Project name: 111

Status: done

Started: 2025-10-28 02:15:12
Settings
Chain sequence(s) A: MRSSKRWAKLAAVAAATTLALSACGGGKSNTPATTAAGESTTSAKSSAPSGQLNLGVAYETTNYDPSTTSSALAMGTNWHVVEGLYEFDMSNYKLFPALAAGEPKKISDTEYEITLRDGAKFSDGKDVTTKDFLESYKRTTADTSIYKQFFTFIDSVAAKDDKTISVKLKYPFVALAERLVDVKVIPASSNQKDMTAKPVGTGPFKYETISNTVVEAVPNEFYNGPKPAKVAKMHWDVLKDDTARLAAALGGTIDVMETVPSATKDQLKAAGWTLDEVPGYNNPFLMFNTTKAPFDKKDVRKAFHYAIDREKLVKDAMGGDATVASSFLPKSNPMYKEAAEQFTMDTAKAKAAFEAAGLKEITLITTDHPWIANLAPQIRKDLEAAGLTVNVQSMASGDLYANFADVDNPTFDVALAPGDPSVFGVDPGIIINWWYGDNVWTQKRGAWGKTNPEGFKKLSEIVSAAEQATGDAAKAKWGEAQDLIADEAPIFPLFHRTMITGINGAKVVGGHGIGTTGLNFVGASVK
input PDB
Selected Chain(s) A
Distance of aggregation 10 Å
FoldX usage Yes
Dynamic mode No
Automated mutations Yes
Downloads Download all the data
Simulation log 
[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:09:23)
[INFO]       Auto_mut: Residue number 19 from chain A and a score of 1.872 (leucine) selected for  
                       automated muatation                                                         (00:09:28)
[INFO]       Auto_mut: Residue number 13 from chain A and a score of 1.856 (valine) selected for   
                       automated muatation                                                         (00:09:28)
[INFO]       Auto_mut: Residue number 21 from chain A and a score of 1.855 (leucine) selected for  
                       automated muatation                                                         (00:09:28)
[INFO]       Auto_mut: Residue number 20 from chain A and a score of 1.505 (alanine) selected for  
                       automated muatation                                                         (00:09:28)
[INFO]       Auto_mut: Residue number 12 from chain A and a score of 1.308 (alanine) selected for  
                       automated muatation                                                         (00:09:28)
[INFO]       Auto_mut: Residue number 174 from chain A and a score of 1.182 (valine) selected for  
                       automated muatation                                                         (00:09:28)
[INFO]       Auto_mut: Mutating residue number 19 from chain A (leucine) into glutamic acid        (00:09:28)
[INFO]       Auto_mut: Mutating residue number 19 from chain A (leucine) into aspartic acid        (00:09:28)
[INFO]       Auto_mut: Mutating residue number 13 from chain A (valine) into glutamic acid         (00:09:28)
[INFO]       Auto_mut: Mutating residue number 13 from chain A (valine) into lysine                (00:13:29)
[INFO]       Auto_mut: Mutating residue number 19 from chain A (leucine) into lysine               (00:13:29)
[INFO]       Auto_mut: Mutating residue number 19 from chain A (leucine) into arginine             (00:13:29)
[INFO]       Auto_mut: Mutating residue number 13 from chain A (valine) into aspartic acid         (00:17:29)
[INFO]       Auto_mut: Mutating residue number 21 from chain A (leucine) into glutamic acid        (00:17:32)
[INFO]       Auto_mut: Mutating residue number 21 from chain A (leucine) into aspartic acid        (00:17:33)
[INFO]       Auto_mut: Mutating residue number 21 from chain A (leucine) into lysine               (00:21:21)
[INFO]       Auto_mut: Mutating residue number 13 from chain A (valine) into arginine              (00:21:26)
[INFO]       Auto_mut: Mutating residue number 21 from chain A (leucine) into arginine             (00:21:31)
[INFO]       Auto_mut: Mutating residue number 20 from chain A (alanine) into glutamic acid        (00:25:19)
[INFO]       Auto_mut: Mutating residue number 20 from chain A (alanine) into aspartic acid        (00:25:24)
[INFO]       Auto_mut: Mutating residue number 12 from chain A (alanine) into glutamic acid        (00:25:33)
[INFO]       Auto_mut: Mutating residue number 20 from chain A (alanine) into lysine               (00:29:06)
[INFO]       Auto_mut: Mutating residue number 20 from chain A (alanine) into arginine             (00:29:20)
[INFO]       Auto_mut: Mutating residue number 12 from chain A (alanine) into lysine               (00:29:31)
[INFO]       Auto_mut: Mutating residue number 12 from chain A (alanine) into aspartic acid        (00:33:10)
[INFO]       Auto_mut: Mutating residue number 174 from chain A (valine) into glutamic acid        (00:33:23)
[INFO]       Auto_mut: Mutating residue number 174 from chain A (valine) into aspartic acid        (00:33:29)
[INFO]       Auto_mut: Mutating residue number 12 from chain A (alanine) into arginine             (00:37:10)
[INFO]       Auto_mut: Mutating residue number 174 from chain A (valine) into lysine               (00:37:20)
[INFO]       Auto_mut: Mutating residue number 174 from chain A (valine) into arginine             (00:37:35)
[INFO]       Auto_mut: Effect of mutation residue number 19 from chain A (leucine) into glutamic   
                       acid: Energy difference: -0.0493 kcal/mol, Difference in average score from 
                       the base case: -0.0149                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 19 from chain A (leucine) into lysine:    
                       Energy difference: 0.1622 kcal/mol, Difference in average score from the    
                       base case: -0.0142                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 19 from chain A (leucine) into aspartic   
                       acid: Energy difference: 0.0365 kcal/mol, Difference in average score from  
                       the base case: -0.0147                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 19 from chain A (leucine) into arginine:  
                       Energy difference: 0.0146 kcal/mol, Difference in average score from the    
                       base case: -0.0150                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 13 from chain A (valine) into glutamic    
                       acid: Energy difference: -0.9763 kcal/mol, Difference in average score from 
                       the base case: -0.0152                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 13 from chain A (valine) into lysine:     
                       Energy difference: -0.6168 kcal/mol, Difference in average score from the   
                       base case: -0.0147                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 13 from chain A (valine) into aspartic    
                       acid: Energy difference: -1.0345 kcal/mol, Difference in average score from 
                       the base case: -0.0151                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 13 from chain A (valine) into arginine:   
                       Energy difference: -0.9422 kcal/mol, Difference in average score from the   
                       base case: -0.0153                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 21 from chain A (leucine) into glutamic   
                       acid: Energy difference: 0.1181 kcal/mol, Difference in average score from  
                       the base case: -0.0188                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 21 from chain A (leucine) into lysine:    
                       Energy difference: 0.0890 kcal/mol, Difference in average score from the    
                       base case: -0.0137                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 21 from chain A (leucine) into aspartic   
                       acid: Energy difference: 0.2830 kcal/mol, Difference in average score from  
                       the base case: -0.0141                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 21 from chain A (leucine) into arginine:  
                       Energy difference: -0.1629 kcal/mol, Difference in average score from the   
                       base case: -0.0144                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 20 from chain A (alanine) into glutamic   
                       acid: Energy difference: -0.4335 kcal/mol, Difference in average score from 
                       the base case: -0.0123                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 20 from chain A (alanine) into lysine:    
                       Energy difference: -0.7522 kcal/mol, Difference in average score from the   
                       base case: -0.0072                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 20 from chain A (alanine) into aspartic   
                       acid: Energy difference: -0.6921 kcal/mol, Difference in average score from 
                       the base case: -0.0103                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 20 from chain A (alanine) into arginine:  
                       Energy difference: -0.9409 kcal/mol, Difference in average score from the   
                       base case: -0.0079                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 12 from chain A (alanine) into glutamic   
                       acid: Energy difference: 0.8789 kcal/mol, Difference in average score from  
                       the base case: -0.0073                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 12 from chain A (alanine) into lysine:    
                       Energy difference: 1.2810 kcal/mol, Difference in average score from the    
                       base case: -0.0067                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 12 from chain A (alanine) into aspartic   
                       acid: Energy difference: 1.5256 kcal/mol, Difference in average score from  
                       the base case: -0.0071                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 12 from chain A (alanine) into arginine:  
                       Energy difference: 1.1966 kcal/mol, Difference in average score from the    
                       base case: -0.0074                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 174 from chain A (valine) into glutamic   
                       acid: Energy difference: 0.0116 kcal/mol, Difference in average score from  
                       the base case: -0.0237                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 174 from chain A (valine) into lysine:    
                       Energy difference: -0.6914 kcal/mol, Difference in average score from the   
                       base case: -0.0186                                                          (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 174 from chain A (valine) into aspartic   
                       acid: Energy difference: -0.3786 kcal/mol, Difference in average score from 
                       the base case: -0.0187                                                      (00:41:57)
[INFO]       Auto_mut: Effect of mutation residue number 174 from chain A (valine) into arginine:  
                       Energy difference: -1.1806 kcal/mol, Difference in average score from the   
                       base case: -0.0204                                                          (00:41:57)
[INFO]       Main:     Simulation completed successfully.                                          (00:42:09)
Show buried residues
Minimal score value
-3.8303
Maximal score value
1.8719
Average score
-0.7861
Total score value
-414.2721
Download the table (csv)

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A 0.1288
2 R A -1.5051
3 S A -1.4526
4 S A -2.0343
5 K A -2.6189
6 R A -2.4275
7 W A -0.2641
8 A A -0.5152
9 K A -0.7190
10 L A 0.7742
11 A A 0.8903
12 A A 1.3082
13 V A 1.8562
14 A A 0.9668
15 A A 0.4754
16 A A 0.0494
17 T A 0.3018
18 T A 0.6736
19 L A 1.8719
20 A A 1.5046
21 L A 1.8554
22 S A 0.8557
23 A A 0.5779
24 C A 0.3482
25 G A -0.3883
26 G A -1.1203
27 G A -1.6830
28 K A -2.3905
29 S A -1.8218
30 N A -1.8100
31 T A -0.8503
32 P A -0.5469
33 A A -0.1277
34 T A -0.1222
35 T A -0.1344
36 A A -0.3045
37 A A -0.6950
38 G A -1.3906
39 E A -2.1601
40 S A -1.3152
41 T A -0.8810
42 T A -0.7561
43 S A -0.7912
44 A A -0.9918
45 K A -1.8998
46 S A -1.4000
47 S A -1.0799
48 A A -0.7555
49 P A -1.0832
50 S A -1.1954
51 G A -1.3274
52 Q A -1.2779
53 L A 0.0000
54 N A -0.6031
55 L A 0.0000
56 G A 0.0000
57 V A 0.0000
58 A A -0.9309
59 Y A -1.0916
60 E A -2.1438
61 T A -1.3420
62 T A -0.9241
63 N A -1.0983
64 Y A 0.0000
65 D A 0.0000
66 P A 0.0000
67 S A 0.0000
68 T A -0.3275
69 T A 0.0000
70 S A -0.2683
71 S A -0.5372
72 A A 0.0000
73 L A 0.0000
74 A A 0.0000
75 M A 0.0000
76 G A 0.0000
77 T A 0.0000
78 N A 0.0000
79 W A 0.0000
80 H A 0.0000
81 V A 0.0000
82 V A 0.0000
83 E A 0.0000
84 G A 0.0000
85 L A 0.0000
86 Y A 0.0000
87 E A 0.0000
88 F A 0.0000
89 D A -1.2574
90 M A 0.0000
91 S A -1.3070
92 N A -1.7723
93 Y A -1.3707
94 K A -2.0897
95 L A -1.0583
96 F A -0.4793
97 P A -0.3811
98 A A 0.0000
99 L A 0.0000
100 A A 0.0000
101 A A -0.9202
102 G A -1.2417
103 E A -2.5247
104 P A -2.2403
105 K A -2.8905
106 K A -2.7479
107 I A -0.5888
108 S A -1.4348
109 D A -2.2189
110 T A -2.0332
111 E A -2.4512
112 Y A 0.0000
113 E A -1.7149
114 I A 0.0000
115 T A -1.6701
116 L A 0.0000
117 R A -1.4717
118 D A -2.4817
119 G A -1.8742
120 A A 0.0000
121 K A -2.2412
122 F A 0.0000
123 S A -1.5268
124 D A -2.5017
125 G A -2.1031
126 K A -2.5824
127 D A -2.4674
128 V A 0.0000
129 T A -2.0577
130 T A 0.0000
131 K A -2.3746
132 D A 0.0000
133 F A 0.0000
134 L A -1.0897
135 E A -1.5553
136 S A 0.0000
137 Y A 0.0000
138 K A -2.2201
139 R A -1.6793
140 T A 0.0000
141 T A -1.5040
142 A A -1.6248
143 D A -2.2001
144 T A -1.0074
145 S A 0.0000
146 I A -0.2442
147 Y A 0.0000
148 K A -1.7012
149 Q A 0.0000
150 F A 0.0000
151 F A 0.0000
152 T A -1.0442
153 F A 0.0000
154 I A 0.0000
155 D A -2.7176
156 S A -1.5170
157 V A -0.8672
158 A A -0.8378
159 A A -2.1006
160 K A -2.8504
161 D A -3.4533
162 D A -3.4437
163 K A -2.7763
164 T A -1.9027
165 I A 0.0000
166 S A -1.1358
167 V A 0.0000
168 K A -2.1205
169 L A 0.0000
170 K A -2.7316
171 Y A -1.5014
172 P A -1.1450
173 F A 0.0000
174 V A 1.1816
175 A A 0.3841
176 L A 0.0000
177 A A -0.3336
178 E A -0.5690
179 R A 0.0000
180 L A 0.0000
181 V A 0.0000
182 D A 0.0000
183 V A 0.0000
184 K A 0.0000
185 V A 0.0000
186 I A 0.0000
187 P A -0.9990
188 A A -0.8398
189 S A -0.7463
190 S A -1.5742
191 N A -2.8606
192 Q A -3.1783
193 K A -3.6784
194 D A -3.5189
195 M A 0.0000
196 T A -2.0544
197 A A -1.7493
198 K A -1.8867
199 P A 0.0000
200 V A -0.2702
201 G A 0.0000
202 T A 0.0000
203 G A 0.0000
204 P A 0.0000
205 F A 0.0000
206 K A -1.2345
207 Y A 0.0000
208 E A -1.8403
209 T A -0.8452
210 I A -0.4764
211 S A -0.7627
212 N A -1.5936
213 T A -0.8419
214 V A -0.3585
215 V A 0.0000
216 E A -0.8065
217 A A 0.0000
218 V A -0.7661
219 P A -0.9758
220 N A 0.0000
221 E A -1.9306
222 F A -1.2342
223 Y A -0.9356
224 N A -1.5806
225 G A -1.0568
226 P A -0.7883
227 K A -1.1392
228 P A -1.3255
229 A A -1.1961
230 K A -1.9375
231 V A 0.0000
232 A A -0.7980
233 K A -1.1876
234 M A 0.0000
235 H A -0.6748
236 W A 0.0000
237 D A -0.6382
238 V A -0.8762
239 L A -0.8879
240 K A -1.8605
241 D A -2.1115
242 D A -1.3119
243 T A -0.7528
244 A A -0.5588
245 R A 0.0000
246 L A -0.1676
247 A A 0.1477
248 A A 0.0028
249 A A 0.0000
250 L A 0.3286
251 G A -0.1889
252 G A -0.3005
253 T A -0.2620
254 I A 0.0000
255 D A 0.0000
256 V A 0.0000
257 M A 0.0000
258 E A 0.0000
259 T A 0.0000
260 V A 0.0000
261 P A -0.2358
262 S A -0.8164
263 A A -0.7966
264 T A -1.2010
265 K A -1.7753
266 D A -2.8616
267 Q A -2.0621
268 L A 0.0000
269 K A -2.7389
270 A A -1.6027
271 A A -1.0836
272 G A -1.2579
273 W A 0.0000
274 T A -0.9336
275 L A -1.0972
276 D A -1.0100
277 E A -1.4136
278 V A -0.7182
279 P A -0.7261
280 G A 0.0000
281 Y A 0.0000
282 N A 0.0000
283 N A 0.0000
284 P A 0.0000
285 F A 0.0000
286 L A 0.0000
287 M A 0.0000
288 F A 0.0000
289 N A 0.0000
290 T A 0.0000
291 T A -1.5788
292 K A -1.5817
293 A A -1.1091
294 P A -1.3937
295 F A 0.0000
296 D A -2.7099
297 K A -2.8334
298 K A -2.7241
299 D A -2.8040
300 V A 0.0000
301 R A 0.0000
302 K A 0.0000
303 A A 0.0000
304 F A 0.0000
305 H A 0.0000
306 Y A -0.3699
307 A A 0.0000
308 I A 0.0000
309 D A -1.3105
310 R A 0.0000
311 E A -2.9233
312 K A -2.9494
313 L A 0.0000
314 V A 0.0000
315 K A -3.6610
316 D A -3.4527
317 A A -2.1225
318 M A 0.0000
319 G A -2.0273
320 G A -2.0598
321 D A -1.0637
322 A A -0.8117
323 T A -0.8154
324 V A -0.7296
325 A A 0.0000
326 S A -0.8706
327 S A 0.0000
328 F A 0.0000
329 L A 0.0000
330 P A -1.1445
331 K A -2.1168
332 S A -1.0036
333 N A 0.0000
334 P A -0.6987
335 M A -0.9462
336 Y A -1.1582
337 K A -1.8970
338 E A -2.0207
339 A A 0.0000
340 A A -1.0390
341 E A -0.9866
342 Q A -0.8246
343 F A 0.0000
344 T A -0.3085
345 M A -0.2829
346 D A -0.8724
347 T A -1.0008
348 A A -1.0786
349 K A -1.8183
350 A A 0.0000
351 K A -2.1717
352 A A -1.5306
353 A A -1.5772
354 F A 0.0000
355 E A -2.4811
356 A A -1.0015
357 A A -1.3580
358 G A -1.5841
359 L A 0.0000
360 K A -3.3035
361 E A -3.0058
362 I A 0.0000
363 T A -0.7647
364 L A 0.0000
365 I A 0.0000
366 T A 0.0000
367 T A 0.0000
368 D A -1.4880
369 H A -1.1955
370 P A -1.2073
371 W A -0.5684
372 I A 0.0000
373 A A -1.0604
374 N A -1.6363
375 L A 0.0000
376 A A 0.0000
377 P A -1.2639
378 Q A -1.8721
379 I A 0.0000
380 R A -2.1186
381 K A -2.7387
382 D A -1.7133
383 L A 0.0000
384 E A -2.5309
385 A A -1.3311
386 A A 0.0000
387 G A -2.1176
388 L A 0.0000
389 T A -2.0382
390 V A 0.0000
391 N A -1.0768
392 V A -0.5494
393 Q A -1.1081
394 S A -0.9665
395 M A -0.9355
396 A A -0.8691
397 S A -0.8625
398 G A -1.0993
399 D A -1.6607
400 L A 0.0000
401 Y A -0.6073
402 A A -0.9148
403 N A -1.3139
404 F A -0.7618
405 A A 0.0000
406 D A -1.1960
407 V A -1.3285
408 D A -2.3859
409 N A -2.2329
410 P A 0.0000
411 T A -0.7891
412 F A 0.0000
413 D A -0.5255
414 V A 0.0000
415 A A 0.0000
416 L A 0.0000
417 A A 0.0000
418 P A -0.1279
419 G A -0.1940
420 D A -0.2639
421 P A 0.0000
422 S A 0.0000
423 V A 0.0000
424 F A 0.0000
425 G A 0.0000
426 V A 0.1677
427 D A -0.2409
428 P A 0.0000
429 G A 0.0000
430 I A 0.0000
431 I A 0.0000
432 I A 0.0000
433 N A -0.6234
434 W A 0.0000
435 W A 0.0000
436 Y A 0.0000
437 G A 0.0000
438 D A -2.2076
439 N A -1.3570
440 V A -0.3852
441 W A 0.0000
442 T A 0.0000
443 Q A -1.3825
444 K A -1.4850
445 R A 0.0000
446 G A 0.0000
447 A A 0.0000
448 W A 0.0000
449 G A 0.0000
450 K A -2.2411
451 T A -1.8472
452 N A -2.0267
453 P A -2.3778
454 E A -3.1940
455 G A 0.0000
456 F A 0.0000
457 K A -3.8303
458 K A -3.4318
459 L A 0.0000
460 S A -2.5017
461 E A -2.7570
462 I A -1.8263
463 V A 0.0000
464 S A -0.9997
465 A A -0.9477
466 A A 0.0000
467 E A -0.4844
468 Q A -0.8353
469 A A -0.9548
470 T A -0.9437
471 G A -1.5708
472 D A -2.4122
473 A A -1.5319
474 A A 0.0000
475 K A -2.1971
476 A A -1.7144
477 K A -1.6965
478 W A 0.0000
479 G A 0.0000
480 E A -2.2375
481 A A 0.0000
482 Q A 0.0000
483 D A -1.5656
484 L A -0.9174
485 I A 0.0000
486 A A 0.0000
487 D A -1.2420
488 E A 0.0000
489 A A 0.0000
490 P A 0.0000
491 I A 0.0000
492 F A 0.0000
493 P A 0.0000
494 L A 0.0000
495 F A 0.0000
496 H A 0.0000
497 R A 0.0000
498 T A -0.5202
499 M A 0.0000
500 I A 0.0000
501 T A 0.0000
502 G A 0.0000
503 I A 0.0000
504 N A -0.4873
505 G A -0.5186
506 A A -0.5834
507 K A -0.9677
508 V A 0.0000
509 V A 0.3450
510 G A -0.2509
511 G A -0.4514
512 H A -1.1515
513 G A 0.0000
514 I A 0.0000
515 G A 0.0000
516 T A 0.0000
517 T A 0.0000
518 G A 0.0000
519 L A 0.0000
520 N A -0.3962
521 F A 0.0000
522 V A -0.4647
523 G A -0.6065
524 A A 0.0000
525 S A -0.7528
526 V A -0.9989
527 K A -1.6814
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Automated mutations analysis

In the automated mutations mode, the server selects aggregation prone resides and each selected residue is mutated to glutamic acid, lysine, aspartic acid and arginine. The table below shows 2 best scored mutants for each mutated residue. Protein variants are ordered according to the mutation effect they had on protein stability (energetic effect) together with the difference in the average per-residue aggregation score between the wild type and the mutant (in the table green values indicate a positive change, grey are neutral, and orange/red mean destabilizing or more aggregation prone mutants).
Summary for all the mutants can be found in this CSV file.

Mutant
Energetic effect
Score comparison
VR174A -1.1806 -0.0204 View CSV PDB
VD13A -1.0345 -0.0151 View CSV PDB
VE13A -0.9763 -0.0152 View CSV PDB
VK174A -0.6914 -0.0186 View CSV PDB
AD20A -0.6921 -0.0103 View CSV PDB
AE20A -0.4335 -0.0123 View CSV PDB
LR21A -0.1629 -0.0144 View CSV PDB
LE19A -0.0493 -0.0149 View CSV PDB
LR19A 0.0146 -0.015 View CSV PDB
LE21A 0.1181 -0.0188 View CSV PDB
AE12A 0.8789 -0.0073 View CSV PDB
AR12A 1.1966 -0.0074 View CSV PDB
 
Laboratory of Theory of Biopolymers 2018