Project name: c919a67d9c422f3

Chain sequence(s)	H: EVQVVESGGGVIQPGGSLRLSCAASGFTVETNFMTWVRQAPGKGPEWVSVTYTSGTTYYADSVKGRFTVSRDNSKNTLFLQMNSLRAEDTAVYYCAKGHIVLIPPTVVRGGALDVWGQGTTVTVSS; L: DIQMTQSPSSLSASVGDRVTITCQASQNINNYLSWYQQKPGEAPRLLIYDGFNLQTGAPSRFSGRRSGTDFSFIISSLQPEDIATYYCQQYDSLPWTFGQGTKVELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:10)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:11)

• Minimal score value: -2.6245
• Maximal score value: 2.5047
• Average score: -0.5276
• Total score value: -122.9295

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.7019
2	V	H	-0.4653
3	Q	H	-0.7993
4	V	H	0.0000
5	V	H	0.3529
6	E	H	0.0000
7	S	H	-0.5224
8	G	H	-0.8001
9	G	H	-0.2486
11	G	H	0.4516
12	V	H	1.4929
13	I	H	0.2650
14	Q	H	-1.2057
15	P	H	-1.3723
16	G	H	-1.4140
17	G	H	-0.9114
18	S	H	-1.0219
19	L	H	-0.5940
20	R	H	-1.5035
21	L	H	0.0000
22	S	H	-0.3521
23	C	H	0.0000
24	A	H	-0.2636
25	A	H	-0.2351
26	S	H	-0.4831
27	G	H	-0.7391
28	F	H	-0.3656
29	T	H	-0.8511
30	V	H	0.0000
35	E	H	-1.6209
36	T	H	-0.6611
37	N	H	0.0000
38	F	H	0.0000
39	M	H	0.0000
40	T	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.8483
45	A	H	-1.2033
46	P	H	-0.9910
47	G	H	-1.4435
48	K	H	-2.3876
49	G	H	-1.6158
50	P	H	0.0000
51	E	H	-1.1009
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	V	H	0.0000
56	T	H	0.0000
57	Y	H	-0.0309
58	T	H	-0.4291
59	S	H	-0.4385
63	G	H	-0.4417
64	T	H	-0.0288
65	T	H	0.2271
66	Y	H	0.2999
67	Y	H	-0.5257
68	A	H	-1.4111
69	D	H	-2.5834
70	S	H	-1.7177
71	V	H	0.0000
72	K	H	-2.4794
74	G	H	-1.6967
75	R	H	-1.6119
76	F	H	0.0000
77	T	H	-0.7145
78	V	H	0.0000
79	S	H	-0.5238
80	R	H	-1.3604
81	D	H	-1.9857
82	N	H	-2.6245
83	S	H	-1.9964
84	K	H	-2.5267
85	N	H	-1.9791
86	T	H	-1.2550
87	L	H	0.0000
88	F	H	-0.4072
89	L	H	0.0000
90	Q	H	-1.0431
91	M	H	0.0000
92	N	H	-1.2494
93	S	H	-1.2285
94	L	H	0.0000
95	R	H	-2.2571
96	A	H	-1.6786
97	E	H	-2.1963
98	D	H	0.0000
99	T	H	-0.6004
100	A	H	0.0000
101	V	H	0.0072
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	K	H	-0.3813
107	G	H	0.0000
108	H	H	-0.0986
109	I	H	0.0000
110	V	H	1.3518
111	L	H	1.7032
111A	I	H	2.5047
111B	P	H	1.2314
111C	P	H	0.7861
112D	T	H	1.1829
112C	V	H	2.2152
112B	V	H	1.6103
112A	R	H	0.5705
112	G	H	0.0000
113	G	H	0.0000
114	A	H	0.0000
115	L	H	0.0000
116	D	H	-0.8149
117	V	H	-0.2632
118	W	H	-0.4239
119	G	H	0.0000
120	Q	H	-1.2050
121	G	H	-0.4983
122	T	H	-0.3103
123	T	H	0.1077
124	V	H	0.0000
125	T	H	0.0838
126	V	H	0.0000
127	S	H	-0.4813
128	S	H	-0.5352
1	D	L	-2.3224
2	I	L	0.0000
3	Q	L	-2.0991
4	M	L	0.0000
5	T	L	-1.0615
6	Q	L	0.0000
7	S	L	-0.7839
8	P	L	-0.7364
9	S	L	-1.0550
10	S	L	-1.2738
11	L	L	-0.9974
12	S	L	-1.3423
13	A	L	0.0000
14	S	L	-0.7465
15	V	L	0.2496
16	G	L	-0.5613
17	D	L	-1.4631
18	R	L	-2.0241
19	V	L	0.0000
20	T	L	-0.4314
21	I	L	0.0000
22	T	L	-0.5898
23	C	L	0.0000
24	Q	L	-1.6381
25	A	L	0.0000
26	S	L	-1.6905
27	Q	L	-2.1213
28	N	L	-2.1847
29	I	L	0.0000
36	N	L	-1.6053
37	N	L	-1.3108
38	Y	L	-0.3889
39	L	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-1.1546
45	K	L	-1.4639
46	P	L	-0.8339
47	G	L	-1.1542
48	E	L	-1.5125
49	A	L	-1.0970
50	P	L	0.0000
51	R	L	-1.5411
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1110
56	D	L	-0.3821
57	G	L	0.0000
65	F	L	0.2106
66	N	L	-0.0677
67	L	L	0.3357
68	Q	L	-0.3241
69	T	L	-0.4228
70	G	L	-0.5187
71	A	L	-0.4833
72	P	L	-0.3657
74	S	L	-0.4202
75	R	L	-0.6794
76	F	L	0.0000
77	S	L	-0.1208
78	G	L	-0.3892
79	R	L	-1.6671
80	R	L	-1.6646
83	S	L	-1.2860
84	G	L	-1.4433
85	T	L	-1.6465
86	D	L	-1.7055
87	F	L	0.0000
88	S	L	0.0000
89	F	L	0.0000
90	I	L	-0.3472
91	I	L	0.0000
92	S	L	-1.0565
93	S	L	-1.0049
94	L	L	0.0000
95	Q	L	-0.7352
96	P	L	-1.0081
97	E	L	-1.9534
98	D	L	0.0000
99	I	L	-1.1198
100	A	L	0.0000
101	T	L	0.0000
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	D	L	-0.5325
109	S	L	-0.2488
114	L	L	0.0643
115	P	L	-0.6120
116	W	L	0.0000
117	T	L	-0.8228
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.9864
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-2.3216
124	V	L	0.0000
125	E	L	-1.7596
126	L	L	-0.7211
127	K	L	-1.5871