Project name: bd68fcf2271d07e

Chain sequence(s)	A: EVQLVEQSPGNVQPGASLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYQNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTATYYCVRHGNFGNSYISYWAYWGQGTNVTVSSGGGSGGGSGGGSQTVVTQEPSLTVSPGATVTLTCGSSTGAVTSGYYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNRWVFGGGTKLTVK
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:32)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:33)

• Minimal score value: -3.0384
• Maximal score value: 1.0641
• Average score: -0.6767
• Total score value: -166.4795

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	A	-2.0209
2	V	A	-1.0422
3	Q	A	-1.0981
4	L	A	0.0000
5	V	A	0.3869
6	E	A	0.0000
7	Q	A	-1.5048
8	S	A	-1.6043
9	P	A	-1.2926
10	G	A	-1.4571
11	N	A	-1.7842
12	V	A	-1.3831
13	Q	A	-2.0812
14	P	A	-2.0242
15	G	A	-1.8424
16	A	A	-1.5146
17	S	A	-1.5470
18	L	A	0.0000
19	K	A	-1.8777
20	L	A	0.0000
21	S	A	-0.5362
22	C	A	0.0000
23	A	A	-0.3620
24	A	A	0.0000
25	S	A	-0.9896
26	G	A	-1.1664
27	F	A	-0.7072
28	T	A	-0.7222
29	F	A	0.0000
30	N	A	-1.9162
31	K	A	-2.0393
32	Y	A	-0.9562
33	A	A	0.0000
34	M	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	0.0000
39	Q	A	-1.0991
40	A	A	-1.4681
41	P	A	-1.2495
42	G	A	-1.4518
43	K	A	-2.2642
44	G	A	-1.4490
45	L	A	0.0000
46	E	A	-0.9255
47	W	A	0.0000
48	V	A	0.0000
49	A	A	0.0000
50	R	A	-0.3529
51	I	A	0.0000
52	R	A	-1.0760
53	S	A	0.0000
54	K	A	-2.0326
55	Y	A	-0.3300
56	Q	A	-0.9045
57	N	A	-1.4881
58	Y	A	-0.8780
59	A	A	-0.5136
60	T	A	-0.2644
61	Y	A	-0.5374
62	Y	A	-1.1819
63	A	A	-1.6725
64	D	A	-2.7300
65	S	A	-1.9255
66	V	A	0.0000
67	K	A	-2.8799
68	D	A	-3.0384
69	R	A	-2.3451
70	F	A	0.0000
71	T	A	-0.8928
72	I	A	0.0000
73	S	A	-0.2732
74	R	A	-1.0503
75	D	A	-1.4760
76	D	A	-2.1051
77	S	A	-1.5995
78	K	A	-2.3850
79	N	A	-1.7565
80	T	A	0.0000
81	A	A	0.0000
82	Y	A	-0.3108
83	L	A	0.0000
84	Q	A	-0.9877
85	M	A	0.0000
86	N	A	-2.1126
87	N	A	-2.5347
88	L	A	0.0000
89	K	A	-2.6947
90	T	A	-2.0831
91	E	A	-2.5507
92	D	A	0.0000
93	T	A	-1.3270
94	A	A	0.0000
95	T	A	-0.7947
96	Y	A	0.0000
97	Y	A	0.0000
98	C	A	0.0000
99	V	A	0.0000
100	R	A	0.0000
101	H	A	0.0000
102	G	A	0.0000
103	N	A	-0.2463
104	F	A	0.2182
105	G	A	-0.7488
106	N	A	-1.1785
107	S	A	-0.1369
108	Y	A	1.0178
109	I	A	0.5806
110	S	A	0.0000
111	Y	A	0.0000
112	W	A	0.0000
113	A	A	-0.0870
114	Y	A	-0.0739
115	W	A	-0.1826
116	G	A	0.0000
117	Q	A	-1.4072
118	G	A	0.0000
119	T	A	-1.1326
120	N	A	-1.7501
121	V	A	0.0000
122	T	A	-1.4388
123	V	A	0.0000
124	S	A	-1.5385
125	S	A	-1.3663
126	G	A	-1.1363
127	G	A	-1.0821
128	G	A	-1.1285
129	S	A	-0.9931
130	G	A	-1.3538
131	G	A	-1.4047
132	G	A	-1.4037
133	S	A	-1.0041
134	G	A	-1.2548
135	G	A	-1.2825
136	G	A	-1.3102
137	S	A	-1.0638
138	Q	A	-1.5096
139	T	A	-0.2652
140	V	A	0.4873
141	V	A	0.0000
142	T	A	-0.2662
143	Q	A	-0.7511
144	E	A	-0.9528
145	P	A	-1.0386
146	S	A	-0.9262
147	L	A	-0.1772
148	T	A	-0.5416
149	V	A	-0.5750
150	S	A	-1.0586
151	P	A	-1.3096
152	G	A	-0.8286
153	A	A	-0.4633
154	T	A	-0.3463
155	V	A	0.0000
156	T	A	0.0735
157	L	A	0.0000
158	T	A	0.0000
159	C	A	0.0000
160	G	A	-0.3924
161	S	A	-0.1887
162	S	A	-0.2541
163	T	A	-0.3288
164	G	A	-0.6239
165	A	A	-0.3385
166	V	A	0.0000
167	T	A	-0.1016
168	S	A	-0.2912
169	G	A	-0.3219
170	Y	A	0.1474
171	Y	A	0.3011
172	P	A	0.0000
173	N	A	0.0000
174	W	A	0.0000
175	V	A	0.0000
176	Q	A	0.0000
177	Q	A	-1.4206
178	K	A	-2.0341
179	P	A	-1.3242
180	G	A	-1.3337
181	Q	A	-2.0499
182	A	A	-1.4364
183	P	A	0.0000
184	R	A	-1.1794
185	G	A	0.0000
186	L	A	0.0000
187	I	A	0.0000
188	G	A	0.0000
189	G	A	0.0000
190	T	A	0.0000
191	K	A	-1.2321
192	F	A	0.0850
193	L	A	0.2961
194	A	A	0.0000
195	P	A	-0.2487
196	G	A	-0.6119
197	T	A	-0.3085
198	P	A	-0.2864
199	A	A	-0.1924
200	R	A	-0.5198
201	F	A	0.0000
202	S	A	-0.5484
203	G	A	-0.4410
204	S	A	-0.1652
205	L	A	0.5706
206	L	A	1.0641
207	G	A	0.0030
208	G	A	-0.2807
209	K	A	-0.4899
210	A	A	0.0000
211	A	A	0.0000
212	L	A	0.0000
213	T	A	-0.2561
214	L	A	0.0000
215	S	A	-0.5521
216	G	A	-0.6946
217	V	A	0.0000
218	Q	A	-1.7962
219	P	A	-2.0317
220	E	A	-2.4878
221	D	A	0.0000
222	E	A	-2.2807
223	A	A	0.0000
224	E	A	-1.3892
225	Y	A	0.0000
226	Y	A	0.0000
227	C	A	0.0000
228	A	A	0.0000
229	L	A	0.0000
230	W	A	-0.1558
231	Y	A	0.0000
232	S	A	-0.9190
233	N	A	-1.4476
234	R	A	-1.2748
235	W	A	0.0000
236	V	A	-0.0070
237	F	A	0.0000
238	G	A	0.0000
239	G	A	-1.0893
240	G	A	0.0000
241	T	A	0.0000
242	K	A	-1.9299
243	L	A	0.0000
244	T	A	-1.2932
245	V	A	0.0000
246	K	A	-1.9846