| Chain sequence(s) |
A: MASKCLKASFSSGSLKVPGGAGGGSARVSTIFSSSSCKLSGLSRGPRSFSACSVGLGKSSCRAASCLPALCLPSGGFATSYGMAGGWFGEGILTGNEKETMQFLNDRLASYLEKVRQLERENAELESRIRDWCEQQVPYLCPDYQSYFQTIEELQKKILCTKSENARLVVQIDNAKLAADDFRTKYETEVTMRQLVESDMNGLRRILDDLTLCKADLEAQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRVLNEMRCQYETLVENNRREAEDWFNTQTEELNQQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHSMRDALESTLAETEARYSSQLAQMQGLIGNVESQLAEIRCDLERQNQEYQVLLDVRARLECEISTYRGLLDSEDCKLPCNPCAPDHSPSKSCLPCLPAASCGPGTAHTTCSPRPICVSCPGSRF
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:10:32)
[INFO] Main: Simulation completed successfully. (00:10:37)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.8326 | |
| 2 | A | A | 0.1061 | |
| 3 | S | A | -0.3469 | |
| 4 | K | A | -1.0991 | |
| 5 | C | A | 0.1564 | |
| 6 | L | A | 0.5799 | |
| 7 | K | A | -0.7702 | |
| 8 | A | A | 0.1271 | |
| 9 | S | A | 0.4144 | |
| 10 | F | A | 1.4436 | |
| 11 | S | A | 0.4225 | |
| 12 | S | A | 0.0854 | |
| 13 | G | A | -0.3084 | |
| 14 | S | A | 0.0033 | |
| 15 | L | A | 0.9025 | |
| 16 | K | A | -0.3206 | |
| 17 | V | A | 1.0433 | |
| 18 | P | A | 0.0135 | |
| 19 | G | A | -0.5974 | |
| 20 | G | A | -0.6774 | |
| 21 | A | A | -0.6229 | |
| 22 | G | A | -0.8710 | |
| 23 | G | A | -0.9616 | |
| 24 | G | A | -1.0908 | |
| 25 | S | A | -0.7314 | |
| 26 | A | A | -0.6828 | |
| 27 | R | A | -1.0983 | |
| 28 | V | A | 0.9448 | |
| 29 | S | A | 0.8480 | |
| 30 | T | A | 1.4990 | |
| 31 | I | A | 2.9783 | |
| 32 | F | A | 2.6969 | |
| 33 | S | A | 1.1022 | |
| 34 | S | A | 0.3871 | |
| 35 | S | A | -0.2594 | |
| 36 | S | A | -0.3311 | |
| 37 | C | A | 0.1395 | |
| 38 | K | A | -0.7958 | |
| 39 | L | A | 0.8828 | |
| 40 | S | A | 0.3337 | |
| 41 | G | A | 0.0754 | |
| 42 | L | A | 0.7842 | |
| 43 | S | A | -0.6427 | |
| 44 | R | A | -2.1070 | |
| 45 | G | A | -1.8350 | |
| 46 | P | A | -1.6366 | |
| 47 | R | A | -1.9365 | |
| 48 | S | A | -0.3356 | |
| 49 | F | A | 1.3104 | |
| 50 | S | A | 0.6510 | |
| 51 | A | A | 0.9533 | |
| 52 | C | A | 1.2711 | |
| 53 | S | A | 1.0445 | |
| 54 | V | A | 1.9675 | |
| 55 | G | A | 0.8422 | |
| 56 | L | A | 1.0118 | |
| 57 | G | A | -0.5204 | |
| 58 | K | A | -1.6265 | |
| 59 | S | A | -1.0875 | |
| 60 | S | A | -1.0148 | |
| 61 | C | A | -0.5273 | |
| 62 | R | A | -1.5614 | |
| 63 | A | A | -0.5940 | |
| 64 | A | A | -0.0280 | |
| 65 | S | A | 0.3732 | |
| 66 | C | A | 1.3542 | |
| 67 | L | A | 1.9552 | |
| 68 | P | A | 1.2302 | |
| 69 | A | A | 1.6022 | |
| 70 | L | A | 2.4102 | |
| 71 | C | A | 2.1641 | |
| 72 | L | A | 2.0155 | |
| 73 | P | A | 0.5586 | |
| 74 | S | A | 0.0600 | |
| 75 | G | A | -0.2225 | |
| 76 | G | A | 0.3488 | |
| 77 | F | A | 1.5266 | |
| 78 | A | A | 0.9083 | |
| 79 | T | A | 0.6248 | |
| 80 | S | A | 0.6386 | |
| 81 | Y | A | 1.2143 | |
| 82 | G | A | 0.7005 | |
| 83 | M | A | 0.9976 | |
| 84 | A | A | 0.4730 | |
| 85 | G | A | 0.1855 | |
| 86 | G | A | 0.5312 | |
| 87 | W | A | 1.4172 | |
| 88 | F | A | 1.5479 | |
| 89 | G | A | 0.1316 | |
| 90 | E | A | -1.0075 | |
| 91 | G | A | -0.0108 | |
| 92 | I | A | 1.4240 | |
| 93 | L | A | 0.1454 | |
| 94 | T | A | -0.6230 | |
| 95 | G | A | -2.0204 | |
| 96 | N | A | -3.2819 | |
| 97 | E | A | -3.1087 | |
| 98 | K | A | -3.1791 | |
| 99 | E | A | -3.2910 | |
| 100 | T | A | -1.8715 | |
| 101 | M | A | -1.5740 | |
| 102 | Q | A | -2.1063 | |
| 103 | F | A | 0.0732 | |
| 104 | L | A | 0.4154 | |
| 105 | N | A | -1.1751 | |
| 106 | D | A | -1.5387 | |
| 107 | R | A | -0.9272 | |
| 108 | L | A | 0.4801 | |
| 109 | A | A | -0.2158 | |
| 110 | S | A | -0.8737 | |
| 111 | Y | A | 0.2716 | |
| 112 | L | A | 0.3226 | |
| 113 | E | A | -2.0258 | |
| 114 | K | A | -1.8734 | |
| 115 | V | A | -1.0420 | |
| 116 | R | A | -3.0922 | |
| 117 | Q | A | -2.9941 | |
| 118 | L | A | -2.4060 | |
| 119 | E | A | -3.5975 | |
| 120 | R | A | -4.1150 | |
| 121 | E | A | -3.5279 | |
| 122 | N | A | -3.5072 | |
| 123 | A | A | -2.8372 | |
| 124 | E | A | -3.2161 | |
| 125 | L | A | -2.0867 | |
| 126 | E | A | -2.8818 | |
| 127 | S | A | -2.7761 | |
| 128 | R | A | -3.0174 | |
| 129 | I | A | -1.7661 | |
| 130 | R | A | -3.5006 | |
| 131 | D | A | -3.3945 | |
| 132 | W | A | -1.4936 | |
| 133 | C | A | -1.1834 | |
| 134 | E | A | -2.4725 | |
| 135 | Q | A | -1.6741 | |
| 136 | Q | A | -0.0647 | |
| 137 | V | A | 1.2158 | |
| 138 | P | A | 0.6622 | |
| 139 | Y | A | 1.7951 | |
| 140 | L | A | 2.2576 | |
| 141 | C | A | 1.7780 | |
| 142 | P | A | 0.3487 | |
| 143 | D | A | -0.8425 | |
| 144 | Y | A | 0.6133 | |
| 145 | Q | A | -0.4372 | |
| 146 | S | A | -0.0687 | |
| 147 | Y | A | 1.3631 | |
| 148 | F | A | 1.3985 | |
| 149 | Q | A | -0.6032 | |
| 150 | T | A | -0.0334 | |
| 151 | I | A | 0.1851 | |
| 152 | E | A | -1.9857 | |
| 153 | E | A | -1.8946 | |
| 154 | L | A | -0.1776 | |
| 155 | Q | A | -1.3440 | |
| 156 | K | A | -2.1733 | |
| 157 | K | A | -1.7551 | |
| 158 | I | A | -0.3541 | |
| 159 | L | A | 0.0120 | |
| 160 | C | A | -0.5427 | |
| 161 | T | A | -1.5989 | |
| 162 | K | A | -2.2407 | |
| 163 | S | A | -1.5839 | |
| 164 | E | A | -1.9447 | |
| 165 | N | A | -1.8687 | |
| 166 | A | A | -0.6917 | |
| 167 | R | A | -0.8940 | |
| 168 | L | A | 0.3465 | |
| 169 | V | A | 1.8502 | |
| 170 | V | A | 1.2584 | |
| 171 | Q | A | 0.2878 | |
| 172 | I | A | 1.3730 | |
| 173 | D | A | -0.6005 | |
| 174 | N | A | -1.0387 | |
| 175 | A | A | -0.8355 | |
| 176 | K | A | -1.6712 | |
| 177 | L | A | -0.7291 | |
| 178 | A | A | -0.8501 | |
| 179 | A | A | -1.5605 | |
| 180 | D | A | -2.2156 | |
| 181 | D | A | -1.9157 | |
| 182 | F | A | -0.5904 | |
| 183 | R | A | -2.4171 | |
| 184 | T | A | -2.3685 | |
| 185 | K | A | -2.4352 | |
| 186 | Y | A | -1.1139 | |
| 187 | E | A | -2.2804 | |
| 188 | T | A | -1.6704 | |
| 189 | E | A | -2.0087 | |
| 190 | V | A | -1.0469 | |
| 191 | T | A | -0.7647 | |
| 192 | M | A | -0.3714 | |
| 193 | R | A | -2.2653 | |
| 194 | Q | A | -1.6943 | |
| 195 | L | A | 0.0577 | |
| 196 | V | A | -0.3707 | |
| 197 | E | A | -1.9807 | |
| 198 | S | A | -1.4686 | |
| 199 | D | A | -1.8790 | |
| 200 | M | A | -0.5981 | |
| 201 | N | A | -1.1644 | |
| 202 | G | A | -0.8998 | |
| 203 | L | A | -0.2772 | |
| 204 | R | A | -1.9224 | |
| 205 | R | A | -2.2761 | |
| 206 | I | A | 0.4514 | |
| 207 | L | A | 0.4536 | |
| 208 | D | A | -1.7934 | |
| 209 | D | A | -1.3156 | |
| 210 | L | A | 0.1281 | |
| 211 | T | A | -0.0741 | |
| 212 | L | A | 0.4653 | |
| 213 | C | A | -0.0979 | |
| 214 | K | A | -1.6154 | |
| 215 | A | A | -1.0760 | |
| 216 | D | A | -1.7040 | |
| 217 | L | A | -0.7476 | |
| 218 | E | A | -2.1364 | |
| 219 | A | A | -1.8376 | |
| 220 | Q | A | -1.7261 | |
| 221 | V | A | -0.4222 | |
| 222 | E | A | -2.6206 | |
| 223 | S | A | -1.7958 | |
| 224 | L | A | -0.5597 | |
| 225 | K | A | -1.9575 | |
| 226 | E | A | -2.6289 | |
| 227 | E | A | -2.0554 | |
| 228 | L | A | -0.7824 | |
| 229 | L | A | -0.7854 | |
| 230 | C | A | -0.8715 | |
| 231 | L | A | -0.9827 | |
| 232 | K | A | -3.1624 | |
| 233 | K | A | -3.8515 | |
| 234 | N | A | -3.7977 | |
| 235 | H | A | -4.2431 | |
| 236 | E | A | -4.9241 | |
| 237 | E | A | -5.1506 | |
| 238 | E | A | -4.3853 | |
| 239 | V | A | -2.9387 | |
| 240 | N | A | -3.2380 | |
| 241 | S | A | -2.0635 | |
| 242 | L | A | -0.7460 | |
| 243 | R | A | -1.9961 | |
| 244 | C | A | -1.0243 | |
| 245 | Q | A | -1.2296 | |
| 246 | L | A | -0.5174 | |
| 247 | G | A | -1.3105 | |
| 248 | D | A | -2.5769 | |
| 249 | R | A | -1.9866 | |
| 250 | L | A | 0.0190 | |
| 251 | N | A | -0.8133 | |
| 252 | V | A | 0.7650 | |
| 253 | E | A | -0.7448 | |
| 254 | V | A | 0.3805 | |
| 255 | D | A | -1.1797 | |
| 256 | A | A | -0.4364 | |
| 257 | A | A | -0.0122 | |
| 258 | P | A | -0.2602 | |
| 259 | P | A | 0.2671 | |
| 260 | V | A | 0.7578 | |
| 261 | D | A | -1.1173 | |
| 262 | L | A | 0.2981 | |
| 263 | N | A | -1.4045 | |
| 264 | R | A | -2.1771 | |
| 265 | V | A | -0.3032 | |
| 266 | L | A | -0.0669 | |
| 267 | N | A | -1.4272 | |
| 268 | E | A | -1.6077 | |
| 269 | M | A | -0.5966 | |
| 270 | R | A | -1.1418 | |
| 271 | C | A | -0.7138 | |
| 272 | Q | A | -0.7695 | |
| 273 | Y | A | 0.2585 | |
| 274 | E | A | -1.2367 | |
| 275 | T | A | -0.7209 | |
| 276 | L | A | 0.1410 | |
| 277 | V | A | -0.6408 | |
| 278 | E | A | -2.4187 | |
| 279 | N | A | -3.3488 | |
| 280 | N | A | -4.0230 | |
| 281 | R | A | -4.6094 | |
| 282 | R | A | -5.0362 | |
| 283 | E | A | -4.7199 | |
| 284 | A | A | -3.2737 | |
| 285 | E | A | -3.9658 | |
| 286 | D | A | -3.5221 | |
| 287 | W | A | -1.0837 | |
| 288 | F | A | -0.4569 | |
| 289 | N | A | -2.0087 | |
| 290 | T | A | -1.8476 | |
| 291 | Q | A | -1.9571 | |
| 292 | T | A | -1.9525 | |
| 293 | E | A | -3.1805 | |
| 294 | E | A | -2.9854 | |
| 295 | L | A | -0.9936 | |
| 296 | N | A | -1.7416 | |
| 297 | Q | A | -2.0693 | |
| 298 | Q | A | -1.3070 | |
| 299 | V | A | 0.6045 | |
| 300 | V | A | 0.6141 | |
| 301 | S | A | -0.4939 | |
| 302 | S | A | -0.4642 | |
| 303 | S | A | -0.4103 | |
| 304 | E | A | -1.8284 | |
| 305 | Q | A | -1.0784 | |
| 306 | L | A | -0.0873 | |
| 307 | Q | A | -1.6314 | |
| 308 | S | A | -0.9798 | |
| 309 | Y | A | 0.0280 | |
| 310 | Q | A | -0.6334 | |
| 311 | A | A | -0.7942 | |
| 312 | E | A | -1.4691 | |
| 313 | I | A | -0.0680 | |
| 314 | I | A | -0.1618 | |
| 315 | E | A | -1.9774 | |
| 316 | L | A | -0.5691 | |
| 317 | R | A | -1.7977 | |
| 318 | R | A | -2.5622 | |
| 319 | T | A | -0.5221 | |
| 320 | V | A | 0.1328 | |
| 321 | N | A | -1.3918 | |
| 322 | A | A | -0.3408 | |
| 323 | L | A | 0.4142 | |
| 324 | E | A | -0.9188 | |
| 325 | I | A | 0.3817 | |
| 326 | E | A | -1.0865 | |
| 327 | L | A | -0.4163 | |
| 328 | Q | A | -1.3725 | |
| 329 | A | A | -1.2852 | |
| 330 | Q | A | -2.0809 | |
| 331 | H | A | -1.8558 | |
| 332 | S | A | -1.6857 | |
| 333 | M | A | -0.9005 | |
| 334 | R | A | -2.1359 | |
| 335 | D | A | -2.2712 | |
| 336 | A | A | -0.8635 | |
| 337 | L | A | -0.1975 | |
| 338 | E | A | -1.7203 | |
| 339 | S | A | -1.3035 | |
| 340 | T | A | -0.6929 | |
| 341 | L | A | -0.2134 | |
| 342 | A | A | -1.1468 | |
| 343 | E | A | -2.2071 | |
| 344 | T | A | -1.7331 | |
| 345 | E | A | -2.2377 | |
| 346 | A | A | -1.7922 | |
| 347 | R | A | -2.2482 | |
| 348 | Y | A | -0.6971 | |
| 349 | S | A | -0.8833 | |
| 350 | S | A | -1.1401 | |
| 351 | Q | A | -1.0827 | |
| 352 | L | A | 0.2534 | |
| 353 | A | A | -0.2889 | |
| 354 | Q | A | -0.5908 | |
| 355 | M | A | 0.1978 | |
| 356 | Q | A | -0.2599 | |
| 357 | G | A | -0.1555 | |
| 358 | L | A | 1.1995 | |
| 359 | I | A | 1.4054 | |
| 360 | G | A | -0.2044 | |
| 361 | N | A | -0.4826 | |
| 362 | V | A | 0.6040 | |
| 363 | E | A | -1.0460 | |
| 364 | S | A | -1.5716 | |
| 365 | Q | A | -1.3830 | |
| 366 | L | A | -0.9948 | |
| 367 | A | A | -1.4497 | |
| 368 | E | A | -2.3300 | |
| 369 | I | A | -1.4298 | |
| 370 | R | A | -2.4598 | |
| 371 | C | A | -2.2787 | |
| 372 | D | A | -3.2038 | |
| 373 | L | A | -2.2549 | |
| 374 | E | A | -4.0080 | |
| 375 | R | A | -4.3795 | |
| 376 | Q | A | -3.7797 | |
| 377 | N | A | -3.3033 | |
| 378 | Q | A | -3.1336 | |
| 379 | E | A | -1.9580 | |
| 380 | Y | A | -0.6307 | |
| 381 | Q | A | -0.7396 | |
| 382 | V | A | 0.7071 | |
| 383 | L | A | 0.8989 | |
| 384 | L | A | 0.0458 | |
| 385 | D | A | -1.1886 | |
| 386 | V | A | -0.1206 | |
| 387 | R | A | -1.6603 | |
| 388 | A | A | -1.5508 | |
| 389 | R | A | -2.1336 | |
| 390 | L | A | -0.9040 | |
| 391 | E | A | -1.8372 | |
| 392 | C | A | -0.7932 | |
| 393 | E | A | -1.0200 | |
| 394 | I | A | 0.0826 | |
| 395 | S | A | -0.2989 | |
| 396 | T | A | 0.2273 | |
| 397 | Y | A | 0.9061 | |
| 398 | R | A | -0.9094 | |
| 399 | G | A | -0.6745 | |
| 400 | L | A | 0.8318 | |
| 401 | L | A | -0.1974 | |
| 402 | D | A | -2.2635 | |
| 403 | S | A | -1.6988 | |
| 404 | E | A | -2.5320 | |
| 405 | D | A | -2.3058 | |
| 406 | C | A | -1.0923 | |
| 407 | K | A | -1.8751 | |
| 408 | L | A | -0.2665 | |
| 409 | P | A | -0.3566 | |
| 410 | C | A | 0.0600 | |
| 411 | N | A | -0.6858 | |
| 412 | P | A | -0.3533 | |
| 413 | C | A | 0.1286 | |
| 414 | A | A | -0.5969 | |
| 415 | P | A | -1.2622 | |
| 416 | D | A | -2.4272 | |
| 417 | H | A | -2.1457 | |
| 418 | S | A | -1.4766 | |
| 419 | P | A | -1.3434 | |
| 420 | S | A | -1.3969 | |
| 421 | K | A | -1.6475 | |
| 422 | S | A | -0.4710 | |
| 423 | C | A | 1.0352 | |
| 424 | L | A | 1.8545 | |
| 425 | P | A | 1.3626 | |
| 426 | C | A | 1.7349 | |
| 427 | L | A | 1.8851 | |
| 428 | P | A | 0.6969 | |
| 429 | A | A | 0.4309 | |
| 430 | A | A | 0.1854 | |
| 431 | S | A | 0.0107 | |
| 432 | C | A | 0.2840 | |
| 433 | G | A | -0.4247 | |
| 434 | P | A | -0.5575 | |
| 435 | G | A | -0.7386 | |
| 436 | T | A | -0.6502 | |
| 437 | A | A | -0.6298 | |
| 438 | H | A | -0.9944 | |
| 439 | T | A | -0.4144 | |
| 440 | T | A | -0.1080 | |
| 441 | C | A | 0.1655 | |
| 442 | S | A | -0.4425 | |
| 443 | P | A | -0.8984 | |
| 444 | R | A | -1.4635 | |
| 445 | P | A | 0.1666 | |
| 446 | I | A | 2.1992 | |
| 447 | C | A | 2.3014 | |
| 448 | V | A | 2.6697 | |
| 449 | S | A | 1.2947 | |
| 450 | C | A | 0.8962 | |
| 451 | P | A | -0.2622 | |
| 452 | G | A | -0.8181 | |
| 453 | S | A | -0.8229 | |
| 454 | R | A | -1.1576 | |
| 455 | F | A | 0.9317 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine