Project name: 2510-15.pdb

Chain sequence(s)	H: EVQLQQSGPELVKPGASVKISCKASGYTFTDYYINWVKQKPGQGLEWIGWIYPGSGNSKYNEKFKGKATLTVDTSSSTAYMQLSSLTSEDTAVYFCARGTGIFAYWGQGTLVTVSS; L: DAVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGFYFCSQSTHVPLTFGAGTKLELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:31)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:33)

• Minimal score value: -3.2454
• Maximal score value: 1.3263
• Average score: -0.5282
• Total score value: -120.4216

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1359
2	V	H	-1.3229
3	Q	H	-2.0863
4	L	H	0.0000
5	Q	H	-1.7365
6	Q	H	0.0000
7	S	H	-0.8561
8	G	H	-0.6203
9	P	H	0.0586
11	E	H	0.0419
12	L	H	1.0799
13	V	H	-0.1705
14	K	H	-1.7129
15	P	H	-1.4065
16	G	H	-1.1067
17	A	H	-0.8590
18	S	H	-0.9594
19	V	H	0.0000
20	K	H	-1.5120
21	I	H	0.0000
22	S	H	-0.6457
23	C	H	0.0000
24	K	H	-1.2298
25	A	H	0.0000
26	S	H	-1.1892
27	G	H	-1.2495
28	Y	H	-0.7197
29	T	H	-0.5777
30	F	H	0.0000
35	T	H	-0.8821
36	D	H	-1.6069
37	Y	H	-0.3027
38	Y	H	0.2234
39	I	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	K	H	0.0000
44	Q	H	-0.8636
45	K	H	-1.3881
46	P	H	-0.9479
47	G	H	-1.3421
48	Q	H	-1.8739
49	G	H	-1.0893
50	L	H	0.0000
51	E	H	-1.2894
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	W	H	-0.0282
56	I	H	0.0000
57	Y	H	-0.3751
58	P	H	0.0000
59	G	H	-0.9941
62	S	H	-1.0172
63	G	H	-0.9368
64	N	H	-1.5231
65	S	H	-0.8995
66	K	H	-1.2538
67	Y	H	-1.3224
68	N	H	0.0000
69	E	H	-3.1922
70	K	H	-3.2454
71	F	H	0.0000
72	K	H	-3.2225
74	G	H	-1.9970
75	K	H	-1.7199
76	A	H	0.0000
77	T	H	-0.8149
78	L	H	0.0000
79	T	H	-0.2801
80	V	H	-0.2112
81	D	H	-0.5794
82	T	H	-0.5203
83	S	H	-0.4305
84	S	H	-0.4989
85	S	H	-0.4734
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.2783
89	M	H	0.0000
90	Q	H	-1.1499
91	L	H	0.0000
92	S	H	-0.8186
93	S	H	-0.8475
94	L	H	0.0000
95	T	H	-1.2988
96	S	H	-1.4158
97	E	H	-2.0091
98	D	H	0.0000
99	T	H	-0.4299
100	A	H	0.0000
101	V	H	0.2980
102	Y	H	0.0000
103	F	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.1265
107	G	H	0.0000
108	T	H	-0.0687
109	G	H	-0.1496
114	I	H	0.2461
115	F	H	0.0000
116	A	H	-0.0034
117	Y	H	-0.4320
118	W	H	-0.7231
119	G	H	0.0000
120	Q	H	-1.6165
121	G	H	-0.7030
122	T	H	0.0000
123	L	H	0.7558
124	V	H	0.0000
125	T	H	0.1382
126	V	H	0.0000
127	S	H	-0.5699
128	S	H	-0.7966
1	D	L	-1.1310
2	A	L	0.0000
3	V	L	0.7917
4	M	L	0.0000
5	T	L	-0.2018
6	Q	L	0.0000
7	T	L	0.0397
8	P	L	0.4482
9	L	L	1.3263
10	S	L	0.3546
11	L	L	0.0934
12	P	L	-0.4996
13	V	L	0.0000
14	S	L	-0.2266
15	L	L	0.5232
16	G	L	-1.0017
17	D	L	-1.4607
18	Q	L	-2.1982
19	A	L	0.0000
20	S	L	-0.8674
21	I	L	0.0000
22	S	L	-0.7116
23	C	L	0.0000
24	R	L	-2.1996
25	S	L	0.0000
26	S	L	-0.8676
27	Q	L	-1.2576
28	S	L	-0.6641
29	L	L	0.0000
30	V	L	0.4814
31	H	L	-0.5140
32	S	L	-0.8876
34	N	L	-1.6246
35	G	L	-1.0908
36	N	L	-0.9235
37	T	L	-0.2158
38	Y	L	0.0451
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	L	L	0.0000
44	Q	L	-0.8044
45	K	L	-1.2180
46	P	L	-0.7296
47	G	L	-1.1688
48	Q	L	-1.5987
49	S	L	-1.2415
50	P	L	0.0000
51	K	L	-1.7581
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.2361
56	K	L	-0.5738
57	V	L	-0.6492
65	S	L	-0.8029
66	N	L	-1.1360
67	R	L	-1.5120
68	F	L	-0.4786
69	S	L	-0.4853
70	G	L	-0.7560
71	V	L	-0.7959
72	P	L	-1.2058
74	D	L	-2.1720
75	R	L	-2.0183
76	F	L	0.0000
77	S	L	-1.3069
78	G	L	0.0000
79	S	L	-0.8332
80	G	L	-1.0308
83	S	L	-0.6418
84	G	L	-0.5730
85	T	L	-1.3034
86	D	L	-1.8917
87	F	L	0.0000
88	T	L	-0.9130
89	L	L	0.0000
90	K	L	-1.6096
91	I	L	0.0000
92	S	L	-2.2893
93	R	L	-2.3883
94	V	L	0.0000
95	E	L	-1.0085
96	A	L	-0.4492
97	E	L	-1.8771
98	D	L	0.0000
99	L	L	-0.2756
100	G	L	0.0000
101	F	L	0.5687
102	Y	L	0.0000
103	F	L	0.0000
104	C	L	0.0000
105	S	L	0.0000
106	Q	L	0.0000
107	S	L	0.4140
108	T	L	0.0726
109	H	L	0.2686
114	V	L	1.0019
115	P	L	-0.1504
116	L	L	0.4764
117	T	L	0.2334
118	F	L	0.2908
119	G	L	0.0000
120	A	L	0.2896
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.1073
124	L	L	0.0000
125	E	L	0.0462
126	L	L	0.8002
127	K	L	-0.8929