| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGSVGHPLFNKFGDTENPTKPQHCGPDNRVNFSFDPKQTQLFIVGCEPPTGEHWDLAPPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRCGPEGHPLPDEPPPSPLYVRPPPSSPHWVRPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPENNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9433 | |
| 2 | L | A | 1.9661 | |
| 3 | P | A | 0.8361 | |
| 4 | P | A | 0.3769 | |
| 5 | T | A | 0.1215 | |
| 6 | T | A | 0.1273 | |
| 7 | P | A | 0.1713 | |
| 8 | V | A | 1.2082 | |
| 9 | A | A | 0.0856 | |
| 10 | K | A | -1.0250 | |
| 11 | V | A | -0.1705 | |
| 12 | Q | A | -1.4121 | |
| 13 | S | A | -1.5620 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4396 | |
| 16 | E | A | -2.4476 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4571 | |
| 20 | P | A | 0.1263 | |
| 21 | T | A | 0.1839 | |
| 22 | S | A | -0.0914 | |
| 23 | L | A | 0.1329 | |
| 24 | F | A | -0.0307 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2797 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8837 | |
| 31 | R | A | -2.6657 | |
| 32 | L | A | -0.7792 | |
| 33 | L | A | 1.1713 | |
| 34 | T | A | 1.3774 | |
| 35 | V | A | 1.8475 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2267 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6261 | |
| 40 | K | A | -1.6464 | |
| 41 | D | A | -0.9472 | |
| 42 | I | A | 0.8121 | |
| 43 | V | A | 1.0057 | |
| 44 | K | A | -1.1823 | |
| 45 | N | A | -1.9299 | |
| 46 | G | A | -1.2326 | |
| 47 | K | A | -0.9896 | |
| 48 | V | A | 1.4212 | |
| 49 | V | A | 2.0101 | |
| 50 | V | A | 1.2257 | |
| 51 | P | A | 0.4238 | |
| 52 | K | A | -0.6503 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1448 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3891 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2285 | |
| 70 | K | A | -1.7781 | |
| 71 | F | A | -0.6244 | |
| 72 | A | A | -0.5805 | |
| 73 | L | A | -0.8715 | |
| 74 | P | A | -1.2128 | |
| 75 | Q | A | -2.5110 | |
| 76 | K | A | -3.1134 | |
| 77 | D | A | -2.9953 | |
| 78 | F | A | -1.6550 | |
| 79 | Y | A | -1.8950 | |
| 80 | D | A | -2.7016 | |
| 81 | P | A | -2.3089 | |
| 82 | E | A | -3.0543 | |
| 83 | K | A | -3.3937 | |
| 84 | E | A | -2.4565 | |
| 85 | R | A | -1.2935 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6912 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9463 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3339 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6906 | |
| 99 | G | A | -0.5400 | |
| 100 | P | A | -0.4128 | |
| 101 | L | A | 0.0269 | |
| 102 | G | A | -0.2346 | |
| 103 | K | A | -0.6873 | |
| 104 | G | A | -0.5170 | |
| 105 | S | A | -0.5485 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.1278 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.1450 | |
| 110 | L | A | -0.2810 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.3228 | |
| 113 | K | A | -0.5141 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | -1.2810 | |
| 116 | D | A | -1.6218 | |
| 117 | T | A | -0.9214 | |
| 118 | E | A | -1.8408 | |
| 119 | N | A | -2.2165 | |
| 120 | P | A | -2.0836 | |
| 121 | T | A | -1.7242 | |
| 122 | K | A | -2.5228 | |
| 123 | P | A | -1.9834 | |
| 124 | Q | A | -2.0025 | |
| 125 | H | A | -1.4206 | |
| 126 | C | A | -0.9777 | |
| 127 | G | A | -1.3159 | |
| 128 | P | A | -1.4455 | |
| 129 | D | A | -2.1953 | |
| 130 | N | A | -1.6966 | |
| 131 | R | A | -1.4300 | |
| 132 | V | A | -0.4427 | |
| 133 | N | A | -0.8849 | |
| 134 | F | A | -0.3897 | |
| 135 | S | A | -0.3854 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7393 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5809 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1989 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.2055 | |
| 157 | D | A | 0.5431 | |
| 158 | L | A | 1.1890 | |
| 159 | A | A | 0.9693 | |
| 160 | P | A | 0.0930 | |
| 161 | P | A | 0.4519 | |
| 162 | C | A | 0.5119 | |
| 163 | P | A | 0.0128 | |
| 164 | G | A | -0.0775 | |
| 165 | L | A | 0.5940 | |
| 166 | P | A | -0.1017 | |
| 167 | P | A | -0.3330 | |
| 168 | G | A | -0.4449 | |
| 169 | A | A | -0.0184 | |
| 170 | C | A | 0.6541 | |
| 171 | P | A | 0.7601 | |
| 172 | P | A | 1.2155 | |
| 173 | I | A | 2.3529 | |
| 174 | Q | A | 1.2743 | |
| 175 | L | A | 1.5853 | |
| 176 | V | A | 0.8944 | |
| 177 | N | A | -0.2788 | |
| 178 | S | A | 0.0330 | |
| 179 | V | A | 0.4348 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3805 | |
| 182 | D | A | 0.0763 | |
| 183 | G | A | -0.1606 | |
| 184 | D | A | -0.5396 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1311 | |
| 190 | F | A | 0.0694 | |
| 191 | G | A | -0.0979 | |
| 192 | N | A | -0.2586 | |
| 193 | M | A | -0.0982 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4120 | |
| 197 | E | A | -2.6235 | |
| 198 | L | A | -1.2352 | |
| 199 | Q | A | -2.5719 | |
| 200 | Q | A | -3.3292 | |
| 201 | D | A | -3.4948 | |
| 202 | R | A | -3.3359 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2186 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3503 | |
| 211 | S | A | -1.8724 | |
| 212 | T | A | -1.4273 | |
| 213 | R | A | -2.0960 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1604 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3429 | |
| 220 | L | A | 0.6081 | |
| 221 | K | A | -1.1101 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8138 | |
| 224 | N | A | -1.4965 | |
| 225 | E | A | -1.2373 | |
| 226 | A | A | -0.6060 | |
| 227 | Y | A | -0.3689 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6599 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0824 | |
| 234 | F | A | 0.2629 | |
| 235 | G | A | -0.8118 | |
| 236 | R | A | -2.5953 | |
| 237 | R | A | -2.8484 | |
| 238 | E | A | -2.1304 | |
| 239 | Q | A | -0.1523 | |
| 240 | V | A | 1.4610 | |
| 241 | Y | A | 1.1825 | |
| 242 | A | A | 0.1667 | |
| 243 | R | A | -1.1664 | |
| 244 | H | A | -1.0195 | |
| 245 | F | A | 0.0397 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.6265 | |
| 249 | C | A | -0.9712 | |
| 250 | G | A | -0.8403 | |
| 251 | P | A | -0.9457 | |
| 252 | E | A | -1.3697 | |
| 253 | G | A | -1.2892 | |
| 254 | H | A | -1.4663 | |
| 255 | P | A | -1.3433 | |
| 256 | L | A | -0.4757 | |
| 257 | P | A | -1.0907 | |
| 258 | D | A | -2.2534 | |
| 259 | E | A | -1.7277 | |
| 260 | P | A | -1.2757 | |
| 261 | P | A | -0.6691 | |
| 262 | P | A | -0.2396 | |
| 263 | S | A | -0.1709 | |
| 264 | P | A | 0.5550 | |
| 265 | L | A | 1.4569 | |
| 266 | Y | A | 1.1631 | |
| 267 | V | A | 1.3609 | |
| 268 | R | A | -0.5115 | |
| 269 | P | A | -0.1858 | |
| 270 | P | A | -0.5382 | |
| 271 | P | A | -0.3861 | |
| 272 | S | A | -0.3253 | |
| 273 | S | A | -0.3850 | |
| 274 | P | A | -0.4646 | |
| 275 | H | A | -0.6499 | |
| 276 | W | A | 0.4024 | |
| 277 | V | A | 1.1978 | |
| 278 | R | A | -0.0594 | |
| 279 | P | A | -0.6071 | |
| 280 | P | A | -0.6023 | |
| 281 | T | A | -0.5148 | |
| 282 | D | A | -0.9522 | |
| 283 | Y | A | 0.8298 | |
| 284 | F | A | 0.6961 | |
| 285 | G | A | 0.2337 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9076 | |
| 291 | L | A | 1.6147 | |
| 292 | V | A | 0.6264 | |
| 293 | S | A | -0.1598 | |
| 294 | S | A | -0.9651 | |
| 295 | D | A | -1.8431 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0990 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6312 | |
| 301 | R | A | -1.8232 | |
| 302 | P | A | -0.9394 | |
| 303 | F | A | -0.1910 | |
| 304 | W | A | -0.5718 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0926 | |
| 307 | R | A | -2.8382 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2482 | |
| 310 | G | A | -1.2194 | |
| 311 | N | A | -1.2793 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8526 | |
| 319 | N | A | -0.9482 | |
| 320 | E | A | -1.0476 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3547 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1055 | |
| 333 | N | A | 0.5450 | |
| 334 | F | A | 1.7495 | |
| 335 | T | A | 0.7498 | |
| 336 | I | A | 0.4341 | |
| 337 | S | A | -0.9751 | |
| 338 | Q | A | -1.7669 | |
| 339 | Q | A | -1.3972 | |
| 340 | L | A | 0.6436 | |
| 341 | C | A | 0.2511 | |
| 342 | T | A | -0.3156 | |
| 343 | P | A | -0.8852 | |
| 344 | E | A | -2.2489 | |
| 345 | N | A | -2.0365 | |
| 346 | N | A | -1.3986 | |
| 347 | V | A | 0.6158 | |
| 348 | Y | A | 0.9684 | |
| 349 | D | A | -0.3162 | |
| 350 | P | A | -0.4188 | |
| 351 | S | A | -0.3316 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.8189 | |
| 354 | K | A | -1.7902 | |
| 355 | N | A | -1.7759 | |
| 356 | Y | A | -0.0936 | |
| 357 | L | A | 0.6438 | |
| 358 | R | A | 0.9723 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3948 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0598 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9937 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6826 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2718 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3017 | |
| 376 | L | A | -1.6962 | |
| 377 | D | A | -1.9528 | |
| 378 | P | A | -1.0200 | |
| 379 | G | A | -1.0038 | |
| 380 | V | A | -0.9225 | |
| 381 | L | A | -0.5221 | |
| 382 | A | A | -0.6508 | |
| 383 | H | A | -0.8055 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4133 | |
| 386 | T | A | -0.5527 | |
| 387 | M | A | -0.3012 | |
| 388 | N | A | -0.8655 | |
| 389 | P | A | -1.2560 | |
| 390 | T | A | -1.4744 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4603 | |
| 393 | E | A | -2.8070 | |
| 394 | N | A | -2.2955 | |
| 395 | W | A | -1.3969 | |
| 396 | N | A | -1.0983 | |
| 397 | L | A | -0.1875 | |
| 398 | G | A | 0.5171 | |
| 399 | F | A | 2.4219 | |
| 400 | V | A | 1.8377 | |
| 401 | P | A | 0.0523 | |
| 402 | P | A | -1.9036 | |
| 403 | K | A | -3.2735 | |
| 404 | E | A | -3.8466 | |
| 405 | R | A | -4.0636 | |
| 406 | E | A | -3.8663 | |
| 407 | D | A | -2.9162 | |
| 408 | P | A | -1.7897 | |
| 409 | Y | A | -0.9939 | |
| 410 | K | A | -2.1274 | |
| 411 | G | A | -0.6428 | |
| 412 | L | A | 0.6664 | |
| 413 | I | A | 1.5868 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3891 | |
| 416 | E | A | -1.6872 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9430 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0371 | |
| 421 | E | A | -2.7675 | |
| 422 | R | A | -2.6018 | |
| 423 | F | A | -1.2614 | |
| 424 | S | A | -1.4425 | |
| 425 | Q | A | -1.7939 | |
| 426 | D | A | -2.8853 | |
| 427 | L | A | -2.0168 | |
| 428 | D | A | -2.8133 | |
| 429 | Q | A | -2.6407 | |
| 430 | F | A | -1.4881 | |
| 431 | A | A | -0.9747 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.7993 | |
| 435 | K | A | -0.8262 | |
| 436 | F | A | 0.0643 | |
| 437 | L | A | 0.9561 | |
| 438 | Y | A | 0.7651 | |
| 439 | Q | A | -0.3129 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine