Project name: c6ab6b791b912a9

Chain sequence(s)	H: EVQLVESGGGLIQPGGSLRLSCAASGFIVSRNYMNWVRQAPGKGLEWVSVIYGSGRTDSADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDADYGLDVWGQGTTVTVSS; L: EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPLYTFGQGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:58)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:00)

• Minimal score value: -3.1512
• Maximal score value: 1.2769
• Average score: -0.6227
• Total score value: -140.1126

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.6471
2	V	H	-0.2775
3	Q	H	-0.4471
4	L	H	0.0000
5	V	H	1.0508
6	E	H	0.0000
7	S	H	-0.3415
8	G	H	-0.7973
9	G	H	-0.2806
11	G	H	0.4735
12	L	H	1.2769
13	I	H	0.1600
14	Q	H	-1.2335
15	P	H	-1.4053
16	G	H	-1.3698
17	G	H	-1.0426
18	S	H	-0.8681
19	L	H	-0.5938
20	R	H	-1.4227
21	L	H	0.0000
22	S	H	-0.2533
23	C	H	0.0000
24	A	H	-0.0121
25	A	H	0.0000
26	S	H	-0.3914
27	G	H	-0.5943
28	F	H	0.0000
29	I	H	0.1425
30	V	H	0.0000
35	S	H	-1.1319
36	R	H	-1.6499
37	N	H	-0.7599
38	Y	H	-0.3250
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.8280
45	A	H	-1.2358
46	P	H	-0.9957
47	G	H	-1.4510
48	K	H	-2.3886
49	G	H	-1.5882
50	L	H	0.0000
51	E	H	-0.9788
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	V	H	0.0000
56	I	H	0.0000
57	Y	H	-0.7382
58	G	H	-0.9964
59	S	H	-1.1110
63	G	H	-1.3677
64	R	H	-1.7167
65	T	H	-0.9624
66	D	H	-1.0881
67	S	H	-1.1568
68	A	H	-1.4907
69	D	H	-2.6036
70	S	H	-1.7988
71	V	H	0.0000
72	K	H	-2.7424
74	G	H	-1.7532
75	R	H	-1.5074
76	F	H	0.0000
77	T	H	-0.8685
78	I	H	0.0000
79	S	H	-0.6464
80	R	H	-1.1131
81	D	H	-1.7206
82	N	H	-2.2250
83	S	H	-1.7226
84	K	H	-2.3239
85	N	H	-1.5060
86	T	H	-0.8334
87	L	H	0.0000
88	Y	H	-0.4118
89	L	H	0.0000
90	Q	H	-0.9643
91	M	H	0.0000
92	N	H	-1.2222
93	S	H	-1.1810
94	L	H	0.0000
95	R	H	-2.2893
96	A	H	-1.7046
97	E	H	-2.2258
98	D	H	0.0000
99	T	H	-0.6515
100	A	H	0.0000
101	V	H	0.0046
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.2094
107	D	H	0.0000
108	A	H	-0.9682
109	D	H	-1.4446
113	Y	H	-0.2753
114	G	H	0.0000
115	L	H	0.0000
116	D	H	-0.8536
117	V	H	-0.3091
118	W	H	-0.2969
119	G	H	0.0000
120	Q	H	-1.1173
121	G	H	-0.5174
122	T	H	-0.2188
123	T	H	-0.0767
124	V	H	0.0000
125	T	H	-0.0104
126	V	H	0.0000
127	S	H	-0.4570
128	S	H	-0.4703
1	E	L	-1.4356
2	I	L	0.0000
3	V	L	0.6856
4	L	L	0.0000
5	T	L	-0.7899
6	Q	L	0.0000
7	S	L	-0.9771
8	P	L	-0.6156
9	G	L	-0.9985
10	T	L	-0.7076
11	L	L	-0.2330
12	S	L	-0.2206
13	L	L	-0.4230
14	S	L	-0.8807
15	P	L	-1.3746
16	G	L	-1.8850
17	E	L	-2.3293
18	R	L	-2.9622
19	A	L	0.0000
20	T	L	-0.5609
21	L	L	0.0000
22	S	L	-0.9301
23	C	L	0.0000
24	R	L	-2.3214
25	A	L	0.0000
26	S	L	-0.9305
27	Q	L	-1.4816
28	S	L	-1.2408
29	V	L	0.0000
30	S	L	-0.3500
36	S	L	-0.4034
37	S	L	-0.0959
38	Y	L	0.2490
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.2225
46	P	L	-0.9034
47	G	L	-1.3313
48	Q	L	-1.7994
49	A	L	-1.1333
50	P	L	0.0000
51	R	L	-0.9719
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.0364
56	G	L	-0.1686
57	A	L	0.0000
65	S	L	-0.5307
66	S	L	-0.4027
67	R	L	-1.1379
68	A	L	-0.6453
69	T	L	-0.5815
70	G	L	-0.8403
71	I	L	0.0000
72	P	L	-1.2783
74	D	L	-2.3435
75	R	L	-2.0138
76	F	L	0.0000
77	S	L	-0.8675
78	G	L	-0.4391
79	S	L	-0.6755
80	G	L	-1.0774
83	S	L	-1.0304
84	G	L	-1.1703
85	T	L	-1.7052
86	D	L	-2.1434
87	F	L	0.0000
88	T	L	-0.7897
89	L	L	0.0000
90	T	L	-0.7975
91	I	L	0.0000
92	S	L	-2.1610
93	R	L	-3.1512
94	L	L	0.0000
95	E	L	-2.0132
96	P	L	-1.3319
97	E	L	-2.0827
98	D	L	0.0000
99	F	L	-0.3019
100	A	L	0.0000
101	V	L	-0.3121
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.1914
108	G	L	0.0376
109	S	L	-0.3297
113	S	L	-0.1651
114	P	L	-0.0609
115	L	L	-0.0498
116	Y	L	0.0800
117	T	L	0.1132
118	F	L	0.1445
119	G	L	0.0000
120	Q	L	-1.5366
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.0668
124	L	L	0.0000
125	E	L	0.0268
126	I	L	0.9140
127	K	L	-0.8096