Project name: Tilvestamab

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGYSFTDFYINWVRQAPGKGLEWVARIFPGGDNTYYNEKFKGRFTLSADTSKSTAYLQMNSLRAEDTAVYYCARRGLYYAMDYWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRSSQSLVHSNGIPYLHWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCSQGTHVPPTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:44)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:45)

• Minimal score value: -3.429
• Maximal score value: 1.8925
• Average score: -0.596
• Total score value: -137.0915

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1051
2	V	H	-1.2450
3	Q	H	-1.2442
4	L	H	0.0000
5	V	H	0.4123
6	E	H	0.0000
7	S	H	-0.3423
8	G	H	-0.6320
9	G	H	0.1128
11	G	H	0.8250
12	L	H	1.3776
13	V	H	-0.0018
14	Q	H	-1.2370
15	P	H	-1.2448
16	G	H	-1.1707
17	G	H	-0.9794
18	S	H	-1.1050
19	L	H	-0.8994
20	R	H	-1.9348
21	L	H	0.0000
22	S	H	-0.4040
23	C	H	0.0000
24	A	H	-0.1911
25	A	H	-0.4064
26	S	H	-0.9542
27	G	H	-1.2566
28	Y	H	-0.7409
29	S	H	-0.7429
30	F	H	0.0000
35	T	H	-1.0541
36	D	H	-1.2639
37	F	H	-0.0358
38	Y	H	-0.0861
39	I	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5595
45	A	H	-0.9754
46	P	H	-0.7989
47	G	H	-1.4481
48	K	H	-2.3001
49	G	H	-1.4677
50	L	H	0.0000
51	E	H	-0.7571
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	R	H	-0.4066
56	I	H	0.0000
57	F	H	-0.9634
58	P	H	0.0000
59	G	H	-1.4780
62	G	H	-1.7064
63	D	H	-2.5741
64	N	H	-2.1371
65	T	H	-0.9454
66	Y	H	-0.2828
67	Y	H	-0.8268
68	N	H	-1.8296
69	E	H	-3.4290
70	K	H	-3.1646
71	F	H	0.0000
72	K	H	-3.0541
74	G	H	-1.9802
75	R	H	-1.6252
76	F	H	0.0000
77	T	H	-0.8519
78	L	H	0.0000
79	S	H	-0.6532
80	A	H	-0.7830
81	D	H	-1.1367
82	T	H	-0.9850
83	S	H	-1.1510
84	K	H	-1.9409
85	S	H	-1.0852
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.4793
89	L	H	0.0000
90	Q	H	-1.1930
91	M	H	0.0000
92	N	H	-1.2362
93	S	H	-1.0800
94	L	H	0.0000
95	R	H	-2.2553
96	A	H	-1.6689
97	E	H	-2.2181
98	D	H	0.0000
99	T	H	-0.3577
100	A	H	0.0000
101	V	H	0.7181
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	R	H	0.4785
108	G	H	0.0000
109	L	H	1.8925
110	Y	H	1.5901
113	Y	H	1.4556
114	A	H	0.0000
115	M	H	0.0000
116	D	H	0.0912
117	Y	H	-0.3193
118	W	H	-0.5700
119	G	H	0.0000
120	Q	H	-1.2123
121	G	H	-0.3448
122	T	H	0.4844
123	L	H	1.4773
124	V	H	0.0000
125	T	H	0.3459
126	V	H	0.0000
127	S	H	-0.4686
128	S	H	-0.4259
1	D	L	-2.2136
2	I	L	0.0000
3	Q	L	-2.2742
4	M	L	0.0000
5	T	L	-1.3922
6	Q	L	0.0000
7	S	L	-0.7166
8	P	L	-0.5536
9	S	L	-0.7493
10	S	L	-0.8079
11	L	L	-0.6381
12	S	L	-0.9006
13	A	L	-1.0160
14	S	L	-0.8107
15	V	L	0.0469
16	G	L	-0.8207
17	D	L	-1.8728
18	R	L	-2.3514
19	V	L	0.0000
20	T	L	-0.6458
21	I	L	0.0000
22	T	L	-0.7987
23	C	L	0.0000
24	R	L	-2.7260
25	S	L	0.0000
26	S	L	-1.9287
27	Q	L	-2.0393
28	S	L	-0.9738
29	L	L	0.0000
30	V	L	0.1696
31	H	L	-0.5839
32	S	L	-0.8518
34	N	L	-1.4208
35	G	L	-0.7663
36	I	L	-0.0322
37	P	L	-0.0249
38	Y	L	0.0000
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.6007
46	P	L	-1.1326
47	G	L	-1.6350
48	K	L	-2.6405
49	A	L	-1.6881
50	P	L	0.0000
51	K	L	-1.8616
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.0728
56	R	L	-0.2500
57	V	L	0.0000
65	S	L	-0.9415
66	N	L	-1.3207
67	R	L	-1.4512
68	F	L	-0.6859
69	S	L	-0.5617
70	G	L	-0.6071
71	V	L	-0.6887
72	P	L	-0.4940
74	S	L	-0.6496
75	R	L	-0.8046
76	F	L	0.0000
77	S	L	-0.6896
78	G	L	0.0000
79	S	L	-0.7161
80	G	L	-1.0100
83	S	L	-0.6788
84	G	L	-0.7397
85	T	L	-1.4711
86	D	L	-2.0225
87	F	L	0.0000
88	T	L	-0.7019
89	L	L	0.0000
90	T	L	-0.6048
91	I	L	0.0000
92	S	L	-1.5152
93	S	L	-1.3481
94	L	L	0.0000
95	Q	L	-0.9678
96	P	L	-1.0592
97	E	L	-1.5239
98	D	L	0.0000
99	F	L	-0.3064
100	A	L	0.0000
101	T	L	-0.6447
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	S	L	0.0000
106	Q	L	0.0000
107	G	L	0.2958
108	T	L	0.3306
109	H	L	-0.0608
114	V	L	1.2043
115	P	L	0.1227
116	P	L	0.0000
117	T	L	-0.5062
118	F	L	-0.3614
119	G	L	0.0000
120	Q	L	-1.5215
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.1717
124	V	L	0.0000
125	E	L	-1.2089
126	I	L	-0.7582
127	K	L	-1.5341