Project name: bd9a77bc256dd8b

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGLTFSRYPMSWVRQAPGKGLVWVSAITSSGGSTYYSDTVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARLPDYWGQGTLVTVSS; L: EIVLTQSPGTLSLSPGERATLSCRASSSVSSSYLHWYQQKPGQAPRLLIYATSNLVAGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHFSGYHFTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:54)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:55)

• Minimal score value: -2.9319
• Maximal score value: 1.6118
• Average score: -0.5034
• Total score value: -111.2507

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0098
2	V	H	-1.0158
3	Q	H	-0.8801
4	L	H	0.0000
5	V	H	0.9786
6	E	H	0.0000
7	S	H	-0.1575
8	G	H	-0.5537
9	G	H	0.2778
11	G	H	0.8556
12	L	H	1.4338
13	V	H	-0.0972
14	Q	H	-1.4377
15	P	H	-1.8576
16	G	H	-1.6123
17	G	H	-1.2691
18	S	H	-1.1223
19	L	H	-0.5410
20	R	H	-1.1971
21	L	H	0.0000
22	S	H	-0.2036
23	C	H	0.0000
24	A	H	-0.1199
25	A	H	0.0000
26	S	H	-0.8787
27	G	H	-1.1541
28	L	H	-0.7419
29	T	H	-0.6859
30	F	H	0.0000
35	S	H	-1.4860
36	R	H	-1.8943
37	Y	H	-0.5791
38	P	H	-0.3369
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.1261
45	A	H	-0.7439
46	P	H	-0.7950
47	G	H	-1.4785
48	K	H	-2.0259
49	G	H	-0.9408
50	L	H	0.0000
51	V	H	0.8569
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	A	H	0.0000
56	I	H	0.0000
57	T	H	-0.5541
58	S	H	-0.9826
59	S	H	-0.9316
62	G	H	-0.7021
63	G	H	-0.6511
64	S	H	-0.2080
65	T	H	0.1228
66	Y	H	0.1476
67	Y	H	-0.6642
68	S	H	-1.1940
69	D	H	-2.4914
70	T	H	-1.7018
71	V	H	0.0000
72	K	H	-2.6296
74	G	H	-1.7866
75	R	H	-1.5397
76	F	H	0.0000
77	T	H	-0.6765
78	I	H	0.0000
79	S	H	-0.3675
80	R	H	-0.8752
81	D	H	-1.3484
82	N	H	-1.7035
83	A	H	-1.2783
84	K	H	-2.1969
85	N	H	-1.6308
86	T	H	-0.8863
87	L	H	0.0000
88	Y	H	-0.2679
89	L	H	0.0000
90	Q	H	-0.7417
91	M	H	0.0000
92	N	H	-1.3357
93	S	H	-1.4449
94	L	H	0.0000
95	R	H	-2.9319
96	A	H	-2.0002
97	E	H	-2.4303
98	D	H	0.0000
99	T	H	-0.4461
100	A	H	0.0000
101	V	H	0.8803
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	L	H	0.9569
115	P	H	0.4386
116	D	H	0.2729
117	Y	H	0.4814
118	W	H	0.1476
119	G	H	0.0000
120	Q	H	-1.0418
121	G	H	-0.1155
122	T	H	0.6023
123	L	H	1.6118
124	V	H	0.0000
125	T	H	0.3046
126	V	H	0.0000
127	S	H	-0.6798
128	S	H	-0.5632
1	E	L	-1.2029
2	I	L	0.1254
3	V	L	1.0013
4	L	L	0.0000
5	T	L	-0.6363
6	Q	L	0.0000
7	S	L	-0.8734
8	P	L	-0.5980
9	G	L	-0.8593
10	T	L	-0.6732
11	L	L	-0.2109
12	S	L	-0.2112
13	L	L	-0.4398
14	S	L	-0.8816
15	P	L	-1.3188
16	G	L	-1.8359
17	E	L	-2.2792
18	R	L	-2.9111
19	A	L	0.0000
20	T	L	-0.6298
21	L	L	0.0000
22	S	L	-0.9089
23	C	L	0.0000
24	R	L	-2.1838
25	A	L	0.0000
26	S	L	-0.4445
27	S	L	-0.5948
28	S	L	-0.7900
29	V	L	0.0000
30	S	L	-0.0924
36	S	L	-0.1550
37	S	L	0.1937
38	Y	L	1.0413
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.6136
44	Q	L	0.0000
45	K	L	-1.5144
46	P	L	-1.1178
47	G	L	-1.4691
48	Q	L	-2.0849
49	A	L	-1.2673
50	P	L	0.0000
51	R	L	-0.9687
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.5133
56	A	L	0.2264
57	T	L	0.0000
65	S	L	-0.6073
66	N	L	-0.7206
67	L	L	-0.1685
68	V	L	0.1168
69	A	L	-0.0425
70	G	L	-0.4477
71	I	L	-0.3875
72	P	L	-0.9524
74	D	L	-1.9019
75	R	L	-1.8102
76	F	L	0.0000
77	S	L	-0.7808
78	G	L	-0.4142
79	S	L	-0.7664
80	G	L	-1.0284
83	S	L	-1.0272
84	G	L	-1.0089
85	T	L	-1.4337
86	D	L	-1.9859
87	F	L	0.0000
88	T	L	-0.7620
89	L	L	0.0000
90	T	L	-0.7990
91	I	L	0.0000
92	S	L	-2.1153
93	R	L	-2.8686
94	L	L	0.0000
95	E	L	-1.8346
96	P	L	-1.1794
97	E	L	-1.9575
98	D	L	0.0000
99	F	L	-0.2988
100	A	L	0.0000
101	V	L	-0.3184
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	H	L	0.0000
107	F	L	0.7232
108	S	L	0.4010
109	G	L	0.2706
114	Y	L	1.0054
115	H	L	0.1956
116	F	L	0.5708
117	T	L	0.5218
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.5068
121	G	L	-0.8269
122	T	L	0.0000
123	K	L	-1.0991
124	V	L	0.0000
125	E	L	0.0330
126	I	L	1.0140
127	K	L	-0.8157