Project name: c3e81b9dfb56486

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFFITNNYWGWVRQAPGKGLEWVGYISYSGSTSYNPSLKSRFTISRDTSKNTFYLQMNSLRAEDTAVYYCARTGSSGYFDFWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASESVDDLLHWYQQKPGKAPKLLIKYASQSISGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGNSLPNTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:27)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:28)

• Minimal score value: -2.7453
• Maximal score value: 1.5885
• Average score: -0.5627
• Total score value: -126.0559

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9414
2	V	H	-0.8075
3	Q	H	-0.9911
4	L	H	0.0000
5	V	H	0.6703
6	E	H	0.0000
7	S	H	-0.2662
8	G	H	-0.5737
9	G	H	0.1138
11	G	H	0.8088
12	L	H	1.3646
13	V	H	-0.0516
14	Q	H	-1.3552
15	P	H	-1.4827
16	G	H	-1.4706
17	G	H	-1.1849
18	S	H	-1.0029
19	L	H	-0.7650
20	R	H	-1.5909
21	L	H	0.0000
22	S	H	-0.3409
23	C	H	0.0000
24	A	H	-0.1297
25	A	H	-0.0222
26	S	H	-0.3823
27	G	H	-0.6821
28	F	H	0.3452
29	F	H	1.4107
30	I	H	0.0000
35	T	H	0.3120
36	N	H	-0.2387
37	N	H	0.1647
38	Y	H	0.3534
39	W	H	0.0000
40	G	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	-0.3872
44	Q	H	-0.7196
45	A	H	-1.1175
46	P	H	-1.0608
47	G	H	-1.4512
48	K	H	-2.3719
49	G	H	-1.6355
50	L	H	0.0000
51	E	H	-0.9517
52	W	H	0.0000
53	V	H	0.0000
54	G	H	0.0000
55	Y	H	0.3306
56	I	H	0.0000
57	S	H	0.0000
58	Y	H	0.9728
59	S	H	0.0815
63	G	H	-0.0099
64	S	H	-0.0795
65	T	H	0.0408
66	S	H	-0.1248
67	Y	H	-0.3987
68	N	H	-0.8375
69	P	H	-1.1407
70	S	H	-0.9000
71	L	H	0.0000
72	K	H	-1.9883
74	S	H	-1.2741
75	R	H	-1.1248
76	F	H	0.0000
77	T	H	-0.7192
78	I	H	0.0000
79	S	H	-0.4132
80	R	H	-0.9056
81	D	H	-1.2486
82	T	H	-0.7918
83	S	H	-1.1050
84	K	H	-1.9164
85	N	H	-0.8681
86	T	H	-0.5742
87	F	H	0.0000
88	Y	H	-0.4835
89	L	H	0.0000
90	Q	H	-1.0229
91	M	H	0.0000
92	N	H	-1.2394
93	S	H	-1.2393
94	L	H	0.0000
95	R	H	-2.3216
96	A	H	-1.7068
97	E	H	-2.2345
98	D	H	0.0000
99	T	H	-0.4150
100	A	H	0.0000
101	V	H	0.5222
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.0669
107	T	H	0.0000
108	G	H	-0.1527
109	S	H	-0.1428
110	S	H	-0.3596
113	G	H	-0.1240
114	Y	H	0.0116
115	F	H	0.0000
116	D	H	-0.1552
117	F	H	0.3447
118	W	H	-0.1660
119	G	H	0.0000
120	Q	H	-1.3257
121	G	H	-0.3985
122	T	H	0.4529
123	L	H	1.5885
124	V	H	0.0000
125	T	H	0.3206
126	V	H	0.0000
127	S	H	-0.5538
128	S	H	-0.5484
1	D	L	-2.1420
2	I	L	0.0000
3	Q	L	-2.3371
4	M	L	0.0000
5	T	L	-1.4478
6	Q	L	0.0000
7	S	L	-0.7475
8	P	L	-0.5402
9	S	L	-0.8907
10	S	L	-0.9908
11	L	L	-0.7405
12	S	L	-0.9555
13	A	L	-0.9604
14	S	L	-0.8793
15	V	L	-0.1459
16	G	L	-0.7843
17	D	L	-1.8973
18	R	L	-2.4164
19	V	L	0.0000
20	T	L	-0.6502
21	I	L	0.0000
22	T	L	-0.8009
23	C	L	0.0000
24	R	L	-2.7453
25	A	L	0.0000
26	S	L	-2.0409
27	E	L	-2.4106
28	S	L	-1.9138
29	V	L	0.0000
36	D	L	-2.4489
37	D	L	-2.1680
38	L	L	-1.0284
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.8602
44	Q	L	0.0000
45	K	L	-1.7043
46	P	L	-1.1661
47	G	L	-1.6770
48	K	L	-2.6186
49	A	L	-1.5513
50	P	L	0.0000
51	K	L	-1.3412
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	K	L	-0.5860
56	Y	L	-0.7709
57	A	L	0.0000
65	S	L	-0.9168
66	Q	L	-1.1675
67	S	L	-0.6583
68	I	L	-0.4049
69	S	L	-0.3938
70	G	L	-0.4659
71	V	L	-0.3237
72	P	L	-0.3581
74	S	L	-0.4957
75	R	L	-0.7911
76	F	L	0.0000
77	S	L	-0.5740
78	G	L	0.0000
79	S	L	-0.8101
80	G	L	-1.3433
83	S	L	-1.7192
84	G	L	-1.9391
85	T	L	-2.0917
86	D	L	-2.2919
87	F	L	0.0000
88	T	L	-0.6845
89	L	L	0.0000
90	T	L	0.0000
91	I	L	0.0000
92	S	L	-1.4279
93	S	L	-1.2705
94	L	L	0.0000
95	Q	L	-0.9114
96	P	L	-0.9745
97	E	L	-1.6008
98	D	L	0.0000
99	F	L	-0.3896
100	A	L	0.0000
101	T	L	-0.9328
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	G	L	-0.4668
108	N	L	-0.9478
109	S	L	-0.2544
114	L	L	0.3182
115	P	L	0.0000
116	N	L	0.0000
117	T	L	-0.7521
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.8108
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.6599
124	V	L	0.0000
125	E	L	-1.0988
126	I	L	-0.6839
127	K	L	-1.5619