| Chain sequence(s) |
A: GPLPLNPEPALKPTSEYVTPTDLLYIAETDLLTRTGDPTSDIVVNGKVLVPRVSAYQYKVFLLKLPDPNTLPLPRDDFVDPSTEILIWRLRAIKIGVGGPLGKGTYGHANYNKLGDVTNPTSYQHCGADDTVNYSFEPKLKQMFIVGDEPPLGVYTTKAAPTPGLPPGAIPPTEKKTTIIQDGDMADIGFGAKDYAALEPSKNNVPDIILNTTTKVPDLEGMKAEPTGRRMFFYDEYEKSENKETYVLCGPDLIPLPDKPPPSKLYIKPPPSSPYYVRPSYRIFNIPDGGEITEEDLLFNKPYFFEKAEGLNDGILWYNRLYITVLDNSRAEIETIRTQIATPAINVYDPSYYVTSKRYTEEYQISLIVQLCRIPLTPETLELLKRIDPRILVNANLPFIPPVDFPDPYAGKKFIEIDLTNKLSSDLSKYELGQLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2154 | |
| 2 | P | A | 0.4136 | |
| 3 | L | A | 1.3965 | |
| 4 | P | A | 0.7024 | |
| 5 | L | A | 0.8547 | |
| 6 | N | A | -1.0317 | |
| 7 | P | A | -1.4380 | |
| 8 | E | A | -2.1238 | |
| 9 | P | A | -1.4719 | |
| 10 | A | A | -0.9050 | |
| 11 | L | A | -0.7610 | |
| 12 | K | A | -1.7387 | |
| 13 | P | A | -1.1922 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.5242 | |
| 16 | E | A | -2.2410 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6709 | |
| 20 | P | A | -0.7500 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6351 | |
| 23 | L | A | -0.5138 | |
| 24 | L | A | -0.2119 | |
| 25 | Y | A | -0.0993 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9285 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2578 | |
| 31 | L | A | 0.4319 | |
| 32 | L | A | 0.1633 | |
| 33 | T | A | -0.2985 | |
| 34 | R | A | -0.6835 | |
| 35 | T | A | -0.5281 | |
| 36 | G | A | 0.0000 | |
| 37 | D | A | -0.8229 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.7056 | |
| 40 | S | A | -0.4336 | |
| 41 | D | A | 0.0172 | |
| 42 | I | A | 1.7629 | |
| 43 | V | A | 2.4631 | |
| 44 | V | A | 1.6070 | |
| 45 | N | A | -0.5787 | |
| 46 | G | A | -0.3821 | |
| 47 | K | A | -0.1351 | |
| 48 | V | A | 2.1330 | |
| 49 | L | A | 2.5212 | |
| 50 | V | A | 1.4491 | |
| 51 | P | A | 0.3262 | |
| 52 | R | A | -0.4522 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0029 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.8631 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.0170 | |
| 70 | T | A | -0.4275 | |
| 71 | L | A | -0.1134 | |
| 72 | P | A | -0.5903 | |
| 73 | L | A | -1.0044 | |
| 74 | P | A | -1.5223 | |
| 75 | R | A | -3.1923 | |
| 76 | D | A | -3.6015 | |
| 77 | D | A | -3.3746 | |
| 78 | F | A | -2.0605 | |
| 79 | V | A | -1.8554 | |
| 80 | D | A | -2.2270 | |
| 81 | P | A | -1.3979 | |
| 82 | S | A | -0.7003 | |
| 83 | T | A | -0.8492 | |
| 84 | E | A | -1.1136 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3564 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6375 | |
| 92 | A | A | 0.0000 | |
| 93 | I | A | 0.0000 | |
| 94 | K | A | -0.9367 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -0.6618 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.5128 | |
| 99 | G | A | -0.8145 | |
| 100 | P | A | -0.5611 | |
| 101 | L | A | -0.3047 | |
| 102 | G | A | -0.9229 | |
| 103 | K | A | -1.4017 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.6417 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.9261 | |
| 108 | H | A | -1.2717 | |
| 109 | A | A | -1.1663 | |
| 110 | N | A | -2.1356 | |
| 111 | Y | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | K | A | -0.4212 | |
| 114 | L | A | -0.1951 | |
| 115 | G | A | -0.1681 | |
| 116 | D | A | -0.6098 | |
| 117 | V | A | 0.0187 | |
| 118 | T | A | -0.7913 | |
| 119 | N | A | -1.5148 | |
| 120 | P | A | -0.9157 | |
| 121 | T | A | -0.5640 | |
| 122 | S | A | -0.3677 | |
| 123 | Y | A | 0.2267 | |
| 124 | Q | A | -0.2843 | |
| 125 | H | A | -0.3292 | |
| 126 | C | A | -0.6741 | |
| 127 | G | A | -1.1522 | |
| 128 | A | A | -1.1418 | |
| 129 | D | A | -2.1970 | |
| 130 | D | A | -1.5657 | |
| 131 | T | A | -1.3072 | |
| 132 | V | A | -0.7599 | |
| 133 | N | A | -1.3450 | |
| 134 | Y | A | -0.6974 | |
| 135 | S | A | -0.5332 | |
| 136 | F | A | 0.0000 | |
| 137 | E | A | -1.1332 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | M | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | 0.1381 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | -0.2088 | |
| 155 | Y | A | -0.9173 | |
| 156 | T | A | -1.6692 | |
| 157 | T | A | 0.0000 | |
| 158 | K | A | -1.4760 | |
| 159 | A | A | -1.2196 | |
| 160 | A | A | -0.4935 | |
| 161 | P | A | -0.4401 | |
| 162 | T | A | -0.2069 | |
| 163 | P | A | -0.3420 | |
| 164 | G | A | -0.2789 | |
| 165 | L | A | 0.5993 | |
| 166 | P | A | 0.2217 | |
| 167 | P | A | -0.0034 | |
| 168 | G | A | 0.5542 | |
| 169 | A | A | 1.2987 | |
| 170 | I | A | 2.0630 | |
| 171 | P | A | 0.5429 | |
| 172 | P | A | -0.0807 | |
| 173 | T | A | -1.1896 | |
| 174 | E | A | -2.2830 | |
| 175 | K | A | -2.6915 | |
| 176 | K | A | -2.0206 | |
| 177 | T | A | -0.6040 | |
| 178 | T | A | -0.1917 | |
| 179 | I | A | -0.0913 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -1.0215 | |
| 182 | D | A | -1.1272 | |
| 183 | G | A | -0.6568 | |
| 184 | D | A | -0.5893 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.8839 | |
| 190 | F | A | 0.0000 | |
| 191 | G | A | -0.3471 | |
| 192 | A | A | -0.4401 | |
| 193 | K | A | -1.2803 | |
| 194 | D | A | -1.0653 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.0660 | |
| 197 | A | A | -0.6314 | |
| 198 | L | A | -0.4626 | |
| 199 | E | A | -1.0775 | |
| 200 | P | A | -1.0424 | |
| 201 | S | A | -1.1733 | |
| 202 | K | A | -2.3421 | |
| 203 | N | A | -1.6184 | |
| 204 | N | A | -1.0874 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.4305 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.2536 | |
| 211 | N | A | -1.6115 | |
| 212 | T | A | -0.8746 | |
| 213 | T | A | -0.5692 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.5481 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | -0.6467 | |
| 219 | L | A | -1.0432 | |
| 220 | E | A | -2.2794 | |
| 221 | G | A | -1.4673 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.2065 | |
| 224 | A | A | -1.4383 | |
| 225 | E | A | -1.0627 | |
| 226 | P | A | -0.5955 | |
| 227 | T | A | -0.4729 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.3940 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.6538 | |
| 234 | Y | A | -0.4063 | |
| 235 | D | A | -0.9783 | |
| 236 | E | A | -1.8546 | |
| 237 | Y | A | -1.6041 | |
| 238 | E | A | -2.3861 | |
| 239 | K | A | -2.1155 | |
| 240 | S | A | -2.3777 | |
| 241 | E | A | -3.0246 | |
| 242 | N | A | -3.1501 | |
| 243 | K | A | -2.8619 | |
| 244 | E | A | -2.1666 | |
| 245 | T | A | -0.8831 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | 0.5556 | |
| 249 | C | A | -0.2470 | |
| 250 | G | A | -0.3129 | |
| 251 | P | A | 0.2436 | |
| 252 | D | A | 0.3694 | |
| 253 | L | A | 2.3346 | |
| 254 | I | A | 1.7558 | |
| 255 | P | A | 0.4670 | |
| 256 | L | A | 0.7720 | |
| 257 | P | A | -0.6455 | |
| 258 | D | A | -2.1447 | |
| 259 | K | A | -2.2611 | |
| 260 | P | A | -1.5044 | |
| 261 | P | A | -0.8718 | |
| 262 | P | A | -0.9684 | |
| 263 | S | A | -0.6780 | |
| 264 | K | A | -0.6591 | |
| 265 | L | A | 1.0522 | |
| 266 | Y | A | 1.2585 | |
| 267 | I | A | 1.3680 | |
| 268 | K | A | -0.1387 | |
| 269 | P | A | 0.0645 | |
| 270 | P | A | -0.1911 | |
| 271 | P | A | -0.1878 | |
| 272 | S | A | -0.2251 | |
| 273 | S | A | 0.2281 | |
| 274 | P | A | 0.5884 | |
| 275 | Y | A | 1.2530 | |
| 276 | Y | A | 1.0621 | |
| 277 | V | A | 1.5962 | |
| 278 | R | A | 0.3446 | |
| 279 | P | A | 0.3403 | |
| 280 | S | A | 0.3908 | |
| 281 | Y | A | 1.1138 | |
| 282 | R | A | 0.8757 | |
| 283 | I | A | 1.9937 | |
| 284 | F | A | 0.5643 | |
| 285 | N | A | -1.4842 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -2.3672 | |
| 289 | G | A | 0.0000 | |
| 290 | G | A | -1.9304 | |
| 291 | E | A | -2.0966 | |
| 292 | I | A | -1.4267 | |
| 293 | T | A | -1.8809 | |
| 294 | E | A | -2.8714 | |
| 295 | E | A | -2.8843 | |
| 296 | D | A | -2.1051 | |
| 297 | L | A | -1.4373 | |
| 298 | L | A | -1.0894 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3143 | |
| 301 | K | A | -1.2686 | |
| 302 | P | A | -0.6454 | |
| 303 | Y | A | -0.1707 | |
| 304 | F | A | -0.3753 | |
| 305 | F | A | 0.0000 | |
| 306 | E | A | -2.5717 | |
| 307 | K | A | -2.9369 | |
| 308 | A | A | 0.0000 | |
| 309 | E | A | -2.2758 | |
| 310 | G | A | -1.3988 | |
| 311 | L | A | -0.9595 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | Y | A | -0.2989 | |
| 319 | N | A | -0.6118 | |
| 320 | R | A | -0.9697 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.7247 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.0819 | |
| 333 | I | A | -1.6334 | |
| 334 | E | A | -2.3388 | |
| 335 | T | A | -1.3244 | |
| 336 | I | A | -0.2062 | |
| 337 | R | A | -0.9881 | |
| 338 | T | A | 0.1019 | |
| 339 | Q | A | 0.4304 | |
| 340 | I | A | 1.9728 | |
| 341 | A | A | 0.9340 | |
| 342 | T | A | 0.2647 | |
| 343 | P | A | -0.1009 | |
| 344 | A | A | -0.0598 | |
| 345 | I | A | 0.5231 | |
| 346 | N | A | -0.0016 | |
| 347 | V | A | 1.7701 | |
| 348 | Y | A | 1.7331 | |
| 349 | D | A | 0.4119 | |
| 350 | P | A | 0.0714 | |
| 351 | S | A | 0.4784 | |
| 352 | Y | A | 1.1073 | |
| 353 | Y | A | 1.1246 | |
| 354 | V | A | 1.4427 | |
| 355 | T | A | -0.0421 | |
| 356 | S | A | -0.5747 | |
| 357 | K | A | -1.5546 | |
| 358 | R | A | -1.3894 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.9687 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.4977 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.7034 | |
| 365 | I | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.4058 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -0.6951 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7012 | |
| 376 | L | A | -0.6601 | |
| 377 | T | A | -0.9862 | |
| 378 | P | A | -1.5459 | |
| 379 | E | A | -2.4838 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.8617 | |
| 382 | E | A | -3.1551 | |
| 383 | L | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | K | A | -2.6992 | |
| 386 | R | A | -1.9380 | |
| 387 | I | A | -1.1635 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.4121 | |
| 390 | R | A | -0.9167 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.4577 | |
| 394 | N | A | -0.9466 | |
| 395 | A | A | -0.9829 | |
| 396 | N | A | -1.1416 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.3522 | |
| 399 | F | A | 1.7001 | |
| 400 | I | A | 0.9158 | |
| 401 | P | A | 0.2035 | |
| 402 | P | A | -0.0974 | |
| 403 | V | A | 0.2029 | |
| 404 | D | A | -1.2039 | |
| 405 | F | A | -0.4563 | |
| 406 | P | A | -1.0856 | |
| 407 | D | A | -2.1352 | |
| 408 | P | A | -1.1297 | |
| 409 | Y | A | 0.0000 | |
| 410 | A | A | -1.4048 | |
| 411 | G | A | -1.5141 | |
| 412 | K | A | -2.1159 | |
| 413 | K | A | -2.4386 | |
| 414 | F | A | -1.3330 | |
| 415 | I | A | -0.9257 | |
| 416 | E | A | -2.3814 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.8298 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.5949 | |
| 421 | N | A | -1.8072 | |
| 422 | K | A | -1.6519 | |
| 423 | L | A | -0.5604 | |
| 424 | S | A | -0.7101 | |
| 425 | S | A | -0.5436 | |
| 426 | D | A | -1.2711 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.5799 | |
| 429 | K | A | -2.4527 | |
| 430 | Y | A | -1.8400 | |
| 431 | E | A | -2.2643 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | Q | A | -1.6716 | |
| 435 | L | A | -0.5758 | |
| 436 | Y | A | -0.2451 | |
| 437 | L | A | 0.2587 | |
| 438 | N | A | -1.4285 | |
| 439 | R | A | -1.8280 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine