Chain sequence(s) |
A: MVSYWDTGVLLCALLSCLLLTGSSSGSDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:46) [INFO] Main: Simulation completed successfully. (00:06:49) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | 2.0012 | |
2 | V | A | 2.6641 | |
3 | S | A | 1.6299 | |
4 | Y | A | 1.8808 | |
5 | W | A | 1.0725 | |
6 | D | A | -0.5423 | |
7 | T | A | 0.3135 | |
8 | G | A | 0.6476 | |
9 | V | A | 2.0113 | |
10 | L | A | 1.8131 | |
11 | L | A | 1.8466 | |
12 | C | A | 1.7588 | |
13 | A | A | 1.3117 | |
14 | L | A | 1.5007 | |
15 | L | A | 1.4959 | |
16 | S | A | 1.3568 | |
17 | C | A | 1.9175 | |
18 | L | A | 2.0933 | |
19 | L | A | 2.5826 | |
20 | L | A | 2.4616 | |
21 | T | A | 0.9128 | |
22 | G | A | -0.1267 | |
23 | S | A | -0.5044 | |
24 | S | A | -0.6999 | |
25 | S | A | -0.8873 | |
26 | G | A | -1.1705 | |
27 | S | A | -1.5602 | |
28 | D | A | -2.3770 | |
29 | T | A | -1.4571 | |
30 | G | A | -1.6479 | |
31 | R | A | -1.7875 | |
32 | P | A | 0.0000 | |
33 | F | A | 0.0000 | |
34 | V | A | 0.1904 | |
35 | E | A | -0.0422 | |
36 | M | A | -0.0684 | |
37 | Y | A | -0.1042 | |
38 | S | A | -0.7078 | |
39 | E | A | -0.7335 | |
40 | I | A | 1.0751 | |
41 | P | A | 0.0000 | |
42 | E | A | -0.4516 | |
43 | I | A | 0.1817 | |
44 | I | A | -0.2958 | |
45 | H | A | -1.1346 | |
46 | M | A | 0.0000 | |
47 | T | A | -2.4634 | |
48 | E | A | -2.9779 | |
49 | G | A | -2.5734 | |
50 | R | A | -3.7943 | |
51 | E | A | -3.3524 | |
52 | L | A | 0.0000 | |
53 | V | A | -0.1715 | |
54 | I | A | 0.0000 | |
55 | P | A | -0.8814 | |
56 | C | A | 0.0000 | |
57 | R | A | -1.6092 | |
58 | V | A | 0.0000 | |
59 | T | A | -0.7701 | |
60 | S | A | -0.9875 | |
61 | P | A | -1.3648 | |
62 | N | A | -1.3217 | |
63 | I | A | -0.5188 | |
64 | T | A | -0.2109 | |
65 | V | A | -0.2456 | |
66 | T | A | 0.1320 | |
67 | L | A | 0.0000 | |
68 | K | A | -0.2266 | |
69 | K | A | -0.1608 | |
70 | F | A | 0.6961 | |
71 | P | A | 0.5781 | |
72 | L | A | 1.1321 | |
73 | D | A | 0.0378 | |
74 | T | A | 0.2933 | |
75 | L | A | 0.0000 | |
76 | I | A | 1.3387 | |
77 | P | A | -0.2185 | |
78 | D | A | -1.9974 | |
79 | G | A | -1.7126 | |
80 | K | A | -2.6709 | |
81 | R | A | -1.9543 | |
82 | I | A | 0.0000 | |
83 | I | A | -0.1675 | |
84 | W | A | -0.0732 | |
85 | D | A | -1.2012 | |
86 | S | A | -1.8839 | |
87 | R | A | -2.7707 | |
88 | K | A | -2.2908 | |
89 | G | A | 0.0000 | |
90 | F | A | 0.0000 | |
91 | I | A | -0.4393 | |
92 | I | A | 0.0000 | |
93 | S | A | -2.0923 | |
94 | N | A | -3.0907 | |
95 | A | A | 0.0000 | |
96 | T | A | -1.0442 | |
97 | Y | A | 0.6048 | |
98 | K | A | -0.3469 | |
99 | E | A | 0.0000 | |
100 | I | A | 0.2825 | |
101 | G | A | 0.3114 | |
102 | L | A | 0.0000 | |
103 | L | A | 0.0000 | |
104 | T | A | 0.0000 | |
105 | C | A | 0.0000 | |
106 | E | A | -0.4007 | |
107 | A | A | 0.0000 | |
108 | T | A | -0.4752 | |
109 | V | A | -0.7408 | |
110 | N | A | -1.5537 | |
111 | G | A | -1.2357 | |
112 | H | A | -1.2070 | |
113 | L | A | -0.0029 | |
114 | Y | A | -0.3344 | |
115 | K | A | -0.9982 | |
116 | T | A | 0.0000 | |
117 | N | A | -0.4695 | |
118 | Y | A | 0.0000 | |
119 | L | A | 0.1954 | |
120 | T | A | 0.0000 | |
121 | H | A | -0.7526 | |
122 | R | A | -1.4036 | |
123 | Q | A | -2.0948 | |
124 | T | A | -1.3384 | |
125 | N | A | -0.4039 | |
126 | T | A | -0.3463 | |
127 | I | A | 0.0000 | |
128 | I | A | -0.0233 | |
129 | D | A | -0.5870 | |
130 | V | A | 0.0000 | |
131 | V | A | 0.1991 | |
132 | L | A | 0.0000 | |
133 | S | A | -0.1448 | |
134 | P | A | -0.3562 | |
135 | S | A | -0.6932 | |
136 | H | A | -1.4134 | |
137 | G | A | -1.6237 | |
138 | I | A | 0.0000 | |
139 | E | A | -2.9932 | |
140 | L | A | -2.7138 | |
141 | S | A | -2.9145 | |
142 | V | A | -2.4546 | |
143 | G | A | -2.2801 | |
144 | E | A | -2.6572 | |
145 | K | A | -2.3925 | |
146 | L | A | 0.0000 | |
147 | V | A | -0.3222 | |
148 | L | A | 0.0000 | |
149 | N | A | -0.0338 | |
150 | C | A | 0.0000 | |
151 | T | A | -0.5179 | |
152 | A | A | 0.0000 | |
153 | R | A | -0.7387 | |
154 | T | A | 0.0000 | |
155 | E | A | -1.3319 | |
156 | L | A | -1.3310 | |
157 | N | A | -1.8113 | |
158 | V | A | 0.0000 | |
159 | G | A | -1.5780 | |
160 | I | A | -1.6276 | |
161 | D | A | -2.2276 | |
162 | F | A | -1.4741 | |
163 | N | A | -2.1262 | |
164 | W | A | 0.0000 | |
165 | E | A | -1.6263 | |
166 | Y | A | -0.5636 | |
167 | P | A | -0.7789 | |
168 | S | A | 0.0000 | |
169 | S | A | -1.6753 | |
170 | K | A | -2.4323 | |
171 | H | A | -2.5636 | |
172 | Q | A | -2.8955 | |
173 | H | A | -3.2086 | |
174 | K | A | -3.0631 | |
175 | K | A | -1.9453 | |
176 | L | A | 0.3529 | |
177 | V | A | 0.2033 | |
178 | N | A | -1.8601 | |
179 | R | A | -3.2015 | |
180 | D | A | -3.4421 | |
181 | L | A | -2.5040 | |
182 | K | A | -2.8119 | |
183 | T | A | -2.0976 | |
184 | Q | A | -2.0862 | |
185 | S | A | -1.4693 | |
186 | G | A | -1.3480 | |
187 | S | A | -1.6017 | |
188 | E | A | -2.2440 | |
189 | M | A | -1.4588 | |
190 | K | A | -2.0287 | |
191 | K | A | -1.7638 | |
192 | F | A | 0.0000 | |
193 | L | A | -1.0813 | |
194 | S | A | 0.0000 | |
195 | T | A | -0.1038 | |
196 | L | A | 0.0000 | |
197 | T | A | -1.1150 | |
198 | I | A | 0.0000 | |
199 | D | A | -3.5475 | |
200 | G | A | -2.2794 | |
201 | V | A | 0.0000 | |
202 | T | A | -1.9877 | |
203 | R | A | -2.9202 | |
204 | S | A | -1.3964 | |
205 | D | A | 0.0000 | |
206 | Q | A | -1.9515 | |
207 | G | A | -0.1236 | |
208 | L | A | 1.1980 | |
209 | Y | A | 0.0000 | |
210 | T | A | -0.8419 | |
211 | C | A | 0.0000 | |
212 | A | A | 0.0000 | |
213 | A | A | 0.0000 | |
214 | S | A | -1.0513 | |
215 | S | A | -0.3474 | |
216 | G | A | -0.0170 | |
217 | L | A | 1.4232 | |
218 | M | A | 0.7633 | |
219 | T | A | -0.6647 | |
220 | K | A | -1.5639 | |
221 | K | A | -2.4388 | |
222 | N | A | -1.3797 | |
223 | S | A | -0.4074 | |
224 | T | A | 0.0000 | |
225 | F | A | 0.2780 | |
226 | V | A | 0.0000 | |
227 | R | A | -2.9352 | |
228 | V | A | 0.0000 | |
229 | H | A | -3.5936 | |
230 | E | A | -3.8422 | |
231 | K | A | -4.2320 | |
232 | D | A | -4.1342 | |
233 | K | A | -3.5373 | |
234 | T | A | -2.1139 | |
235 | H | A | -1.8005 | |
236 | T | A | -0.6034 | |
237 | C | A | 0.3458 | |
238 | P | A | 0.0006 | |
239 | P | A | 0.0924 | |
240 | C | A | 0.5093 | |
241 | P | A | -0.2375 | |
242 | A | A | -0.2708 | |
243 | P | A | -0.4477 | |
244 | E | A | -0.8419 | |
245 | L | A | 1.1649 | |
246 | L | A | 1.4849 | |
247 | G | A | 0.2633 | |
248 | G | A | -0.1477 | |
249 | P | A | 0.0000 | |
250 | S | A | -0.1850 | |
251 | V | A | 0.0000 | |
252 | F | A | 0.7129 | |
253 | L | A | 0.7350 | |
254 | F | A | 0.9958 | |
255 | P | A | -0.2163 | |
256 | P | A | 0.0000 | |
257 | K | A | -2.1556 | |
258 | P | A | -1.5260 | |
259 | K | A | -1.5172 | |
260 | D | A | 0.0000 | |
261 | T | A | 0.0000 | |
262 | L | A | 0.0000 | |
263 | M | A | 0.1150 | |
264 | I | A | 1.2642 | |
265 | S | A | -0.0830 | |
266 | R | A | -1.5217 | |
267 | T | A | -0.9708 | |
268 | P | A | 0.0000 | |
269 | E | A | -1.3047 | |
270 | V | A | 0.0000 | |
271 | T | A | 0.1083 | |
272 | C | A | 0.0000 | |
273 | V | A | 0.0000 | |
274 | V | A | 0.0000 | |
275 | V | A | -0.9866 | |
276 | D | A | -1.4723 | |
277 | V | A | 0.0000 | |
278 | S | A | -2.1512 | |
279 | H | A | -2.6931 | |
280 | E | A | -3.0477 | |
281 | D | A | -2.7630 | |
282 | P | A | -2.7089 | |
283 | E | A | -3.2439 | |
284 | V | A | -2.1073 | |
285 | K | A | -2.2483 | |
286 | F | A | -1.1011 | |
287 | N | A | -1.0658 | |
288 | W | A | 0.0000 | |
289 | Y | A | -0.5965 | |
290 | V | A | -0.8843 | |
291 | D | A | -2.1751 | |
292 | G | A | -0.8924 | |
293 | V | A | 0.5901 | |
294 | E | A | -0.6390 | |
295 | V | A | -0.5396 | |
296 | H | A | -1.8816 | |
297 | N | A | -2.1792 | |
298 | A | A | -1.9010 | |
299 | K | A | -2.3730 | |
300 | T | A | -1.8696 | |
301 | K | A | -2.2457 | |
302 | P | A | -2.4756 | |
303 | R | A | -3.8579 | |
304 | E | A | -3.9750 | |
305 | E | A | -3.6217 | |
306 | Q | A | -2.3372 | |
307 | Y | A | -1.1821 | |
308 | N | A | -1.1479 | |
309 | S | A | -1.3286 | |
310 | T | A | -2.0643 | |
311 | Y | A | 0.0000 | |
312 | R | A | -2.4675 | |
313 | V | A | 0.0000 | |
314 | V | A | -0.9822 | |
315 | S | A | 0.0000 | |
316 | V | A | 0.0000 | |
317 | L | A | 0.0000 | |
318 | T | A | -0.7763 | |
319 | V | A | 0.0000 | |
320 | L | A | 0.5058 | |
321 | H | A | -0.2718 | |
322 | Q | A | -1.1780 | |
323 | D | A | -1.4462 | |
324 | W | A | 0.0000 | |
325 | L | A | -0.9704 | |
326 | N | A | -2.0816 | |
327 | G | A | -2.1058 | |
328 | K | A | -2.2227 | |
329 | E | A | -2.2392 | |
330 | Y | A | 0.0000 | |
331 | K | A | -1.4103 | |
332 | C | A | 0.0000 | |
333 | K | A | -1.2068 | |
334 | V | A | 0.0000 | |
335 | S | A | -1.3776 | |
336 | N | A | 0.0000 | |
337 | K | A | -2.6177 | |
338 | A | A | -1.2148 | |
339 | L | A | -0.4835 | |
340 | P | A | -0.3159 | |
341 | A | A | -0.3465 | |
342 | P | A | -0.7017 | |
343 | I | A | -0.3112 | |
344 | E | A | -1.2865 | |
345 | K | A | -0.9130 | |
346 | T | A | -0.8826 | |
347 | I | A | -0.2255 | |
348 | S | A | -1.1996 | |
349 | K | A | -1.3028 | |
350 | A | A | -1.1724 | |
351 | K | A | -2.3455 | |
352 | G | A | -1.9682 | |
353 | Q | A | -2.1232 | |
354 | P | A | -1.7467 | |
355 | R | A | -2.1975 | |
356 | E | A | -2.8216 | |
357 | P | A | 0.0000 | |
358 | Q | A | -1.5479 | |
359 | V | A | -0.5094 | |
360 | Y | A | 0.5776 | |
361 | T | A | 0.3363 | |
362 | L | A | 0.5259 | |
363 | P | A | -0.2215 | |
364 | P | A | -0.9451 | |
365 | S | A | -1.7272 | |
366 | R | A | -2.8746 | |
367 | D | A | -3.1173 | |
368 | E | A | -2.6217 | |
369 | L | A | -2.2904 | |
370 | T | A | -2.1372 | |
371 | K | A | -3.0759 | |
372 | N | A | -2.8810 | |
373 | Q | A | -2.5468 | |
374 | V | A | 0.0000 | |
375 | S | A | -0.7177 | |
376 | L | A | 0.0000 | |
377 | T | A | -0.1616 | |
378 | C | A | 0.0000 | |
379 | L | A | 0.5043 | |
380 | V | A | 0.0000 | |
381 | K | A | -0.6411 | |
382 | G | A | -1.3539 | |
383 | F | A | 0.0000 | |
384 | Y | A | -1.0129 | |
385 | P | A | 0.0000 | |
386 | S | A | 0.0033 | |
387 | D | A | -1.2036 | |
388 | I | A | 0.0000 | |
389 | A | A | -0.7128 | |
390 | V | A | 0.0000 | |
391 | E | A | -1.2945 | |
392 | W | A | 0.0000 | |
393 | E | A | -2.0041 | |
394 | S | A | 0.0000 | |
395 | N | A | -1.9296 | |
396 | G | A | -1.8280 | |
397 | Q | A | -2.3392 | |
398 | P | A | -2.0675 | |
399 | E | A | -2.0535 | |
400 | N | A | -2.4920 | |
401 | N | A | -2.3100 | |
402 | Y | A | -2.1258 | |
403 | K | A | -2.4368 | |
404 | T | A | -1.0675 | |
405 | T | A | -0.3216 | |
406 | P | A | 0.0598 | |
407 | P | A | 0.6900 | |
408 | V | A | 1.6434 | |
409 | L | A | 1.3694 | |
410 | D | A | -0.4581 | |
411 | S | A | -1.0412 | |
412 | D | A | -1.9796 | |
413 | G | A | -0.7849 | |
414 | S | A | 0.0000 | |
415 | F | A | 0.4418 | |
416 | F | A | 0.7668 | |
417 | L | A | 0.0000 | |
418 | Y | A | 0.4199 | |
419 | S | A | 0.0000 | |
420 | K | A | -1.6869 | |
421 | L | A | 0.0000 | |
422 | T | A | -1.4923 | |
423 | V | A | 0.0000 | |
424 | D | A | -2.5345 | |
425 | K | A | -2.6978 | |
426 | S | A | -2.1595 | |
427 | R | A | -2.0003 | |
428 | W | A | 0.0000 | |
429 | Q | A | -2.3072 | |
430 | Q | A | -2.1293 | |
431 | G | A | -1.2504 | |
432 | N | A | -0.8982 | |
433 | V | A | -0.0569 | |
434 | F | A | 0.0000 | |
435 | S | A | -1.0788 | |
436 | C | A | 0.0000 | |
437 | S | A | 0.0000 | |
438 | V | A | 0.0000 | |
439 | M | A | 0.0000 | |
440 | H | A | 0.0000 | |
441 | E | A | -1.1487 | |
442 | A | A | -1.5119 | |
443 | L | A | -1.5074 | |
444 | H | A | -1.7712 | |
445 | N | A | -1.6974 | |
446 | H | A | -1.0697 | |
447 | Y | A | -0.5545 | |
448 | T | A | -1.0123 | |
449 | Q | A | -1.5116 | |
450 | K | A | -1.1866 | |
451 | S | A | -0.5892 | |
452 | L | A | 0.0000 | |
453 | S | A | -0.1924 | |
454 | L | A | -0.4085 | |
455 | S | A | -0.7381 | |
456 | P | A | -0.9459 | |
457 | G | A | -1.4161 | |
458 | K | A | -2.0250 |