| Chain sequence(s) |
A: LPFGEVFNATRFASVYAWNRKRISNVADYSVLYNSASFSTFKYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPNGVEGFNYFPLQSYGFQPTNGVGYQPYRVVVLSFELVKLVESGGGLVKPGGSLKLSAASGFTFSSYAMSWVRQTPEKRLEWVATISSGGTYTYYPDSVKGRFTISRDNAENTLYLQMSSLRSEDTAMYYVRDGNSMDYWGQGTSVDIQMTQTTSSLSASLGDRVTIIRASQDINNYLNWYQQKPDGTVKLLIYYTSRLSGVPSRFSGSGSGSDYSLTISNLEQEDIATYFQQANTLPPTFGAGTKLEL
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:14)
[INFO] Main: Simulation completed successfully. (00:03:17)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | L | A | 1.9096 | |
| 3 | P | A | 0.1865 | |
| 4 | F | A | 0.0000 | |
| 5 | G | A | -0.9925 | |
| 6 | E | A | -2.0799 | |
| 7 | V | A | -0.6761 | |
| 8 | F | A | 0.0000 | |
| 9 | N | A | -1.9761 | |
| 10 | A | A | -1.2217 | |
| 11 | T | A | -1.4367 | |
| 12 | R | A | -2.4026 | |
| 13 | F | A | 0.0000 | |
| 14 | A | A | -0.6055 | |
| 15 | S | A | -0.2169 | |
| 16 | V | A | 0.0000 | |
| 17 | Y | A | 0.3312 | |
| 18 | A | A | 0.0000 | |
| 19 | W | A | 0.0000 | |
| 20 | N | A | -1.0777 | |
| 21 | R | A | -1.3027 | |
| 22 | K | A | -1.6028 | |
| 23 | R | A | -2.1412 | |
| 24 | I | A | -0.6173 | |
| 25 | S | A | -0.7155 | |
| 26 | N | A | -0.8952 | |
| 28 | V | A | 1.8059 | |
| 29 | A | A | 0.8180 | |
| 30 | D | A | 0.5577 | |
| 31 | Y | A | 0.0000 | |
| 32 | S | A | -0.5468 | |
| 33 | V | A | 0.5837 | |
| 34 | L | A | 0.0000 | |
| 35 | Y | A | -0.0268 | |
| 36 | N | A | -0.9130 | |
| 37 | S | A | -0.4062 | |
| 38 | A | A | -0.1542 | |
| 39 | S | A | 0.0193 | |
| 40 | F | A | 0.3335 | |
| 41 | S | A | 0.0425 | |
| 42 | T | A | -0.1433 | |
| 43 | F | A | -0.3423 | |
| 44 | K | A | -1.4632 | |
| 46 | Y | A | -0.4866 | |
| 47 | G | A | -0.4666 | |
| 48 | V | A | -0.4590 | |
| 49 | S | A | -0.9639 | |
| 50 | P | A | -0.9837 | |
| 51 | T | A | -1.1558 | |
| 52 | K | A | -2.0013 | |
| 53 | L | A | 0.0000 | |
| 54 | N | A | -1.3560 | |
| 55 | D | A | -2.1911 | |
| 56 | L | A | -0.4138 | |
| 57 | C | A | 0.2078 | |
| 58 | F | A | 0.3484 | |
| 59 | T | A | 0.0230 | |
| 60 | N | A | -0.5920 | |
| 61 | V | A | -0.6797 | |
| 62 | Y | A | -0.8564 | |
| 63 | A | A | 0.0000 | |
| 64 | D | A | 0.0000 | |
| 65 | S | A | 0.0000 | |
| 66 | F | A | 0.0000 | |
| 67 | V | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | R | A | 0.0000 | |
| 70 | G | A | -0.6754 | |
| 71 | D | A | -1.7876 | |
| 72 | E | A | -1.5018 | |
| 73 | V | A | -1.1833 | |
| 74 | R | A | -2.1769 | |
| 75 | Q | A | 0.0000 | |
| 76 | I | A | 0.0000 | |
| 77 | A | A | -1.1253 | |
| 78 | P | A | -1.7695 | |
| 79 | G | A | -1.9765 | |
| 80 | Q | A | -1.4293 | |
| 81 | T | A | -0.7741 | |
| 82 | G | A | -0.6276 | |
| 83 | K | A | -0.6435 | |
| 84 | I | A | 0.0000 | |
| 85 | A | A | 0.0000 | |
| 86 | D | A | -1.1995 | |
| 87 | Y | A | -0.8310 | |
| 88 | N | A | 0.0000 | |
| 89 | Y | A | 0.0000 | |
| 90 | K | A | -1.3718 | |
| 91 | L | A | 0.0000 | |
| 92 | P | A | -1.9953 | |
| 93 | D | A | -3.0004 | |
| 94 | D | A | -2.6990 | |
| 95 | F | A | -1.2937 | |
| 96 | T | A | -0.5844 | |
| 97 | G | A | 0.0000 | |
| 99 | V | A | -0.2184 | |
| 100 | I | A | 0.0000 | |
| 101 | A | A | 0.0000 | |
| 102 | W | A | 0.2059 | |
| 103 | N | A | -0.0781 | |
| 104 | S | A | 0.0000 | |
| 105 | N | A | -0.5033 | |
| 106 | N | A | -1.0266 | |
| 107 | L | A | 0.4756 | |
| 108 | D | A | -0.3793 | |
| 109 | S | A | -0.5472 | |
| 110 | K | A | -0.3457 | |
| 111 | V | A | 0.9532 | |
| 112 | G | A | 0.1466 | |
| 113 | G | A | -0.0937 | |
| 114 | N | A | 0.0649 | |
| 115 | Y | A | 0.8311 | |
| 116 | N | A | 0.2140 | |
| 117 | Y | A | 0.3360 | |
| 118 | L | A | 0.3645 | |
| 119 | Y | A | 0.0000 | |
| 120 | R | A | 0.0000 | |
| 121 | L | A | 0.5882 | |
| 122 | F | A | -0.0424 | |
| 123 | R | A | -1.4111 | |
| 124 | K | A | -2.3872 | |
| 125 | S | A | -1.8754 | |
| 126 | N | A | -2.4106 | |
| 127 | L | A | 0.0000 | |
| 128 | K | A | -2.2926 | |
| 129 | P | A | -1.5737 | |
| 130 | F | A | -0.4505 | |
| 131 | E | A | -1.3393 | |
| 132 | R | A | -0.7888 | |
| 133 | D | A | -0.4867 | |
| 134 | I | A | 0.0290 | |
| 135 | S | A | -0.6580 | |
| 136 | T | A | -0.8841 | |
| 137 | E | A | -1.8555 | |
| 138 | I | A | -0.6905 | |
| 139 | Y | A | -0.7359 | |
| 140 | Q | A | -0.9140 | |
| 141 | A | A | -0.5712 | |
| 142 | G | A | -1.0400 | |
| 143 | S | A | -0.7900 | |
| 144 | T | A | -0.7977 | |
| 145 | P | A | -1.0095 | |
| 147 | N | A | -1.3938 | |
| 148 | G | A | -0.9988 | |
| 149 | V | A | 0.0205 | |
| 150 | E | A | -0.8184 | |
| 151 | G | A | -0.1770 | |
| 152 | F | A | 0.9468 | |
| 153 | N | A | -0.6040 | |
| 155 | Y | A | 0.7081 | |
| 156 | F | A | 0.5375 | |
| 157 | P | A | 0.0000 | |
| 158 | L | A | 0.3796 | |
| 159 | Q | A | 0.0882 | |
| 160 | S | A | 0.0000 | |
| 161 | Y | A | 0.0000 | |
| 162 | G | A | -0.2386 | |
| 163 | F | A | 0.0000 | |
| 164 | Q | A | -0.7014 | |
| 165 | P | A | -0.7391 | |
| 166 | T | A | -0.2180 | |
| 167 | N | A | -0.0895 | |
| 168 | G | A | 0.3861 | |
| 169 | V | A | 1.2887 | |
| 170 | G | A | 0.2029 | |
| 171 | Y | A | 0.5182 | |
| 172 | Q | A | -0.1006 | |
| 173 | P | A | 0.0000 | |
| 174 | Y | A | 0.1020 | |
| 175 | R | A | -0.4064 | |
| 176 | V | A | 0.0000 | |
| 177 | V | A | 0.0000 | |
| 178 | V | A | 0.0000 | |
| 179 | L | A | 0.0000 | |
| 180 | S | A | -0.1908 | |
| 181 | F | A | 0.0000 | |
| 182 | E | A | -0.3597 | |
| 183 | L | A | 1.2109 | |
| 184 | V | A | 0.8279 | |
| 185 | K | A | -0.7073 | |
| 186 | L | A | -0.0763 | |
| 187 | V | A | 0.4478 | |
| 188 | E | A | -0.0229 | |
| 189 | S | A | -0.6519 | |
| 190 | G | A | -1.1367 | |
| 191 | G | A | -0.4664 | |
| 192 | G | A | 0.1009 | |
| 193 | L | A | 1.2871 | |
| 194 | V | A | 0.2036 | |
| 195 | K | A | -1.5979 | |
| 196 | P | A | -1.8797 | |
| 197 | G | A | -1.4879 | |
| 198 | G | A | -0.9439 | |
| 199 | S | A | -0.9529 | |
| 200 | L | A | -0.8544 | |
| 201 | K | A | -1.9400 | |
| 202 | L | A | 0.0000 | |
| 203 | S | A | -0.4379 | |
| 205 | A | A | -0.4223 | |
| 206 | A | A | 0.0000 | |
| 207 | S | A | -0.4474 | |
| 208 | G | A | -0.0907 | |
| 209 | F | A | 0.3144 | |
| 210 | T | A | 0.1179 | |
| 211 | F | A | 0.0000 | |
| 212 | S | A | -0.7471 | |
| 213 | S | A | 0.0000 | |
| 214 | Y | A | -0.2895 | |
| 215 | A | A | 0.0000 | |
| 216 | M | A | 0.0000 | |
| 217 | S | A | 0.0000 | |
| 218 | W | A | 0.0000 | |
| 219 | V | A | 0.0000 | |
| 220 | R | A | 0.0000 | |
| 221 | Q | A | 0.0000 | |
| 222 | T | A | 0.0000 | |
| 223 | P | A | -1.7324 | |
| 224 | E | A | -2.9792 | |
| 225 | K | A | -3.0615 | |
| 226 | R | A | -2.2667 | |
| 227 | L | A | 0.0000 | |
| 228 | E | A | -0.8845 | |
| 229 | W | A | 0.0000 | |
| 230 | V | A | 0.0000 | |
| 231 | A | A | 0.0000 | |
| 232 | T | A | 0.0000 | |
| 233 | I | A | 0.0000 | |
| 234 | S | A | 0.2004 | |
| 235 | S | A | 0.0000 | |
| 236 | G | A | -0.7357 | |
| 237 | G | A | -0.3992 | |
| 238 | T | A | 0.2843 | |
| 239 | Y | A | 1.1022 | |
| 240 | T | A | 0.8001 | |
| 241 | Y | A | 0.3532 | |
| 242 | Y | A | -0.5805 | |
| 243 | P | A | -1.3869 | |
| 244 | D | A | -2.6231 | |
| 245 | S | A | -1.6095 | |
| 246 | V | A | 0.0000 | |
| 247 | K | A | -2.5948 | |
| 248 | G | A | -1.6513 | |
| 249 | R | A | -1.1602 | |
| 250 | F | A | 0.0000 | |
| 251 | T | A | -0.7285 | |
| 252 | I | A | 0.0000 | |
| 253 | S | A | -0.3210 | |
| 254 | R | A | -1.0925 | |
| 255 | D | A | -1.8309 | |
| 256 | N | A | -1.8584 | |
| 257 | A | A | -1.4743 | |
| 258 | E | A | -2.4017 | |
| 259 | N | A | -1.7394 | |
| 260 | T | A | 0.0000 | |
| 261 | L | A | 0.0000 | |
| 262 | Y | A | -0.3418 | |
| 263 | L | A | 0.0000 | |
| 264 | Q | A | -1.0360 | |
| 265 | M | A | 0.0000 | |
| 266 | S | A | -1.0174 | |
| 267 | S | A | -0.9406 | |
| 268 | L | A | 0.0000 | |
| 269 | R | A | -2.7332 | |
| 270 | S | A | -2.0813 | |
| 271 | E | A | -2.0810 | |
| 272 | D | A | 0.0000 | |
| 273 | T | A | -0.4555 | |
| 274 | A | A | 0.0000 | |
| 275 | M | A | -0.0005 | |
| 276 | Y | A | 0.0000 | |
| 277 | Y | A | 0.0000 | |
| 279 | V | A | 0.0000 | |
| 280 | R | A | -0.6172 | |
| 281 | D | A | -0.8127 | |
| 282 | G | A | -0.9599 | |
| 283 | N | A | -1.4531 | |
| 284 | S | A | -0.8338 | |
| 285 | M | A | 0.0000 | |
| 286 | D | A | -0.7668 | |
| 287 | Y | A | -0.2033 | |
| 288 | W | A | 0.0000 | |
| 289 | G | A | -0.5727 | |
| 290 | Q | A | -1.1109 | |
| 291 | G | A | -0.3788 | |
| 292 | T | A | -0.2854 | |
| 293 | S | A | 0.0587 | |
| 294 | V | A | 0.3672 | |
| 295 | D | A | -2.3704 | |
| 296 | I | A | 0.0000 | |
| 297 | Q | A | -2.1224 | |
| 298 | M | A | -1.4574 | |
| 299 | T | A | -0.9544 | |
| 300 | Q | A | -0.5449 | |
| 301 | T | A | -0.2283 | |
| 302 | T | A | -0.1954 | |
| 303 | S | A | -0.4534 | |
| 304 | S | A | -0.7078 | |
| 305 | L | A | -0.2019 | |
| 306 | S | A | -0.2515 | |
| 307 | A | A | -0.2908 | |
| 308 | S | A | -0.7602 | |
| 309 | L | A | -0.7287 | |
| 310 | G | A | -1.7694 | |
| 311 | D | A | -2.4609 | |
| 312 | R | A | -2.8639 | |
| 313 | V | A | 0.0000 | |
| 314 | T | A | -0.2940 | |
| 315 | I | A | 0.0000 | |
| 316 | I | A | 0.0588 | |
| 318 | R | A | -2.7195 | |
| 319 | A | A | -2.3459 | |
| 320 | S | A | -2.2285 | |
| 321 | Q | A | -2.9967 | |
| 322 | D | A | -2.9564 | |
| 323 | I | A | 0.0000 | |
| 324 | N | A | -1.2767 | |
| 325 | N | A | -0.7772 | |
| 326 | Y | A | 0.0000 | |
| 327 | L | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | W | A | 0.0000 | |
| 330 | Y | A | 0.0000 | |
| 331 | Q | A | 0.0000 | |
| 332 | Q | A | -1.0505 | |
| 333 | K | A | -1.8816 | |
| 334 | P | A | -1.7783 | |
| 335 | D | A | -2.2367 | |
| 336 | G | A | -1.5869 | |
| 337 | T | A | -1.3780 | |
| 338 | V | A | 0.0000 | |
| 339 | K | A | -0.7222 | |
| 340 | L | A | -0.0141 | |
| 341 | L | A | 0.0000 | |
| 342 | I | A | 0.0000 | |
| 343 | Y | A | 0.0976 | |
| 344 | Y | A | -0.0940 | |
| 345 | T | A | 0.0000 | |
| 346 | S | A | -0.8479 | |
| 347 | R | A | -1.3727 | |
| 348 | L | A | -0.0176 | |
| 350 | S | A | -0.4343 | |
| 351 | G | A | -0.4622 | |
| 352 | V | A | 0.0000 | |
| 353 | P | A | -0.2957 | |
| 354 | S | A | -0.3540 | |
| 355 | R | A | -1.0049 | |
| 356 | F | A | 0.0000 | |
| 357 | S | A | -0.5716 | |
| 358 | G | A | -0.4107 | |
| 359 | S | A | -0.7398 | |
| 360 | G | A | -1.0139 | |
| 361 | S | A | -1.1204 | |
| 362 | G | A | -1.7343 | |
| 363 | S | A | -2.3056 | |
| 364 | D | A | -2.3226 | |
| 365 | Y | A | 0.0000 | |
| 366 | S | A | -0.4083 | |
| 367 | L | A | 0.0000 | |
| 368 | T | A | -0.5787 | |
| 369 | I | A | 0.0000 | |
| 370 | S | A | -1.9620 | |
| 371 | N | A | -2.3290 | |
| 372 | L | A | 0.0000 | |
| 373 | E | A | -2.8361 | |
| 374 | Q | A | -2.2717 | |
| 375 | E | A | -2.8637 | |
| 376 | D | A | 0.0000 | |
| 377 | I | A | -1.1794 | |
| 378 | A | A | 0.0000 | |
| 379 | T | A | -0.8855 | |
| 380 | Y | A | 0.0000 | |
| 381 | F | A | 0.0000 | |
| 383 | Q | A | 0.0000 | |
| 384 | Q | A | 0.0000 | |
| 385 | A | A | 0.0052 | |
| 386 | N | A | -0.4352 | |
| 387 | T | A | -0.2833 | |
| 388 | L | A | -0.0686 | |
| 389 | P | A | -0.6403 | |
| 390 | P | A | -0.2611 | |
| 391 | T | A | -0.5667 | |
| 392 | F | A | -0.2701 | |
| 393 | G | A | -0.6878 | |
| 394 | A | A | -0.8503 | |
| 395 | G | A | -0.7601 | |
| 396 | T | A | 0.0000 | |
| 397 | K | A | -0.9164 | |
| 398 | L | A | 0.0000 | |
| 399 | E | A | -0.5380 | |
| 400 | L | A | 0.8724 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine