Project name: c09f99b685fa557

Chain sequence(s)	H: QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGEISPFGGRTNYNEKFKSRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARERPLYASDLWGQGTTVTVSSATKGPSVFPLAPSSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVER; L: IQMTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQRYSLWRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGES
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	No
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       runJob:   FoldX not utilized. Treating input pdb file as it was already optimized.    (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:01)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:04)

• Minimal score value: -3.5885
• Maximal score value: 1.8528
• Average score: -0.607
• Total score value: -257.3796

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.0121
2	V	H	-0.0293
3	Q	H	-0.6776
4	L	H	0.0000
5	V	H	0.1098
6	Q	H	0.0000
7	S	H	-0.6373
8	G	H	-0.8748
9	A	H	-0.7515
10	E	H	-1.1189
11	V	H	-0.7586
12	K	H	-1.5929
13	K	H	-2.3790
14	P	H	-1.8617
15	G	H	-1.5062
16	A	H	-1.1671
17	S	H	-1.1075
18	V	H	0.0000
19	K	H	-1.7599
20	V	H	0.0000
21	S	H	-0.6487
22	C	H	0.0000
23	K	H	-1.1283
24	A	H	0.0000
25	S	H	-0.5091
26	G	H	-0.4706
27	Y	H	-0.0347
28	T	H	0.0731
29	F	H	-0.0100
30	T	H	0.3992
31	S	H	0.3308
32	Y	H	0.6438
33	Y	H	0.9467
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.6088
40	A	H	-1.0583
41	P	H	-0.9832
42	G	H	-1.2158
43	Q	H	-1.8131
44	G	H	-1.2402
45	L	H	0.0000
46	E	H	-0.8228
47	W	H	0.0000
48	M	H	0.0000
49	G	H	0.0000
50	E	H	-0.2342
51	I	H	0.0000
52	S	H	0.0000
52A	P	H	0.5463
53	F	H	1.3710
54	G	H	-0.2491
55	G	H	-0.8147
56	R	H	-1.8580
57	T	H	-1.1872
58	N	H	-1.0169
59	Y	H	-1.1801
60	N	H	-1.7426
61	E	H	-3.0760
62	K	H	-2.5806
63	F	H	0.0000
64	K	H	-2.9069
65	S	H	-1.6930
66	R	H	-1.3975
67	V	H	0.0000
68	T	H	-0.8540
69	M	H	0.0000
70	T	H	-0.9366
71	R	H	-1.3494
72	D	H	-1.1781
73	T	H	-0.6802
74	S	H	-0.5500
75	T	H	-0.6648
76	S	H	-0.8005
77	T	H	0.0000
78	V	H	0.0000
79	Y	H	-0.7079
80	M	H	0.0000
81	E	H	-1.3605
82	L	H	0.0000
82A	S	H	-0.9349
82B	S	H	-1.0583
82C	L	H	0.0000
83	R	H	-2.4258
84	S	H	-1.9765
85	E	H	-2.3451
86	D	H	0.0000
87	T	H	-0.8710
88	A	H	0.0000
89	V	H	0.1226
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	R	H	0.0000
95	E	H	0.0000
96	R	H	0.1666
97	P	H	0.3103
98	L	H	1.1152
99	Y	H	0.8216
100	A	H	0.0000
100A	S	H	0.0000
101	D	H	-0.2082
102	L	H	-0.2080
103	W	H	-0.3648
104	G	H	0.0000
105	Q	H	-1.4020
106	G	H	-0.7391
107	T	H	0.0000
108	T	H	-0.3003
109	V	H	0.0000
110	T	H	0.0000
111	V	H	0.0000
112	S	H	-1.0898
113	S	H	-0.8733
114	A	H	-0.5811
120	T	H	-1.1565
121	K	H	-1.9815
122	G	H	-1.7080
123	P	H	0.0000
124	S	H	-0.7167
125	V	H	0.0000
126	F	H	-0.4633
127	P	H	-0.9169
128	L	H	0.0000
129	A	H	-1.0235
130	P	H	-1.1027
131	S	H	-1.2233
132	S	H	-0.8557
139	T	H	-0.2092
140	A	H	-0.1825
141	A	H	0.0000
142	L	H	0.0000
143	G	H	0.0000
144	C	H	0.0000
145	L	H	0.0000
146	V	H	0.0000
147	K	H	-0.2525
148	D	H	-0.5333
149	Y	H	0.0000
150	F	H	0.0000
151	P	H	0.0000
152	E	H	-0.6095
153	P	H	-0.6369
154	V	H	0.0000
155	T	H	-0.3479
156	V	H	-0.4589
157	S	H	-0.3042
158	W	H	0.0000
159	N	H	-0.8177
160	S	H	-0.7549
161	G	H	-0.5115
162	A	H	-0.2323
163	L	H	0.0153
164	T	H	-0.1455
165	S	H	-0.1890
166	G	H	-0.2157
167	V	H	0.1800
168	H	H	-0.2079
169	T	H	-0.0703
170	F	H	0.0000
171	P	H	-0.2811
172	A	H	0.2250
173	V	H	0.6522
174	L	H	1.4691
175	Q	H	0.4136
176	S	H	-0.0666
177	S	H	-0.1721
178	G	H	0.1363
179	L	H	0.1220
180	Y	H	0.4223
181	S	H	0.0000
182	L	H	0.0000
183	S	H	0.0000
184	S	H	0.0000
185	V	H	0.0000
186	V	H	0.0000
187	T	H	-0.0725
188	V	H	-0.0300
189	P	H	-0.3190
190	S	H	-0.3431
191	S	H	-0.4334
192	N	H	-0.6275
193	F	H	-0.3786
194	G	H	-0.8074
195	T	H	-0.6611
196	Q	H	-0.9835
197	T	H	-1.2875
198	Y	H	0.0000
199	T	H	-0.9808
200	C	H	0.0000
201	N	H	-1.4008
202	V	H	0.0000
203	D	H	-1.7329
204	H	H	0.0000
205	K	H	-2.2422
206	P	H	-1.6134
207	S	H	-1.8730
208	N	H	-2.3845
209	T	H	-2.1495
210	K	H	-2.4826
211	V	H	-1.4607
212	D	H	-2.0968
213	K	H	-1.1726
214	T	H	-1.3244
215	V	H	0.0000
216	E	H	-2.7434
217	R	H	-2.7625
2	I	L	0.1558
3	Q	L	-1.4166
4	M	L	0.0000
5	T	L	-1.2835
6	Q	L	0.0000
7	S	L	-0.7313
8	P	L	-0.4518
9	S	L	-0.6867
10	S	L	-0.4954
11	L	L	-0.2576
12	S	L	-0.6491
13	A	L	-0.8059
14	S	L	-0.7014
15	V	L	0.3787
16	G	L	-0.6661
17	D	L	-1.7038
18	R	L	-2.2900
19	V	L	0.0000
20	T	L	-0.5718
21	I	L	0.0000
22	T	L	-0.8919
23	C	L	0.0000
24	R	L	-2.9582
25	A	L	0.0000
26	S	L	-1.5524
27	Q	L	-1.4917
28	G	L	-1.1766
29	I	L	0.0000
30	S	L	-0.5903
31	S	L	-0.4587
32	A	L	0.2198
33	L	L	0.0000
34	A	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-1.9545
40	P	L	-1.4640
41	G	L	-1.8245
42	K	L	-2.6709
43	A	L	-1.6972
44	P	L	0.0000
45	K	L	-1.8202
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.5924
50	S	L	0.3463
51	A	L	0.0000
52	S	L	0.1137
53	Y	L	0.9664
54	R	L	-0.3010
55	Y	L	-0.1418
56	T	L	-0.2821
57	G	L	-0.6177
58	V	L	0.0000
59	P	L	-0.5791
60	S	L	-0.6916
61	R	L	-0.9298
62	F	L	0.0000
63	S	L	-0.2937
64	G	L	-0.1715
65	S	L	-0.5013
66	G	L	-1.2733
67	S	L	-1.2965
68	G	L	-1.4480
69	T	L	-2.0855
70	D	L	-2.8173
71	F	L	0.0000
72	T	L	-0.8651
73	F	L	0.0000
74	T	L	-0.5975
75	I	L	0.0000
76	S	L	-1.3645
77	S	L	-1.1197
78	L	L	0.0000
79	Q	L	-0.7357
80	P	L	-1.5870
81	E	L	-2.0098
82	D	L	0.0000
83	I	L	0.0000
84	A	L	0.0000
85	T	L	-0.6793
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	R	L	0.6375
92	Y	L	1.2784
93	S	L	1.4052
94	L	L	1.8528
95	W	L	0.9438
96	R	L	0.3554
97	T	L	-0.1012
98	F	L	0.0000
99	G	L	0.0000
100	Q	L	-1.5772
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-0.9222
104	L	L	0.0000
105	E	L	-1.0895
106	I	L	0.0000
107	K	L	-1.2315
108	R	L	-0.7700
109	T	L	-0.0038
110	V	L	0.7158
111	A	L	0.2171
112	A	L	-0.0992
113	P	L	0.0000
114	S	L	-0.1498
115	V	L	0.0000
116	F	L	0.1124
117	I	L	0.0240
118	F	L	0.0000
119	P	L	0.0000
120	P	L	0.0000
121	S	L	-1.2247
122	D	L	-2.4986
123	E	L	-2.0666
124	Q	L	0.0000
125	L	L	-1.8843
126	K	L	-2.5594
127	S	L	-1.6097
128	G	L	-1.2050
129	T	L	-0.9947
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-0.8019
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	-1.3788
142	R	L	-2.2325
143	E	L	-2.7673
144	A	L	-1.8513
145	K	L	-1.5984
146	V	L	-0.6887
147	Q	L	-0.3139
148	W	L	0.0000
149	K	L	-0.4935
150	V	L	0.0000
151	D	L	-1.6531
152	N	L	-1.2929
153	A	L	-0.2206
154	L	L	0.6568
155	Q	L	-0.1082
156	S	L	-0.4616
157	G	L	-0.9210
158	N	L	-0.8943
159	S	L	-1.1532
160	Q	L	-1.2881
161	E	L	-1.9125
162	S	L	-0.9307
163	V	L	-0.5760
164	T	L	-0.6191
165	E	L	-1.3206
166	Q	L	0.0000
167	D	L	-1.8953
168	S	L	-2.1587
169	K	L	-2.7004
170	D	L	-2.1992
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	L	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	-0.6722
179	L	L	0.0000
180	T	L	-0.3904
181	L	L	-0.7334
182	S	L	-1.1731
183	K	L	-2.2010
184	A	L	-1.9491
185	D	L	-2.6448
186	Y	L	0.0000
187	E	L	-3.5885
188	K	L	-3.5725
189	H	L	-2.9672
190	K	L	-3.0602
191	V	L	-1.6192
192	Y	L	0.0000
193	A	L	0.0000
194	C	L	0.0000
195	E	L	-0.5834
196	V	L	0.0000
197	T	L	-0.9514
198	H	L	0.0000
199	Q	L	-1.3446
200	G	L	-0.4300
201	L	L	-0.2863
202	S	L	-0.4987
203	S	L	-0.4411
204	P	L	-0.4471
205	V	L	0.0071
206	T	L	-0.5392
207	K	L	-0.9924
208	S	L	-0.7859
209	F	L	0.0000
210	N	L	-2.1238
211	R	L	-2.7745
212	G	L	-2.4540
213	E	L	-2.7303
214	S	L	-2.0411