| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTAPQHCGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRCGPEGHPRPDAPPPSPLYVRPPPTSPYATPPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPLPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9419 | |
| 2 | L | A | 1.9625 | |
| 3 | P | A | 0.8363 | |
| 4 | P | A | 0.3780 | |
| 5 | T | A | 0.1263 | |
| 6 | T | A | 0.1315 | |
| 7 | P | A | 0.1769 | |
| 8 | V | A | 1.2145 | |
| 9 | A | A | 0.0897 | |
| 10 | K | A | -1.0168 | |
| 11 | V | A | -0.1449 | |
| 12 | Q | A | -1.4047 | |
| 13 | S | A | -1.5512 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4233 | |
| 16 | E | A | -2.4416 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4577 | |
| 20 | P | A | 0.1283 | |
| 21 | T | A | 0.1834 | |
| 22 | S | A | -0.0904 | |
| 23 | L | A | 0.1093 | |
| 24 | F | A | -0.0236 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2835 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8945 | |
| 31 | R | A | -2.6786 | |
| 32 | L | A | -0.7968 | |
| 33 | L | A | 1.1646 | |
| 34 | T | A | 1.3729 | |
| 35 | V | A | 1.8319 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2856 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6903 | |
| 40 | E | A | -1.8189 | |
| 41 | D | A | -0.8316 | |
| 42 | I | A | 1.2092 | |
| 43 | V | A | 2.1530 | |
| 44 | V | A | 1.6293 | |
| 45 | N | A | -0.5543 | |
| 46 | G | A | -0.3822 | |
| 47 | K | A | -0.1592 | |
| 48 | V | A | 1.9636 | |
| 49 | L | A | 2.5019 | |
| 50 | V | A | 1.3995 | |
| 51 | P | A | 0.2762 | |
| 52 | K | A | -0.7603 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1233 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3689 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2321 | |
| 70 | K | A | -1.7797 | |
| 71 | F | A | -0.6225 | |
| 72 | A | A | -0.5785 | |
| 73 | L | A | -0.8717 | |
| 74 | P | A | -1.2146 | |
| 75 | Q | A | -2.5118 | |
| 76 | K | A | -3.1150 | |
| 77 | D | A | -2.9977 | |
| 78 | F | A | -1.6774 | |
| 79 | Y | A | -1.9030 | |
| 80 | D | A | -2.7071 | |
| 81 | P | A | -2.3154 | |
| 82 | E | A | -3.0573 | |
| 83 | K | A | -3.4057 | |
| 84 | E | A | -2.4710 | |
| 85 | R | A | -1.2972 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6895 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9658 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3582 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6946 | |
| 99 | G | A | -0.5363 | |
| 100 | P | A | -0.4015 | |
| 101 | L | A | 0.0491 | |
| 102 | G | A | -0.1874 | |
| 103 | K | A | -0.5579 | |
| 104 | G | A | -0.4192 | |
| 105 | T | A | -0.4328 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | 0.1424 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4314 | |
| 110 | L | A | 0.3211 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0873 | |
| 113 | K | A | -0.3515 | |
| 114 | L | A | -0.8423 | |
| 115 | G | A | -0.8498 | |
| 116 | D | A | -1.1807 | |
| 117 | T | A | -0.9352 | |
| 118 | E | A | -1.8947 | |
| 119 | N | A | -2.0234 | |
| 120 | P | A | -1.4417 | |
| 121 | T | A | -0.7502 | |
| 122 | A | A | -0.5409 | |
| 123 | P | A | -0.3613 | |
| 124 | Q | A | -0.6895 | |
| 125 | H | A | -0.9940 | |
| 126 | C | A | -0.8337 | |
| 127 | G | A | -1.2883 | |
| 128 | A | A | -1.1590 | |
| 129 | D | A | -2.1652 | |
| 130 | D | A | -1.7185 | |
| 131 | R | A | -1.1098 | |
| 132 | V | A | 0.2565 | |
| 133 | A | A | 0.4632 | |
| 134 | F | A | 0.2868 | |
| 135 | S | A | -0.0706 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6041 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5642 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2039 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1135 | |
| 157 | D | A | 0.2852 | |
| 158 | I | A | 0.8283 | |
| 159 | A | A | 0.1096 | |
| 160 | E | A | -1.4834 | |
| 161 | P | A | -0.2265 | |
| 162 | C | A | 0.1893 | |
| 163 | P | A | -0.1645 | |
| 164 | G | A | -0.0643 | |
| 165 | L | A | 0.6175 | |
| 166 | P | A | -0.0986 | |
| 167 | P | A | -0.3329 | |
| 168 | G | A | -0.4225 | |
| 169 | A | A | -0.0329 | |
| 170 | C | A | 0.7347 | |
| 171 | P | A | 0.5546 | |
| 172 | P | A | 0.8460 | |
| 173 | I | A | 2.0425 | |
| 174 | Q | A | 0.8421 | |
| 175 | L | A | 1.4454 | |
| 176 | V | A | 0.8310 | |
| 177 | N | A | -0.3065 | |
| 178 | S | A | 0.0275 | |
| 179 | V | A | 0.4320 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3799 | |
| 182 | D | A | 0.0908 | |
| 183 | G | A | -0.1581 | |
| 184 | D | A | -0.5259 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1099 | |
| 190 | F | A | 0.0594 | |
| 191 | G | A | -0.1048 | |
| 192 | N | A | -0.2511 | |
| 193 | M | A | -0.1097 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3809 | |
| 197 | E | A | -2.6167 | |
| 198 | L | A | -1.2186 | |
| 199 | Q | A | -2.5500 | |
| 200 | Q | A | -3.3172 | |
| 201 | D | A | -3.5815 | |
| 202 | R | A | -3.3320 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1784 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3607 | |
| 211 | S | A | -1.8986 | |
| 212 | T | A | -1.4186 | |
| 213 | R | A | -2.0404 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1533 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3338 | |
| 220 | L | A | 0.5923 | |
| 221 | K | A | -1.1370 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8214 | |
| 224 | N | A | -1.4990 | |
| 225 | E | A | -1.2363 | |
| 226 | A | A | -0.5896 | |
| 227 | Y | A | -0.3533 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6599 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0755 | |
| 234 | F | A | 0.2543 | |
| 235 | G | A | -0.8013 | |
| 236 | R | A | -2.5641 | |
| 237 | R | A | -2.7796 | |
| 238 | E | A | -2.0599 | |
| 239 | Q | A | -0.1427 | |
| 240 | V | A | 1.4664 | |
| 241 | Y | A | 1.1429 | |
| 242 | A | A | 0.2583 | |
| 243 | R | A | -0.8612 | |
| 244 | H | A | -0.9106 | |
| 245 | F | A | 0.0310 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.5819 | |
| 249 | C | A | -0.9526 | |
| 250 | G | A | -0.9343 | |
| 251 | P | A | -0.9277 | |
| 252 | E | A | -1.5442 | |
| 253 | G | A | -1.4180 | |
| 254 | H | A | -1.5394 | |
| 255 | P | A | -1.6240 | |
| 256 | R | A | -1.2954 | |
| 257 | P | A | -1.2694 | |
| 258 | D | A | -2.1665 | |
| 259 | A | A | -1.0005 | |
| 260 | P | A | -1.0351 | |
| 261 | P | A | -0.7387 | |
| 262 | P | A | -0.1439 | |
| 263 | S | A | -0.0001 | |
| 264 | P | A | 0.7344 | |
| 265 | L | A | 1.5054 | |
| 266 | Y | A | 1.2343 | |
| 267 | V | A | 1.1707 | |
| 268 | R | A | -1.0017 | |
| 269 | P | A | -0.4530 | |
| 270 | P | A | -0.5458 | |
| 271 | P | A | -0.5836 | |
| 272 | T | A | -0.2125 | |
| 273 | S | A | -0.2351 | |
| 274 | P | A | -0.0923 | |
| 275 | Y | A | 0.2274 | |
| 276 | A | A | -0.1732 | |
| 277 | T | A | -0.2571 | |
| 278 | P | A | -0.2921 | |
| 279 | P | A | -0.4842 | |
| 280 | P | A | -0.6294 | |
| 281 | T | A | -0.4845 | |
| 282 | D | A | -0.9480 | |
| 283 | Y | A | 0.7658 | |
| 284 | F | A | 0.6456 | |
| 285 | G | A | 0.2384 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9536 | |
| 291 | L | A | 1.6381 | |
| 292 | V | A | 0.6530 | |
| 293 | S | A | -0.1562 | |
| 294 | S | A | -0.9609 | |
| 295 | D | A | -1.8422 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0922 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6428 | |
| 301 | R | A | -1.8577 | |
| 302 | P | A | -0.9792 | |
| 303 | F | A | -0.1996 | |
| 304 | W | A | -0.5731 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0935 | |
| 307 | R | A | -2.8408 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2671 | |
| 310 | G | A | -1.2231 | |
| 311 | N | A | -1.2667 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7539 | |
| 319 | N | A | -0.8269 | |
| 320 | E | A | -1.0218 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3296 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0674 | |
| 333 | N | A | 0.5479 | |
| 334 | F | A | 1.7159 | |
| 335 | T | A | 0.8501 | |
| 336 | I | A | 0.4367 | |
| 337 | S | A | -0.9584 | |
| 338 | Q | A | -1.7441 | |
| 339 | Q | A | -1.1517 | |
| 340 | L | A | 0.7097 | |
| 341 | C | A | 0.6062 | |
| 342 | T | A | 0.4458 | |
| 343 | P | A | 0.2445 | |
| 344 | L | A | 1.2021 | |
| 345 | P | A | 0.6236 | |
| 346 | N | A | 0.0194 | |
| 347 | V | A | 1.7241 | |
| 348 | Y | A | 1.6129 | |
| 349 | D | A | 0.2371 | |
| 350 | P | A | -0.3861 | |
| 351 | S | A | -0.3380 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7088 | |
| 354 | K | A | -1.8068 | |
| 355 | N | A | -1.7711 | |
| 356 | Y | A | -0.1006 | |
| 357 | L | A | 0.6255 | |
| 358 | R | A | 0.9481 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3859 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0721 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0389 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6874 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2751 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3155 | |
| 376 | L | A | -1.7100 | |
| 377 | D | A | -1.9952 | |
| 378 | P | A | -1.0396 | |
| 379 | G | A | -1.0187 | |
| 380 | V | A | -0.9361 | |
| 381 | L | A | -0.5338 | |
| 382 | A | A | -0.6593 | |
| 383 | H | A | -0.8091 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4202 | |
| 386 | T | A | -0.5564 | |
| 387 | M | A | -0.3018 | |
| 388 | N | A | -0.8711 | |
| 389 | P | A | -1.2386 | |
| 390 | T | A | -1.4319 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4287 | |
| 393 | E | A | -2.7625 | |
| 394 | N | A | -2.3108 | |
| 395 | W | A | -1.3640 | |
| 396 | N | A | -1.1678 | |
| 397 | L | A | -0.2116 | |
| 398 | G | A | 0.5231 | |
| 399 | F | A | 2.3950 | |
| 400 | V | A | 1.7818 | |
| 401 | P | A | 0.0383 | |
| 402 | P | A | -1.8246 | |
| 403 | K | A | -3.3202 | |
| 404 | E | A | -3.7718 | |
| 405 | R | A | -3.8952 | |
| 406 | E | A | -3.7718 | |
| 407 | D | A | -2.8352 | |
| 408 | P | A | -1.7497 | |
| 409 | Y | A | -0.9721 | |
| 410 | K | A | -2.1013 | |
| 411 | G | A | -0.6264 | |
| 412 | L | A | 0.6800 | |
| 413 | I | A | 1.5955 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3684 | |
| 416 | E | A | -1.6357 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9332 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0417 | |
| 421 | E | A | -2.7741 | |
| 422 | R | A | -2.6169 | |
| 423 | F | A | -1.2670 | |
| 424 | S | A | -1.4504 | |
| 425 | Q | A | -1.8128 | |
| 426 | D | A | -2.8813 | |
| 427 | L | A | -1.9833 | |
| 428 | D | A | -2.7746 | |
| 429 | Q | A | -2.6160 | |
| 430 | F | A | -1.4375 | |
| 431 | A | A | -0.9157 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6359 | |
| 435 | K | A | -0.7445 | |
| 436 | F | A | 0.1271 | |
| 437 | L | A | 1.0133 | |
| 438 | Y | A | 0.8084 | |
| 439 | Q | A | -0.2838 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine