| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGGGGGSGGGGSGGGGSFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:09)
[INFO] Main: Simulation completed successfully. (00:02:11)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.4367 | |
| 2 | S | A | -0.1862 | |
| 3 | R | A | -1.6112 | |
| 4 | P | A | -1.0816 | |
| 5 | G | A | -1.0032 | |
| 6 | L | A | -0.6943 | |
| 7 | P | A | -0.3503 | |
| 8 | V | A | -0.1553 | |
| 9 | E | A | -0.2208 | |
| 10 | Y | A | 0.6226 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.8713 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.6280 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -0.9855 | |
| 17 | S | A | -0.6851 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3361 | |
| 20 | R | A | -1.9714 | |
| 21 | D | A | -2.7439 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.6552 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.9092 | |
| 29 | G | A | -1.0709 | |
| 30 | G | A | -1.6641 | |
| 31 | N | A | -2.2325 | |
| 32 | N | A | -2.2332 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.0773 | |
| 43 | R | A | -2.4650 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.3357 | |
| 46 | D | A | -2.9004 | |
| 47 | D | A | -1.9531 | |
| 48 | Y | A | -0.3883 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.9451 | |
| 54 | N | A | 0.0270 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.2241 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.8889 | |
| 60 | W | A | -0.4309 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | -0.2129 | |
| 63 | Q | A | -1.2172 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.2798 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | 0.0000 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.4153 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.6057 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.9003 | |
| 84 | S | A | 0.0277 | |
| 85 | P | A | -0.3321 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.5591 | |
| 88 | G | A | -1.5291 | |
| 89 | K | A | -1.9745 | |
| 90 | A | A | -0.8360 | |
| 91 | G | A | -0.5060 | |
| 92 | C | A | 0.1234 | |
| 93 | Q | A | -0.4342 | |
| 94 | T | A | -0.4211 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.8348 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | 0.0000 | |
| 99 | T | A | -0.4609 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3319 | |
| 103 | S | A | -0.5546 | |
| 104 | E | A | -0.6972 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.4725 | |
| 108 | W | A | -0.8698 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.3310 | |
| 111 | A | A | -0.8808 | |
| 112 | N | A | -1.3062 | |
| 113 | R | A | -1.6560 | |
| 114 | A | A | -1.6580 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.3792 | |
| 117 | P | A | -0.9546 | |
| 118 | T | A | -0.6596 | |
| 119 | G | A | -0.3584 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | -0.0950 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.2615 | |
| 139 | H | A | -0.4920 | |
| 140 | P | A | -0.8726 | |
| 141 | Q | A | -1.2023 | |
| 142 | Q | A | 0.0000 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.1699 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.1917 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | -1.0361 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.1683 | |
| 157 | Q | A | -1.2413 | |
| 158 | G | A | -0.4534 | |
| 159 | M | A | 0.5292 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | 0.0226 | |
| 162 | S | A | 0.4209 | |
| 163 | L | A | 0.9024 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.0736 | |
| 166 | L | A | 0.6895 | |
| 167 | A | A | -0.3514 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.4487 | |
| 170 | D | A | -2.1957 | |
| 171 | A | A | 0.0000 | |
| 172 | G | A | -1.8783 | |
| 173 | G | A | -1.8335 | |
| 174 | Y | A | 0.0000 | |
| 175 | K | A | -1.9601 | |
| 176 | A | A | 0.0000 | |
| 177 | A | A | -0.7314 | |
| 178 | D | A | -0.6228 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6410 | |
| 183 | S | A | -0.8241 | |
| 184 | S | A | -0.7773 | |
| 185 | D | A | -0.9934 | |
| 186 | P | A | -1.0338 | |
| 187 | A | A | -0.7293 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -1.9048 | |
| 190 | R | A | -1.4042 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.3721 | |
| 195 | Q | A | -1.6812 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -1.0125 | |
| 199 | K | A | -1.2870 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.2642 | |
| 202 | A | A | -0.9266 | |
| 203 | N | A | -1.5045 | |
| 204 | N | A | -1.7916 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.9064 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.6929 | |
| 214 | G | A | 0.0000 | |
| 215 | T | A | -0.7229 | |
| 216 | P | A | -1.0603 | |
| 217 | N | A | -1.3290 | |
| 218 | E | A | -1.7828 | |
| 219 | L | A | -0.6706 | |
| 220 | G | A | -0.9092 | |
| 221 | G | A | -0.6999 | |
| 222 | A | A | -0.4840 | |
| 223 | N | A | -0.0246 | |
| 224 | I | A | 1.8220 | |
| 225 | P | A | 1.0502 | |
| 226 | A | A | 0.0000 | |
| 227 | E | A | 0.4956 | |
| 228 | F | A | 1.8993 | |
| 229 | L | A | 1.2843 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.6251 | |
| 232 | F | A | 0.3026 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.5959 | |
| 235 | S | A | -0.7228 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.6575 | |
| 239 | K | A | -2.1993 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.7267 | |
| 242 | D | A | -2.7291 | |
| 243 | A | A | -1.9043 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.4616 | |
| 246 | A | A | -1.3542 | |
| 247 | A | A | -0.9992 | |
| 248 | G | A | -1.1331 | |
| 249 | G | A | -1.7770 | |
| 250 | H | A | -1.6782 | |
| 251 | N | A | -1.2649 | |
| 252 | A | A | -0.5737 | |
| 253 | V | A | 0.2827 | |
| 254 | F | A | 0.5056 | |
| 255 | N | A | 0.0998 | |
| 256 | F | A | 0.1908 | |
| 257 | P | A | -0.2571 | |
| 258 | P | A | -0.5644 | |
| 259 | N | A | -0.8153 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.3673 | |
| 263 | S | A | -0.5043 | |
| 264 | W | A | -0.3927 | |
| 265 | E | A | -1.0787 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.4543 | |
| 270 | Q | A | -0.5763 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.8993 | |
| 273 | A | A | -0.6090 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0211 | |
| 276 | G | A | -1.0997 | |
| 277 | D | A | -0.8540 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -1.0647 | |
| 280 | S | A | -0.9375 | |
| 281 | S | A | -0.6213 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | -0.9612 | |
| 284 | A | A | 0.0000 | |
| 285 | G | A | -1.4127 | |
| 286 | G | A | -1.3187 | |
| 287 | G | A | -1.3971 | |
| 288 | G | A | -1.4394 | |
| 289 | G | A | -1.3449 | |
| 290 | S | A | -1.1285 | |
| 291 | G | A | -1.2196 | |
| 292 | G | A | -1.2174 | |
| 293 | G | A | -1.2284 | |
| 294 | G | A | -1.2006 | |
| 295 | S | A | -1.0240 | |
| 296 | G | A | -1.2005 | |
| 297 | G | A | -1.1755 | |
| 298 | G | A | -0.9148 | |
| 299 | G | A | -0.4505 | |
| 300 | S | A | 0.5867 | |
| 301 | F | A | 2.1725 | |
| 302 | A | A | 1.5714 | |
| 303 | V | A | 1.7576 | |
| 304 | T | A | 0.0024 | |
| 305 | N | A | -1.8450 | |
| 306 | D | A | -1.9049 | |
| 307 | G | A | -0.2956 | |
| 308 | V | A | 2.2035 | |
| 309 | I | A | 2.5935 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine