Project name: bc7d1693f61380b

Chain sequence(s)	H: QVQLVESGGGLVQPGGSLRLSCAVSGIDLSHDDISWVRQAPGKGLEWVSIISYAGSTYYASWAKGRLTISKDTSKNQVVLTMTNMDPVDTATYYCARGVPAYSHGGDLWGQGTLTVTVSS; L: DIVMTQSPATLSLSPGERATLSCTTSQSVYHENWLSWFQQKPGQPPKLLIYWASTLAYGVPSRFSGSGSGTDFTLTISSLQPEDAATYYCAGGYGGGRYAFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:41)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:43)

• Minimal score value: -2.7327
• Maximal score value: 1.2632
• Average score: -0.4817
• Total score value: -110.8015

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.0069
2	V	H	-0.1320
3	Q	H	-0.0821
4	L	H	0.0000
5	V	H	1.0088
6	E	H	0.2885
7	S	H	-0.3480
8	G	H	-0.8558
9	G	H	-0.0993
11	G	H	0.7467
12	L	H	1.2290
13	V	H	-0.0933
14	Q	H	-1.5199
15	P	H	-1.5927
16	G	H	-1.8531
17	G	H	-1.4494
18	S	H	-1.3716
19	L	H	-0.8712
20	R	H	-1.9031
21	L	H	0.0000
22	S	H	-0.5107
23	C	H	0.0000
24	A	H	-0.1706
25	V	H	0.0000
26	S	H	-0.5002
27	G	H	-0.6589
28	I	H	-0.5332
29	D	H	-1.1003
30	L	H	0.0000
35	S	H	-0.8100
36	H	H	-0.9669
37	D	H	0.0000
38	D	H	0.0000
39	I	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.7845
45	A	H	-0.5370
46	P	H	-0.8929
47	G	H	-1.4829
48	K	H	-2.3721
49	G	H	-1.6199
50	L	H	0.0000
51	E	H	-1.0283
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	I	H	0.0000
56	I	H	0.0000
57	S	H	0.1508
58	Y	H	0.2433
59	A	H	0.1021
63	G	H	-0.1405
64	S	H	0.0595
65	T	H	0.2283
66	Y	H	0.0888
67	Y	H	-0.3056
68	A	H	-0.6735
69	S	H	-0.8623
70	W	H	-0.2045
71	A	H	0.0000
72	K	H	-1.8487
74	G	H	-1.4545
75	R	H	-1.4287
76	L	H	0.0000
77	T	H	-0.6334
78	I	H	0.0000
79	S	H	-0.4273
80	K	H	-0.9334
81	D	H	-1.5167
82	T	H	-1.4956
83	S	H	-1.4358
84	K	H	-2.2940
85	N	H	-1.8201
86	Q	H	-1.1545
87	V	H	0.0000
88	V	H	-0.6286
89	L	H	0.0000
90	T	H	-0.8285
91	M	H	0.0000
92	T	H	-1.4399
93	N	H	-2.1155
94	M	H	0.0000
95	D	H	-1.3587
96	P	H	-0.2389
97	V	H	1.2632
98	D	H	0.0000
99	T	H	0.6078
100	A	H	0.0000
101	T	H	0.4069
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.2183
107	G	H	0.1070
108	V	H	0.2333
109	P	H	0.3611
110	A	H	0.6999
111	Y	H	1.2394
112	S	H	0.0000
113	H	H	0.0000
114	G	H	0.0000
115	G	H	-0.3868
116	D	H	-0.4025
117	L	H	-0.0844
118	W	H	-0.2311
119	G	H	0.0000
120	Q	H	-0.9796
121	G	H	0.0000
122	T	H	0.0000
123	L	H	1.1469
123A	T	H	0.9695
124	V	H	0.0000
125	T	H	0.4856
126	V	H	0.0000
127	S	H	-0.5843
128	S	H	-0.6155
1	D	L	-1.6468
2	I	L	-0.2955
3	V	L	1.1198
4	M	L	0.0000
5	T	L	-0.1131
6	Q	L	0.0000
7	S	L	-0.5142
8	P	L	-0.3290
9	A	L	-0.4714
10	T	L	-0.6610
11	L	L	-0.5192
12	S	L	-0.8209
13	L	L	-1.2438
14	S	L	-1.4836
15	P	L	-1.7055
16	G	L	-1.7938
17	E	L	-2.5075
18	R	L	-2.7327
19	A	L	0.0000
20	T	L	-0.6821
21	L	L	0.0000
22	S	L	-0.5759
23	C	L	0.0000
24	T	L	-0.7454
25	T	L	0.0000
26	S	L	-0.5536
27	Q	L	-1.3181
28	S	L	-1.4569
29	V	L	0.0000
30	Y	L	-0.5900
35	H	L	-1.4743
36	E	L	-2.3740
37	N	L	-1.4652
38	W	L	0.0000
39	L	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	F	L	0.0000
43	Q	L	-0.7595
44	Q	L	0.0000
45	K	L	-1.4592
46	P	L	-1.0543
47	G	L	-1.3290
48	Q	L	-1.8668
49	P	L	-1.3602
50	P	L	0.0000
51	K	L	-1.2821
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.0000
56	W	L	-0.0511
57	A	L	0.0000
65	S	L	-0.2054
66	T	L	0.2931
67	L	L	0.7180
68	A	L	0.0000
69	Y	L	1.1861
70	G	L	0.2700
71	V	L	0.1827
72	P	L	-0.1647
74	S	L	-0.4152
75	R	L	-0.8565
76	F	L	0.0000
77	S	L	-0.2508
78	G	L	0.0000
79	S	L	-0.7164
80	G	L	-1.2690
83	S	L	-1.5909
84	G	L	-1.7137
85	T	L	-1.7115
86	D	L	-2.1826
87	F	L	0.0000
88	T	L	-0.6286
89	L	L	0.0000
90	T	L	-0.6094
91	I	L	0.0000
92	S	L	-1.4248
93	S	L	-1.7425
94	L	L	0.0000
95	Q	L	-1.9260
96	P	L	-1.5305
97	E	L	-2.1261
98	D	L	0.0000
99	A	L	-1.2072
100	A	L	0.0000
101	T	L	-0.9030
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	A	L	0.0000
106	G	L	0.0000
107	G	L	0.0000
108	Y	L	0.0000
109	G	L	-0.6261
113	G	L	-0.7760
114	G	L	0.0000
115	R	L	-1.4716
116	Y	L	-0.5565
117	A	L	-0.1533
118	F	L	0.0697
119	G	L	0.0000
120	Q	L	-1.4553
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.4697
124	V	L	0.0000
125	E	L	-1.4254
126	I	L	-0.6220
127	K	L	-1.4524