Project name: c0a3354975f899e

Chain sequence(s)	H: QIQLVQSGAEVKKPGASVKVSCKASGYTFTKYGMNWVRQAPGQGLEWMGWINTYTGEPTYADDFKGRITFTLDTSTSTAYMELSSLRSEDTAVYFCARDHGKYAMDYWGQGTTVTVSS; L: DFQLTQSPSTLSASVGDRVTITCSASSSVSYMHWFQQKPGTAPKRWIYDTSKLASGVPSRFSGSGSGTEYTLTISSLQPDDFATYYCQQWSFEPPNTFGQGTRLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:02)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:04)

• Minimal score value: -3.2482
• Maximal score value: 1.3477
• Average score: -0.5265
• Total score value: -118.4618

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.3638
2	I	H	-0.5372
3	Q	H	-0.9211
4	L	H	0.0000
5	V	H	0.2535
6	Q	H	0.0000
7	S	H	-0.6024
8	G	H	-0.6118
9	A	H	-0.0234
11	E	H	-0.1151
12	V	H	0.9249
13	K	H	-0.8893
14	K	H	-2.1589
15	P	H	-2.2703
16	G	H	-1.5935
17	A	H	-1.2266
18	S	H	-1.3252
19	V	H	0.0000
20	K	H	-1.9734
21	V	H	0.0000
22	S	H	-0.5234
23	C	H	0.0000
24	K	H	-0.7536
25	A	H	0.0000
26	S	H	-0.7137
27	G	H	-0.8769
28	Y	H	-0.5389
29	T	H	-0.5407
30	F	H	0.0000
35	T	H	-0.3672
36	K	H	-1.4688
37	Y	H	-0.6775
38	G	H	0.0000
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6215
45	A	H	-1.0069
46	P	H	-1.0061
47	G	H	-1.2100
48	Q	H	-1.8335
49	G	H	-1.2786
50	L	H	0.0000
51	E	H	-0.7996
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	W	H	-0.0707
56	I	H	0.0000
57	N	H	-0.5445
58	T	H	0.0000
59	Y	H	0.5890
62	T	H	-0.0718
63	G	H	-0.6729
64	E	H	-1.4350
65	P	H	-0.8521
66	T	H	-0.7684
67	Y	H	-1.0882
68	A	H	0.0000
69	D	H	-3.2482
70	D	H	-3.1923
71	F	H	0.0000
72	K	H	-3.0394
74	G	H	-1.9348
75	R	H	-1.5212
76	I	H	0.0000
77	T	H	-0.8122
78	F	H	0.0000
79	T	H	-0.4483
80	L	H	-0.0090
81	D	H	-0.4946
82	T	H	-0.1740
83	S	H	-0.3802
84	T	H	-0.4618
85	S	H	-0.5080
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.4357
89	M	H	0.0000
90	E	H	-1.3284
91	L	H	0.0000
92	S	H	-1.1216
93	S	H	-1.2512
94	L	H	0.0000
95	R	H	-3.0760
96	S	H	-2.3868
97	E	H	-2.5219
98	D	H	0.0000
99	T	H	-0.8843
100	A	H	0.0000
101	V	H	0.1774
102	Y	H	0.0000
103	F	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	D	H	0.0000
108	H	H	-0.8505
109	G	H	-0.9941
110	K	H	-0.5821
113	Y	H	-0.2488
114	A	H	0.0000
115	M	H	0.0000
116	D	H	-0.2770
117	Y	H	0.0661
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.0113
121	G	H	-0.4522
122	T	H	0.0000
123	T	H	0.0258
124	V	H	0.0000
125	T	H	-0.2898
126	V	H	0.0000
127	S	H	-0.9532
128	S	H	-0.7800
1	D	L	-1.8504
2	F	L	-0.9663
3	Q	L	-1.7274
4	L	L	0.0000
5	T	L	-0.8399
6	Q	L	0.0000
7	S	L	-0.3673
8	P	L	-0.3995
9	S	L	-0.7183
10	T	L	-0.6507
11	L	L	-0.2518
12	S	L	-0.4336
13	A	L	0.0000
14	S	L	-0.1638
15	V	L	0.6034
16	G	L	-0.6074
17	D	L	-1.6775
18	R	L	-2.2393
19	V	L	0.0000
20	T	L	-0.5791
21	I	L	0.0000
22	T	L	-0.5487
23	C	L	0.0000
24	S	L	-1.1200
25	A	L	0.0000
26	S	L	-1.0863
27	S	L	-0.6408
28	S	L	-0.4211
29	V	L	0.0000
37	S	L	0.0636
38	Y	L	0.1420
39	M	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	F	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-0.9613
46	P	L	-0.6489
47	G	L	-0.7948
48	T	L	-0.8408
49	A	L	-0.7024
50	P	L	0.0000
51	K	L	-0.8794
52	R	L	-0.4769
53	W	L	-0.4561
54	I	L	0.0000
55	Y	L	-0.4248
56	D	L	-0.6197
57	T	L	-0.6070
65	S	L	-1.0115
66	K	L	-1.6304
67	L	L	-0.5898
68	A	L	-0.5080
69	S	L	-0.5289
70	G	L	-0.4417
71	V	L	-0.4187
72	P	L	-0.2967
74	S	L	-0.4437
75	R	L	-0.9194
76	F	L	0.0000
77	S	L	-0.6338
78	G	L	-0.6318
79	S	L	-0.9457
80	G	L	-1.0491
83	S	L	-0.9923
84	G	L	-0.9422
85	T	L	-1.1868
86	E	L	-2.0373
87	Y	L	0.0000
88	T	L	-0.6365
89	L	L	0.0000
90	T	L	-0.6169
91	I	L	0.0000
92	S	L	-1.4423
93	S	L	-1.1890
94	L	L	0.0000
95	Q	L	-0.7156
96	P	L	-0.7689
97	D	L	-1.8907
98	D	L	0.0000
99	F	L	-0.3682
100	A	L	0.0000
101	T	L	-0.7601
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	W	L	0.6956
108	S	L	0.8497
109	F	L	1.3477
113	E	L	0.0883
114	P	L	-0.5391
115	P	L	-0.7869
116	N	L	0.0000
117	T	L	-0.4389
118	F	L	-0.3157
119	G	L	0.0000
120	Q	L	-1.4798
121	G	L	0.0000
122	T	L	0.0000
123	R	L	-1.3528
124	L	L	0.0000
125	E	L	-0.4073
126	I	L	1.0609
127	K	L	-0.7305