| Chain sequence(s) |
A: TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:06)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:06)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:06)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:06)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:06)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:52)
[INFO] Main: Simulation completed successfully. (00:05:55)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | T | A | 0.1154 | |
| 2 | C | A | 0.3943 | |
| 3 | P | A | 0.0355 | |
| 4 | P | A | -0.0120 | |
| 5 | C | A | 0.2950 | |
| 6 | P | A | -0.3973 | |
| 7 | A | A | -0.3973 | |
| 8 | P | A | -0.7701 | |
| 9 | E | A | -0.9825 | |
| 10 | L | A | 1.2101 | |
| 11 | L | A | 1.5854 | |
| 12 | G | A | 0.1105 | |
| 13 | G | A | -0.3225 | |
| 14 | P | A | 0.0000 | |
| 15 | S | A | -0.0804 | |
| 16 | V | A | 0.0000 | |
| 17 | F | A | 1.1754 | |
| 18 | L | A | 0.8949 | |
| 19 | F | A | 1.0943 | |
| 20 | P | A | -0.2497 | |
| 21 | P | A | 0.0000 | |
| 22 | K | A | -2.0783 | |
| 23 | P | A | -1.3863 | |
| 24 | K | A | -1.1590 | |
| 25 | D | A | 0.0000 | |
| 26 | T | A | 0.0000 | |
| 27 | L | A | 0.0000 | |
| 28 | M | A | 0.3850 | |
| 29 | I | A | 1.5128 | |
| 30 | S | A | 0.2182 | |
| 31 | R | A | -0.8873 | |
| 32 | T | A | -0.6145 | |
| 33 | P | A | 0.0000 | |
| 34 | E | A | -1.0623 | |
| 35 | V | A | 0.0000 | |
| 36 | T | A | 0.1736 | |
| 37 | C | A | 0.0000 | |
| 38 | V | A | 0.0000 | |
| 39 | V | A | 0.0000 | |
| 40 | V | A | -0.7007 | |
| 41 | D | A | -1.5571 | |
| 42 | V | A | 0.0000 | |
| 43 | S | A | -2.1199 | |
| 44 | H | A | -2.6365 | |
| 45 | E | A | -2.9751 | |
| 46 | D | A | -2.6272 | |
| 47 | P | A | -2.7805 | |
| 48 | E | A | -3.1600 | |
| 49 | V | A | -1.9895 | |
| 50 | K | A | -2.2572 | |
| 51 | F | A | -1.1771 | |
| 52 | N | A | -1.2246 | |
| 53 | W | A | 0.0000 | |
| 54 | Y | A | -0.7185 | |
| 55 | V | A | -0.8728 | |
| 56 | D | A | -1.9876 | |
| 57 | G | A | -0.8557 | |
| 58 | V | A | 0.5088 | |
| 59 | E | A | -0.8469 | |
| 60 | V | A | -0.8326 | |
| 61 | H | A | -1.9529 | |
| 62 | N | A | -2.2139 | |
| 63 | A | A | -1.9052 | |
| 64 | K | A | -2.4179 | |
| 65 | T | A | -1.9484 | |
| 66 | K | A | -2.2966 | |
| 67 | P | A | -2.4613 | |
| 68 | R | A | -3.7822 | |
| 69 | E | A | -3.6094 | |
| 70 | E | A | -3.4140 | |
| 71 | Q | A | -1.8197 | |
| 72 | Y | A | 0.0728 | |
| 73 | N | A | -0.9196 | |
| 74 | S | A | -1.1807 | |
| 75 | T | A | -2.0259 | |
| 76 | Y | A | 0.0000 | |
| 77 | R | A | -2.6377 | |
| 78 | V | A | 0.0000 | |
| 79 | V | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | V | A | 0.0000 | |
| 82 | L | A | 0.0000 | |
| 83 | T | A | -0.7892 | |
| 84 | V | A | 0.0000 | |
| 85 | L | A | 0.8002 | |
| 86 | H | A | -0.1549 | |
| 87 | Q | A | -1.2234 | |
| 88 | D | A | -1.5329 | |
| 89 | W | A | 0.0000 | |
| 90 | L | A | -1.0614 | |
| 91 | N | A | -2.3176 | |
| 92 | G | A | -2.2428 | |
| 93 | K | A | -2.4692 | |
| 94 | E | A | -2.3890 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -1.6211 | |
| 97 | C | A | 0.0000 | |
| 98 | K | A | -1.5852 | |
| 99 | V | A | 0.0000 | |
| 100 | S | A | -1.5028 | |
| 101 | N | A | 0.0000 | |
| 102 | K | A | -2.5969 | |
| 103 | A | A | -1.6131 | |
| 104 | L | A | -0.8396 | |
| 105 | P | A | -0.4058 | |
| 106 | A | A | -0.2687 | |
| 107 | P | A | -0.9806 | |
| 108 | I | A | -0.6474 | |
| 109 | E | A | -1.9862 | |
| 110 | K | A | -1.2048 | |
| 111 | T | A | -0.8645 | |
| 112 | I | A | -0.3467 | |
| 113 | S | A | -1.3363 | |
| 114 | K | A | -1.4843 | |
| 115 | A | A | -1.2668 | |
| 116 | K | A | -2.3883 | |
| 117 | G | A | -2.0154 | |
| 118 | Q | A | -2.1982 | |
| 119 | P | A | -1.8780 | |
| 120 | R | A | -2.2770 | |
| 121 | E | A | -2.7537 | |
| 122 | P | A | 0.0000 | |
| 123 | Q | A | -1.4075 | |
| 124 | V | A | 0.0000 | |
| 125 | Y | A | 0.0000 | |
| 126 | T | A | 0.0000 | |
| 127 | L | A | 0.0000 | |
| 128 | P | A | -0.3412 | |
| 129 | P | A | -0.9209 | |
| 130 | S | A | 0.0000 | |
| 131 | R | A | -2.7924 | |
| 132 | D | A | -2.8022 | |
| 133 | E | A | 0.0000 | |
| 134 | L | A | -1.9617 | |
| 135 | T | A | -1.7278 | |
| 136 | K | A | -2.5974 | |
| 137 | N | A | -2.7020 | |
| 138 | Q | A | -2.6810 | |
| 139 | V | A | 0.0000 | |
| 140 | S | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | T | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.6061 | |
| 147 | G | A | -1.0866 | |
| 148 | F | A | 0.0000 | |
| 149 | Y | A | -1.1178 | |
| 150 | P | A | 0.0000 | |
| 151 | S | A | -0.0652 | |
| 152 | D | A | -1.1447 | |
| 153 | I | A | -0.6149 | |
| 154 | A | A | 0.0000 | |
| 155 | V | A | 0.0000 | |
| 156 | E | A | -1.4233 | |
| 157 | W | A | 0.0000 | |
| 158 | E | A | -2.0283 | |
| 159 | S | A | 0.0000 | |
| 160 | N | A | -1.9259 | |
| 161 | G | A | -1.8313 | |
| 162 | Q | A | -2.3235 | |
| 163 | P | A | -2.0128 | |
| 164 | E | A | -1.9113 | |
| 165 | N | A | -2.0738 | |
| 166 | N | A | -1.3760 | |
| 167 | Y | A | -0.9896 | |
| 168 | K | A | -0.7199 | |
| 169 | T | A | -0.2504 | |
| 170 | T | A | 0.0000 | |
| 171 | P | A | -0.1020 | |
| 172 | P | A | 0.2103 | |
| 173 | V | A | 0.5918 | |
| 174 | L | A | 0.9907 | |
| 175 | D | A | -0.4196 | |
| 176 | S | A | -1.1248 | |
| 177 | D | A | -1.8600 | |
| 178 | G | A | -0.8185 | |
| 179 | S | A | 0.0000 | |
| 180 | F | A | 0.2028 | |
| 181 | F | A | 0.0000 | |
| 182 | L | A | 0.0000 | |
| 183 | Y | A | 0.0000 | |
| 184 | S | A | 0.0000 | |
| 185 | K | A | 0.0000 | |
| 186 | L | A | 0.0000 | |
| 187 | T | A | -0.9624 | |
| 188 | V | A | 0.0000 | |
| 189 | D | A | -2.6397 | |
| 190 | K | A | -2.6550 | |
| 191 | S | A | -2.2375 | |
| 192 | R | A | -2.1643 | |
| 193 | W | A | 0.0000 | |
| 194 | Q | A | -2.1976 | |
| 195 | Q | A | -2.1054 | |
| 196 | G | A | -1.2599 | |
| 197 | N | A | -1.0117 | |
| 198 | V | A | -0.1659 | |
| 199 | F | A | 0.0000 | |
| 200 | S | A | -1.1428 | |
| 201 | C | A | 0.0000 | |
| 202 | S | A | 0.0000 | |
| 203 | V | A | 0.0000 | |
| 204 | M | A | -0.5755 | |
| 205 | H | A | 0.0000 | |
| 206 | E | A | -1.1070 | |
| 207 | A | A | -1.5063 | |
| 208 | L | A | -1.4893 | |
| 209 | H | A | -1.7703 | |
| 210 | N | A | -1.6923 | |
| 211 | H | A | -1.2048 | |
| 212 | Y | A | -0.6375 | |
| 213 | T | A | -0.9436 | |
| 214 | Q | A | -1.5096 | |
| 215 | K | A | -1.1187 | |
| 216 | S | A | -0.5215 | |
| 217 | L | A | 0.1141 | |
| 218 | S | A | -0.0843 | |
| 219 | L | A | -0.2597 | |
| 220 | S | A | -0.6571 | |
| 221 | P | A | -0.9831 | |
| 222 | G | A | -1.4434 | |
| 223 | K | A | -2.2523 | |
| 424 | T | A | 0.1058 | |
| 425 | C | A | 0.3680 | |
| 426 | P | A | 0.0219 | |
| 427 | P | A | -0.0207 | |
| 428 | C | A | 0.2909 | |
| 429 | P | A | -0.3833 | |
| 430 | A | A | -0.3709 | |
| 431 | P | A | -0.8062 | |
| 432 | E | A | -1.0012 | |
| 433 | L | A | 1.2041 | |
| 434 | L | A | 1.5797 | |
| 435 | G | A | 0.1023 | |
| 436 | G | A | -0.5881 | |
| 437 | P | A | 0.0000 | |
| 438 | S | A | -0.1564 | |
| 439 | V | A | 0.0000 | |
| 440 | F | A | 0.9886 | |
| 441 | L | A | 0.7875 | |
| 442 | F | A | 1.1064 | |
| 443 | P | A | -0.1358 | |
| 444 | P | A | 0.0000 | |
| 445 | K | A | -1.9155 | |
| 446 | P | A | -1.2668 | |
| 447 | K | A | -1.1523 | |
| 448 | D | A | 0.0000 | |
| 449 | T | A | 0.0000 | |
| 450 | L | A | 0.0000 | |
| 451 | M | A | 0.4795 | |
| 452 | I | A | 1.5548 | |
| 453 | S | A | 0.1686 | |
| 454 | R | A | -0.8522 | |
| 455 | T | A | -0.5844 | |
| 456 | P | A | 0.0000 | |
| 457 | E | A | -1.0017 | |
| 458 | V | A | 0.0000 | |
| 459 | T | A | 0.1710 | |
| 460 | C | A | 0.0000 | |
| 461 | V | A | 0.0000 | |
| 462 | V | A | 0.0000 | |
| 463 | V | A | -0.9115 | |
| 464 | D | A | -1.6345 | |
| 465 | V | A | 0.0000 | |
| 466 | S | A | -2.1543 | |
| 467 | H | A | -2.6211 | |
| 468 | E | A | -2.9636 | |
| 469 | D | A | -2.6145 | |
| 470 | P | A | -2.7682 | |
| 471 | E | A | -3.0992 | |
| 472 | V | A | -2.0718 | |
| 473 | K | A | -2.3168 | |
| 474 | F | A | -1.5080 | |
| 475 | N | A | -1.5094 | |
| 476 | W | A | 0.0000 | |
| 477 | Y | A | -0.7814 | |
| 478 | V | A | -0.8941 | |
| 479 | D | A | -2.1098 | |
| 480 | G | A | -0.9326 | |
| 481 | V | A | 0.4821 | |
| 482 | E | A | -0.8342 | |
| 483 | V | A | -0.7354 | |
| 484 | H | A | -1.7543 | |
| 485 | N | A | -1.7535 | |
| 486 | A | A | -1.7842 | |
| 487 | K | A | -2.4640 | |
| 488 | T | A | -2.1869 | |
| 489 | K | A | -2.9420 | |
| 490 | P | A | -2.7836 | |
| 491 | R | A | -3.9870 | |
| 492 | E | A | -4.0823 | |
| 493 | E | A | -3.5439 | |
| 494 | Q | A | -1.7612 | |
| 495 | Y | A | 0.1957 | |
| 496 | N | A | -0.6755 | |
| 497 | S | A | -1.2528 | |
| 498 | T | A | -2.0308 | |
| 499 | Y | A | 0.0000 | |
| 500 | R | A | -3.0233 | |
| 501 | V | A | 0.0000 | |
| 502 | V | A | 0.0000 | |
| 503 | S | A | 0.0000 | |
| 504 | V | A | 0.0000 | |
| 505 | L | A | 0.0000 | |
| 506 | T | A | -0.5022 | |
| 507 | V | A | 0.0000 | |
| 508 | L | A | 0.9581 | |
| 509 | H | A | 0.0245 | |
| 510 | Q | A | -1.0215 | |
| 511 | D | A | -1.0906 | |
| 512 | W | A | 0.0000 | |
| 513 | L | A | -0.9755 | |
| 514 | N | A | -2.2032 | |
| 515 | G | A | -2.0683 | |
| 516 | K | A | -2.1367 | |
| 517 | E | A | -2.1249 | |
| 518 | Y | A | 0.0000 | |
| 519 | K | A | -1.7403 | |
| 520 | C | A | 0.0000 | |
| 521 | K | A | -1.7941 | |
| 522 | V | A | 0.0000 | |
| 523 | S | A | -1.5624 | |
| 524 | N | A | 0.0000 | |
| 525 | K | A | -2.5923 | |
| 526 | A | A | -1.6519 | |
| 527 | L | A | -0.6592 | |
| 528 | P | A | -0.0927 | |
| 529 | A | A | -0.2893 | |
| 530 | P | A | -0.9875 | |
| 531 | I | A | -0.7478 | |
| 532 | E | A | -2.2331 | |
| 533 | K | A | -1.3909 | |
| 534 | T | A | -1.0855 | |
| 535 | I | A | -0.2300 | |
| 536 | S | A | -1.1823 | |
| 537 | K | A | -1.3739 | |
| 538 | A | A | -1.2261 | |
| 539 | K | A | -2.3753 | |
| 540 | G | A | -2.0354 | |
| 541 | Q | A | -2.2396 | |
| 542 | P | A | -1.9564 | |
| 543 | R | A | -2.3668 | |
| 544 | E | A | -2.7592 | |
| 545 | P | A | 0.0000 | |
| 546 | Q | A | -1.2692 | |
| 547 | V | A | 0.0000 | |
| 548 | Y | A | 0.0000 | |
| 549 | T | A | -0.8293 | |
| 550 | L | A | 0.0000 | |
| 551 | P | A | -0.3797 | |
| 552 | P | A | -0.8961 | |
| 553 | S | A | 0.0000 | |
| 554 | R | A | -2.6576 | |
| 555 | D | A | -2.7533 | |
| 556 | E | A | 0.0000 | |
| 557 | L | A | -1.9478 | |
| 558 | T | A | -1.7198 | |
| 559 | K | A | -2.3867 | |
| 560 | N | A | -2.6374 | |
| 561 | Q | A | -2.4370 | |
| 562 | V | A | 0.0000 | |
| 563 | S | A | 0.0000 | |
| 564 | L | A | 0.0000 | |
| 565 | T | A | 0.0000 | |
| 566 | C | A | 0.0000 | |
| 567 | L | A | 0.0000 | |
| 568 | V | A | 0.0000 | |
| 569 | K | A | -0.5253 | |
| 570 | G | A | -1.0318 | |
| 571 | F | A | 0.0000 | |
| 572 | Y | A | -1.1017 | |
| 573 | P | A | 0.0000 | |
| 574 | S | A | -0.0909 | |
| 575 | D | A | -0.9825 | |
| 576 | I | A | -0.5143 | |
| 577 | A | A | 0.0000 | |
| 578 | V | A | 0.0000 | |
| 579 | E | A | -1.8604 | |
| 580 | W | A | 0.0000 | |
| 581 | E | A | -1.9327 | |
| 582 | S | A | 0.0000 | |
| 583 | N | A | -1.8130 | |
| 584 | G | A | -1.7686 | |
| 585 | Q | A | -2.3029 | |
| 586 | P | A | -2.0697 | |
| 587 | E | A | -2.0013 | |
| 588 | N | A | -2.2414 | |
| 589 | N | A | -1.5376 | |
| 590 | Y | A | -1.3133 | |
| 591 | K | A | -1.2254 | |
| 592 | T | A | -0.6487 | |
| 593 | T | A | 0.0000 | |
| 594 | P | A | -0.1428 | |
| 595 | P | A | 0.2372 | |
| 596 | V | A | 0.6995 | |
| 597 | L | A | 1.0671 | |
| 598 | D | A | -0.3066 | |
| 599 | S | A | -1.0369 | |
| 600 | D | A | -1.8327 | |
| 601 | G | A | -0.7708 | |
| 602 | S | A | 0.0000 | |
| 603 | F | A | 0.2743 | |
| 604 | F | A | 0.0000 | |
| 605 | L | A | 0.0000 | |
| 606 | Y | A | 0.0000 | |
| 607 | S | A | 0.0000 | |
| 608 | K | A | 0.0000 | |
| 609 | L | A | 0.0000 | |
| 610 | T | A | -0.9613 | |
| 611 | V | A | 0.0000 | |
| 612 | D | A | -2.6033 | |
| 613 | K | A | -2.8061 | |
| 614 | S | A | -2.3366 | |
| 615 | R | A | -2.1224 | |
| 616 | W | A | 0.0000 | |
| 617 | Q | A | -2.4121 | |
| 618 | Q | A | -2.1332 | |
| 619 | G | A | -1.1567 | |
| 620 | N | A | -0.8749 | |
| 621 | V | A | 0.1375 | |
| 622 | F | A | 0.0000 | |
| 623 | S | A | 0.0000 | |
| 624 | C | A | 0.0000 | |
| 625 | S | A | 0.0000 | |
| 626 | V | A | 0.0000 | |
| 627 | M | A | 0.0000 | |
| 628 | H | A | 0.0000 | |
| 629 | E | A | -1.0499 | |
| 630 | A | A | -1.5106 | |
| 631 | L | A | -1.4234 | |
| 632 | H | A | -1.7035 | |
| 633 | N | A | -1.5738 | |
| 634 | H | A | -1.0264 | |
| 635 | Y | A | -0.0634 | |
| 636 | T | A | -0.4695 | |
| 637 | Q | A | -0.9297 | |
| 638 | K | A | -1.2932 | |
| 639 | S | A | -0.5561 | |
| 640 | L | A | 0.0000 | |
| 641 | S | A | -0.1094 | |
| 642 | L | A | -0.2883 | |
| 643 | S | A | -0.6794 | |
| 644 | P | A | -1.0397 | |
| 645 | G | A | -1.4238 | |
| 646 | K | A | -2.2487 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine