Chain sequence(s) |
A: HHRWIFVCFFLMPLSILFDVYYQLRAWAVRRMHSAPRLHGQRVRHIQEQVREWKEEGGRRYMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDVLEVDSERQVVRVEPLVTMGQLTAYLNPMGWTIPVVPELDDLTVGGLIMGTGIESSSHIYGLFQHTCMAYELVLADGSLVRCSPTENSDLFYAVPWSCGTLGFLVAAEIKMIPAKKYIRLHYEPVRGLRSICEKFTEESKNKENSFVEGLVYSLEEAVIMTGVLTDEAEPSKINRIGNYYKPWFFKHVEKYLKANKTGIEYIPSRHYYHRHTRSIFWELQDIIPFGNNPVFRYLFGWMVPPKISLLKLTQGEAIRKLYEQHHVVQDMLVPMKSLEKSIQTFHVDLNVYPLWLCPFLLPNNPGMVHPKGDETELYVDIGAYGEPKTKQFEARASMRQMEKFVRSVHGFQMLYADCYMTREEFWDMFDGSLYHSLREQMNCKDAFPEVYDKICKAARH
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | Yes |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:08:46) [INFO] Auto_mut: Residue number 9 from chain A and a score of 3.374 (phenylalanine) selected for automated muatation (00:08:49) [INFO] Auto_mut: Residue number 10 from chain A and a score of 3.124 (phenylalanine) selected for automated muatation (00:08:49) [INFO] Auto_mut: Residue number 325 from chain A and a score of 2.855 (tyrosine) selected for automated muatation (00:08:49) [INFO] Auto_mut: Residue number 326 from chain A and a score of 2.781 (leucine) selected for automated muatation (00:08:49) [INFO] Auto_mut: Residue number 327 from chain A and a score of 2.574 (phenylalanine) selected for automated muatation (00:08:49) [INFO] Auto_mut: Residue number 21 from chain A and a score of 2.396 (tyrosine) selected for automated muatation (00:08:49) [INFO] Auto_mut: Mutating residue number 9 from chain A (phenylalanine) into glutamic acid (00:08:49) [INFO] Auto_mut: Mutating residue number 9 from chain A (phenylalanine) into aspartic acid (00:08:49) [INFO] Auto_mut: Mutating residue number 10 from chain A (phenylalanine) into glutamic acid Mutating residue number 10 from chain A (phenylalanine) into glutamic acid (00:08:49) [INFO] Auto_mut: Mutating residue number 9 from chain A (phenylalanine) into arginine (00:12:43) [INFO] Auto_mut: Mutating residue number 9 from chain A (phenylalanine) into lysine (00:12:44) [INFO] Auto_mut: Mutating residue number 10 from chain A (phenylalanine) into lysine (00:12:48) [INFO] Auto_mut: Mutating residue number 10 from chain A (phenylalanine) into aspartic acid Mutating residue number 10 from chain A (phenylalanine) into aspartic acid (00:16:42) [INFO] Auto_mut: Mutating residue number 325 from chain A (tyrosine) into glutamic acid (00:17:05) [INFO] Auto_mut: Mutating residue number 325 from chain A (tyrosine) into aspartic acid (00:17:09) [INFO] Auto_mut: Mutating residue number 10 from chain A (phenylalanine) into arginine (00:20:34) [INFO] Auto_mut: Mutating residue number 325 from chain A (tyrosine) into lysine (00:21:02) [INFO] Auto_mut: Mutating residue number 325 from chain A (tyrosine) into arginine (00:21:02) [INFO] Auto_mut: Mutating residue number 326 from chain A (leucine) into glutamic acid (00:24:36) [INFO] Auto_mut: Mutating residue number 326 from chain A (leucine) into aspartic acid (00:25:10) [INFO] Auto_mut: Mutating residue number 327 from chain A (phenylalanine) into glutamic acid Mutating residue number 327 from chain A (phenylalanine) into glutamic acid (00:25:16) [INFO] Auto_mut: Mutating residue number 326 from chain A (leucine) into lysine (00:28:32) [INFO] Auto_mut: Mutating residue number 326 from chain A (leucine) into arginine (00:28:58) [INFO] Auto_mut: Mutating residue number 327 from chain A (phenylalanine) into lysine (00:29:11) [INFO] Auto_mut: Mutating residue number 327 from chain A (phenylalanine) into aspartic acid Mutating residue number 327 from chain A (phenylalanine) into aspartic acid (00:32:38) [INFO] Auto_mut: Mutating residue number 21 from chain A (tyrosine) into glutamic acid (00:32:54) [INFO] Auto_mut: Mutating residue number 21 from chain A (tyrosine) into aspartic acid (00:33:27) [INFO] Auto_mut: Mutating residue number 327 from chain A (phenylalanine) into arginine (00:36:48) [INFO] Auto_mut: Mutating residue number 21 from chain A (tyrosine) into lysine (00:37:19) [INFO] Auto_mut: Mutating residue number 21 from chain A (tyrosine) into arginine (00:37:53) [INFO] Auto_mut: Effect of mutation residue number 9 from chain A (phenylalanine) into glutamic acid: Energy difference: 0.4756 kcal/mol, Difference in average score from the base case: -0.0166 (00:42:22) [INFO] Auto_mut: Effect of mutation residue number 9 from chain A (phenylalanine) into lysine: Energy difference: 0.1535 kcal/mol, Difference in average score from the base case: -0.0210 (00:42:22) [INFO] Auto_mut: Effect of mutation residue number 9 from chain A (phenylalanine) into aspartic acid: Energy difference: 0.7715 kcal/mol, Difference in average score from the base case: -0.0201 (00:42:22) [INFO] Auto_mut: Effect of mutation residue number 9 from chain A (phenylalanine) into arginine: Energy difference: 0.0524 kcal/mol, Difference in average score from the base case: -0.0250 (00:42:22) [INFO] Auto_mut: Effect of mutation residue number 10 from chain A (phenylalanine) into glutamic acid: Energy difference: 0.5914 kcal/mol, Difference in average score from the base case: -0.0170 (00:42:22) [INFO] Auto_mut: Effect of mutation residue number 10 from chain A (phenylalanine) into lysine: Energy difference: 0.2055 kcal/mol, Difference in average score from the base case: -0.0209 (00:42:22) [INFO] Auto_mut: Effect of mutation residue number 10 from chain A (phenylalanine) into aspartic acid: Energy difference: 1.6801 kcal/mol, Difference in average score from the base case: -0.0212 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 10 from chain A (phenylalanine) into arginine: Energy difference: 0.1045 kcal/mol, Difference in average score from the base case: -0.0213 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 325 from chain A (tyrosine) into glutamic acid: Energy difference: -0.0414 kcal/mol, Difference in average score from the base case: -0.0269 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 325 from chain A (tyrosine) into lysine: Energy difference: -0.1446 kcal/mol, Difference in average score from the base case: -0.0281 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 325 from chain A (tyrosine) into aspartic acid: Energy difference: 0.3855 kcal/mol, Difference in average score from the base case: -0.0256 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 325 from chain A (tyrosine) into arginine: Energy difference: -1.3755 kcal/mol, Difference in average score from the base case: -0.0305 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 326 from chain A (leucine) into glutamic acid: Energy difference: 0.5293 kcal/mol, Difference in average score from the base case: -0.0268 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 326 from chain A (leucine) into lysine: Energy difference: 0.7279 kcal/mol, Difference in average score from the base case: -0.0207 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 326 from chain A (leucine) into aspartic acid: Energy difference: 1.0587 kcal/mol, Difference in average score from the base case: -0.0253 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 326 from chain A (leucine) into arginine: Energy difference: 0.9724 kcal/mol, Difference in average score from the base case: -0.0251 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 327 from chain A (phenylalanine) into glutamic acid: Energy difference: 0.6885 kcal/mol, Difference in average score from the base case: -0.0112 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 327 from chain A (phenylalanine) into lysine: Energy difference: 0.3866 kcal/mol, Difference in average score from the base case: -0.0125 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 327 from chain A (phenylalanine) into aspartic acid: Energy difference: 1.4553 kcal/mol, Difference in average score from the base case: -0.0057 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 327 from chain A (phenylalanine) into arginine: Energy difference: 0.0314 kcal/mol, Difference in average score from the base case: -0.0171 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 21 from chain A (tyrosine) into glutamic acid: Energy difference: 0.4744 kcal/mol, Difference in average score from the base case: -0.0264 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 21 from chain A (tyrosine) into lysine: Energy difference: 0.3016 kcal/mol, Difference in average score from the base case: -0.0334 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 21 from chain A (tyrosine) into aspartic acid: Energy difference: 0.7906 kcal/mol, Difference in average score from the base case: -0.0308 (00:42:23) [INFO] Auto_mut: Effect of mutation residue number 21 from chain A (tyrosine) into arginine: Energy difference: -0.9273 kcal/mol, Difference in average score from the base case: -0.0272 (00:42:23) [INFO] Main: Simulation completed successfully. (00:42:30) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | H | A | -1.3631 | |
2 | H | A | -1.0309 | |
3 | R | A | -0.3669 | |
4 | W | A | 0.8144 | |
5 | I | A | 1.8968 | |
6 | F | A | 2.3832 | |
7 | V | A | 0.0000 | |
8 | C | A | 0.0000 | |
9 | F | A | 3.3744 | |
10 | F | A | 3.1243 | |
11 | L | A | 0.0000 | |
12 | M | A | 0.0000 | |
13 | P | A | 1.4407 | |
14 | L | A | 1.5904 | |
15 | S | A | 0.0000 | |
16 | I | A | 1.5975 | |
17 | L | A | 2.0871 | |
18 | F | A | 1.7911 | |
19 | D | A | 1.0302 | |
20 | V | A | 2.0234 | |
21 | Y | A | 2.3963 | |
22 | Y | A | 1.4801 | |
23 | Q | A | 0.8449 | |
24 | L | A | 1.5254 | |
25 | R | A | 0.3173 | |
26 | A | A | 0.2881 | |
27 | W | A | 0.4511 | |
28 | A | A | -0.2185 | |
29 | V | A | 0.0000 | |
30 | R | A | -1.3258 | |
31 | R | A | -1.7045 | |
32 | M | A | -0.5541 | |
33 | H | A | -1.5707 | |
34 | S | A | -0.9683 | |
35 | A | A | -0.5472 | |
36 | P | A | -1.1576 | |
37 | R | A | -1.7564 | |
38 | L | A | -0.6678 | |
39 | H | A | 0.0000 | |
40 | G | A | -1.6633 | |
41 | Q | A | -2.2765 | |
42 | R | A | -2.0729 | |
43 | V | A | 0.0000 | |
44 | R | A | -3.0764 | |
45 | H | A | -2.9206 | |
46 | I | A | 0.0000 | |
47 | Q | A | -2.8614 | |
48 | E | A | -3.7161 | |
49 | Q | A | -2.9468 | |
50 | V | A | 0.0000 | |
51 | R | A | -4.9130 | |
52 | E | A | -4.7183 | |
53 | W | A | 0.0000 | |
54 | K | A | -4.7901 | |
55 | E | A | -4.4673 | |
56 | E | A | -4.5645 | |
57 | G | A | -3.4028 | |
58 | G | A | -3.8250 | |
59 | R | A | -3.7024 | |
60 | R | A | -3.4628 | |
61 | Y | A | -1.7476 | |
62 | M | A | 0.0000 | |
63 | C | A | 0.0000 | |
64 | T | A | -0.4437 | |
65 | G | A | -0.7643 | |
66 | R | A | -0.5303 | |
67 | P | A | -0.3032 | |
68 | G | A | 0.0000 | |
69 | W | A | 1.0355 | |
70 | L | A | 0.7393 | |
71 | T | A | 0.5715 | |
72 | V | A | 0.8043 | |
73 | S | A | 0.7898 | |
74 | L | A | 0.5878 | |
75 | R | A | 0.0000 | |
76 | V | A | 0.2270 | |
77 | G | A | -0.8400 | |
78 | K | A | -1.3199 | |
79 | Y | A | -1.1849 | |
80 | K | A | -1.4867 | |
81 | K | A | -2.2079 | |
82 | T | A | -1.5675 | |
83 | H | A | -1.7500 | |
84 | K | A | -1.6932 | |
85 | N | A | -1.1031 | |
86 | I | A | 0.0000 | |
87 | M | A | -0.3773 | |
88 | I | A | 0.0000 | |
89 | N | A | -1.1908 | |
90 | L | A | 0.0000 | |
91 | M | A | -0.1103 | |
92 | D | A | 0.0000 | |
93 | V | A | 0.0000 | |
94 | L | A | 0.0000 | |
95 | E | A | -2.0210 | |
96 | V | A | -1.3091 | |
97 | D | A | -2.2739 | |
98 | S | A | -2.0761 | |
99 | E | A | -3.0375 | |
100 | R | A | -3.1502 | |
101 | Q | A | -2.1382 | |
102 | V | A | 0.0000 | |
103 | V | A | 0.0000 | |
104 | R | A | -0.9092 | |
105 | V | A | 0.0000 | |
106 | E | A | 0.0000 | |
107 | P | A | 0.0000 | |
108 | L | A | 0.0000 | |
109 | V | A | 0.0000 | |
110 | T | A | 0.0000 | |
111 | M | A | 0.0000 | |
112 | G | A | 0.0000 | |
113 | Q | A | -0.2874 | |
114 | L | A | 0.0000 | |
115 | T | A | 0.0000 | |
116 | A | A | -0.2389 | |
117 | Y | A | 0.0607 | |
118 | L | A | 0.0000 | |
119 | N | A | -0.6672 | |
120 | P | A | -0.2463 | |
121 | M | A | 0.1559 | |
122 | G | A | -0.5437 | |
123 | W | A | -0.1123 | |
124 | T | A | 0.0000 | |
125 | I | A | 0.0000 | |
126 | P | A | 0.0000 | |
127 | V | A | 0.0000 | |
128 | V | A | 0.0000 | |
129 | P | A | 0.0000 | |
130 | E | A | 0.0000 | |
131 | L | A | 0.0621 | |
132 | D | A | -0.4782 | |
133 | D | A | -0.1864 | |
134 | L | A | 0.1507 | |
135 | T | A | -0.0023 | |
136 | V | A | 0.0000 | |
137 | G | A | 0.0000 | |
138 | G | A | -0.1296 | |
139 | L | A | 0.0000 | |
140 | I | A | 0.0000 | |
141 | M | A | 0.0000 | |
142 | G | A | 0.0000 | |
143 | T | A | 0.0483 | |
144 | G | A | 0.0000 | |
145 | I | A | 0.2879 | |
146 | E | A | 0.0000 | |
147 | S | A | 0.0000 | |
148 | S | A | 0.0000 | |
149 | S | A | 0.0000 | |
150 | H | A | 0.0000 | |
151 | I | A | 0.1682 | |
152 | Y | A | 0.8702 | |
153 | G | A | 0.0000 | |
154 | L | A | 0.0000 | |
155 | F | A | 0.0000 | |
156 | Q | A | 0.0000 | |
157 | H | A | -0.1839 | |
158 | T | A | 0.0000 | |
159 | C | A | 0.0000 | |
160 | M | A | 0.0788 | |
161 | A | A | 0.0000 | |
162 | Y | A | 0.0000 | |
163 | E | A | -0.3672 | |
164 | L | A | 0.0000 | |
165 | V | A | 0.0000 | |
166 | L | A | -0.5506 | |
167 | A | A | 0.0000 | |
168 | D | A | -2.4456 | |
169 | G | A | 0.0000 | |
170 | S | A | -0.8114 | |
171 | L | A | 0.0608 | |
172 | V | A | -0.2142 | |
173 | R | A | -1.2401 | |
174 | C | A | 0.0000 | |
175 | S | A | -1.1346 | |
176 | P | A | -0.8525 | |
177 | T | A | -1.1421 | |
178 | E | A | -2.2014 | |
179 | N | A | -2.0655 | |
180 | S | A | -1.7476 | |
181 | D | A | -1.8257 | |
182 | L | A | 0.0000 | |
183 | F | A | 0.0000 | |
184 | Y | A | -0.4699 | |
185 | A | A | 0.0000 | |
186 | V | A | 0.0000 | |
187 | P | A | -0.0340 | |
188 | W | A | 0.0000 | |
189 | S | A | 0.0000 | |
190 | C | A | 0.0000 | |
191 | G | A | -0.1108 | |
192 | T | A | 0.0000 | |
193 | L | A | 0.0000 | |
194 | G | A | 0.0000 | |
195 | F | A | 0.0000 | |
196 | L | A | 0.0000 | |
197 | V | A | 0.0000 | |
198 | A | A | 0.0000 | |
199 | A | A | 0.0000 | |
200 | E | A | 0.0000 | |
201 | I | A | 0.0000 | |
202 | K | A | -1.0141 | |
203 | M | A | 0.0000 | |
204 | I | A | -0.1665 | |
205 | P | A | -0.3320 | |
206 | A | A | -1.0984 | |
207 | K | A | -2.3918 | |
208 | K | A | -3.2332 | |
209 | Y | A | 0.0000 | |
210 | I | A | 0.0000 | |
211 | R | A | -1.2860 | |
212 | L | A | 0.0000 | |
213 | H | A | -0.4447 | |
214 | Y | A | 0.0000 | |
215 | E | A | -1.1011 | |
216 | P | A | -1.9382 | |
217 | V | A | -2.0664 | |
218 | R | A | -2.7846 | |
219 | G | A | -2.2227 | |
220 | L | A | -2.3388 | |
221 | R | A | -3.1112 | |
222 | S | A | -2.4737 | |
223 | I | A | 0.0000 | |
224 | C | A | 0.0000 | |
225 | E | A | -3.3379 | |
226 | K | A | -2.4879 | |
227 | F | A | 0.0000 | |
228 | T | A | -2.4918 | |
229 | E | A | -3.2660 | |
230 | E | A | -2.7260 | |
231 | S | A | 0.0000 | |
232 | K | A | -3.2339 | |
233 | N | A | -3.1998 | |
234 | K | A | -3.2230 | |
235 | E | A | -2.9145 | |
236 | N | A | 0.0000 | |
237 | S | A | -0.5679 | |
238 | F | A | 0.0000 | |
239 | V | A | 0.0000 | |
240 | E | A | 0.0000 | |
241 | G | A | 0.0000 | |
242 | L | A | 0.0000 | |
243 | V | A | 0.0000 | |
244 | Y | A | -0.1666 | |
245 | S | A | -0.6191 | |
246 | L | A | -0.7707 | |
247 | E | A | -1.9893 | |
248 | E | A | -1.9595 | |
249 | A | A | 0.0000 | |
250 | V | A | 0.0000 | |
251 | I | A | 0.0000 | |
252 | M | A | 0.0000 | |
253 | T | A | -0.4793 | |
254 | G | A | 0.0000 | |
255 | V | A | -0.0277 | |
256 | L | A | -0.6818 | |
257 | T | A | -1.9720 | |
258 | D | A | -3.5387 | |
259 | E | A | -3.3707 | |
260 | A | A | -2.3015 | |
261 | E | A | -1.8141 | |
262 | P | A | -1.1798 | |
263 | S | A | -0.8772 | |
264 | K | A | -1.2129 | |
265 | I | A | -0.7482 | |
266 | N | A | 0.0000 | |
267 | R | A | -1.8464 | |
268 | I | A | 0.0000 | |
269 | G | A | -0.9378 | |
270 | N | A | -0.4227 | |
271 | Y | A | 1.2252 | |
272 | Y | A | 1.5919 | |
273 | K | A | -0.1596 | |
274 | P | A | -0.4558 | |
275 | W | A | 0.0000 | |
276 | F | A | 0.0000 | |
277 | F | A | 0.0000 | |
278 | K | A | -1.1194 | |
279 | H | A | 0.0000 | |
280 | V | A | 0.0000 | |
281 | E | A | -1.9551 | |
282 | K | A | -2.8315 | |
283 | Y | A | -2.3337 | |
284 | L | A | 0.0000 | |
285 | K | A | -3.0514 | |
286 | A | A | -2.3949 | |
287 | N | A | -3.1637 | |
288 | K | A | -2.8815 | |
289 | T | A | -1.3049 | |
290 | G | A | -0.7049 | |
291 | I | A | -0.0938 | |
292 | E | A | -0.7421 | |
293 | Y | A | -1.3292 | |
294 | I | A | 0.0000 | |
295 | P | A | -1.5835 | |
296 | S | A | 0.0000 | |
297 | R | A | -1.5029 | |
298 | H | A | -1.1319 | |
299 | Y | A | 0.0000 | |
300 | Y | A | 0.0000 | |
301 | H | A | 0.0000 | |
302 | R | A | 0.0000 | |
303 | H | A | 0.0000 | |
304 | T | A | 0.0000 | |
305 | R | A | -0.0452 | |
306 | S | A | 0.0000 | |
307 | I | A | 0.0112 | |
308 | F | A | 0.0000 | |
309 | W | A | 0.0000 | |
310 | E | A | -0.8785 | |
311 | L | A | 0.0000 | |
312 | Q | A | -1.2448 | |
313 | D | A | -2.0925 | |
314 | I | A | -0.8177 | |
315 | I | A | 0.0000 | |
316 | P | A | -0.7276 | |
317 | F | A | 0.1183 | |
318 | G | A | 0.0000 | |
319 | N | A | -0.3196 | |
320 | N | A | -0.1821 | |
321 | P | A | 0.8217 | |
322 | V | A | 2.3016 | |
323 | F | A | 0.0000 | |
324 | R | A | 1.8430 | |
325 | Y | A | 2.8547 | |
326 | L | A | 2.7813 | |
327 | F | A | 2.5741 | |
328 | G | A | 0.0000 | |
329 | W | A | 2.1985 | |
330 | M | A | 1.1500 | |
331 | V | A | 0.0000 | |
332 | P | A | 0.2006 | |
333 | P | A | 0.0000 | |
334 | K | A | 0.0922 | |
335 | I | A | 0.5766 | |
336 | S | A | 0.0000 | |
337 | L | A | 0.0000 | |
338 | L | A | 0.0000 | |
339 | K | A | 0.0000 | |
340 | L | A | 1.3084 | |
341 | T | A | 0.2875 | |
342 | Q | A | -0.5623 | |
343 | G | A | -1.3487 | |
344 | E | A | -2.2558 | |
345 | A | A | -1.1609 | |
346 | I | A | -0.9035 | |
347 | R | A | -1.5450 | |
348 | K | A | -1.9371 | |
349 | L | A | -0.4553 | |
350 | Y | A | -0.7431 | |
351 | E | A | -1.2132 | |
352 | Q | A | -2.0139 | |
353 | H | A | -1.7570 | |
354 | H | A | 0.0000 | |
355 | V | A | 0.0000 | |
356 | V | A | 0.3312 | |
357 | Q | A | 0.0000 | |
358 | D | A | 0.0099 | |
359 | M | A | 0.0000 | |
360 | L | A | 0.0000 | |
361 | V | A | 0.0000 | |
362 | P | A | 0.0000 | |
363 | M | A | 0.0000 | |
364 | K | A | -2.2288 | |
365 | S | A | 0.0000 | |
366 | L | A | 0.0000 | |
367 | E | A | -2.5217 | |
368 | K | A | -2.4359 | |
369 | S | A | 0.0000 | |
370 | I | A | 0.0000 | |
371 | Q | A | -1.0328 | |
372 | T | A | -0.5826 | |
373 | F | A | 0.0000 | |
374 | H | A | -0.2275 | |
375 | V | A | 0.4865 | |
376 | D | A | 0.0000 | |
377 | L | A | 0.0000 | |
378 | N | A | -1.0428 | |
379 | V | A | 0.0000 | |
380 | Y | A | -0.1416 | |
381 | P | A | 0.0000 | |
382 | L | A | 0.0000 | |
383 | W | A | 0.0000 | |
384 | L | A | 0.0000 | |
385 | C | A | 0.0000 | |
386 | P | A | 0.0000 | |
387 | F | A | 0.0000 | |
388 | L | A | 0.2571 | |
389 | L | A | 0.0000 | |
390 | P | A | -1.1839 | |
391 | N | A | -2.3333 | |
392 | N | A | -1.3051 | |
393 | P | A | -0.8799 | |
394 | G | A | -0.6470 | |
395 | M | A | 0.0000 | |
396 | V | A | 0.0000 | |
397 | H | A | -1.7369 | |
398 | P | A | 0.0000 | |
399 | K | A | -2.8214 | |
400 | G | A | -2.9492 | |
401 | D | A | -3.6008 | |
402 | E | A | -3.5087 | |
403 | T | A | -2.0776 | |
404 | E | A | -1.8271 | |
405 | L | A | -0.6882 | |
406 | Y | A | 0.0000 | |
407 | V | A | 0.0000 | |
408 | D | A | 0.0000 | |
409 | I | A | 0.0000 | |
410 | G | A | 0.0000 | |
411 | A | A | 0.0000 | |
412 | Y | A | -0.0021 | |
413 | G | A | -1.0958 | |
414 | E | A | -2.0366 | |
415 | P | A | -2.2852 | |
416 | K | A | -2.6476 | |
417 | T | A | -2.1619 | |
418 | K | A | -2.7519 | |
419 | Q | A | -2.3328 | |
420 | F | A | -2.1396 | |
421 | E | A | -2.6430 | |
422 | A | A | -2.1491 | |
423 | R | A | -2.6188 | |
424 | A | A | -1.7983 | |
425 | S | A | 0.0000 | |
426 | M | A | 0.0000 | |
427 | R | A | -1.9494 | |
428 | Q | A | -2.0608 | |
429 | M | A | 0.0000 | |
430 | E | A | 0.0000 | |
431 | K | A | -2.2792 | |
432 | F | A | -1.2732 | |
433 | V | A | 0.0000 | |
434 | R | A | -1.4079 | |
435 | S | A | -0.7131 | |
436 | V | A | -0.7988 | |
437 | H | A | -0.8787 | |
438 | G | A | 0.0000 | |
439 | F | A | 0.0000 | |
440 | Q | A | 0.0000 | |
441 | M | A | 0.2161 | |
442 | L | A | 0.0000 | |
443 | Y | A | 0.7011 | |
444 | A | A | 0.0000 | |
445 | D | A | -0.2996 | |
446 | C | A | 0.0000 | |
447 | Y | A | -0.8994 | |
448 | M | A | 0.0000 | |
449 | T | A | -1.8173 | |
450 | R | A | -3.2477 | |
451 | E | A | -3.2699 | |
452 | E | A | -2.6777 | |
453 | F | A | 0.0000 | |
454 | W | A | -2.0644 | |
455 | D | A | -2.8204 | |
456 | M | A | 0.0000 | |
457 | F | A | 0.0000 | |
458 | D | A | -1.2207 | |
459 | G | A | -0.7712 | |
460 | S | A | -0.5004 | |
461 | L | A | -0.4515 | |
462 | Y | A | 0.0000 | |
463 | H | A | -1.3644 | |
464 | S | A | -1.4831 | |
465 | L | A | 0.0000 | |
466 | R | A | 0.0000 | |
467 | E | A | -3.4634 | |
468 | Q | A | -2.6447 | |
469 | M | A | -2.2963 | |
470 | N | A | -3.3298 | |
471 | C | A | 0.0000 | |
472 | K | A | -3.3372 | |
473 | D | A | -3.5515 | |
474 | A | A | 0.0000 | |
475 | F | A | 0.0000 | |
476 | P | A | 0.0000 | |
477 | E | A | -1.0736 | |
478 | V | A | 0.0000 | |
479 | Y | A | -1.4185 | |
480 | D | A | -2.0684 | |
481 | K | A | 0.0000 | |
482 | I | A | 0.0000 | |
483 | C | A | 0.0000 | |
484 | K | A | -0.8300 | |
485 | A | A | -0.6073 | |
486 | A | A | -0.8018 | |
487 | R | A | 0.0000 | |
488 | H | A | -0.7836 |
Automated mutations analysis
In the automated mutations mode, the server selects aggregation prone resides
and each selected residue is mutated to glutamic acid, lysine, aspartic acid and arginine.
The table below shows 2 best scored mutants for each mutated residue. Protein variants
are ordered according to the mutation effect they had on protein stability
(energetic effect) together with the difference in the average per-residue aggregation score
between the wild type and the mutant (in the table green values indicate a positive change,
grey are neutral, and orange/red mean destabilizing or more aggregation prone mutants).
Summary for all the mutants can be found in this
CSV file.
Mutant |
Energetic effect |
Score comparison |
|||
YR325A | -1.3755 | -0.0305 | View | CSV | PDB |
YR21A | -0.9273 | -0.0272 | View | CSV | PDB |
YK325A | -0.1446 | -0.0281 | View | CSV | PDB |
FR327A | 0.0314 | -0.0171 | View | CSV | PDB |
FR9A | 0.0524 | -0.025 | View | CSV | PDB |
FR10A | 0.1045 | -0.0213 | View | CSV | PDB |
FK9A | 0.1535 | -0.021 | View | CSV | PDB |
YK21A | 0.3016 | -0.0334 | View | CSV | PDB |
FK10A | 0.2055 | -0.0209 | View | CSV | PDB |
LE326A | 0.5293 | -0.0268 | View | CSV | PDB |
FK327A | 0.3866 | -0.0125 | View | CSV | PDB |
LK326A | 0.7279 | -0.0207 | View | CSV | PDB |