| Chain sequence(s) |
A: GLPLLDPSPPLLSTDEYVEPTDLLYYAETDLIEEKGHPTKDIVVNGKVVVPKVSAYQWRVYRLKLPDPNKLPLPSEDFVDFSTEILIWRLLAFKIHVYGPLGKGTVGHANFNRLGDITNPTAPVHETADVTVALSFEPKLKQEYIIGDRPPIGKYIAPAKPAPGLPPGALPPTETVTTLIEHGDMADIGFGAKDYAALEPEKNNVPDIILDTKTIEIDYEGMKAEPTGDRLFTYDKYEKSYASETYVLSGPDLVPLPNSPPPSPLYKKPPASSPTAVPPSTRTFTLPDAGEITEDDLLFNKPIFIEETEGLNNAILWHNQLYITVLDNTRAEIETITTQTSTPAENVYNASNYVTSKRYTRKYRLSLIVQLCKIPLTPETLELLRRIDPRILVNANLPDIPPVERPDPYEGLKFHELDLTDKLSSDLSKSELGQAYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.4157 | |
| 2 | L | A | 1.8147 | |
| 3 | P | A | 1.2596 | |
| 4 | L | A | 1.9728 | |
| 5 | L | A | 1.4806 | |
| 6 | D | A | -0.9029 | |
| 7 | P | A | -0.6681 | |
| 8 | S | A | -0.7104 | |
| 9 | P | A | -0.6253 | |
| 10 | P | A | -0.1597 | |
| 11 | L | A | 0.4144 | |
| 12 | L | A | 0.2251 | |
| 13 | S | A | -0.5525 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.9121 | |
| 16 | E | A | -2.6372 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.1233 | |
| 20 | P | A | -1.5805 | |
| 21 | T | A | -1.1990 | |
| 22 | D | A | -1.6349 | |
| 23 | L | A | -0.4984 | |
| 24 | L | A | -0.0931 | |
| 25 | Y | A | 0.0549 | |
| 26 | Y | A | -0.2250 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9108 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.7319 | |
| 31 | L | A | -0.5482 | |
| 32 | I | A | 0.0000 | |
| 33 | E | A | -1.5248 | |
| 34 | E | A | -1.3689 | |
| 35 | K | A | -1.8933 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.9522 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.6504 | |
| 40 | K | A | -1.9442 | |
| 41 | D | A | -0.6218 | |
| 42 | I | A | 1.4967 | |
| 43 | V | A | 2.3983 | |
| 44 | V | A | 1.8770 | |
| 45 | N | A | -0.4795 | |
| 46 | G | A | -0.3200 | |
| 47 | K | A | -0.0461 | |
| 48 | V | A | 2.0800 | |
| 49 | V | A | 2.7438 | |
| 50 | V | A | 1.3344 | |
| 51 | P | A | -0.0781 | |
| 52 | K | A | -1.2676 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | Y | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.8528 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.5815 | |
| 67 | D | A | -1.3424 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2655 | |
| 70 | K | A | -1.8025 | |
| 71 | L | A | -0.7607 | |
| 72 | P | A | -0.6432 | |
| 73 | L | A | -0.6486 | |
| 74 | P | A | -0.6925 | |
| 75 | S | A | -1.5490 | |
| 76 | E | A | -2.8872 | |
| 77 | D | A | -2.7989 | |
| 78 | F | A | -1.4301 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -1.8195 | |
| 81 | F | A | -0.2055 | |
| 82 | S | A | -0.2844 | |
| 83 | T | A | -0.3915 | |
| 84 | E | A | -0.4834 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.2852 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.2391 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.6206 | |
| 97 | V | A | 0.0000 | |
| 98 | Y | A | -0.1202 | |
| 99 | G | A | -0.6030 | |
| 100 | P | A | -0.5185 | |
| 101 | L | A | -0.3708 | |
| 102 | G | A | -0.8752 | |
| 103 | K | A | -1.5341 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.7142 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.6556 | |
| 108 | H | A | -0.9069 | |
| 109 | A | A | -0.6199 | |
| 110 | N | A | -1.6150 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -0.8148 | |
| 114 | L | A | -0.8393 | |
| 115 | G | A | -0.6485 | |
| 116 | D | A | -0.7326 | |
| 117 | I | A | -0.1386 | |
| 118 | T | A | -0.7842 | |
| 119 | N | A | -1.4183 | |
| 120 | P | A | -0.7578 | |
| 121 | T | A | -0.4502 | |
| 122 | A | A | -0.3359 | |
| 123 | P | A | -0.3719 | |
| 124 | V | A | -0.6820 | |
| 125 | H | A | -1.5578 | |
| 126 | E | A | -2.3471 | |
| 127 | T | A | -1.6138 | |
| 128 | A | A | -1.1856 | |
| 129 | D | A | -2.0789 | |
| 130 | V | A | -1.2571 | |
| 131 | T | A | -0.8209 | |
| 132 | V | A | -0.1786 | |
| 133 | A | A | -0.1458 | |
| 134 | L | A | -0.1262 | |
| 135 | S | A | -0.3002 | |
| 136 | F | A | 0.0000 | |
| 137 | E | A | -0.7162 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.3506 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | -0.2932 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.4136 | |
| 155 | Y | A | -0.2621 | |
| 156 | I | A | 0.4168 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.7201 | |
| 159 | A | A | -1.2905 | |
| 160 | K | A | -2.1011 | |
| 161 | P | A | -0.9111 | |
| 162 | A | A | -0.5164 | |
| 163 | P | A | -0.5301 | |
| 164 | G | A | -0.3116 | |
| 165 | L | A | 0.4071 | |
| 166 | P | A | -0.0793 | |
| 167 | P | A | -0.2734 | |
| 168 | G | A | 0.0768 | |
| 169 | A | A | 0.8259 | |
| 170 | L | A | 1.6340 | |
| 171 | P | A | 0.2708 | |
| 172 | P | A | -0.4924 | |
| 173 | T | A | -0.6472 | |
| 174 | E | A | -1.2985 | |
| 175 | T | A | -0.2176 | |
| 176 | V | A | 0.1423 | |
| 177 | T | A | -0.0914 | |
| 178 | T | A | -0.0207 | |
| 179 | L | A | 0.0488 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -0.9636 | |
| 182 | H | A | -1.1361 | |
| 183 | G | A | -0.7600 | |
| 184 | D | A | -0.8099 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.6864 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2591 | |
| 190 | F | A | -0.0593 | |
| 191 | G | A | -0.4011 | |
| 192 | A | A | -0.5370 | |
| 193 | K | A | -0.4345 | |
| 194 | D | A | -0.6352 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.4561 | |
| 197 | A | A | -0.5436 | |
| 198 | L | A | -0.5767 | |
| 199 | E | A | -1.4872 | |
| 200 | P | A | -1.6409 | |
| 201 | E | A | -2.2319 | |
| 202 | K | A | -2.8578 | |
| 203 | N | A | -2.0002 | |
| 204 | N | A | -1.3446 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.7573 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.8652 | |
| 211 | D | A | -2.2587 | |
| 212 | T | A | -1.3859 | |
| 213 | K | A | -1.1440 | |
| 214 | T | A | 0.0000 | |
| 215 | I | A | 0.0000 | |
| 216 | E | A | -1.2393 | |
| 217 | I | A | 0.0000 | |
| 218 | D | A | -1.2591 | |
| 219 | Y | A | -1.4665 | |
| 220 | E | A | -2.3848 | |
| 221 | G | A | -1.6204 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.5655 | |
| 224 | A | A | -1.4240 | |
| 225 | E | A | -1.1849 | |
| 226 | P | A | -0.4409 | |
| 227 | T | A | -0.2933 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.5577 | |
| 231 | L | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.5333 | |
| 234 | Y | A | -0.4453 | |
| 235 | D | A | -1.4307 | |
| 236 | K | A | -2.2333 | |
| 237 | Y | A | -1.6407 | |
| 238 | E | A | -2.1926 | |
| 239 | K | A | -1.2814 | |
| 240 | S | A | -0.6112 | |
| 241 | Y | A | 0.6210 | |
| 242 | A | A | 0.2295 | |
| 243 | S | A | -0.3261 | |
| 244 | E | A | -0.8046 | |
| 245 | T | A | -0.4831 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | 0.0000 | |
| 249 | S | A | -1.1790 | |
| 250 | G | A | -0.7972 | |
| 251 | P | A | -0.1619 | |
| 252 | D | A | 0.8264 | |
| 253 | L | A | 2.3321 | |
| 254 | V | A | 2.3527 | |
| 255 | P | A | 0.7730 | |
| 256 | L | A | 0.9089 | |
| 257 | P | A | -0.1778 | |
| 258 | N | A | -1.0856 | |
| 259 | S | A | -0.9035 | |
| 260 | P | A | -1.1680 | |
| 261 | P | A | -1.1722 | |
| 262 | P | A | -0.8150 | |
| 263 | S | A | -0.6538 | |
| 264 | P | A | 0.1740 | |
| 265 | L | A | 0.9808 | |
| 266 | Y | A | -0.2709 | |
| 267 | K | A | -1.9105 | |
| 268 | K | A | -1.7198 | |
| 269 | P | A | -0.8433 | |
| 270 | P | A | -0.5934 | |
| 271 | A | A | -0.0997 | |
| 272 | S | A | -0.3618 | |
| 273 | S | A | -0.1936 | |
| 274 | P | A | -0.1742 | |
| 275 | T | A | 0.0537 | |
| 276 | A | A | 0.2783 | |
| 277 | V | A | 0.9859 | |
| 278 | P | A | 0.2994 | |
| 279 | P | A | -0.3419 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.1288 | |
| 282 | R | A | -0.3364 | |
| 283 | T | A | -0.1226 | |
| 284 | F | A | 0.0276 | |
| 285 | T | A | -0.0134 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -0.6440 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -1.0114 | |
| 291 | E | A | -2.1708 | |
| 292 | I | A | -1.4620 | |
| 293 | T | A | -1.8891 | |
| 294 | E | A | -2.8600 | |
| 295 | D | A | -2.8547 | |
| 296 | D | A | -2.1792 | |
| 297 | L | A | -1.4179 | |
| 298 | L | A | -1.1429 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.2088 | |
| 301 | K | A | -1.5018 | |
| 302 | P | A | -0.7878 | |
| 303 | I | A | 0.0683 | |
| 304 | F | A | -0.2561 | |
| 305 | I | A | 0.0000 | |
| 306 | E | A | -2.5170 | |
| 307 | E | A | -3.2248 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.4342 | |
| 310 | G | A | -1.4661 | |
| 311 | L | A | -0.4883 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | A | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9056 | |
| 319 | N | A | -1.0736 | |
| 320 | Q | A | -1.2387 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.7733 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.3779 | |
| 333 | I | A | -1.8232 | |
| 334 | E | A | -2.2605 | |
| 335 | T | A | -1.2419 | |
| 336 | I | A | 0.2622 | |
| 337 | T | A | 0.3016 | |
| 338 | T | A | 0.1105 | |
| 339 | Q | A | -0.8703 | |
| 340 | T | A | -0.3754 | |
| 341 | S | A | -0.6330 | |
| 342 | T | A | -0.7135 | |
| 343 | P | A | -0.6138 | |
| 344 | A | A | -0.6401 | |
| 345 | E | A | -1.7420 | |
| 346 | N | A | -1.0775 | |
| 347 | V | A | 1.0573 | |
| 348 | Y | A | 1.1238 | |
| 349 | N | A | -0.0796 | |
| 350 | A | A | 0.1390 | |
| 351 | S | A | -0.1961 | |
| 352 | N | A | -0.2964 | |
| 353 | Y | A | 0.4942 | |
| 354 | V | A | 1.4603 | |
| 355 | T | A | 0.5174 | |
| 356 | S | A | -0.6497 | |
| 357 | K | A | -2.2349 | |
| 358 | R | A | -2.6077 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -1.6167 | |
| 361 | R | A | 0.0000 | |
| 362 | K | A | -1.0195 | |
| 363 | Y | A | 0.0000 | |
| 364 | R | A | -1.0116 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3423 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.9259 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6409 | |
| 376 | L | A | -0.3186 | |
| 377 | T | A | -0.8767 | |
| 378 | P | A | -1.4060 | |
| 379 | E | A | -2.3220 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.5502 | |
| 382 | E | A | -2.6550 | |
| 383 | L | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | R | A | -2.3349 | |
| 386 | R | A | -1.7177 | |
| 387 | I | A | -0.8903 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.3456 | |
| 390 | R | A | -1.0975 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.2125 | |
| 394 | N | A | -1.6372 | |
| 395 | A | A | -1.2092 | |
| 396 | N | A | -1.5273 | |
| 397 | L | A | -1.0747 | |
| 398 | P | A | -1.2253 | |
| 399 | D | A | -1.9302 | |
| 400 | I | A | -0.7517 | |
| 401 | P | A | -0.5309 | |
| 402 | P | A | -0.7337 | |
| 403 | V | A | 0.0011 | |
| 404 | E | A | -2.1673 | |
| 405 | R | A | -2.6095 | |
| 406 | P | A | -2.1488 | |
| 407 | D | A | -2.2742 | |
| 408 | P | A | -1.4859 | |
| 409 | Y | A | -1.4046 | |
| 410 | E | A | -2.4837 | |
| 411 | G | A | -1.6106 | |
| 412 | L | A | -1.2618 | |
| 413 | K | A | -2.3156 | |
| 414 | F | A | 0.0000 | |
| 415 | H | A | -1.7266 | |
| 416 | E | A | -2.8327 | |
| 417 | L | A | -2.3470 | |
| 418 | D | A | -3.2200 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.9952 | |
| 421 | D | A | -2.3134 | |
| 422 | K | A | -1.8475 | |
| 423 | L | A | -0.6421 | |
| 424 | S | A | -0.7437 | |
| 425 | S | A | -0.4719 | |
| 426 | D | A | -1.2447 | |
| 427 | L | A | -0.9638 | |
| 428 | S | A | -1.5487 | |
| 429 | K | A | -2.5423 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.5209 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | Q | A | -2.0325 | |
| 435 | A | A | -1.3190 | |
| 436 | Y | A | -0.4478 | |
| 437 | L | A | 0.0907 | |
| 438 | N | A | -1.6211 | |
| 439 | R | A | -1.9684 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine