| Chain sequence(s) |
A: GPLILNPEPEVKSTSEYVTPTDILYYAETDLLTETGHPTKDIVVNGKVVVPKVNAYQWRVFRLTLPDPNKLPLPSSNFVNPETEILIWKLLAFKIGVYGPLGKGTYGHDNFNRLGNVDNPTEYLQETEDDRVAYSFTPVYKQMFIIGNEPPIGKYTALAAPAPGLPPGALPPTTEVTTIIQHGDMADIGFGARDFAALEPEKDDVPDIIRDTVTKVPDIEGMKAEKYGNRMFTYDEYRKSYDSETFVRCGPDLVPLPAADPPSPLYVPPPPTSPFATLPSYNIFTTPDRGEITEEDELFNKPIFLEKTEGKNDGILWNNQLYVTILDNSRDEIETIRTQICTPEENVYDESCYVTSKRYTREYQLSLIVQLCKIPLTPETLEYLKRLDPSILVNANLPDIPPVVRPDPLAGLKFHEIDLTDKLSTDLSSSSLGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.1070 | |
| 2 | P | A | 1.0189 | |
| 3 | L | A | 2.5502 | |
| 4 | I | A | 2.9770 | |
| 5 | L | A | 1.9647 | |
| 6 | N | A | -0.4242 | |
| 7 | P | A | -1.3423 | |
| 8 | E | A | -2.5266 | |
| 9 | P | A | -2.3687 | |
| 10 | E | A | -2.6297 | |
| 11 | V | A | -1.7655 | |
| 12 | K | A | -2.1097 | |
| 13 | S | A | -1.8145 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.5233 | |
| 16 | E | A | -2.2504 | |
| 17 | Y | A | -1.2472 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6135 | |
| 20 | P | A | -0.7698 | |
| 21 | T | A | -0.9537 | |
| 22 | D | A | -1.6642 | |
| 23 | I | A | -0.5302 | |
| 24 | L | A | -0.2684 | |
| 25 | Y | A | -0.0089 | |
| 26 | Y | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.1112 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.4399 | |
| 31 | L | A | 0.1880 | |
| 32 | L | A | 0.0186 | |
| 33 | T | A | -0.1511 | |
| 34 | E | A | -0.3861 | |
| 35 | T | A | -0.4398 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.5796 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.5979 | |
| 40 | K | A | -1.8768 | |
| 41 | D | A | -0.5248 | |
| 42 | I | A | 1.6868 | |
| 43 | V | A | 2.5122 | |
| 44 | V | A | 1.9186 | |
| 45 | N | A | -0.4809 | |
| 46 | G | A | -0.2904 | |
| 47 | K | A | 0.0036 | |
| 48 | V | A | 2.1792 | |
| 49 | V | A | 2.8044 | |
| 50 | V | A | 1.5700 | |
| 51 | P | A | 0.1968 | |
| 52 | K | A | -1.0241 | |
| 53 | V | A | 0.0000 | |
| 54 | N | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | -1.5229 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2482 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.2941 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.6690 | |
| 70 | K | A | -2.0219 | |
| 71 | L | A | -0.7702 | |
| 72 | P | A | -0.4330 | |
| 73 | L | A | -0.1497 | |
| 74 | P | A | -0.2271 | |
| 75 | S | A | -0.5703 | |
| 76 | S | A | -0.9104 | |
| 77 | N | A | -1.4958 | |
| 78 | F | A | -0.6698 | |
| 79 | V | A | 0.0000 | |
| 80 | N | A | -2.1243 | |
| 81 | P | A | -2.0816 | |
| 82 | E | A | -2.6053 | |
| 83 | T | A | -1.5275 | |
| 84 | E | A | -1.4446 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | K | A | -0.3514 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.2032 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -0.8868 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | V | A | 0.0000 | |
| 98 | Y | A | 0.3248 | |
| 99 | G | A | -0.4200 | |
| 100 | P | A | -0.4120 | |
| 101 | L | A | -0.3355 | |
| 102 | G | A | -1.0355 | |
| 103 | K | A | -1.6062 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5241 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.9084 | |
| 108 | H | A | -1.7952 | |
| 109 | D | A | -2.3732 | |
| 110 | N | A | -2.5840 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.7675 | |
| 113 | R | A | -0.7780 | |
| 114 | L | A | -0.8163 | |
| 115 | G | A | 0.0000 | |
| 116 | N | A | -1.1885 | |
| 117 | V | A | -1.0650 | |
| 118 | D | A | -2.5574 | |
| 119 | N | A | -2.5223 | |
| 120 | P | A | -1.7879 | |
| 121 | T | A | -1.4785 | |
| 122 | E | A | -2.0004 | |
| 123 | Y | A | -0.4616 | |
| 124 | L | A | -0.7828 | |
| 125 | Q | A | -1.6000 | |
| 126 | E | A | -2.3791 | |
| 127 | T | A | -2.4884 | |
| 128 | E | A | -3.1379 | |
| 129 | D | A | -3.3847 | |
| 130 | D | A | -2.5444 | |
| 131 | R | A | -2.3900 | |
| 132 | V | A | -1.0419 | |
| 133 | A | A | -1.0401 | |
| 134 | Y | A | -0.5827 | |
| 135 | S | A | -0.4033 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.4807 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | -0.6029 | |
| 140 | Y | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | M | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | N | A | 0.0000 | |
| 149 | E | A | -0.6613 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | 0.1307 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.5998 | |
| 155 | Y | A | -0.7225 | |
| 156 | T | A | -0.7404 | |
| 157 | A | A | -0.1614 | |
| 158 | L | A | 0.4352 | |
| 159 | A | A | 0.0618 | |
| 160 | A | A | 0.0522 | |
| 161 | P | A | 0.0687 | |
| 162 | A | A | -0.1417 | |
| 163 | P | A | -0.3151 | |
| 164 | G | A | -0.3220 | |
| 165 | L | A | 0.3955 | |
| 166 | P | A | -0.0802 | |
| 167 | P | A | -0.2773 | |
| 168 | G | A | 0.1152 | |
| 169 | A | A | 1.0037 | |
| 170 | L | A | 1.8368 | |
| 171 | P | A | 0.7386 | |
| 172 | P | A | 0.4397 | |
| 173 | T | A | -0.0226 | |
| 174 | T | A | -0.6822 | |
| 175 | E | A | -1.6796 | |
| 176 | V | A | -0.6114 | |
| 177 | T | A | -0.3313 | |
| 178 | T | A | 0.1391 | |
| 179 | I | A | 0.0819 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.7700 | |
| 182 | H | A | -1.0820 | |
| 183 | G | A | -0.7301 | |
| 184 | D | A | -0.5649 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2839 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.4145 | |
| 190 | F | A | -0.1686 | |
| 191 | G | A | -0.4008 | |
| 192 | A | A | -0.5495 | |
| 193 | R | A | -0.6050 | |
| 194 | D | A | -0.3537 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.1536 | |
| 197 | A | A | -0.4295 | |
| 198 | L | A | -0.3630 | |
| 199 | E | A | -1.5463 | |
| 200 | P | A | -1.8034 | |
| 201 | E | A | -2.7390 | |
| 202 | K | A | -2.9873 | |
| 203 | D | A | -2.4992 | |
| 204 | D | A | -1.6537 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.9191 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -2.0090 | |
| 211 | D | A | -1.8081 | |
| 212 | T | A | -0.8231 | |
| 213 | V | A | -0.2593 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.0875 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | -0.8609 | |
| 219 | I | A | -1.1229 | |
| 220 | E | A | -2.3028 | |
| 221 | G | A | -1.6841 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.4375 | |
| 224 | A | A | -1.6872 | |
| 225 | E | A | -1.9269 | |
| 226 | K | A | -1.8534 | |
| 227 | Y | A | -1.3629 | |
| 228 | G | A | 0.0000 | |
| 229 | N | A | 0.0000 | |
| 230 | R | A | -0.8586 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.8626 | |
| 234 | Y | A | -0.4510 | |
| 235 | D | A | -0.9265 | |
| 236 | E | A | -1.1545 | |
| 237 | Y | A | -1.0424 | |
| 238 | R | A | -2.0183 | |
| 239 | K | A | -1.3793 | |
| 240 | S | A | -1.0339 | |
| 241 | Y | A | -0.3347 | |
| 242 | D | A | -1.6727 | |
| 243 | S | A | -1.4134 | |
| 244 | E | A | -1.6857 | |
| 245 | T | A | -0.9428 | |
| 246 | F | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | C | A | -1.1872 | |
| 250 | G | A | -0.8285 | |
| 251 | P | A | -0.0676 | |
| 252 | D | A | 0.7220 | |
| 253 | L | A | 2.2299 | |
| 254 | V | A | 2.5891 | |
| 255 | P | A | 1.2565 | |
| 256 | L | A | 1.3696 | |
| 257 | P | A | 0.3009 | |
| 258 | A | A | -0.3546 | |
| 259 | A | A | -0.3212 | |
| 260 | D | A | -1.7365 | |
| 261 | P | A | -0.7732 | |
| 262 | P | A | -0.3855 | |
| 263 | S | A | 0.2072 | |
| 264 | P | A | 0.5803 | |
| 265 | L | A | 1.9196 | |
| 266 | Y | A | 1.6079 | |
| 267 | V | A | 1.7583 | |
| 268 | P | A | 0.7763 | |
| 269 | P | A | 0.5861 | |
| 270 | P | A | -0.0492 | |
| 271 | P | A | -0.2645 | |
| 272 | T | A | -0.1474 | |
| 273 | S | A | 0.1158 | |
| 274 | P | A | 0.2846 | |
| 275 | F | A | 1.2032 | |
| 276 | A | A | 0.5514 | |
| 277 | T | A | 0.2946 | |
| 278 | L | A | 0.7975 | |
| 279 | P | A | -0.0422 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.8337 | |
| 282 | N | A | 0.1305 | |
| 283 | I | A | 1.6931 | |
| 284 | F | A | 0.6162 | |
| 285 | T | A | -0.3406 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.0835 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.2546 | |
| 291 | E | A | -2.0543 | |
| 292 | I | A | -1.5561 | |
| 293 | T | A | -1.9114 | |
| 294 | E | A | -2.7418 | |
| 295 | E | A | -2.8927 | |
| 296 | D | A | -2.2160 | |
| 297 | E | A | -1.5867 | |
| 298 | L | A | -1.0941 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.4205 | |
| 301 | K | A | -2.0282 | |
| 302 | P | A | -0.9516 | |
| 303 | I | A | -0.1492 | |
| 304 | F | A | -0.3824 | |
| 305 | L | A | -1.1436 | |
| 306 | E | A | -2.4235 | |
| 307 | K | A | -3.1153 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.7958 | |
| 310 | G | A | -2.4239 | |
| 311 | K | A | -2.5449 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | -1.8696 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | N | A | -0.8035 | |
| 319 | N | A | -0.6562 | |
| 320 | Q | A | -0.7294 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | D | A | 0.0000 | |
| 332 | E | A | -1.9977 | |
| 333 | I | A | -1.7012 | |
| 334 | E | A | -2.1431 | |
| 335 | T | A | -1.2846 | |
| 336 | I | A | -0.1579 | |
| 337 | R | A | -0.3725 | |
| 338 | T | A | 0.3233 | |
| 339 | Q | A | 0.0047 | |
| 340 | I | A | 1.9509 | |
| 341 | C | A | 0.9306 | |
| 342 | T | A | -0.4384 | |
| 343 | P | A | -1.1766 | |
| 344 | E | A | -2.4017 | |
| 345 | E | A | -2.6647 | |
| 346 | N | A | -1.6598 | |
| 347 | V | A | -0.0188 | |
| 348 | Y | A | 0.3499 | |
| 349 | D | A | -1.0824 | |
| 350 | E | A | -1.5850 | |
| 351 | S | A | -0.5738 | |
| 352 | C | A | 0.0000 | |
| 353 | Y | A | 0.4560 | |
| 354 | V | A | 1.2677 | |
| 355 | T | A | -0.0348 | |
| 356 | S | A | -0.7357 | |
| 357 | K | A | -2.0553 | |
| 358 | R | A | -2.0955 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.8285 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.1555 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.4724 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3875 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.5725 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7823 | |
| 376 | L | A | -0.9761 | |
| 377 | T | A | -0.9319 | |
| 378 | P | A | -1.4863 | |
| 379 | E | A | -2.4139 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.7964 | |
| 382 | E | A | -3.2008 | |
| 383 | Y | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | K | A | -3.0523 | |
| 386 | R | A | -2.6942 | |
| 387 | L | A | -1.6280 | |
| 388 | D | A | -1.5466 | |
| 389 | P | A | -1.7166 | |
| 390 | S | A | -0.5548 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.5664 | |
| 394 | N | A | -1.0267 | |
| 395 | A | A | 0.0000 | |
| 396 | N | A | -1.8454 | |
| 397 | L | A | -1.6323 | |
| 398 | P | A | -1.6305 | |
| 399 | D | A | -2.0646 | |
| 400 | I | A | -0.6101 | |
| 401 | P | A | -0.1508 | |
| 402 | P | A | 0.3344 | |
| 403 | V | A | 2.0099 | |
| 404 | V | A | 1.8573 | |
| 405 | R | A | 0.0166 | |
| 406 | P | A | -0.4216 | |
| 407 | D | A | -0.8804 | |
| 408 | P | A | -0.6984 | |
| 409 | L | A | -0.3902 | |
| 410 | A | A | -0.5477 | |
| 411 | G | A | -0.6683 | |
| 412 | L | A | -0.6005 | |
| 413 | K | A | -1.9790 | |
| 414 | F | A | 0.0000 | |
| 415 | H | A | -1.7588 | |
| 416 | E | A | -2.6717 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.7102 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6176 | |
| 421 | D | A | -2.3499 | |
| 422 | K | A | -1.9817 | |
| 423 | L | A | -0.8499 | |
| 424 | S | A | -0.8937 | |
| 425 | T | A | -0.6738 | |
| 426 | D | A | -1.7921 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.3147 | |
| 429 | S | A | -1.1343 | |
| 430 | S | A | 0.0000 | |
| 431 | S | A | -0.9882 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.3061 | |
| 435 | E | A | -2.0035 | |
| 436 | Y | A | -0.7855 | |
| 437 | L | A | -0.3802 | |
| 438 | N | A | -2.0451 | |
| 439 | R | A | -2.2232 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine