Project name: c049ec529cb38e9

Chain sequence(s)	H: EVQLLESGGGLVQPGGSLRLSCAASGIDLSTYAMGWVRQAPGKGLEWVGLIHRSGRTYYATWAKGRFTISKDSSKNTLYLQMNSLRAEDTAVYYCTRSYPDYSATASIWGQGTTVTVSS; L: DIQVTQSPSSLSASVGDRVTITCQASENIANALAWYQQKPGKPPKFLIYGASNLASGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQAYYGNSFVEGTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:16)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:18)

• Minimal score value: -2.8289
• Maximal score value: 1.1355
• Average score: -0.6227
• Total score value: -143.2154

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.7788
2	V	H	-0.6964
3	Q	H	-0.7747
4	L	H	0.0000
5	L	H	0.6917
6	E	H	0.0000
7	S	H	-0.5408
8	G	H	-0.8354
9	G	H	-0.4258
11	G	H	0.3743
12	L	H	1.1355
13	V	H	-0.0604
14	Q	H	-1.3370
15	P	H	-1.4412
16	G	H	-1.3457
17	G	H	-1.1049
18	S	H	-0.9972
19	L	H	-0.8214
20	R	H	-1.7194
21	L	H	0.0000
22	S	H	-0.4311
23	C	H	0.0000
24	A	H	-0.1997
25	A	H	-0.4730
26	S	H	-0.8402
27	G	H	-1.1868
28	I	H	0.0000
29	D	H	-1.2578
30	L	H	0.0000
35	S	H	-1.3058
36	T	H	-1.0042
37	Y	H	-0.6290
38	A	H	-0.8314
39	M	H	0.0000
40	G	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.8314
45	A	H	-1.2502
46	P	H	-1.1978
47	G	H	-1.4553
48	K	H	-2.2469
49	G	H	-1.4062
50	L	H	0.0000
51	E	H	-0.8422
52	W	H	0.0000
53	V	H	0.0000
54	G	H	0.0000
55	L	H	0.0000
56	I	H	0.0000
57	H	H	-1.6463
58	R	H	-2.4507
59	S	H	-1.5998
63	G	H	-1.6105
64	R	H	-1.5590
65	T	H	-0.7476
66	Y	H	-0.3273
67	Y	H	-0.2421
68	A	H	0.0000
69	T	H	-0.5233
70	W	H	-0.1100
71	A	H	0.0000
72	K	H	-1.6414
74	G	H	-1.3893
75	R	H	-1.2708
76	F	H	0.0000
77	T	H	-0.8132
78	I	H	0.0000
79	S	H	-0.5966
80	K	H	-1.1906
81	D	H	-1.2668
82	S	H	-1.4141
83	S	H	-1.3626
84	K	H	-2.1590
85	N	H	-1.7406
86	T	H	0.0000
87	L	H	0.0000
88	Y	H	-0.5740
89	L	H	0.0000
90	Q	H	-1.1753
91	M	H	0.0000
92	N	H	-1.2773
93	S	H	-1.2552
94	L	H	0.0000
95	R	H	-2.5844
96	A	H	-1.8342
97	E	H	-2.3493
98	D	H	0.0000
99	T	H	-0.7409
100	A	H	0.0000
101	V	H	-0.0732
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	T	H	0.0000
106	R	H	0.0000
107	S	H	0.1861
108	Y	H	0.4781
109	P	H	-0.3756
110	D	H	-1.0999
111	Y	H	0.5746
112	S	H	0.0000
113	A	H	0.4308
114	T	H	0.0000
115	A	H	0.0000
116	S	H	0.2381
117	I	H	0.3025
118	W	H	-0.3179
119	G	H	0.0000
120	Q	H	-1.4605
121	G	H	-0.7383
122	T	H	-0.3070
123	T	H	-0.1145
124	V	H	0.0000
125	T	H	-0.1213
126	V	H	0.0000
127	S	H	-0.5491
128	S	H	-0.4678
1	D	L	-2.3282
2	I	L	0.0000
3	Q	L	-2.2423
4	V	L	0.0000
5	T	L	-1.1218
6	Q	L	-0.6858
7	S	L	-0.5585
8	P	L	-0.5928
9	S	L	-0.7955
10	S	L	-1.0223
11	L	L	-0.6143
12	S	L	-0.9227
13	A	L	-1.0877
14	S	L	-0.8812
15	V	L	0.0123
16	G	L	-0.7582
17	D	L	-1.8243
18	R	L	-2.3683
19	V	L	0.0000
20	T	L	-0.6570
21	I	L	0.0000
22	T	L	-0.7539
23	C	L	0.0000
24	Q	L	-2.2604
25	A	L	0.0000
26	S	L	-2.2837
27	E	L	-2.8289
28	N	L	-2.4258
29	I	L	0.0000
36	A	L	-1.1132
37	N	L	-1.1870
38	A	L	-0.0091
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7316
44	Q	L	0.0000
45	K	L	-1.6148
46	P	L	-1.1433
47	G	L	-1.6838
48	K	L	-2.6489
49	P	L	-1.6450
50	P	L	0.0000
51	K	L	-1.2623
52	F	L	-0.1554
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.2857
56	G	L	0.0000
57	A	L	0.0000
65	S	L	-0.5627
66	N	L	-0.3700
67	L	L	0.2181
68	A	L	0.0000
69	S	L	-0.2916
70	G	L	-0.4268
71	V	L	-0.2427
72	P	L	-0.3211
74	S	L	-0.3772
75	R	L	-0.7402
76	F	L	0.0000
77	S	L	-0.3831
78	G	L	-0.3249
79	S	L	-0.9027
80	G	L	-1.2803
83	S	L	-1.5054
84	G	L	-1.7693
85	T	L	-2.2100
86	D	L	-2.4712
87	F	L	0.0000
88	T	L	-0.7447
89	F	L	0.0000
90	T	L	0.0000
91	I	L	0.0000
92	S	L	-1.3976
93	S	L	-1.2308
94	L	L	0.0000
95	Q	L	-0.8566
96	P	L	-0.9450
97	E	L	-1.6838
98	D	L	0.0000
99	I	L	-0.2392
100	A	L	0.0000
101	T	L	-0.7922
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	A	L	0.0000
108	Y	L	0.9084
109	Y	L	0.4785
110	G	L	-0.2465
111	N	L	-1.1133
112	S	L	-0.9766
113	F	L	-0.7740
114	V	L	0.0000
115	E	L	-0.6771
116	G	L	0.0000
117	T	L	-0.6683
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-1.1977
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.5038
124	V	L	0.0000
125	E	L	-1.4046
126	I	L	-0.7776
127	K	L	-1.5681