| Chain sequence(s) |
A: TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSWDERTKEEVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVEASRWWQGNVFSCSVMHEALHNHYTQKSLSRSPGKTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSWDERTKEEVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVEASRWWQGNVFSCSVMHEALHNHYTQKSLSRSPGK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:34)
[INFO] Main: Simulation completed successfully. (00:05:37)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | T | A | 0.1359 | |
| 2 | C | A | 0.4452 | |
| 3 | P | A | 0.0185 | |
| 4 | P | A | 0.0252 | |
| 5 | C | A | 0.3886 | |
| 6 | P | A | -0.3324 | |
| 7 | A | A | -0.4742 | |
| 8 | P | A | -0.6874 | |
| 9 | E | A | -1.2021 | |
| 10 | L | A | 0.6677 | |
| 11 | L | A | 1.1459 | |
| 12 | G | A | 0.0163 | |
| 13 | G | A | -0.2958 | |
| 14 | P | A | 0.0000 | |
| 15 | S | A | -0.1578 | |
| 16 | V | A | 0.0000 | |
| 17 | F | A | 1.0104 | |
| 18 | L | A | 0.8108 | |
| 19 | F | A | 1.0636 | |
| 20 | P | A | -0.2228 | |
| 21 | P | A | 0.0000 | |
| 22 | K | A | -2.0125 | |
| 23 | P | A | -1.3080 | |
| 24 | K | A | -0.9519 | |
| 25 | D | A | 0.0000 | |
| 26 | T | A | 0.0000 | |
| 27 | L | A | 0.0000 | |
| 28 | M | A | 0.5149 | |
| 29 | I | A | 1.6197 | |
| 30 | S | A | 0.3526 | |
| 31 | R | A | -0.5816 | |
| 32 | T | A | -0.4529 | |
| 33 | P | A | 0.0000 | |
| 34 | E | A | -0.9907 | |
| 35 | V | A | 0.0000 | |
| 36 | T | A | 0.2289 | |
| 37 | C | A | 0.0000 | |
| 38 | V | A | 0.0000 | |
| 39 | V | A | 0.0000 | |
| 40 | V | A | -0.8357 | |
| 41 | D | A | -1.6576 | |
| 42 | V | A | 0.0000 | |
| 43 | S | A | -1.9450 | |
| 44 | H | A | -2.6203 | |
| 45 | E | A | -2.9401 | |
| 46 | D | A | -2.5507 | |
| 47 | P | A | -2.7433 | |
| 48 | E | A | -3.1314 | |
| 49 | V | A | -1.9552 | |
| 50 | K | A | -2.2574 | |
| 51 | F | A | -1.1525 | |
| 52 | N | A | -1.1420 | |
| 53 | W | A | 0.0000 | |
| 54 | Y | A | -0.5619 | |
| 55 | V | A | -0.8731 | |
| 56 | D | A | -2.1908 | |
| 57 | G | A | -0.8768 | |
| 58 | V | A | 0.6435 | |
| 59 | E | A | -0.4141 | |
| 60 | V | A | -0.5207 | |
| 61 | H | A | -1.6209 | |
| 62 | N | A | -1.6991 | |
| 63 | A | A | -1.7052 | |
| 64 | K | A | -2.3373 | |
| 65 | T | A | -2.1377 | |
| 66 | K | A | -2.9497 | |
| 67 | P | A | -2.8493 | |
| 68 | R | A | -4.0985 | |
| 69 | E | A | -4.0535 | |
| 70 | E | A | -3.5359 | |
| 71 | Q | A | -1.7416 | |
| 72 | Y | A | 0.1485 | |
| 73 | N | A | -0.8255 | |
| 74 | S | A | -1.1114 | |
| 75 | T | A | -2.0595 | |
| 76 | Y | A | 0.0000 | |
| 77 | R | A | -2.8114 | |
| 78 | V | A | 0.0000 | |
| 79 | V | A | -1.1822 | |
| 80 | S | A | 0.0000 | |
| 81 | V | A | 0.0000 | |
| 82 | L | A | 0.0000 | |
| 83 | T | A | -0.6465 | |
| 84 | V | A | 0.0000 | |
| 85 | L | A | 0.8145 | |
| 86 | H | A | -0.0837 | |
| 87 | Q | A | -1.1748 | |
| 88 | D | A | -1.4619 | |
| 89 | W | A | 0.0000 | |
| 90 | L | A | -1.0059 | |
| 91 | N | A | -2.2565 | |
| 92 | G | A | -2.2268 | |
| 93 | K | A | -2.4833 | |
| 94 | E | A | -2.3858 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -1.6147 | |
| 97 | C | A | 0.0000 | |
| 98 | K | A | -1.5837 | |
| 99 | V | A | 0.0000 | |
| 100 | S | A | -1.5265 | |
| 101 | N | A | 0.0000 | |
| 102 | K | A | -2.5728 | |
| 103 | A | A | -1.4124 | |
| 104 | L | A | -0.6316 | |
| 105 | P | A | -0.5503 | |
| 106 | A | A | -0.3216 | |
| 107 | P | A | -0.9606 | |
| 108 | I | A | -0.7257 | |
| 109 | E | A | -2.1329 | |
| 110 | K | A | -1.3222 | |
| 111 | T | A | -1.0820 | |
| 112 | I | A | -0.3252 | |
| 113 | S | A | -1.3159 | |
| 114 | K | A | -1.4386 | |
| 115 | A | A | -1.2514 | |
| 116 | K | A | -2.3910 | |
| 117 | G | A | -2.0113 | |
| 118 | Q | A | -2.1917 | |
| 119 | P | A | -1.8732 | |
| 120 | R | A | -2.2065 | |
| 121 | E | A | -2.6722 | |
| 122 | P | A | 0.0000 | |
| 123 | Q | A | -1.1787 | |
| 124 | V | A | 0.0000 | |
| 125 | Y | A | 0.0000 | |
| 126 | T | A | 0.0000 | |
| 127 | L | A | 0.0000 | |
| 128 | P | A | -0.3137 | |
| 129 | P | A | -0.8211 | |
| 130 | S | A | 0.0000 | |
| 131 | W | A | -0.7841 | |
| 132 | D | A | -1.8379 | |
| 133 | E | A | 0.0000 | |
| 134 | R | A | -2.8291 | |
| 135 | T | A | -2.1544 | |
| 136 | K | A | -3.1163 | |
| 137 | E | A | -3.7327 | |
| 138 | E | A | -3.8388 | |
| 139 | V | A | 0.0000 | |
| 140 | S | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | T | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.5008 | |
| 147 | G | A | -0.9758 | |
| 148 | F | A | 0.0000 | |
| 149 | Y | A | -1.0753 | |
| 150 | P | A | 0.0000 | |
| 151 | S | A | -0.1103 | |
| 152 | D | A | -1.0669 | |
| 153 | I | A | -0.5656 | |
| 154 | A | A | -0.5321 | |
| 155 | V | A | 0.0000 | |
| 156 | E | A | -1.1593 | |
| 157 | W | A | 0.0000 | |
| 158 | E | A | -1.9771 | |
| 159 | S | A | 0.0000 | |
| 160 | N | A | -1.8807 | |
| 161 | G | A | -1.8196 | |
| 162 | Q | A | -2.3530 | |
| 163 | P | A | -2.0254 | |
| 164 | E | A | -1.9775 | |
| 165 | N | A | -2.2011 | |
| 166 | N | A | -1.6658 | |
| 167 | Y | A | -1.1874 | |
| 168 | K | A | -0.9867 | |
| 169 | T | A | -0.3327 | |
| 170 | T | A | 0.0000 | |
| 171 | P | A | -0.1239 | |
| 172 | P | A | 0.2214 | |
| 173 | V | A | 0.5959 | |
| 174 | L | A | 1.0155 | |
| 175 | D | A | -0.4483 | |
| 176 | S | A | -1.1561 | |
| 177 | D | A | -1.8356 | |
| 178 | G | A | -0.7647 | |
| 179 | S | A | 0.0000 | |
| 180 | F | A | 0.2520 | |
| 181 | F | A | 0.0000 | |
| 182 | L | A | 0.0000 | |
| 183 | Y | A | 0.0000 | |
| 184 | S | A | 0.0000 | |
| 185 | K | A | 0.0000 | |
| 186 | L | A | 0.0000 | |
| 187 | T | A | -1.3310 | |
| 188 | V | A | 0.0000 | |
| 189 | E | A | -3.2270 | |
| 190 | A | A | 0.0000 | |
| 191 | S | A | -1.8946 | |
| 192 | R | A | -1.6786 | |
| 193 | W | A | 0.0000 | |
| 194 | W | A | -1.3463 | |
| 195 | Q | A | -1.5290 | |
| 196 | G | A | -1.2293 | |
| 197 | N | A | -0.8716 | |
| 198 | V | A | -0.2448 | |
| 199 | F | A | 0.0000 | |
| 200 | S | A | -1.1496 | |
| 201 | C | A | 0.0000 | |
| 202 | S | A | 0.0000 | |
| 203 | V | A | 0.0000 | |
| 204 | M | A | -0.4951 | |
| 205 | H | A | 0.0000 | |
| 206 | E | A | -1.1059 | |
| 207 | A | A | -1.5001 | |
| 208 | L | A | -1.4556 | |
| 209 | H | A | -1.7651 | |
| 210 | N | A | -1.6850 | |
| 211 | H | A | -1.1755 | |
| 212 | Y | A | -0.6043 | |
| 213 | T | A | -0.9537 | |
| 214 | Q | A | -1.5966 | |
| 215 | K | A | -1.3846 | |
| 216 | S | A | -0.7021 | |
| 217 | L | A | 0.0000 | |
| 218 | S | A | -0.9170 | |
| 219 | R | A | -1.8586 | |
| 220 | S | A | -1.5369 | |
| 221 | P | A | -1.3331 | |
| 222 | G | A | -1.6925 | |
| 223 | K | A | -2.0381 | |
| 424 | T | A | 0.1288 | |
| 425 | C | A | 0.4224 | |
| 426 | P | A | 0.0042 | |
| 427 | P | A | 0.0122 | |
| 428 | C | A | 0.3705 | |
| 429 | P | A | -0.3254 | |
| 430 | A | A | -0.4412 | |
| 431 | P | A | -0.5760 | |
| 432 | E | A | -0.9776 | |
| 433 | L | A | 1.0463 | |
| 434 | L | A | 1.3041 | |
| 435 | G | A | 0.1696 | |
| 436 | G | A | -0.2401 | |
| 437 | P | A | 0.0000 | |
| 438 | S | A | -0.1360 | |
| 439 | V | A | 0.0000 | |
| 440 | F | A | 0.9861 | |
| 441 | L | A | 0.8117 | |
| 442 | F | A | 1.0737 | |
| 443 | P | A | -0.1614 | |
| 444 | P | A | 0.0000 | |
| 445 | K | A | -2.0297 | |
| 446 | P | A | -1.2726 | |
| 447 | K | A | -1.1300 | |
| 448 | D | A | -1.3948 | |
| 449 | T | A | 0.0000 | |
| 450 | L | A | 0.0000 | |
| 451 | M | A | 0.2437 | |
| 452 | I | A | 1.3179 | |
| 453 | S | A | -0.0072 | |
| 454 | R | A | -1.2346 | |
| 455 | T | A | -0.9105 | |
| 456 | P | A | 0.0000 | |
| 457 | E | A | -1.2486 | |
| 458 | V | A | 0.0000 | |
| 459 | T | A | 0.2523 | |
| 460 | C | A | 0.0000 | |
| 461 | V | A | 0.0000 | |
| 462 | V | A | 0.0000 | |
| 463 | V | A | -0.9889 | |
| 464 | D | A | -1.3792 | |
| 465 | V | A | 0.0000 | |
| 466 | S | A | -1.8899 | |
| 467 | H | A | -2.5746 | |
| 468 | E | A | -2.8970 | |
| 469 | D | A | -2.4656 | |
| 470 | P | A | -2.6725 | |
| 471 | E | A | -3.0806 | |
| 472 | V | A | -1.9914 | |
| 473 | K | A | -2.2568 | |
| 474 | F | A | -1.1331 | |
| 475 | N | A | -1.3768 | |
| 476 | W | A | 0.0000 | |
| 477 | Y | A | -1.0283 | |
| 478 | V | A | -1.1311 | |
| 479 | D | A | -2.3092 | |
| 480 | G | A | -1.1303 | |
| 481 | V | A | 0.1406 | |
| 482 | E | A | -1.4048 | |
| 483 | V | A | -0.9602 | |
| 484 | H | A | -1.7942 | |
| 485 | N | A | -1.7763 | |
| 486 | A | A | -1.5464 | |
| 487 | K | A | -1.9590 | |
| 488 | T | A | -1.8671 | |
| 489 | K | A | -2.6563 | |
| 490 | P | A | -2.6458 | |
| 491 | R | A | -3.8683 | |
| 492 | E | A | -4.1001 | |
| 493 | E | A | -3.4674 | |
| 494 | Q | A | -1.6538 | |
| 495 | Y | A | 0.4028 | |
| 496 | N | A | -0.6462 | |
| 497 | S | A | -1.2008 | |
| 498 | T | A | -1.9620 | |
| 499 | Y | A | 0.0000 | |
| 500 | R | A | -2.7334 | |
| 501 | V | A | 0.0000 | |
| 502 | V | A | -1.0469 | |
| 503 | S | A | 0.0000 | |
| 504 | V | A | 0.0000 | |
| 505 | L | A | 0.0000 | |
| 506 | T | A | -0.6185 | |
| 507 | V | A | 0.0000 | |
| 508 | L | A | 0.2484 | |
| 509 | H | A | -0.4396 | |
| 510 | Q | A | -1.2780 | |
| 511 | D | A | -1.4013 | |
| 512 | W | A | 0.0000 | |
| 513 | L | A | -1.0394 | |
| 514 | N | A | -2.2679 | |
| 515 | G | A | -2.2213 | |
| 516 | K | A | -2.3805 | |
| 517 | E | A | -2.4534 | |
| 518 | Y | A | 0.0000 | |
| 519 | K | A | -1.8016 | |
| 520 | C | A | 0.0000 | |
| 521 | K | A | -1.6706 | |
| 522 | V | A | 0.0000 | |
| 523 | S | A | -1.5139 | |
| 524 | N | A | 0.0000 | |
| 525 | K | A | -2.5417 | |
| 526 | A | A | -1.1508 | |
| 527 | L | A | -0.3853 | |
| 528 | P | A | -0.3697 | |
| 529 | A | A | -0.3463 | |
| 530 | P | A | -0.9422 | |
| 531 | I | A | -0.7298 | |
| 532 | E | A | -2.1836 | |
| 533 | K | A | -1.3915 | |
| 534 | T | A | -1.1476 | |
| 535 | I | A | -0.3340 | |
| 536 | S | A | -1.3382 | |
| 537 | K | A | -1.4504 | |
| 538 | A | A | -1.2224 | |
| 539 | K | A | -2.3930 | |
| 540 | G | A | -2.0558 | |
| 541 | Q | A | -2.2655 | |
| 542 | P | A | -1.9988 | |
| 543 | R | A | -2.5381 | |
| 544 | E | A | -2.8263 | |
| 545 | P | A | 0.0000 | |
| 546 | Q | A | -1.4517 | |
| 547 | V | A | 0.0000 | |
| 548 | Y | A | 0.0000 | |
| 549 | T | A | 0.0000 | |
| 550 | L | A | 0.0000 | |
| 551 | P | A | -0.3641 | |
| 552 | P | A | -0.8861 | |
| 553 | S | A | 0.0000 | |
| 554 | W | A | -0.8939 | |
| 555 | D | A | -2.1086 | |
| 556 | E | A | 0.0000 | |
| 557 | R | A | -2.9231 | |
| 558 | T | A | -2.2257 | |
| 559 | K | A | -3.1908 | |
| 560 | E | A | -3.7014 | |
| 561 | E | A | -3.7266 | |
| 562 | V | A | 0.0000 | |
| 563 | S | A | 0.0000 | |
| 564 | L | A | 0.0000 | |
| 565 | T | A | 0.0000 | |
| 566 | C | A | 0.0000 | |
| 567 | L | A | 0.0000 | |
| 568 | V | A | 0.0000 | |
| 569 | K | A | -0.6634 | |
| 570 | G | A | -1.1641 | |
| 571 | F | A | 0.0000 | |
| 572 | Y | A | -1.1223 | |
| 573 | P | A | 0.0000 | |
| 574 | S | A | -0.0364 | |
| 575 | D | A | -0.8352 | |
| 576 | I | A | -0.4342 | |
| 577 | A | A | 0.0000 | |
| 578 | V | A | 0.0000 | |
| 579 | E | A | -1.2904 | |
| 580 | W | A | 0.0000 | |
| 581 | E | A | -2.0782 | |
| 582 | S | A | 0.0000 | |
| 583 | N | A | -1.9751 | |
| 584 | G | A | -1.8601 | |
| 585 | Q | A | -2.3682 | |
| 586 | P | A | -2.0511 | |
| 587 | E | A | -1.9960 | |
| 588 | N | A | -2.2528 | |
| 589 | N | A | -1.7184 | |
| 590 | Y | A | -1.3097 | |
| 591 | K | A | -1.1800 | |
| 592 | T | A | -0.4315 | |
| 593 | T | A | 0.0000 | |
| 594 | P | A | -0.1390 | |
| 595 | P | A | 0.2346 | |
| 596 | V | A | 0.5984 | |
| 597 | L | A | 0.9512 | |
| 598 | D | A | -0.4972 | |
| 599 | S | A | -1.1763 | |
| 600 | D | A | -1.9081 | |
| 601 | G | A | -0.9010 | |
| 602 | S | A | 0.0000 | |
| 603 | F | A | 0.1991 | |
| 604 | F | A | 0.0000 | |
| 605 | L | A | 0.0000 | |
| 606 | Y | A | 0.0000 | |
| 607 | S | A | 0.0000 | |
| 608 | K | A | 0.0000 | |
| 609 | L | A | 0.0000 | |
| 610 | T | A | -1.3209 | |
| 611 | V | A | 0.0000 | |
| 612 | E | A | -3.1778 | |
| 613 | A | A | 0.0000 | |
| 614 | S | A | -1.9005 | |
| 615 | R | A | -1.7529 | |
| 616 | W | A | 0.0000 | |
| 617 | W | A | -1.5397 | |
| 618 | Q | A | -1.7393 | |
| 619 | G | A | -1.5669 | |
| 620 | N | A | -1.2525 | |
| 621 | V | A | -0.6371 | |
| 622 | F | A | 0.0000 | |
| 623 | S | A | -1.1617 | |
| 624 | C | A | 0.0000 | |
| 625 | S | A | 0.0000 | |
| 626 | V | A | 0.0000 | |
| 627 | M | A | 0.0000 | |
| 628 | H | A | 0.0000 | |
| 629 | E | A | -1.0197 | |
| 630 | A | A | -1.5556 | |
| 631 | L | A | -1.5184 | |
| 632 | H | A | -1.7543 | |
| 633 | N | A | -1.6649 | |
| 634 | H | A | -1.1333 | |
| 635 | Y | A | -0.5555 | |
| 636 | T | A | -0.9239 | |
| 637 | Q | A | -1.5009 | |
| 638 | K | A | -1.1817 | |
| 639 | S | A | -0.6136 | |
| 640 | L | A | 0.0000 | |
| 641 | S | A | -1.1912 | |
| 642 | R | A | -2.2061 | |
| 643 | S | A | -1.7536 | |
| 644 | P | A | -1.3832 | |
| 645 | G | A | -1.6924 | |
| 646 | K | A | -2.0122 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine