231 | |
| 412 | L | A | 0.6744 | |
| 413 | I | A | 1.6512 | |
| 414 | F | A | 0.7096 | |
| 415 | W | A | -0.2815 | |
| 416 | E | A | -1.6142 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9604 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0984 | |
| 421 | E | A | -2.7283 | |
| 422 | R | A | -2.3207 | |
| 423 | F | A | -1.2757 | |
| 424 | S | A | -1.5346 | |
| 425 | Q | A | -1.9500 | |
| 426 | D | A | -3.0492 | |
| 427 | L | A | 0.0000 | |
| 428 | D | A | -2.9151 | |
| 429 | Q | A | -2.6785 | |
| 430 | F | A | -1.4754 | |
| 431 | A | A | -0.9141 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6908 | |
| 435 | K | A | -0.8535 | |
| 436 | F | A | 0.1095 | |
| 437 | L | A | 0.9451 | |
| 438 | Y | A | 0.7984 | |
| 439 | Q | A | -0.3230 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine