| Chain sequence(s) |
A: FAKATRNFLREVDADGDLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQFLSLTLGDVLIEDQFPSPVVVESDFVKYEGKFANHVSGTLETALGKVKLNLGGSSRVESQSSFGTLRKQEVDLQQLIRDSAERTINLRNPVLQQVLEGRNEVLCVLTQKITTMQKCVISEHMQVEEKCGGIVGIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELYVKLDGQFEFCLLRGKQGGFENKKRIDSVYLDPLVFREFAFIDMPDAAHGISSQDGPLSVLKQATLLLERNFHPFAELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGLSPTVAVLGELKPRQQQDLVAFLQLVGCSLQGGCPGPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLLRALSDDGVSDLEDPTLTPLKDTERFGIVQRLFASADISLERLKSSVKAVILKDSKVFPLLLCITLNGLCALGREHS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:09:48)
[INFO] Main: Simulation completed successfully. (00:09:51)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 54 | F | A | -0.4593 | |
| 55 | A | A | -1.2423 | |
| 56 | K | A | -2.2926 | |
| 57 | A | A | 0.0000 | |
| 58 | T | A | 0.0000 | |
| 59 | R | A | -2.7629 | |
| 60 | N | A | -2.4107 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | R | A | -3.3534 | |
| 64 | E | A | -2.9602 | |
| 65 | V | A | -1.3710 | |
| 66 | D | A | -2.2030 | |
| 67 | A | A | -2.2909 | |
| 68 | D | A | -2.9172 | |
| 69 | G | A | -2.1352 | |
| 70 | D | A | -2.2815 | |
| 71 | L | A | -1.1645 | |
| 72 | I | A | -0.6689 | |
| 73 | A | A | -1.0658 | |
| 74 | V | A | 0.0000 | |
| 75 | S | A | -1.2351 | |
| 76 | N | A | -1.3314 | |
| 77 | L | A | -1.1061 | |
| 78 | N | A | -2.4059 | |
| 79 | D | A | -2.6335 | |
| 80 | S | A | -2.3993 | |
| 81 | D | A | -3.2785 | |
| 82 | K | A | -3.2698 | |
| 83 | L | A | 0.0000 | |
| 84 | Q | A | -1.9652 | |
| 85 | L | A | -0.6237 | |
| 86 | L | A | 0.0000 | |
| 87 | S | A | 0.0000 | |
| 88 | L | A | 0.0000 | |
| 89 | V | A | 0.0000 | |
| 90 | T | A | 0.0000 | |
| 91 | K | A | 0.0000 | |
| 92 | K | A | -2.2428 | |
| 93 | K | A | -2.1943 | |
| 94 | R | A | -1.0900 | |
| 95 | F | A | 0.2481 | |
| 96 | W | A | 0.0000 | |
| 97 | C | A | -0.1707 | |
| 98 | W | A | 0.0000 | |
| 99 | Q | A | 0.0000 | |
| 100 | R | A | -1.6383 | |
| 101 | P | A | -1.6498 | |
| 102 | K | A | -1.8641 | |
| 103 | Y | A | -1.1780 | |
| 104 | Q | A | -1.4053 | |
| 105 | F | A | -0.9170 | |
| 106 | L | A | 0.0000 | |
| 107 | S | A | -0.7659 | |
| 108 | L | A | -0.5707 | |
| 109 | T | A | -0.7072 | |
| 110 | L | A | 0.0000 | |
| 111 | G | A | -1.5126 | |
| 112 | D | A | -2.2763 | |
| 113 | V | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | I | A | -0.8140 | |
| 116 | E | A | -2.9322 | |
| 117 | D | A | -3.1864 | |
| 118 | Q | A | -2.5655 | |
| 119 | F | A | -1.4225 | |
| 120 | P | A | -0.4660 | |
| 121 | S | A | 0.0232 | |
| 122 | P | A | 0.6573 | |
| 123 | V | A | 1.4019 | |
| 124 | V | A | 1.0273 | |
| 125 | V | A | 0.8131 | |
| 126 | E | A | -1.4938 | |
| 127 | S | A | -1.6662 | |
| 128 | D | A | -2.2378 | |
| 129 | F | A | -0.8153 | |
| 130 | V | A | -0.6284 | |
| 131 | K | A | -1.9272 | |
| 132 | Y | A | 0.0000 | |
| 133 | E | A | -2.6179 | |
| 134 | G | A | 0.0000 | |
| 135 | K | A | -2.4390 | |
| 136 | F | A | -1.3120 | |
| 137 | A | A | -1.2605 | |
| 138 | N | A | -1.4186 | |
| 139 | H | A | -1.3889 | |
| 140 | V | A | -0.6515 | |
| 141 | S | A | -0.5063 | |
| 142 | G | A | -0.4550 | |
| 143 | T | A | -0.5634 | |
| 144 | L | A | -0.6517 | |
| 145 | E | A | -1.7851 | |
| 146 | T | A | -0.6066 | |
| 147 | A | A | 0.2345 | |
| 148 | L | A | 1.0198 | |
| 149 | G | A | -0.4625 | |
| 150 | K | A | -1.4967 | |
| 151 | V | A | 0.0825 | |
| 152 | K | A | -1.3485 | |
| 153 | L | A | -0.0540 | |
| 154 | N | A | -1.0979 | |
| 155 | L | A | 0.2435 | |
| 156 | G | A | -0.7175 | |
| 157 | G | A | -1.3928 | |
| 158 | S | A | -1.2529 | |
| 159 | S | A | -1.4334 | |
| 160 | R | A | -1.6477 | |
| 161 | V | A | -1.2902 | |
| 162 | E | A | -2.2389 | |
| 163 | S | A | -1.4620 | |
| 164 | Q | A | -1.6165 | |
| 165 | S | A | 0.0000 | |
| 166 | S | A | -1.5198 | |
| 167 | F | A | 0.0000 | |
| 168 | G | A | -1.3155 | |
| 169 | T | A | -1.2729 | |
| 170 | L | A | 0.0000 | |
| 171 | R | A | -1.5313 | |
| 172 | K | A | -1.4025 | |
| 173 | Q | A | -1.2942 | |
| 174 | E | A | -0.7240 | |
| 175 | V | A | 0.0000 | |
| 176 | D | A | -0.0584 | |
| 177 | L | A | -0.4596 | |
| 178 | Q | A | -1.4378 | |
| 179 | Q | A | -1.1015 | |
| 180 | L | A | 0.0000 | |
| 181 | I | A | -0.9631 | |
| 182 | R | A | -2.1710 | |
| 183 | D | A | -1.4884 | |
| 184 | S | A | 0.0000 | |
| 185 | A | A | -1.6328 | |
| 186 | E | A | -2.3446 | |
| 187 | R | A | -1.6657 | |
| 188 | T | A | -1.2086 | |
| 189 | I | A | 0.0000 | |
| 190 | N | A | -1.4589 | |
| 191 | L | A | -1.2633 | |
| 192 | R | A | -2.0985 | |
| 193 | N | A | -1.6300 | |
| 194 | P | A | -1.0475 | |
| 195 | V | A | -0.3349 | |
| 196 | L | A | 0.0000 | |
| 197 | Q | A | -2.0716 | |
| 198 | Q | A | -2.1567 | |
| 199 | V | A | 0.0000 | |
| 200 | L | A | -1.6157 | |
| 201 | E | A | -2.8922 | |
| 202 | G | A | -2.6597 | |
| 203 | R | A | -3.2453 | |
| 204 | N | A | -2.7361 | |
| 205 | E | A | -2.3305 | |
| 206 | V | A | 0.0000 | |
| 207 | L | A | 0.0000 | |
| 208 | C | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | L | A | 0.0000 | |
| 211 | T | A | 0.0000 | |
| 212 | Q | A | -0.7570 | |
| 213 | K | A | -0.7869 | |
| 214 | I | A | 0.0000 | |
| 215 | T | A | 0.0000 | |
| 216 | T | A | 0.0000 | |
| 217 | M | A | -0.6157 | |
| 218 | Q | A | -1.0337 | |
| 219 | K | A | -2.1512 | |
| 220 | C | A | 0.0000 | |
| 221 | V | A | -0.1140 | |
| 222 | I | A | 0.0000 | |
| 223 | S | A | 0.0000 | |
| 224 | E | A | -0.4516 | |
| 225 | H | A | -1.2388 | |
| 226 | M | A | -1.4303 | |
| 227 | Q | A | -2.3934 | |
| 228 | V | A | -1.6732 | |
| 229 | E | A | -2.2683 | |
| 230 | E | A | -2.3379 | |
| 231 | K | A | -2.3072 | |
| 232 | C | A | -0.1052 | |
| 233 | G | A | -0.2226 | |
| 234 | G | A | 0.8152 | |
| 235 | I | A | 2.8622 | |
| 236 | V | A | 2.8193 | |
| 237 | G | A | 1.5465 | |
| 238 | I | A | 1.8403 | |
| 239 | Q | A | -0.5999 | |
| 240 | T | A | -0.7583 | |
| 241 | K | A | -1.4687 | |
| 242 | T | A | -0.3116 | |
| 243 | V | A | 0.9608 | |
| 244 | Q | A | -0.1644 | |
| 245 | V | A | 0.7237 | |
| 246 | S | A | -0.1184 | |
| 247 | A | A | -0.7388 | |
| 248 | T | A | -1.4475 | |
| 249 | E | A | -2.8282 | |
| 250 | D | A | -3.0274 | |
| 251 | G | A | -2.1145 | |
| 252 | N | A | -1.9061 | |
| 253 | V | A | -1.1732 | |
| 254 | T | A | -1.5240 | |
| 255 | K | A | -2.2833 | |
| 256 | D | A | -2.6865 | |
| 257 | S | A | -1.3858 | |
| 258 | N | A | -0.8178 | |
| 259 | V | A | 1.5245 | |
| 260 | V | A | 1.9775 | |
| 261 | L | A | 0.8215 | |
| 262 | E | A | -1.1386 | |
| 263 | I | A | 0.0000 | |
| 264 | P | A | -1.1956 | |
| 265 | A | A | -0.9863 | |
| 266 | A | A | -0.4839 | |
| 267 | T | A | 0.0000 | |
| 268 | T | A | 0.0000 | |
| 269 | I | A | 0.0000 | |
| 270 | A | A | 0.0000 | |
| 271 | Y | A | 0.0000 | |
| 272 | G | A | 0.0000 | |
| 273 | V | A | 0.0842 | |
| 274 | I | A | 0.2442 | |
| 275 | E | A | -0.3164 | |
| 276 | L | A | 0.0000 | |
| 277 | Y | A | -0.7503 | |
| 278 | V | A | 0.0000 | |
| 279 | K | A | -1.7115 | |
| 280 | L | A | -1.3185 | |
| 281 | D | A | -1.9959 | |
| 282 | G | A | 0.0000 | |
| 283 | Q | A | -2.1255 | |
| 284 | F | A | -1.4056 | |
| 285 | E | A | -1.1692 | |
| 286 | F | A | 0.0637 | |
| 287 | C | A | -0.2442 | |
| 288 | L | A | 0.8813 | |
| 289 | L | A | 0.4842 | |
| 290 | R | A | -1.7317 | |
| 291 | G | A | -1.9186 | |
| 292 | K | A | -2.1802 | |
| 293 | Q | A | -1.7240 | |
| 294 | G | A | 0.0000 | |
| 295 | G | A | -0.8795 | |
| 296 | F | A | -0.5767 | |
| 297 | E | A | -1.9356 | |
| 298 | N | A | -3.1874 | |
| 299 | K | A | -3.4376 | |
| 300 | K | A | -3.6548 | |
| 301 | R | A | -2.7335 | |
| 302 | I | A | -0.1849 | |
| 303 | D | A | -0.7324 | |
| 304 | S | A | 0.6647 | |
| 305 | V | A | 1.8592 | |
| 306 | Y | A | 1.5600 | |
| 307 | L | A | 0.8097 | |
| 308 | D | A | -0.4614 | |
| 309 | P | A | 0.0000 | |
| 310 | L | A | 0.5664 | |
| 311 | V | A | -0.0324 | |
| 312 | F | A | 0.0000 | |
| 313 | R | A | -1.2351 | |
| 314 | E | A | -0.6438 | |
| 315 | F | A | 0.0000 | |
| 316 | A | A | 0.3063 | |
| 317 | F | A | 1.2241 | |
| 318 | I | A | 0.7854 | |
| 319 | D | A | -0.8594 | |
| 320 | M | A | -0.4788 | |
| 321 | P | A | -1.6468 | |
| 322 | D | A | -1.4957 | |
| 323 | A | A | -1.5846 | |
| 324 | A | A | -1.1983 | |
| 325 | H | A | -1.5668 | |
| 326 | G | A | -0.2328 | |
| 327 | I | A | 1.3238 | |
| 328 | S | A | -0.4379 | |
| 329 | S | A | -0.8841 | |
| 330 | Q | A | -1.9831 | |
| 331 | D | A | -2.7592 | |
| 332 | G | A | -2.1834 | |
| 333 | P | A | -1.6825 | |
| 334 | L | A | 0.0000 | |
| 335 | S | A | -1.8731 | |
| 336 | V | A | -0.8223 | |
| 337 | L | A | 0.0000 | |
| 338 | K | A | -1.3195 | |
| 339 | Q | A | -0.9007 | |
| 340 | A | A | 0.0000 | |
| 341 | T | A | 0.0000 | |
| 342 | L | A | -0.8688 | |
| 343 | L | A | -0.7460 | |
| 344 | L | A | 0.0000 | |
| 345 | E | A | -2.5992 | |
| 346 | R | A | -2.6896 | |
| 347 | N | A | 0.0000 | |
| 348 | F | A | 0.0000 | |
| 349 | H | A | -2.3711 | |
| 350 | P | A | -1.4526 | |
| 351 | F | A | 0.0000 | |
| 352 | A | A | -2.1799 | |
| 353 | E | A | -2.3020 | |
| 354 | L | A | -1.5278 | |
| 355 | P | A | -1.6407 | |
| 356 | E | A | -2.6267 | |
| 357 | P | A | -1.3522 | |
| 358 | Q | A | -1.3859 | |
| 359 | Q | A | -1.7799 | |
| 360 | T | A | -1.5880 | |
| 361 | A | A | -1.1030 | |
| 362 | L | A | 0.0000 | |
| 363 | S | A | -1.2900 | |
| 364 | D | A | -1.9851 | |
| 365 | I | A | 0.0000 | |
| 366 | F | A | 0.0000 | |
| 367 | Q | A | -0.7234 | |
| 368 | A | A | -0.4109 | |
| 369 | V | A | 0.0000 | |
| 370 | L | A | 0.0000 | |
| 371 | F | A | 0.7559 | |
| 372 | D | A | -0.5979 | |
| 373 | D | A | -2.0197 | |
| 374 | E | A | -1.5780 | |
| 375 | L | A | 0.0000 | |
| 376 | L | A | -0.2142 | |
| 377 | M | A | 0.2006 | |
| 378 | V | A | 0.0000 | |
| 379 | L | A | 0.0000 | |
| 380 | E | A | 0.0203 | |
| 381 | P | A | 0.0522 | |
| 382 | V | A | 0.0000 | |
| 383 | C | A | 0.0000 | |
| 384 | D | A | 0.0000 | |
| 385 | D | A | 0.0164 | |
| 386 | L | A | 0.0000 | |
| 387 | V | A | 0.3952 | |
| 388 | S | A | -0.0550 | |
| 389 | G | A | 0.0715 | |
| 390 | L | A | 0.9906 | |
| 391 | S | A | 0.3029 | |
| 392 | P | A | 0.0000 | |
| 393 | T | A | 1.0319 | |
| 394 | V | A | 1.6084 | |
| 395 | A | A | 0.6132 | |
| 396 | V | A | 0.4288 | |
| 397 | L | A | -0.0893 | |
| 398 | G | A | -1.0224 | |
| 399 | E | A | -2.0931 | |
| 400 | L | A | 0.0000 | |
| 401 | K | A | -3.1727 | |
| 402 | P | A | -2.7425 | |
| 403 | R | A | -3.1011 | |
| 404 | Q | A | 0.0000 | |
| 405 | Q | A | -2.4590 | |
| 406 | Q | A | -2.3728 | |
| 407 | D | A | -1.9693 | |
| 408 | L | A | 0.0000 | |
| 409 | V | A | -0.3531 | |
| 410 | A | A | -0.5936 | |
| 411 | F | A | 0.0000 | |
| 412 | L | A | 0.0000 | |
| 413 | Q | A | -1.0244 | |
| 414 | L | A | -0.4252 | |
| 415 | V | A | 0.0000 | |
| 416 | G | A | -1.1119 | |
| 417 | C | A | 0.0000 | |
| 418 | S | A | -0.7387 | |
| 419 | L | A | -0.2974 | |
| 420 | Q | A | -1.3625 | |
| 421 | G | A | -1.1967 | |
| 422 | G | A | -0.7818 | |
| 423 | C | A | -0.5666 | |
| 424 | P | A | -1.3092 | |
| 425 | G | A | -1.5406 | |
| 426 | P | A | -1.5439 | |
| 427 | E | A | -2.7983 | |
| 428 | D | A | -2.6899 | |
| 429 | A | A | -1.6578 | |
| 430 | G | A | -1.4289 | |
| 431 | S | A | -1.3020 | |
| 432 | K | A | -1.3388 | |
| 433 | Q | A | -1.0439 | |
| 434 | L | A | 0.0000 | |
| 435 | F | A | 0.0000 | |
| 436 | M | A | 0.0000 | |
| 437 | T | A | 0.0000 | |
| 438 | A | A | 0.0000 | |
| 439 | Y | A | 0.0000 | |
| 440 | F | A | 0.0000 | |
| 441 | L | A | 0.0000 | |
| 442 | V | A | 0.0000 | |
| 443 | S | A | 0.0000 | |
| 444 | A | A | 0.0000 | |
| 445 | L | A | 0.0000 | |
| 446 | A | A | -0.4164 | |
| 447 | E | A | -0.5686 | |
| 448 | M | A | 0.0000 | |
| 449 | P | A | -0.9380 | |
| 450 | D | A | -2.4236 | |
| 451 | S | A | -1.2743 | |
| 452 | A | A | 0.0000 | |
| 453 | A | A | -0.4814 | |
| 454 | A | A | -0.0739 | |
| 455 | L | A | 0.0000 | |
| 456 | L | A | 0.0000 | |
| 457 | G | A | 0.0000 | |
| 458 | T | A | -0.4830 | |
| 459 | C | A | 0.0000 | |
| 460 | C | A | -1.0944 | |
| 461 | K | A | -1.8980 | |
| 462 | L | A | -1.0385 | |
| 463 | Q | A | -1.7763 | |
| 464 | I | A | 0.0000 | |
| 465 | I | A | 0.0000 | |
| 466 | P | A | -0.9062 | |
| 467 | T | A | 0.0000 | |
| 468 | L | A | 0.0000 | |
| 469 | C | A | 0.0000 | |
| 470 | H | A | -0.4769 | |
| 471 | L | A | 0.0000 | |
| 472 | L | A | 0.0000 | |
| 473 | R | A | -1.1025 | |
| 474 | A | A | -0.9808 | |
| 475 | L | A | 0.0000 | |
| 476 | S | A | -1.9113 | |
| 477 | D | A | -2.9998 | |
| 478 | D | A | -2.5765 | |
| 479 | G | A | 0.0000 | |
| 480 | V | A | -1.1220 | |
| 481 | S | A | 0.0000 | |
| 482 | D | A | -2.7043 | |
| 483 | L | A | 0.0000 | |
| 484 | E | A | -2.9712 | |
| 485 | D | A | -2.0271 | |
| 486 | P | A | -1.2131 | |
| 487 | T | A | -0.6753 | |
| 488 | L | A | 0.0000 | |
| 489 | T | A | -1.2386 | |
| 490 | P | A | -1.0631 | |
| 491 | L | A | 0.0000 | |
| 492 | K | A | -2.5469 | |
| 493 | D | A | -1.7029 | |
| 494 | T | A | -1.2136 | |
| 495 | E | A | -1.2005 | |
| 496 | R | A | -1.2749 | |
| 497 | F | A | 0.0000 | |
| 498 | G | A | -1.2133 | |
| 499 | I | A | -0.7566 | |
| 500 | V | A | 0.0000 | |
| 501 | Q | A | -1.8401 | |
| 502 | R | A | -1.8584 | |
| 503 | L | A | 0.0000 | |
| 504 | F | A | 0.0000 | |
| 505 | A | A | -0.3811 | |
| 506 | S | A | -0.7769 | |
| 507 | A | A | 0.0000 | |
| 508 | D | A | -0.2146 | |
| 509 | I | A | 0.0000 | |
| 510 | S | A | -0.3814 | |
| 511 | L | A | 0.0000 | |
| 512 | E | A | -1.9033 | |
| 513 | R | A | -2.2263 | |
| 514 | L | A | -1.4016 | |
| 515 | K | A | -2.0874 | |
| 516 | S | A | -2.1281 | |
| 517 | S | A | -2.1565 | |
| 518 | V | A | 0.0000 | |
| 519 | K | A | -1.3279 | |
| 520 | A | A | 0.0000 | |
| 521 | V | A | 0.6928 | |
| 522 | I | A | 0.4533 | |
| 523 | L | A | 0.5870 | |
| 524 | K | A | -1.7835 | |
| 525 | D | A | -2.4583 | |
| 526 | S | A | -1.4207 | |
| 527 | K | A | -0.6236 | |
| 528 | V | A | -0.2350 | |
| 529 | F | A | 0.2710 | |
| 530 | P | A | 0.0000 | |
| 531 | L | A | 0.0000 | |
| 532 | L | A | 0.0000 | |
| 533 | L | A | 0.0000 | |
| 534 | C | A | 0.0000 | |
| 535 | I | A | 0.0000 | |
| 536 | T | A | 0.0000 | |
| 537 | L | A | 0.0000 | |
| 538 | N | A | 0.0000 | |
| 539 | G | A | 0.0000 | |
| 540 | L | A | 0.0000 | |
| 541 | C | A | -0.8871 | |
| 542 | A | A | -1.4863 | |
| 543 | L | A | 0.0000 | |
| 544 | G | A | -2.0114 | |
| 545 | R | A | -3.5470 | |
| 546 | E | A | -3.3155 | |
| 547 | H | A | -2.5844 | |
| 548 | S | A | -1.6263 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine