| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFRDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTAPVHEGADDRVAFSWDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRSGPDGHPLPSDPPPSPLYVPPPPDSPYAVLPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9479 | |
| 2 | L | A | 1.9729 | |
| 3 | P | A | 0.6555 | |
| 4 | P | A | 0.3505 | |
| 5 | T | A | 0.1096 | |
| 6 | T | A | 0.1282 | |
| 7 | P | A | 0.1612 | |
| 8 | V | A | 1.2145 | |
| 9 | A | A | 0.0297 | |
| 10 | K | A | -1.1452 | |
| 11 | V | A | -0.3932 | |
| 12 | Q | A | -1.5267 | |
| 13 | S | A | -1.6007 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4215 | |
| 16 | E | A | -2.4427 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4590 | |
| 20 | P | A | 0.1069 | |
| 21 | T | A | 0.1171 | |
| 22 | S | A | -0.1690 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.0934 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1875 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8184 | |
| 31 | R | A | -2.6463 | |
| 32 | L | A | -0.7651 | |
| 33 | L | A | 1.2245 | |
| 34 | T | A | 1.4648 | |
| 35 | V | A | 2.0232 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | 0.0000 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6875 | |
| 40 | R | A | -1.9250 | |
| 41 | D | A | -0.7678 | |
| 42 | I | A | 1.2327 | |
| 43 | V | A | 2.2122 | |
| 44 | V | A | 1.6564 | |
| 45 | N | A | -0.5182 | |
| 46 | G | A | -0.3610 | |
| 47 | K | A | -0.1247 | |
| 48 | V | A | 2.1970 | |
| 49 | L | A | 2.5279 | |
| 50 | V | A | 1.4861 | |
| 51 | P | A | 0.3728 | |
| 52 | K | A | -0.6635 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1148 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4659 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2614 | |
| 70 | K | A | -1.8046 | |
| 71 | F | A | -0.6558 | |
| 72 | A | A | -0.5760 | |
| 73 | L | A | -0.8667 | |
| 74 | P | A | -1.2649 | |
| 75 | Q | A | -2.4773 | |
| 76 | K | A | -3.0933 | |
| 77 | D | A | -2.9881 | |
| 78 | F | A | -1.6374 | |
| 79 | Y | A | -1.9186 | |
| 80 | D | A | -2.7709 | |
| 81 | P | A | -2.3552 | |
| 82 | E | A | -3.0732 | |
| 83 | K | A | -3.4382 | |
| 84 | E | A | -2.4977 | |
| 85 | R | A | -1.3117 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6269 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9491 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3064 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6727 | |
| 99 | G | A | -0.5372 | |
| 100 | P | A | -0.4242 | |
| 101 | L | A | 0.0119 | |
| 102 | G | A | -0.2158 | |
| 103 | K | A | -0.6097 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4341 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1140 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4030 | |
| 110 | L | A | 0.2806 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1187 | |
| 113 | K | A | -0.4490 | |
| 114 | L | A | -1.1811 | |
| 115 | G | A | -0.8629 | |
| 116 | D | A | -1.0605 | |
| 117 | T | A | -0.7775 | |
| 118 | E | A | -1.8564 | |
| 119 | N | A | -1.9950 | |
| 120 | P | A | -1.2901 | |
| 121 | T | A | -0.6549 | |
| 122 | A | A | -0.3349 | |
| 123 | P | A | 0.0454 | |
| 124 | V | A | -0.3088 | |
| 125 | H | A | -1.3202 | |
| 126 | E | A | -2.7393 | |
| 127 | G | A | -2.2269 | |
| 128 | A | A | -1.6011 | |
| 129 | D | A | -2.4953 | |
| 130 | D | A | -2.1074 | |
| 131 | R | A | -1.1281 | |
| 132 | V | A | 0.2574 | |
| 133 | A | A | 0.4580 | |
| 134 | F | A | 0.3099 | |
| 135 | S | A | -0.0709 | |
| 136 | W | A | 0.0000 | |
| 137 | D | A | -0.5085 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5680 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2569 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0972 | |
| 157 | D | A | 0.3422 | |
| 158 | I | A | 0.8400 | |
| 159 | A | A | 0.1155 | |
| 160 | E | A | -1.4823 | |
| 161 | P | A | -0.2632 | |
| 162 | C | A | 0.1628 | |
| 163 | P | A | -0.1875 | |
| 164 | G | A | -0.0964 | |
| 165 | L | A | 0.5448 | |
| 166 | P | A | -0.1293 | |
| 167 | P | A | -0.3485 | |
| 168 | G | A | -0.4181 | |
| 169 | A | A | -0.0166 | |
| 170 | C | A | 0.7535 | |
| 171 | P | A | 0.5364 | |
| 172 | P | A | 0.7727 | |
| 173 | I | A | 2.0296 | |
| 174 | Q | A | 0.8298 | |
| 175 | L | A | 1.4293 | |
| 176 | V | A | 0.8118 | |
| 177 | N | A | -0.3409 | |
| 178 | S | A | -0.0037 | |
| 179 | V | A | 0.3817 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3650 | |
| 182 | D | A | 0.0781 | |
| 183 | G | A | -0.1600 | |
| 184 | D | A | -0.5656 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1547 | |
| 190 | F | A | 0.0609 | |
| 191 | G | A | -0.1004 | |
| 192 | N | A | -0.2796 | |
| 193 | M | A | -0.1581 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4153 | |
| 197 | E | A | -2.6408 | |
| 198 | L | A | -1.2324 | |
| 199 | Q | A | -2.5515 | |
| 200 | Q | A | -3.3499 | |
| 201 | D | A | -3.6079 | |
| 202 | R | A | -3.3688 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.0354 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.4254 | |
| 211 | S | A | -1.9290 | |
| 212 | T | A | -1.4756 | |
| 213 | R | A | -2.1428 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1720 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2772 | |
| 220 | L | A | 0.4717 | |
| 221 | K | A | -1.3675 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9802 | |
| 224 | N | A | -1.5923 | |
| 225 | E | A | -1.3271 | |
| 226 | A | A | -0.6645 | |
| 227 | Y | A | -0.4494 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7207 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1262 | |
| 234 | F | A | 0.0036 | |
| 235 | G | A | -0.8971 | |
| 236 | R | A | -2.6327 | |
| 237 | R | A | -2.8484 | |
| 238 | E | A | -2.0737 | |
| 239 | Q | A | -0.0528 | |
| 240 | V | A | 1.5412 | |
| 241 | Y | A | 1.2628 | |
| 242 | A | A | 0.1982 | |
| 243 | R | A | -1.1874 | |
| 244 | H | A | -0.9612 | |
| 245 | F | A | 0.0848 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.8476 | |
| 249 | S | A | -1.4337 | |
| 250 | G | A | -1.2513 | |
| 251 | P | A | -1.2028 | |
| 252 | D | A | -1.4374 | |
| 253 | G | A | -1.3055 | |
| 254 | H | A | -1.4510 | |
| 255 | P | A | -0.9006 | |
| 256 | L | A | 0.1221 | |
| 257 | P | A | -0.4306 | |
| 258 | S | A | -0.7890 | |
| 259 | D | A | -1.4214 | |
| 260 | P | A | -1.0614 | |
| 261 | P | A | -0.4336 | |
| 262 | P | A | -0.2185 | |
| 263 | S | A | 0.0980 | |
| 264 | P | A | 0.4796 | |
| 265 | L | A | 1.7018 | |
| 266 | Y | A | 1.5779 | |
| 267 | V | A | 1.7767 | |
| 268 | P | A | 0.7983 | |
| 269 | P | A | 0.4473 | |
| 270 | P | A | -0.6255 | |
| 271 | P | A | -0.9010 | |
| 272 | D | A | -1.8708 | |
| 273 | S | A | -0.5177 | |
| 274 | P | A | 0.2055 | |
| 275 | Y | A | 1.4273 | |
| 276 | A | A | 0.9999 | |
| 277 | V | A | 2.2741 | |
| 278 | L | A | 1.7646 | |
| 279 | P | A | 0.2634 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.2463 | |
| 282 | D | A | -0.7608 | |
| 283 | Y | A | 0.9443 | |
| 284 | F | A | 0.7675 | |
| 285 | G | A | 0.2398 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8652 | |
| 291 | L | A | 1.6629 | |
| 292 | V | A | 0.6442 | |
| 293 | S | A | -0.1405 | |
| 294 | S | A | -0.9647 | |
| 295 | D | A | -1.8370 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1058 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6256 | |
| 301 | R | A | -1.8358 | |
| 302 | P | A | -0.9291 | |
| 303 | F | A | -0.1778 | |
| 304 | W | A | -0.4937 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0755 | |
| 307 | R | A | -2.9222 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6529 | |
| 310 | G | A | -1.4149 | |
| 311 | N | A | -1.3848 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9446 | |
| 319 | N | A | -0.8872 | |
| 320 | E | A | -1.0523 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3360 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1458 | |
| 333 | N | A | 0.4143 | |
| 334 | F | A | 1.4209 | |
| 335 | T | A | 0.7092 | |
| 336 | I | A | 0.3779 | |
| 337 | S | A | -0.8432 | |
| 338 | Q | A | -1.4281 | |
| 339 | Q | A | -1.0654 | |
| 340 | L | A | 0.6139 | |
| 341 | C | A | 0.0091 | |
| 342 | T | A | -0.4293 | |
| 343 | P | A | -1.1821 | |
| 344 | E | A | -1.7536 | |
| 345 | P | A | -0.7418 | |
| 346 | N | A | -0.7546 | |
| 347 | V | A | 1.2922 | |
| 348 | Y | A | 1.2371 | |
| 349 | D | A | 0.0447 | |
| 350 | P | A | -0.3364 | |
| 351 | S | A | -0.2661 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5232 | |
| 354 | K | A | -1.6615 | |
| 355 | N | A | -1.6927 | |
| 356 | Y | A | -0.1073 | |
| 357 | L | A | 0.5736 | |
| 358 | R | A | 0.9252 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4897 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | 0.0000 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9156 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6834 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2771 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3205 | |
| 376 | L | A | -1.7430 | |
| 377 | D | A | -2.0196 | |
| 378 | P | A | -1.0575 | |
| 379 | G | A | -1.0200 | |
| 380 | V | A | -0.9277 | |
| 381 | L | A | -0.5401 | |
| 382 | A | A | -0.6606 | |
| 383 | H | A | -0.8474 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4100 | |
| 386 | T | A | -0.5776 | |
| 387 | M | A | -0.3357 | |
| 388 | N | A | -0.8745 | |
| 389 | P | A | -1.2890 | |
| 390 | T | A | -1.6001 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5804 | |
| 393 | E | A | -3.0057 | |
| 394 | N | A | -2.8057 | |
| 395 | W | A | -1.6024 | |
| 396 | N | A | -1.2705 | |
| 397 | L | A | -0.2472 | |
| 398 | G | A | 0.5053 | |
| 399 | F | A | 2.4056 | |
| 400 | V | A | 1.8293 | |
| 401 | P | A | 0.0459 | |
| 402 | P | A | -1.9877 | |
| 403 | K | A | -3.5112 | |
| 404 | E | A | -4.0269 | |
| 405 | R | A | -4.4878 | |
| 406 | E | A | -4.0276 | |
| 407 | D | A | -2.9620 | |
| 408 | P | A | -1.8157 | |
| 409 | Y | A | -0.9862 | |
| 410 | K | A | -2.0981 | |
| 411 | G | A | -0.6317 | |
| 412 | L | A | 0.6580 | |
| 413 | I | A | 1.5752 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3965 | |
| 416 | E | A | -1.6675 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8364 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8730 | |
| 421 | E | A | -2.4807 | |
| 422 | R | A | -2.0443 | |
| 423 | F | A | -1.0060 | |
| 424 | S | A | -1.3092 | |
| 425 | Q | A | -1.8382 | |
| 426 | D | A | -2.8892 | |
| 427 | L | A | -1.9927 | |
| 428 | D | A | -2.7779 | |
| 429 | Q | A | -2.6118 | |
| 430 | F | A | -1.4536 | |
| 431 | A | A | -0.8921 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6257 | |
| 435 | K | A | -0.7591 | |
| 436 | F | A | 0.1427 | |
| 437 | L | A | 1.0206 | |
| 438 | Y | A | 0.8118 | |
| 439 | Q | A | -0.2841 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine