| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVVNGKVVVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTAPVHEGPDVRVNFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRAGPEGVPLPAAPPPSPLFVPPPPSSPYAVPPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQVSTPEINVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:02)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9462 | |
| 2 | L | A | 1.9710 | |
| 3 | P | A | 0.7047 | |
| 4 | P | A | 0.1154 | |
| 5 | T | A | 0.1914 | |
| 6 | T | A | 0.1636 | |
| 7 | P | A | 0.2731 | |
| 8 | V | A | 1.2592 | |
| 9 | A | A | 0.0663 | |
| 10 | K | A | -1.0954 | |
| 11 | V | A | -0.2863 | |
| 12 | Q | A | -1.3768 | |
| 13 | S | A | -1.5652 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4993 | |
| 16 | E | A | -2.4702 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4473 | |
| 20 | P | A | 0.0890 | |
| 21 | T | A | 0.0955 | |
| 22 | S | A | -0.1815 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1041 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.3276 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7794 | |
| 31 | R | A | -2.6968 | |
| 32 | L | A | -0.8159 | |
| 33 | L | A | 1.0924 | |
| 34 | T | A | 1.3573 | |
| 35 | V | A | 1.8795 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2593 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.7165 | |
| 40 | E | A | -1.9910 | |
| 41 | D | A | -0.8245 | |
| 42 | I | A | 1.2543 | |
| 43 | V | A | 2.2082 | |
| 44 | V | A | 1.6926 | |
| 45 | N | A | -0.5222 | |
| 46 | G | A | -0.3539 | |
| 47 | K | A | -0.1125 | |
| 48 | V | A | 2.1516 | |
| 49 | V | A | 2.4589 | |
| 50 | V | A | 1.4386 | |
| 51 | P | A | 0.2800 | |
| 52 | K | A | -0.7533 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1195 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.6258 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.3770 | |
| 70 | K | A | -1.8941 | |
| 71 | F | A | -0.9432 | |
| 72 | A | A | -0.6168 | |
| 73 | L | A | -0.9582 | |
| 74 | P | A | -1.2696 | |
| 75 | Q | A | -2.4754 | |
| 76 | K | A | -3.0913 | |
| 77 | D | A | -2.9790 | |
| 78 | F | A | -1.6593 | |
| 79 | Y | A | -1.8937 | |
| 80 | D | A | -2.7056 | |
| 81 | P | A | -2.3367 | |
| 82 | E | A | -3.0386 | |
| 83 | K | A | -3.4283 | |
| 84 | E | A | -2.4852 | |
| 85 | R | A | -1.2930 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.5030 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -1.0448 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.4553 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7743 | |
| 99 | G | A | -0.5857 | |
| 100 | P | A | -0.4822 | |
| 101 | L | A | -0.0993 | |
| 102 | G | A | -0.6372 | |
| 103 | K | A | -1.0708 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4933 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | -0.0561 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.2982 | |
| 110 | L | A | -0.0622 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0314 | |
| 113 | K | A | -0.3639 | |
| 114 | L | A | -0.7393 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -0.9100 | |
| 117 | T | A | -0.9427 | |
| 118 | E | A | -2.4495 | |
| 119 | N | A | -2.0549 | |
| 120 | P | A | -1.2613 | |
| 121 | T | A | -0.7331 | |
| 122 | A | A | -0.6877 | |
| 123 | P | A | -0.4208 | |
| 124 | V | A | -0.0578 | |
| 125 | H | A | -1.6014 | |
| 126 | E | A | -2.4692 | |
| 127 | G | A | -2.2085 | |
| 128 | P | A | -1.8203 | |
| 129 | D | A | -2.4536 | |
| 130 | V | A | -1.7142 | |
| 131 | R | A | -1.3021 | |
| 132 | V | A | -0.7208 | |
| 133 | N | A | -1.0579 | |
| 134 | F | A | -0.4367 | |
| 135 | S | A | -0.4023 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2294 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.4680 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2580 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0623 | |
| 157 | D | A | 0.3161 | |
| 158 | L | A | 0.5914 | |
| 159 | A | A | 0.0295 | |
| 160 | E | A | -1.4939 | |
| 161 | P | A | -0.2801 | |
| 162 | C | A | 0.1398 | |
| 163 | P | A | -0.2165 | |
| 164 | G | A | -0.1729 | |
| 165 | L | A | 0.4097 | |
| 166 | P | A | -0.1463 | |
| 167 | P | A | -0.3908 | |
| 168 | G | A | -0.4554 | |
| 169 | A | A | 0.2268 | |
| 170 | C | A | 0.9397 | |
| 171 | P | A | 0.5028 | |
| 172 | P | A | 0.6444 | |
| 173 | I | A | 1.6338 | |
| 174 | Q | A | 0.6478 | |
| 175 | L | A | 1.3005 | |
| 176 | V | A | 0.7618 | |
| 177 | N | A | -0.3920 | |
| 178 | S | A | -0.0308 | |
| 179 | V | A | 0.3042 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3814 | |
| 182 | D | A | 0.0781 | |
| 183 | G | A | -0.1663 | |
| 184 | D | A | -0.5525 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.3960 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1262 | |
| 190 | F | A | 0.1054 | |
| 191 | G | A | -0.0578 | |
| 192 | N | A | -0.2514 | |
| 193 | M | A | 0.0004 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -2.4156 | |
| 197 | E | A | -1.9611 | |
| 198 | L | A | -0.8123 | |
| 199 | Q | A | -1.8296 | |
| 200 | Q | A | -2.6509 | |
| 201 | D | A | -2.6875 | |
| 202 | R | A | -1.9866 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2901 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | 0.0000 | |
| 211 | S | A | -1.4788 | |
| 212 | T | A | -1.2718 | |
| 213 | R | A | -1.8611 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2037 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2624 | |
| 220 | L | A | 0.4388 | |
| 221 | K | A | -1.4317 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9723 | |
| 224 | N | A | -1.7073 | |
| 225 | E | A | -1.3331 | |
| 226 | A | A | -0.8089 | |
| 227 | Y | A | -0.3828 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6709 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1065 | |
| 234 | F | A | 0.1496 | |
| 235 | G | A | -0.7815 | |
| 236 | R | A | -2.3260 | |
| 237 | R | A | -2.6349 | |
| 238 | E | A | -1.7488 | |
| 239 | Q | A | -0.3112 | |
| 240 | V | A | 1.3078 | |
| 241 | Y | A | 0.8592 | |
| 242 | A | A | 0.1360 | |
| 243 | R | A | -1.1474 | |
| 244 | H | A | -0.9098 | |
| 245 | F | A | -0.0623 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | -0.3214 | |
| 248 | R | A | -0.7098 | |
| 249 | A | A | -1.0811 | |
| 250 | G | A | -0.9008 | |
| 251 | P | A | -0.7007 | |
| 252 | E | A | -0.4061 | |
| 253 | G | A | 0.0856 | |
| 254 | V | A | 1.3380 | |
| 255 | P | A | 0.3726 | |
| 256 | L | A | 1.0690 | |
| 257 | P | A | 0.5075 | |
| 258 | A | A | 0.1947 | |
| 259 | A | A | 0.4795 | |
| 260 | P | A | -0.1904 | |
| 261 | P | A | 0.0366 | |
| 262 | P | A | 0.0672 | |
| 263 | S | A | 0.6476 | |
| 264 | P | A | 0.7826 | |
| 265 | L | A | 1.9847 | |
| 266 | F | A | 1.9517 | |
| 267 | V | A | 2.0420 | |
| 268 | P | A | 1.2095 | |
| 269 | P | A | 0.6384 | |
| 270 | P | A | -0.1497 | |
| 271 | P | A | -0.1164 | |
| 272 | S | A | -0.2976 | |
| 273 | S | A | 0.2878 | |
| 274 | P | A | 0.5851 | |
| 275 | Y | A | 1.6205 | |
| 276 | A | A | 1.1739 | |
| 277 | V | A | 2.1167 | |
| 278 | P | A | 1.1168 | |
| 279 | P | A | 0.2659 | |
| 280 | S | A | -0.0656 | |
| 281 | T | A | -0.0395 | |
| 282 | D | A | -0.5611 | |
| 283 | Y | A | 0.8608 | |
| 284 | F | A | 0.6575 | |
| 285 | G | A | 0.1000 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.6534 | |
| 291 | L | A | 1.5318 | |
| 292 | V | A | 0.5260 | |
| 293 | S | A | -0.0486 | |
| 294 | S | A | -0.7800 | |
| 295 | D | A | -1.8332 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1345 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.7618 | |
| 301 | R | A | -2.0645 | |
| 302 | P | A | -1.0441 | |
| 303 | F | A | -0.0985 | |
| 304 | W | A | -0.4869 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0518 | |
| 307 | R | A | -2.8766 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.5708 | |
| 310 | G | A | -1.3514 | |
| 311 | N | A | -1.3490 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7054 | |
| 319 | N | A | -0.6655 | |
| 320 | E | A | 0.0000 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.4680 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.3321 | |
| 333 | N | A | 0.3468 | |
| 334 | F | A | 1.4542 | |
| 335 | T | A | 0.7064 | |
| 336 | I | A | 0.4092 | |
| 337 | S | A | -0.9419 | |
| 338 | Q | A | -1.6607 | |
| 339 | Q | A | -1.2166 | |
| 340 | V | A | 0.5911 | |
| 341 | S | A | 0.0284 | |
| 342 | T | A | -0.4648 | |
| 343 | P | A | -1.1363 | |
| 344 | E | A | -1.8989 | |
| 345 | I | A | -0.4700 | |
| 346 | N | A | -0.4517 | |
| 347 | V | A | 1.4640 | |
| 348 | Y | A | 1.5112 | |
| 349 | D | A | -0.0470 | |
| 350 | P | A | -0.7337 | |
| 351 | S | A | -0.5671 | |
| 352 | N | A | -0.3138 | |
| 353 | F | A | -0.9861 | |
| 354 | K | A | -2.1474 | |
| 355 | N | A | -1.8060 | |
| 356 | Y | A | 0.0349 | |
| 357 | L | A | 0.8321 | |
| 358 | R | A | 0.9951 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.1455 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.1959 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0564 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6475 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2855 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3613 | |
| 376 | L | A | -1.7740 | |
| 377 | D | A | -2.0791 | |
| 378 | P | A | -1.0896 | |
| 379 | G | A | -1.0309 | |
| 380 | V | A | -0.9382 | |
| 381 | L | A | -0.5604 | |
| 382 | A | A | -0.6660 | |
| 383 | H | A | -0.6652 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3862 | |
| 386 | T | A | -0.5544 | |
| 387 | M | A | -0.3558 | |
| 388 | N | A | -0.8474 | |
| 389 | P | A | -1.2832 | |
| 390 | T | A | -1.5526 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4950 | |
| 393 | E | A | -2.9431 | |
| 394 | N | A | -2.8342 | |
| 395 | W | A | -1.4707 | |
| 396 | N | A | -1.2176 | |
| 397 | L | A | -0.0338 | |
| 398 | G | A | 0.7607 | |
| 399 | F | A | 2.4552 | |
| 400 | V | A | 1.8366 | |
| 401 | P | A | 0.0863 | |
| 402 | P | A | -1.8947 | |
| 403 | K | A | -3.5722 | |
| 404 | E | A | -3.9687 | |
| 405 | R | A | -4.1125 | |
| 406 | E | A | -3.8093 | |
| 407 | D | A | -2.8646 | |
| 408 | P | A | -1.7642 | |
| 409 | Y | A | -0.9952 | |
| 410 | K | A | -2.0791 | |
| 411 | G | A | -0.6385 | |
| 412 | L | A | 0.6608 | |
| 413 | I | A | 1.6252 | |
| 414 | F | A | 0.6666 | |
| 415 | W | A | -0.3391 | |
| 416 | E | A | -1.7438 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9584 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0850 | |
| 421 | E | A | -2.7774 | |
| 422 | R | A | -2.2868 | |
| 423 | F | A | -1.2332 | |
| 424 | S | A | -1.4732 | |
| 425 | Q | A | -1.7649 | |
| 426 | D | A | -2.9748 | |
| 427 | L | A | 0.0000 | |
| 428 | D | A | -2.8238 | |
| 429 | Q | A | -2.6447 | |
| 430 | F | A | -1.5537 | |
| 431 | A | A | -0.9394 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.7933 | |
| 435 | K | A | -0.8309 | |
| 436 | F | A | 0.1604 | |
| 437 | L | A | 0.9286 | |
| 438 | Y | A | 0.7785 | |
| 439 | Q | A | -0.2806 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine