| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGEAAAKEAAAKEAAAKFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:29)
[INFO] Main: Simulation completed successfully. (00:03:31)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.3421 | |
| 2 | S | A | -0.2967 | |
| 3 | R | A | -1.6613 | |
| 4 | P | A | -1.1320 | |
| 5 | G | A | -1.1066 | |
| 6 | L | A | 0.0000 | |
| 7 | P | A | -0.3103 | |
| 8 | V | A | -0.2207 | |
| 9 | E | A | -0.2983 | |
| 10 | Y | A | 0.6189 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.7910 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.5460 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -0.9934 | |
| 17 | S | A | -0.8761 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3605 | |
| 20 | R | A | -1.9413 | |
| 21 | D | A | -2.6883 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.3869 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.8871 | |
| 29 | G | A | -0.9681 | |
| 30 | G | A | -1.5495 | |
| 31 | N | A | -2.4889 | |
| 32 | N | A | -2.5073 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.0393 | |
| 43 | R | A | -2.4277 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.4339 | |
| 46 | D | A | -2.9835 | |
| 47 | D | A | -2.1645 | |
| 48 | Y | A | -0.4995 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.7911 | |
| 54 | N | A | -0.2178 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.3633 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -1.0530 | |
| 60 | W | A | -0.5066 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | -0.2285 | |
| 63 | Q | A | -1.0587 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | 0.0000 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | -1.5582 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.2751 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.6052 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.9483 | |
| 84 | S | A | 0.0601 | |
| 85 | P | A | -0.1994 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.5249 | |
| 88 | G | A | -1.5155 | |
| 89 | K | A | -1.9980 | |
| 90 | A | A | -0.9274 | |
| 91 | G | A | -0.6729 | |
| 92 | C | A | -0.0246 | |
| 93 | Q | A | -0.7173 | |
| 94 | T | A | -0.5350 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.9162 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.5859 | |
| 99 | T | A | -0.5233 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3706 | |
| 103 | S | A | -0.5298 | |
| 104 | E | A | -0.6742 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.4852 | |
| 108 | W | A | -0.8399 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.3960 | |
| 111 | A | A | -0.8953 | |
| 112 | N | A | -1.2698 | |
| 113 | R | A | -1.6338 | |
| 114 | A | A | -1.7096 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.5632 | |
| 117 | P | A | -1.0733 | |
| 118 | T | A | -0.7747 | |
| 119 | G | A | -0.4482 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | 0.0146 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.1581 | |
| 139 | H | A | -0.4073 | |
| 140 | P | A | -0.9410 | |
| 141 | Q | A | -1.2630 | |
| 142 | Q | A | -0.7409 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.2758 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.2605 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | 0.0000 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.1445 | |
| 157 | Q | A | -1.1252 | |
| 158 | G | A | -0.4647 | |
| 159 | M | A | 0.3801 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | -0.0155 | |
| 162 | S | A | 0.3117 | |
| 163 | L | A | 0.7980 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.1278 | |
| 166 | L | A | 0.6464 | |
| 167 | A | A | -0.3661 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.4244 | |
| 170 | D | A | -2.1457 | |
| 171 | A | A | 0.0000 | |
| 172 | G | A | 0.0000 | |
| 173 | G | A | -1.7873 | |
| 174 | Y | A | -1.4303 | |
| 175 | K | A | -1.8348 | |
| 176 | A | A | -0.7423 | |
| 177 | A | A | -0.6622 | |
| 178 | D | A | -0.4762 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6320 | |
| 183 | S | A | -0.9396 | |
| 184 | S | A | -0.8713 | |
| 185 | D | A | -1.0964 | |
| 186 | P | A | -1.1624 | |
| 187 | A | A | 0.0000 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -2.1386 | |
| 190 | R | A | -1.2952 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.0983 | |
| 195 | Q | A | -1.3428 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -0.9348 | |
| 199 | K | A | -1.2083 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.1898 | |
| 202 | A | A | -0.8902 | |
| 203 | N | A | -1.4065 | |
| 204 | N | A | -1.7790 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.8798 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -1.0429 | |
| 214 | G | A | 0.0000 | |
| 215 | T | A | -1.3247 | |
| 216 | P | A | -1.6120 | |
| 217 | N | A | -2.1606 | |
| 218 | E | A | -2.1514 | |
| 219 | L | A | -1.0185 | |
| 220 | G | A | -1.0918 | |
| 221 | G | A | -0.8030 | |
| 222 | A | A | -0.8327 | |
| 223 | N | A | -1.0277 | |
| 224 | I | A | 0.1745 | |
| 225 | P | A | -0.4060 | |
| 226 | A | A | -0.5325 | |
| 227 | E | A | -0.8956 | |
| 228 | F | A | 0.4223 | |
| 229 | L | A | 0.3379 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -1.0702 | |
| 232 | F | A | 0.0829 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.4407 | |
| 235 | S | A | -0.5735 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.3897 | |
| 239 | K | A | -1.7715 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.5572 | |
| 242 | D | A | -2.5754 | |
| 243 | A | A | -1.7547 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.4342 | |
| 246 | A | A | -1.3453 | |
| 247 | A | A | -0.9945 | |
| 248 | G | A | -1.1220 | |
| 249 | G | A | -1.7489 | |
| 250 | H | A | -1.6556 | |
| 251 | N | A | -1.2025 | |
| 252 | A | A | -0.5893 | |
| 253 | V | A | 0.2003 | |
| 254 | F | A | 0.4158 | |
| 255 | N | A | -0.1484 | |
| 256 | F | A | -0.0010 | |
| 257 | P | A | -0.4322 | |
| 258 | P | A | -0.6834 | |
| 259 | N | A | -1.1533 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.6123 | |
| 263 | S | A | -0.6279 | |
| 264 | W | A | -0.7492 | |
| 265 | E | A | -1.5977 | |
| 266 | Y | A | -0.7147 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.6184 | |
| 270 | Q | A | -0.6278 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.9411 | |
| 273 | A | A | -0.6408 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0972 | |
| 276 | G | A | -1.1151 | |
| 277 | D | A | -0.8991 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -1.2228 | |
| 280 | S | A | -1.0768 | |
| 281 | S | A | -0.5802 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | -1.1108 | |
| 284 | A | A | 0.0000 | |
| 285 | G | A | -1.7539 | |
| 286 | E | A | -2.6429 | |
| 287 | A | A | -2.2542 | |
| 288 | A | A | -1.9305 | |
| 289 | A | A | -1.6116 | |
| 290 | K | A | -3.0612 | |
| 291 | E | A | -2.5830 | |
| 292 | A | A | -1.8526 | |
| 293 | A | A | -1.7550 | |
| 294 | A | A | -2.0487 | |
| 295 | K | A | -2.8692 | |
| 296 | E | A | -2.9502 | |
| 297 | A | A | -1.4471 | |
| 298 | A | A | -0.6600 | |
| 299 | A | A | -0.7315 | |
| 300 | K | A | -0.9720 | |
| 301 | F | A | 0.7354 | |
| 302 | A | A | 0.2153 | |
| 303 | V | A | 0.9343 | |
| 304 | T | A | 0.0613 | |
| 305 | N | A | -0.6589 | |
| 306 | D | A | -0.8990 | |
| 307 | G | A | 0.0142 | |
| 308 | V | A | 1.8069 | |
| 309 | I | A | 2.2000 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine