| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVKDGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEPLHDSADVRVPFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRAGPVGHPLPAAPPPSPLYTPPPPTSPYAVLPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPEKNVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9439 | |
| 2 | L | A | 1.9648 | |
| 3 | P | A | 0.8276 | |
| 4 | P | A | 0.3780 | |
| 5 | T | A | 0.1242 | |
| 6 | T | A | 0.1330 | |
| 7 | P | A | 0.1935 | |
| 8 | V | A | 1.2068 | |
| 9 | A | A | 0.0790 | |
| 10 | K | A | -1.0410 | |
| 11 | V | A | -0.2011 | |
| 12 | Q | A | -1.4288 | |
| 13 | S | A | -1.5607 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4057 | |
| 16 | E | A | -2.4346 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4596 | |
| 20 | P | A | 0.1256 | |
| 21 | T | A | 0.1743 | |
| 22 | S | A | -0.1042 | |
| 23 | L | A | 0.0776 | |
| 24 | F | A | -0.0597 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.3005 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9071 | |
| 31 | R | A | -2.6880 | |
| 32 | L | A | -0.8032 | |
| 33 | L | A | 1.1601 | |
| 34 | T | A | 1.3708 | |
| 35 | V | A | 1.8243 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2460 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6653 | |
| 40 | E | A | -1.7485 | |
| 41 | D | A | -0.9732 | |
| 42 | I | A | 0.8471 | |
| 43 | V | A | 0.9047 | |
| 44 | K | A | -1.3996 | |
| 45 | D | A | -2.4408 | |
| 46 | G | A | -1.4769 | |
| 47 | K | A | -1.1384 | |
| 48 | V | A | 1.3301 | |
| 49 | V | A | 1.9453 | |
| 50 | V | A | 1.2227 | |
| 51 | P | A | 0.4072 | |
| 52 | K | A | -0.6963 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1436 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3887 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2677 | |
| 70 | K | A | -1.7868 | |
| 71 | F | A | -0.6335 | |
| 72 | A | A | -0.5753 | |
| 73 | L | A | -0.8645 | |
| 74 | P | A | -1.2732 | |
| 75 | Q | A | -2.5039 | |
| 76 | K | A | -3.1056 | |
| 77 | D | A | -2.9877 | |
| 78 | F | A | -1.6670 | |
| 79 | Y | A | -1.8831 | |
| 80 | D | A | -2.6836 | |
| 81 | P | A | -2.3070 | |
| 82 | E | A | -3.0536 | |
| 83 | K | A | -3.3958 | |
| 84 | E | A | -2.4633 | |
| 85 | R | A | -1.2984 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6979 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9668 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3664 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6912 | |
| 99 | G | A | -0.5206 | |
| 100 | P | A | -0.3678 | |
| 101 | L | A | 0.1180 | |
| 102 | G | A | -0.1468 | |
| 103 | K | A | -0.4942 | |
| 104 | G | A | -0.3639 | |
| 105 | T | A | -0.3589 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1036 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.2337 | |
| 110 | L | A | 0.2726 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0156 | |
| 113 | K | A | -0.3499 | |
| 114 | L | A | -1.0330 | |
| 115 | G | A | -1.1338 | |
| 116 | D | A | -1.3312 | |
| 117 | T | A | -0.9413 | |
| 118 | E | A | -1.6611 | |
| 119 | N | A | -2.1495 | |
| 120 | P | A | -1.8628 | |
| 121 | T | A | -1.5801 | |
| 122 | E | A | -2.2950 | |
| 123 | P | A | -0.9977 | |
| 124 | L | A | -1.1120 | |
| 125 | H | A | -1.6452 | |
| 126 | D | A | -2.5882 | |
| 127 | S | A | -1.8143 | |
| 128 | A | A | -1.3121 | |
| 129 | D | A | -2.0872 | |
| 130 | V | A | -1.3701 | |
| 131 | R | A | -0.8186 | |
| 132 | V | A | 0.1598 | |
| 133 | P | A | 0.0773 | |
| 134 | F | A | 0.0919 | |
| 135 | S | A | -0.1183 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5617 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2084 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1466 | |
| 157 | D | A | 0.3051 | |
| 158 | L | A | 0.7753 | |
| 159 | A | A | 0.1633 | |
| 160 | E | A | -1.4608 | |
| 161 | P | A | -0.2139 | |
| 162 | C | A | 0.1902 | |
| 163 | P | A | -0.1687 | |
| 164 | G | A | -0.0772 | |
| 165 | L | A | 0.5897 | |
| 166 | P | A | -0.1195 | |
| 167 | P | A | -0.3421 | |
| 168 | G | A | -0.4527 | |
| 169 | A | A | -0.0337 | |
| 170 | C | A | 0.6528 | |
| 171 | P | A | 0.5221 | |
| 172 | P | A | 0.8423 | |
| 173 | I | A | 1.9948 | |
| 174 | Q | A | 0.8484 | |
| 175 | L | A | 1.4979 | |
| 176 | V | A | 0.8646 | |
| 177 | N | A | -0.2931 | |
| 178 | S | A | 0.0325 | |
| 179 | V | A | 0.4325 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3866 | |
| 182 | D | A | 0.0896 | |
| 183 | G | A | -0.1552 | |
| 184 | D | A | -0.5431 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1392 | |
| 190 | F | A | 0.0626 | |
| 191 | G | A | -0.1042 | |
| 192 | N | A | -0.2661 | |
| 193 | M | A | -0.1313 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4245 | |
| 197 | E | A | -2.6568 | |
| 198 | L | A | -1.2498 | |
| 199 | Q | A | -2.5714 | |
| 200 | Q | A | -3.3285 | |
| 201 | D | A | -3.5845 | |
| 202 | R | A | -3.3408 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1583 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3692 | |
| 211 | S | A | -1.9236 | |
| 212 | T | A | -1.4602 | |
| 213 | R | A | -2.1290 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1681 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3582 | |
| 220 | L | A | 0.5880 | |
| 221 | K | A | -1.1442 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8288 | |
| 224 | N | A | -1.5900 | |
| 225 | E | A | -1.2447 | |
| 226 | A | A | -0.6079 | |
| 227 | Y | A | -0.3614 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6784 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0693 | |
| 234 | F | A | 0.2450 | |
| 235 | G | A | -0.8094 | |
| 236 | R | A | -2.5634 | |
| 237 | R | A | -2.7767 | |
| 238 | E | A | -2.0660 | |
| 239 | Q | A | -0.1516 | |
| 240 | V | A | 1.4888 | |
| 241 | Y | A | 1.2427 | |
| 242 | A | A | 0.3921 | |
| 243 | R | A | -0.5798 | |
| 244 | H | A | -0.7685 | |
| 245 | F | A | 0.1588 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.6011 | |
| 249 | A | A | -1.1235 | |
| 250 | G | A | -0.9289 | |
| 251 | P | A | -0.8490 | |
| 252 | V | A | -0.5108 | |
| 253 | G | A | -0.9325 | |
| 254 | H | A | -1.1539 | |
| 255 | P | A | -0.4759 | |
| 256 | L | A | 0.4740 | |
| 257 | P | A | 0.0120 | |
| 258 | A | A | 0.1197 | |
| 259 | A | A | -0.0070 | |
| 260 | P | A | -0.5226 | |
| 261 | P | A | -0.4070 | |
| 262 | P | A | -0.3084 | |
| 263 | S | A | 0.1834 | |
| 264 | P | A | 0.4062 | |
| 265 | L | A | 1.5375 | |
| 266 | Y | A | 0.8906 | |
| 267 | T | A | 0.0983 | |
| 268 | P | A | 0.2426 | |
| 269 | P | A | 0.2018 | |
| 270 | P | A | -0.3650 | |
| 271 | P | A | -0.0892 | |
| 272 | T | A | -0.2134 | |
| 273 | S | A | 0.2111 | |
| 274 | P | A | 0.2155 | |
| 275 | Y | A | 1.3909 | |
| 276 | A | A | 1.2062 | |
| 277 | V | A | 2.1761 | |
| 278 | L | A | 1.7584 | |
| 279 | P | A | 0.3630 | |
| 280 | P | A | 0.0004 | |
| 281 | Y | A | 0.2467 | |
| 282 | D | A | -0.4136 | |
| 283 | Y | A | 1.0333 | |
| 284 | F | A | 0.7697 | |
| 285 | G | A | 0.3315 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 1.0182 | |
| 291 | L | A | 1.6368 | |
| 292 | V | A | 0.6687 | |
| 293 | S | A | -0.1465 | |
| 294 | S | A | -0.9474 | |
| 295 | D | A | -1.8412 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0905 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6394 | |
| 301 | R | A | -1.8399 | |
| 302 | P | A | -0.9556 | |
| 303 | F | A | -0.1971 | |
| 304 | W | A | -0.5716 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0922 | |
| 307 | R | A | -2.8396 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.4035 | |
| 310 | G | A | -1.2281 | |
| 311 | N | A | -1.2739 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7998 | |
| 319 | N | A | -0.9244 | |
| 320 | E | A | -1.0346 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.2999 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0560 | |
| 333 | N | A | 0.5379 | |
| 334 | F | A | 1.7212 | |
| 335 | T | A | 0.8593 | |
| 336 | I | A | 0.4181 | |
| 337 | S | A | -1.0788 | |
| 338 | Q | A | -1.9450 | |
| 339 | Q | A | -1.7542 | |
| 340 | L | A | 0.1969 | |
| 341 | S | A | -0.2771 | |
| 342 | T | A | -0.8418 | |
| 343 | P | A | -1.4105 | |
| 344 | E | A | -2.5236 | |
| 345 | K | A | -2.5815 | |
| 346 | N | A | -1.5956 | |
| 347 | V | A | 0.6688 | |
| 348 | Y | A | 0.8952 | |
| 349 | D | A | -0.3294 | |
| 350 | P | A | -0.7246 | |
| 351 | S | A | -0.5916 | |
| 352 | N | A | -0.5650 | |
| 353 | F | A | -1.2100 | |
| 354 | K | A | -2.0574 | |
| 355 | N | A | -1.8438 | |
| 356 | Y | A | -0.1452 | |
| 357 | L | A | 0.6231 | |
| 358 | R | A | 0.9501 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3798 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0722 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0655 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6927 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3017 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3127 | |
| 376 | L | A | -1.7145 | |
| 377 | D | A | -1.9828 | |
| 378 | P | A | -1.0340 | |
| 379 | G | A | -1.0111 | |
| 380 | V | A | -0.9324 | |
| 381 | L | A | -0.5240 | |
| 382 | A | A | -0.6482 | |
| 383 | H | A | -0.8063 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3915 | |
| 386 | T | A | -0.5456 | |
| 387 | M | A | -0.2955 | |
| 388 | N | A | -0.8591 | |
| 389 | P | A | -1.2304 | |
| 390 | T | A | -1.4224 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4251 | |
| 393 | E | A | -2.7524 | |
| 394 | N | A | -2.3321 | |
| 395 | W | A | -1.3555 | |
| 396 | N | A | -1.1216 | |
| 397 | L | A | -0.2350 | |
| 398 | G | A | 0.4997 | |
| 399 | F | A | 2.4105 | |
| 400 | V | A | 1.8235 | |
| 401 | P | A | 0.0337 | |
| 402 | P | A | -1.7976 | |
| 403 | K | A | -3.3014 | |
| 404 | E | A | -3.7436 | |
| 405 | R | A | -3.8352 | |
| 406 | E | A | -3.7486 | |
| 407 | D | A | -2.8355 | |
| 408 | P | A | -1.7455 | |
| 409 | Y | A | -0.9805 | |
| 410 | K | A | -2.1104 | |
| 411 | G | A | -0.6338 | |
| 412 | L | A | 0.6782 | |
| 413 | I | A | 1.5903 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3827 | |
| 416 | E | A | -1.6714 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9516 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0661 | |
| 421 | E | A | -2.8056 | |
| 422 | R | A | -2.6810 | |
| 423 | F | A | -1.3053 | |
| 424 | S | A | -1.4791 | |
| 425 | Q | A | -1.8791 | |
| 426 | D | A | -2.9642 | |
| 427 | L | A | -2.1632 | |
| 428 | D | A | -3.0145 | |
| 429 | Q | A | -2.7453 | |
| 430 | F | A | -1.6099 | |
| 431 | A | A | -1.1447 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.3059 | |
| 435 | K | A | -1.1069 | |
| 436 | F | A | -0.1178 | |
| 437 | L | A | 0.7765 | |
| 438 | Y | A | 0.6170 | |
| 439 | Q | A | -0.3954 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine