| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIIKNGKVVVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTAPVHETADVRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRAGPEGHPLPDAPPPSKLYTPPPPSSPTAVRPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEVNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9497 | |
| 2 | L | A | 1.9701 | |
| 3 | P | A | 0.6496 | |
| 4 | P | A | 0.3769 | |
| 5 | T | A | 0.1244 | |
| 6 | T | A | 0.1307 | |
| 7 | P | A | 0.1952 | |
| 8 | V | A | 1.2468 | |
| 9 | A | A | 0.0897 | |
| 10 | K | A | -1.0574 | |
| 11 | V | A | -0.2024 | |
| 12 | Q | A | -1.4344 | |
| 13 | S | A | -1.5608 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4421 | |
| 16 | E | A | -2.4512 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4560 | |
| 20 | P | A | 0.1057 | |
| 21 | T | A | 0.1164 | |
| 22 | S | A | -0.1692 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1038 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1267 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.6185 | |
| 31 | R | A | -2.5428 | |
| 32 | L | A | -0.7135 | |
| 33 | L | A | 1.2480 | |
| 34 | T | A | 1.4732 | |
| 35 | V | A | 2.0249 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.1745 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.5929 | |
| 40 | K | A | -1.5066 | |
| 41 | D | A | -0.6450 | |
| 42 | I | A | 1.0501 | |
| 43 | I | A | 1.3023 | |
| 44 | K | A | -1.0412 | |
| 45 | N | A | -1.8680 | |
| 46 | G | A | -1.1616 | |
| 47 | K | A | -0.8410 | |
| 48 | V | A | 1.6405 | |
| 49 | V | A | 2.1610 | |
| 50 | V | A | 1.4084 | |
| 51 | P | A | 0.6096 | |
| 52 | K | A | -0.5353 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1088 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3632 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2612 | |
| 70 | K | A | -1.8065 | |
| 71 | F | A | -0.6550 | |
| 72 | A | A | -0.5678 | |
| 73 | L | A | -0.8596 | |
| 74 | P | A | -1.2635 | |
| 75 | Q | A | -2.4831 | |
| 76 | K | A | -3.0972 | |
| 77 | D | A | -2.9939 | |
| 78 | F | A | -1.6461 | |
| 79 | Y | A | -1.9182 | |
| 80 | D | A | -2.7534 | |
| 81 | P | A | -2.3431 | |
| 82 | E | A | -3.0664 | |
| 83 | K | A | -3.4449 | |
| 84 | E | A | -2.5080 | |
| 85 | R | A | -1.3100 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6652 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9542 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3111 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6692 | |
| 99 | G | A | -0.5265 | |
| 100 | P | A | -0.4240 | |
| 101 | L | A | -0.0007 | |
| 102 | G | A | -0.3450 | |
| 103 | K | A | -0.8911 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4990 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | 0.1374 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3994 | |
| 110 | L | A | 0.3436 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0581 | |
| 113 | K | A | -0.5977 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.4545 | |
| 117 | T | A | -1.3763 | |
| 118 | E | A | -2.7403 | |
| 119 | N | A | -2.4267 | |
| 120 | P | A | -1.5230 | |
| 121 | T | A | -0.7882 | |
| 122 | A | A | -0.3077 | |
| 123 | P | A | -0.4526 | |
| 124 | V | A | -0.2619 | |
| 125 | H | A | -1.2968 | |
| 126 | E | A | -2.4390 | |
| 127 | T | A | -1.6840 | |
| 128 | A | A | -1.2902 | |
| 129 | D | A | -2.1267 | |
| 130 | V | A | -1.3851 | |
| 131 | R | A | -0.8325 | |
| 132 | V | A | 0.3204 | |
| 133 | A | A | 0.4123 | |
| 134 | F | A | 0.2570 | |
| 135 | S | A | -0.0787 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7254 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5687 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2297 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1355 | |
| 157 | D | A | 0.3065 | |
| 158 | L | A | 0.7979 | |
| 159 | A | A | 0.1666 | |
| 160 | E | A | -1.4504 | |
| 161 | P | A | -0.2289 | |
| 162 | C | A | 0.1740 | |
| 163 | P | A | -0.1809 | |
| 164 | G | A | -0.0982 | |
| 165 | L | A | 0.5500 | |
| 166 | P | A | -0.1366 | |
| 167 | P | A | -0.3514 | |
| 168 | G | A | -0.4259 | |
| 169 | A | A | -0.0300 | |
| 170 | C | A | 0.6549 | |
| 171 | P | A | 0.5113 | |
| 172 | P | A | 0.6774 | |
| 173 | I | A | 1.9634 | |
| 174 | Q | A | 0.8443 | |
| 175 | L | A | 1.5071 | |
| 176 | V | A | 0.8597 | |
| 177 | N | A | -0.3187 | |
| 178 | S | A | 0.0262 | |
| 179 | V | A | 0.4090 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3704 | |
| 182 | D | A | 0.0802 | |
| 183 | G | A | -0.1647 | |
| 184 | D | A | -0.5690 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1496 | |
| 190 | F | A | 0.0584 | |
| 191 | G | A | -0.1072 | |
| 192 | N | A | -0.2824 | |
| 193 | M | A | -0.1540 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4439 | |
| 197 | E | A | -2.6478 | |
| 198 | L | A | -1.2511 | |
| 199 | Q | A | -2.5590 | |
| 200 | Q | A | -3.3607 | |
| 201 | D | A | -3.6094 | |
| 202 | R | A | -3.3553 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1828 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3966 | |
| 211 | S | A | -1.9211 | |
| 212 | T | A | -1.4841 | |
| 213 | R | A | -2.1760 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1743 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2867 | |
| 220 | L | A | 0.4891 | |
| 221 | K | A | -1.3341 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9722 | |
| 224 | N | A | -1.5836 | |
| 225 | E | A | -1.3284 | |
| 226 | A | A | -0.6241 | |
| 227 | Y | A | -0.4036 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7122 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1428 | |
| 234 | F | A | 0.0282 | |
| 235 | G | A | -0.9572 | |
| 236 | R | A | -2.7624 | |
| 237 | R | A | -3.1069 | |
| 238 | E | A | -2.2085 | |
| 239 | Q | A | -0.1483 | |
| 240 | V | A | 1.5626 | |
| 241 | Y | A | 1.2614 | |
| 242 | A | A | 0.1724 | |
| 243 | R | A | -1.3100 | |
| 244 | H | A | -1.1997 | |
| 245 | F | A | -0.2966 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | -0.3858 | |
| 248 | R | A | -0.6817 | |
| 249 | A | A | -1.3427 | |
| 250 | G | A | -1.1098 | |
| 251 | P | A | -0.9616 | |
| 252 | E | A | -1.3569 | |
| 253 | G | A | -1.2645 | |
| 254 | H | A | -1.4587 | |
| 255 | P | A | -1.3757 | |
| 256 | L | A | -0.4520 | |
| 257 | P | A | -1.0652 | |
| 258 | D | A | -1.9072 | |
| 259 | A | A | -1.1612 | |
| 260 | P | A | -1.1230 | |
| 261 | P | A | -0.8600 | |
| 262 | P | A | -0.7129 | |
| 263 | S | A | -0.9101 | |
| 264 | K | A | -1.0376 | |
| 265 | L | A | 0.8044 | |
| 266 | Y | A | 0.2979 | |
| 267 | T | A | -0.1202 | |
| 268 | P | A | -0.4318 | |
| 269 | P | A | -0.2716 | |
| 270 | P | A | -0.5698 | |
| 271 | P | A | -0.3677 | |
| 272 | S | A | -0.3293 | |
| 273 | S | A | -0.1828 | |
| 274 | P | A | -0.1102 | |
| 275 | T | A | 0.0167 | |
| 276 | A | A | 0.3027 | |
| 277 | V | A | 1.1142 | |
| 278 | R | A | 0.0294 | |
| 279 | P | A | -0.6408 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.5234 | |
| 282 | D | A | -0.8796 | |
| 283 | Y | A | 0.8395 | |
| 284 | F | A | 0.6620 | |
| 285 | G | A | 0.0885 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8184 | |
| 291 | L | A | 1.5915 | |
| 292 | V | A | 0.5778 | |
| 293 | S | A | -0.1624 | |
| 294 | S | A | -0.9677 | |
| 295 | D | A | -1.8458 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1642 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6354 | |
| 301 | R | A | -1.8548 | |
| 302 | P | A | -0.9520 | |
| 303 | F | A | -0.1757 | |
| 304 | W | A | -0.5218 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0869 | |
| 307 | R | A | -2.9286 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6528 | |
| 310 | G | A | -1.4224 | |
| 311 | N | A | -1.3592 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9808 | |
| 319 | N | A | -0.8986 | |
| 320 | E | A | -1.0542 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3922 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.2160 | |
| 333 | N | A | 0.3997 | |
| 334 | F | A | 1.4645 | |
| 335 | T | A | 0.7381 | |
| 336 | I | A | 0.4036 | |
| 337 | S | A | -0.8532 | |
| 338 | Q | A | -1.4897 | |
| 339 | Q | A | -1.1320 | |
| 340 | L | A | 0.6675 | |
| 341 | C | A | 0.1940 | |
| 342 | T | A | -0.2631 | |
| 343 | P | A | -1.0059 | |
| 344 | E | A | -1.6959 | |
| 345 | V | A | -0.1069 | |
| 346 | N | A | -0.4863 | |
| 347 | V | A | 1.5027 | |
| 348 | Y | A | 1.5958 | |
| 349 | D | A | 0.0870 | |
| 350 | P | A | -0.3434 | |
| 351 | S | A | -0.2684 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.4984 | |
| 354 | K | A | -1.6500 | |
| 355 | N | A | -1.6882 | |
| 356 | Y | A | -0.1061 | |
| 357 | L | A | 0.5634 | |
| 358 | R | A | 0.9112 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4777 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0022 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.8677 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6488 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2811 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3319 | |
| 376 | L | A | -1.7619 | |
| 377 | D | A | -2.0570 | |
| 378 | P | A | -1.0732 | |
| 379 | G | A | -1.0278 | |
| 380 | V | A | -0.9369 | |
| 381 | L | A | -0.5503 | |
| 382 | A | A | -0.6663 | |
| 383 | H | A | -0.8234 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4176 | |
| 386 | T | A | -0.5593 | |
| 387 | M | A | -0.3059 | |
| 388 | N | A | -0.8740 | |
| 389 | P | A | -1.3078 | |
| 390 | T | A | -1.6332 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5655 | |
| 393 | E | A | -2.8044 | |
| 394 | N | A | -2.7908 | |
| 395 | W | A | -1.5268 | |
| 396 | N | A | -1.0509 | |
| 397 | L | A | -0.1246 | |
| 398 | G | A | 0.5893 | |
| 399 | F | A | 2.4635 | |
| 400 | V | A | 1.8919 | |
| 401 | P | A | 0.0810 | |
| 402 | P | A | -1.9953 | |
| 403 | K | A | -3.5796 | |
| 404 | E | A | -4.1494 | |
| 405 | R | A | -4.5745 | |
| 406 | E | A | -4.1715 | |
| 407 | D | A | -3.0491 | |
| 408 | P | A | -1.8641 | |
| 409 | Y | A | -0.9857 | |
| 410 | K | A | -2.0994 | |
| 411 | G | A | -0.6350 | |
| 412 | L | A | 0.6640 | |
| 413 | I | A | 1.5801 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3905 | |
| 416 | E | A | -1.6535 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8416 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8973 | |
| 421 | E | A | -2.5142 | |
| 422 | R | A | -2.0209 | |
| 423 | F | A | -1.0375 | |
| 424 | S | A | -1.3312 | |
| 425 | Q | A | -1.7842 | |
| 426 | D | A | -2.8931 | |
| 427 | L | A | -2.0016 | |
| 428 | D | A | -2.7724 | |
| 429 | Q | A | -2.6124 | |
| 430 | F | A | -1.4589 | |
| 431 | A | A | -0.9342 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6928 | |
| 435 | K | A | -0.7953 | |
| 436 | F | A | 0.1074 | |
| 437 | L | A | 0.9967 | |
| 438 | Y | A | 0.7916 | |
| 439 | Q | A | -0.2888 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine