Project name: bb5b7246565c9b3

Chain sequence(s)	H: QVQLVQSGAEVKKPGSSVKVSCKASGYTFTDNYMIWVRQAPGQGLEWMGDINPYNGGTTFNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARESPYFSNLYVMDYWGQGTLVTVSS; L: EIVLTQSPATLSLSPGERATLSCKASQSVDYDGDNYMNWYQQKPGQAPRLLIYAASNLESGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCHLSNEDLSTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:03:26)
[INFO]       Main:     Simulation completed successfully.                                          (00:03:29)

• Minimal score value: -2.6599
• Maximal score value: 2.2667
• Average score: -0.5095
• Total score value: -118.7154

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.5604
2	V	H	0.0000
3	Q	H	-1.3928
4	L	H	0.0000
5	V	H	0.7798
6	Q	H	0.0000
7	S	H	-0.2871
8	G	H	-0.4205
9	A	H	0.2037
11	E	H	0.2690
12	V	H	1.2120
13	K	H	-0.4971
14	K	H	-1.5707
15	P	H	-1.8356
16	G	H	-1.2846
17	S	H	-1.0481
18	S	H	-0.9911
19	V	H	0.0000
20	K	H	-1.1122
21	V	H	0.0000
22	S	H	-0.2026
23	C	H	0.0000
24	K	H	-0.4111
25	A	H	0.0000
26	S	H	-0.7431
27	G	H	-1.0617
28	Y	H	-0.4785
29	T	H	-0.3629
30	F	H	0.0000
35	T	H	-0.0613
36	D	H	0.4570
37	N	H	0.0000
38	Y	H	0.4423
39	M	H	0.0000
40	I	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.4778
45	A	H	-0.9198
46	P	H	-0.7481
47	G	H	-1.1921
48	Q	H	-1.7167
49	G	H	-1.0636
50	L	H	0.0000
51	E	H	-0.7299
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	D	H	-0.1996
56	I	H	0.0000
57	N	H	0.0000
58	P	H	0.0000
59	Y	H	0.3307
62	N	H	-0.9517
63	G	H	-1.1153
64	G	H	-0.7697
65	T	H	-0.4358
66	T	H	-0.7101
67	F	H	-1.0213
68	N	H	-1.9901
69	Q	H	-2.6599
70	K	H	-2.5010
71	F	H	0.0000
72	K	H	-2.0748
74	G	H	-1.4435
75	R	H	-1.2368
76	V	H	0.0000
77	T	H	-0.5418
78	I	H	0.0000
79	T	H	-0.3509
80	A	H	-0.6427
81	D	H	-1.3241
82	K	H	-1.9658
83	S	H	-1.2360
84	T	H	-0.9771
85	S	H	-1.2494
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.2301
89	M	H	0.0000
90	E	H	-0.7611
91	L	H	0.0000
92	S	H	-0.8318
93	S	H	-0.9750
94	L	H	0.0000
95	R	H	-2.1847
96	S	H	-1.8127
97	E	H	-2.2640
98	D	H	0.0000
99	T	H	-0.5412
100	A	H	0.0000
101	V	H	0.4171
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.3283
107	E	H	0.0000
108	S	H	0.0000
109	P	H	0.8677
110	Y	H	2.1056
111	F	H	2.2667
111A	S	H	0.7209
112A	N	H	-0.6592
112	L	H	0.0002
113	Y	H	0.2375
114	V	H	0.2598
115	M	H	0.0000
116	D	H	-0.4633
117	Y	H	-0.5086
118	W	H	-0.2419
119	G	H	0.0000
120	Q	H	-1.0836
121	G	H	-0.3357
122	T	H	0.0000
123	L	H	0.7612
124	V	H	0.0000
125	T	H	0.1103
126	V	H	0.0000
127	S	H	-0.6274
128	S	H	-0.7280
1	E	L	-2.0931
2	I	L	0.0000
3	V	L	0.8362
4	L	L	0.0000
5	T	L	-0.5143
6	Q	L	-0.5611
7	S	L	-0.6851
8	P	L	-0.4338
9	A	L	-0.4076
10	T	L	-0.4642
11	L	L	-0.0534
12	S	L	-0.1960
13	L	L	-0.5290
14	S	L	-0.9226
15	P	L	-1.3206
16	G	L	-1.6649
17	E	L	-2.0388
18	R	L	-2.4985
19	A	L	0.0000
20	T	L	-0.5437
21	L	L	0.0000
22	S	L	-0.8905
23	C	L	0.0000
24	K	L	-1.9866
25	A	L	0.0000
26	S	L	-0.6833
27	Q	L	-1.1089
28	S	L	-0.9106
29	V	L	0.0000
30	D	L	-0.9824
31	Y	L	-0.2914
34	D	L	-1.7039
35	G	L	-1.3760
36	D	L	-1.2236
37	N	L	-0.9711
38	Y	L	-0.2232
39	M	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.1536
46	P	L	-0.9302
47	G	L	-1.2034
48	Q	L	-1.8298
49	A	L	-1.0870
50	P	L	0.0000
51	R	L	-0.7121
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1232
56	A	L	-0.4011
57	A	L	0.0000
65	S	L	-0.7506
66	N	L	-1.0247
67	L	L	-0.1835
68	E	L	0.0000
69	S	L	-0.4660
70	G	L	-0.4095
71	I	L	-0.1318
72	P	L	-0.2470
74	A	L	-0.0889
75	R	L	-0.5594
76	F	L	0.0000
77	S	L	-0.4934
78	G	L	-0.5166
79	S	L	-0.9394
80	G	L	-1.3524
83	S	L	-1.3364
84	G	L	-1.1963
85	T	L	-1.7917
86	D	L	-2.6357
87	F	L	0.0000
88	T	L	-0.8864
89	L	L	0.0000
90	T	L	-0.5943
91	I	L	0.0000
92	S	L	-1.1749
93	S	L	-1.5255
94	L	L	0.0000
95	E	L	-2.0623
96	P	L	-1.3770
97	E	L	-2.1864
98	D	L	0.0000
99	F	L	-0.3573
100	A	L	0.0000
101	V	L	-0.2018
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	H	L	0.0000
106	L	L	0.0000
107	S	L	-0.8714
108	N	L	-1.6011
109	E	L	-2.1738
114	D	L	-2.5863
115	L	L	0.0000
116	S	L	0.0000
117	T	L	-0.4584
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.5807
121	G	L	-0.7562
122	T	L	0.0000
123	K	L	-1.0248
124	V	L	0.0000
125	E	L	0.0873
126	I	L	0.9623
127	K	L	-0.8852