| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGGGGGSGGGGSFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:35)
[INFO] Main: Simulation completed successfully. (00:01:37)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.4510 | |
| 2 | S | A | -0.1581 | |
| 3 | R | A | -1.6743 | |
| 4 | P | A | -1.1174 | |
| 5 | G | A | -0.9837 | |
| 6 | L | A | -0.5575 | |
| 7 | P | A | -0.2116 | |
| 8 | V | A | 0.0221 | |
| 9 | E | A | 0.0465 | |
| 10 | Y | A | 0.6326 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -2.0662 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.7030 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -0.9730 | |
| 17 | S | A | -0.7008 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3334 | |
| 20 | R | A | -2.0393 | |
| 21 | D | A | -2.8655 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -2.2236 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.8732 | |
| 29 | G | A | -1.1243 | |
| 30 | G | A | -1.7148 | |
| 31 | N | A | -2.3052 | |
| 32 | N | A | -2.3731 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.0659 | |
| 43 | R | A | -2.5016 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.3992 | |
| 46 | D | A | -2.9999 | |
| 47 | D | A | -1.9441 | |
| 48 | Y | A | -0.3466 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.9053 | |
| 54 | N | A | -0.2420 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.2344 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.6326 | |
| 60 | W | A | -0.2469 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | -0.0396 | |
| 63 | Q | A | -1.1685 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.3012 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | -1.8119 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.4349 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.5945 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.8933 | |
| 84 | S | A | 0.0036 | |
| 85 | P | A | -0.1249 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.5634 | |
| 88 | G | A | -1.4429 | |
| 89 | K | A | -1.9295 | |
| 90 | A | A | -0.8303 | |
| 91 | G | A | -0.5334 | |
| 92 | C | A | 0.0885 | |
| 93 | Q | A | -0.4759 | |
| 94 | T | A | -0.4393 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.8795 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.5891 | |
| 99 | T | A | -0.5200 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3445 | |
| 103 | S | A | -0.5247 | |
| 104 | E | A | -0.6927 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.5014 | |
| 108 | W | A | -0.8516 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.4248 | |
| 111 | A | A | -0.9182 | |
| 112 | N | A | -1.3228 | |
| 113 | R | A | -1.7126 | |
| 114 | A | A | -1.7434 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.7297 | |
| 117 | P | A | -1.1027 | |
| 118 | T | A | -0.7685 | |
| 119 | G | A | -0.4206 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | -0.1148 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.2417 | |
| 139 | H | A | -0.4036 | |
| 140 | P | A | -0.8372 | |
| 141 | Q | A | -1.1846 | |
| 142 | Q | A | 0.0000 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.0591 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.1982 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | -1.0602 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.2073 | |
| 157 | Q | A | -1.3787 | |
| 158 | G | A | -0.5147 | |
| 159 | M | A | 0.5088 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | 0.0160 | |
| 162 | S | A | 0.4454 | |
| 163 | L | A | 0.9345 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.0415 | |
| 166 | L | A | 0.7542 | |
| 167 | A | A | -0.2815 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.2705 | |
| 170 | D | A | -2.1134 | |
| 171 | A | A | 0.0000 | |
| 172 | G | A | -1.8049 | |
| 173 | G | A | -1.6396 | |
| 174 | Y | A | 0.0000 | |
| 175 | K | A | -1.8845 | |
| 176 | A | A | 0.0000 | |
| 177 | A | A | -0.7452 | |
| 178 | D | A | -0.6479 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | -0.4431 | |
| 182 | P | A | -0.6338 | |
| 183 | S | A | -0.8131 | |
| 184 | S | A | -0.7443 | |
| 185 | D | A | -0.9181 | |
| 186 | P | A | -0.9655 | |
| 187 | A | A | 0.0000 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -1.8429 | |
| 190 | R | A | -1.2886 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.2399 | |
| 195 | Q | A | -1.8817 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -1.1125 | |
| 199 | K | A | -1.4419 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.2096 | |
| 202 | A | A | -0.9008 | |
| 203 | N | A | -1.3430 | |
| 204 | N | A | -1.5808 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.7823 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.7174 | |
| 214 | G | A | -0.3519 | |
| 215 | T | A | -0.4958 | |
| 216 | P | A | -1.0240 | |
| 217 | N | A | -1.3322 | |
| 218 | E | A | -1.8837 | |
| 219 | L | A | -0.6192 | |
| 220 | G | A | -0.8406 | |
| 221 | G | A | -0.5872 | |
| 222 | A | A | -0.3685 | |
| 223 | N | A | 0.2264 | |
| 224 | I | A | 1.9473 | |
| 225 | P | A | 1.0565 | |
| 226 | A | A | 0.0000 | |
| 227 | E | A | 0.5405 | |
| 228 | F | A | 1.9250 | |
| 229 | L | A | 1.1228 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.6433 | |
| 232 | F | A | 0.3919 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.5423 | |
| 235 | S | A | -0.5719 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.4974 | |
| 239 | K | A | -1.9625 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.5103 | |
| 242 | D | A | -2.5599 | |
| 243 | A | A | -1.7657 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.2037 | |
| 246 | A | A | -1.1179 | |
| 247 | A | A | -0.9238 | |
| 248 | G | A | -1.0676 | |
| 249 | G | A | -1.6515 | |
| 250 | H | A | -1.6229 | |
| 251 | N | A | -1.1973 | |
| 252 | A | A | -0.5210 | |
| 253 | V | A | 0.2932 | |
| 254 | F | A | 0.6146 | |
| 255 | N | A | 0.1327 | |
| 256 | F | A | 0.2189 | |
| 257 | P | A | -0.2361 | |
| 258 | P | A | -0.5627 | |
| 259 | N | A | -0.8595 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.2859 | |
| 263 | S | A | -0.5007 | |
| 264 | W | A | -0.4343 | |
| 265 | E | A | -1.1032 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.4077 | |
| 270 | Q | A | -0.5577 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.9029 | |
| 273 | A | A | -0.6112 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0271 | |
| 276 | G | A | -1.1042 | |
| 277 | D | A | -0.8388 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -1.0309 | |
| 280 | S | A | -0.8979 | |
| 281 | S | A | -0.6117 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | -0.9094 | |
| 284 | A | A | 0.0000 | |
| 285 | G | A | -1.2832 | |
| 286 | G | A | -1.2619 | |
| 287 | G | A | -1.4280 | |
| 288 | G | A | -1.4320 | |
| 289 | G | A | -1.3548 | |
| 290 | S | A | -1.1349 | |
| 291 | G | A | -1.1963 | |
| 292 | G | A | -1.2211 | |
| 293 | G | A | -0.9347 | |
| 294 | G | A | -0.4027 | |
| 295 | S | A | 0.5642 | |
| 296 | F | A | 2.1700 | |
| 297 | A | A | 1.5699 | |
| 298 | V | A | 1.7266 | |
| 299 | T | A | -0.0869 | |
| 300 | N | A | -1.6075 | |
| 301 | D | A | -1.7729 | |
| 302 | G | A | -0.3996 | |
| 303 | V | A | 2.0029 | |
| 304 | I | A | 2.5917 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine