Chain sequence(s) |
A: YEVRNASGLYHVTNDCSNASIVYETTDMIMHTPGCVPCVREDNSSRCWVALTPTLAARNASVPTVAIRRHVDLLVGAAAFCSAMYVGDLCGSVFLVSQLFTFSPRRHETVQDCNCSIYPGHVSGHRMAWDMMMNWSPTAALVVSQLLRIPQAVVDMVAGAHWGILAGLAYYSMVGNWAKVLIVMLLFTGVDG
B: VQLINTNGSWHINRTALNCNDSLHTGFLAALFYTHKFNASGCPERMAHCRPIDEFAQGWGPITYAEGHGSDQRPYCWHYAPRQCGTIPASQVCGPVYCFTPSPVVVGTTDRFGAPTYTWGENETDVLILNNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLNAACNWTRGERCDLQDRDRSELSPLLLSTTEWQILPCSFTTLPALSTGLIHLHQNIVDVQYLYGIGSAVVSFAIKWEYVVLLFLLLADARVCACLWMMLLIVQ input PDB |
Selected Chain(s) | A,B |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:19) [INFO] Main: Simulation completed successfully. (00:04:23) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
192 | Y | A | 0.4951 | |
193 | E | A | 0.1204 | |
194 | V | A | 0.0455 | |
195 | R | A | -1.0263 | |
196 | N | A | -1.0540 | |
197 | A | A | -0.8493 | |
198 | S | A | -0.5392 | |
199 | G | A | -0.7652 | |
200 | L | A | -0.6186 | |
201 | Y | A | -0.3581 | |
202 | H | A | -0.5093 | |
203 | V | A | 0.0000 | |
204 | T | A | 0.0000 | |
205 | N | A | 0.0000 | |
206 | D | A | 0.0000 | |
207 | C | A | 0.0000 | |
208 | S | A | -0.5815 | |
209 | N | A | -1.4976 | |
210 | A | A | -0.6300 | |
211 | S | A | 0.0000 | |
212 | I | A | -0.3153 | |
213 | V | A | -0.1707 | |
214 | Y | A | -0.1251 | |
215 | E | A | -0.9102 | |
216 | T | A | -0.9084 | |
217 | T | A | -1.1743 | |
218 | D | A | -1.8417 | |
219 | M | A | 0.0000 | |
220 | I | A | 0.0000 | |
221 | M | A | 0.0000 | |
222 | H | A | 0.0000 | |
223 | T | A | 0.1768 | |
224 | P | A | 0.0000 | |
225 | G | A | 0.0000 | |
226 | C | A | 0.0000 | |
227 | V | A | 0.0000 | |
228 | P | A | 0.0000 | |
229 | C | A | 0.0000 | |
230 | V | A | 0.0000 | |
231 | R | A | -2.8375 | |
232 | E | A | -2.7502 | |
233 | D | A | -2.8002 | |
234 | N | A | -2.4866 | |
235 | S | A | -2.2468 | |
236 | S | A | -2.5853 | |
237 | R | A | -2.4792 | |
238 | C | A | -1.1549 | |
239 | W | A | 0.0000 | |
240 | V | A | 0.1586 | |
241 | A | A | 0.4198 | |
242 | L | A | 0.2454 | |
243 | T | A | 0.1734 | |
244 | P | A | 0.0623 | |
245 | T | A | 0.0000 | |
246 | L | A | 0.0000 | |
247 | A | A | 0.0000 | |
248 | A | A | 0.0000 | |
249 | R | A | -2.3807 | |
250 | N | A | -1.8929 | |
251 | A | A | -0.6669 | |
252 | S | A | -0.6541 | |
253 | V | A | -0.4257 | |
254 | P | A | 0.2254 | |
255 | T | A | 0.5955 | |
256 | V | A | 1.1680 | |
257 | A | A | 0.1527 | |
258 | I | A | 0.0000 | |
259 | R | A | -0.2487 | |
260 | R | A | -0.6598 | |
261 | H | A | -0.3994 | |
262 | V | A | 0.0000 | |
263 | D | A | 0.0000 | |
264 | L | A | 0.9800 | |
265 | L | A | 0.0000 | |
266 | V | A | 0.0000 | |
267 | G | A | 1.1754 | |
268 | A | A | 1.0331 | |
269 | A | A | 0.0000 | |
270 | A | A | 0.0000 | |
271 | F | A | 2.4128 | |
272 | C | A | 0.0000 | |
273 | S | A | 0.0000 | |
274 | A | A | 1.7942 | |
275 | M | A | 2.3809 | |
276 | Y | A | 2.3703 | |
277 | V | A | 2.0347 | |
278 | G | A | 0.0000 | |
279 | D | A | 0.5819 | |
280 | L | A | 2.2028 | |
281 | C | A | 1.8993 | |
282 | G | A | 0.0000 | |
283 | S | A | 1.9498 | |
284 | V | A | 2.8019 | |
285 | F | A | 2.0864 | |
286 | L | A | 2.3008 | |
287 | V | A | 3.4085 | |
288 | S | A | 2.7995 | |
289 | Q | A | 0.0000 | |
290 | L | A | 3.6785 | |
291 | F | A | 3.6159 | |
292 | T | A | 2.3961 | |
293 | F | A | 2.6476 | |
294 | S | A | 0.5054 | |
295 | P | A | -0.9505 | |
296 | R | A | -2.4280 | |
297 | R | A | -3.0793 | |
298 | H | A | -2.6129 | |
299 | E | A | -2.9082 | |
300 | T | A | 0.0000 | |
301 | V | A | -1.4763 | |
302 | Q | A | -1.6914 | |
303 | D | A | -2.4033 | |
304 | C | A | -1.8978 | |
305 | N | A | -1.6692 | |
306 | C | A | 0.0000 | |
307 | S | A | 0.3800 | |
308 | I | A | 1.4303 | |
309 | Y | A | 0.8228 | |
310 | P | A | 0.0114 | |
311 | G | A | -0.6368 | |
312 | H | A | -1.2434 | |
313 | V | A | -0.8059 | |
314 | S | A | -1.0391 | |
315 | G | A | -1.0741 | |
316 | H | A | -1.0521 | |
317 | R | A | -0.9516 | |
318 | M | A | -0.3985 | |
319 | A | A | -0.2162 | |
320 | W | A | 0.0395 | |
321 | D | A | 0.0000 | |
322 | M | A | 0.6307 | |
323 | M | A | 0.8385 | |
324 | M | A | 0.0000 | |
325 | N | A | 0.0000 | |
326 | W | A | 1.3461 | |
327 | S | A | 0.5585 | |
328 | P | A | 0.7391 | |
329 | T | A | 0.8087 | |
330 | A | A | 0.9629 | |
331 | A | A | 0.0000 | |
332 | L | A | 1.6042 | |
333 | V | A | 2.3005 | |
334 | V | A | 1.8969 | |
335 | S | A | 1.2127 | |
336 | Q | A | 0.8262 | |
337 | L | A | 2.0377 | |
338 | L | A | 1.1628 | |
339 | R | A | 0.3297 | |
340 | I | A | 1.1167 | |
341 | P | A | 0.5941 | |
342 | Q | A | 0.2465 | |
343 | A | A | 0.0000 | |
344 | V | A | 1.9424 | |
345 | V | A | 2.2132 | |
346 | D | A | 0.8652 | |
347 | M | A | 0.0000 | |
348 | V | A | 2.5557 | |
349 | A | A | 1.2290 | |
350 | G | A | 0.7678 | |
351 | A | A | 0.8868 | |
352 | H | A | 0.0000 | |
353 | W | A | 1.6127 | |
354 | G | A | 1.0535 | |
355 | I | A | 0.0000 | |
356 | L | A | 1.3807 | |
357 | A | A | 0.9016 | |
358 | G | A | 0.0000 | |
359 | L | A | 0.9947 | |
360 | A | A | 0.7131 | |
361 | Y | A | 1.0622 | |
362 | Y | A | 0.0000 | |
363 | S | A | 0.8264 | |
364 | M | A | 1.4869 | |
365 | V | A | 1.3861 | |
366 | G | A | 0.5003 | |
367 | N | A | 0.5809 | |
368 | W | A | 1.4978 | |
369 | A | A | 0.9968 | |
370 | K | A | 0.0000 | |
371 | V | A | 1.2462 | |
372 | L | A | 1.8273 | |
373 | I | A | 1.4263 | |
374 | V | A | 0.0000 | |
375 | M | A | 1.1834 | |
376 | L | A | 1.2005 | |
377 | L | A | 0.0000 | |
378 | F | A | 0.0000 | |
379 | T | A | 0.0000 | |
380 | G | A | 0.0000 | |
381 | V | A | 0.0000 | |
382 | D | A | -0.4112 | |
383 | G | A | -0.2493 | |
411 | V | B | 2.0611 | |
412 | Q | B | 0.3049 | |
413 | L | B | 0.8449 | |
414 | I | B | 0.9773 | |
415 | N | B | -0.1121 | |
416 | T | B | -0.7107 | |
417 | N | B | -1.3899 | |
418 | G | B | -0.9977 | |
419 | S | B | -0.5875 | |
420 | W | B | -0.1843 | |
421 | H | B | -0.1242 | |
422 | I | B | 0.7474 | |
423 | N | B | 0.3991 | |
424 | R | B | 0.3351 | |
425 | T | B | 0.0000 | |
426 | A | B | 0.0000 | |
427 | L | B | -0.2881 | |
428 | N | B | -0.9960 | |
429 | C | B | -0.8396 | |
430 | N | B | -1.5070 | |
431 | D | B | -0.9367 | |
432 | S | B | -0.3986 | |
433 | L | B | 0.5840 | |
434 | H | B | -0.6782 | |
435 | T | B | -0.2531 | |
436 | G | B | -0.4055 | |
437 | F | B | 0.0000 | |
438 | L | B | 0.3910 | |
439 | A | B | 0.8030 | |
440 | A | B | 0.6285 | |
441 | L | B | 0.0000 | |
442 | F | B | 2.6931 | |
443 | Y | B | 1.8965 | |
444 | T | B | 0.2241 | |
445 | H | B | -1.0804 | |
446 | K | B | -2.0989 | |
447 | F | B | -1.3417 | |
448 | N | B | -1.7638 | |
449 | A | B | -1.1634 | |
450 | S | B | -1.0845 | |
451 | G | B | -1.3659 | |
452 | C | B | -1.3343 | |
453 | P | B | -1.6860 | |
454 | E | B | -2.8652 | |
455 | R | B | -2.7964 | |
456 | M | B | -1.5787 | |
457 | A | B | -1.6199 | |
458 | H | B | -1.9873 | |
459 | C | B | -1.2451 | |
460 | R | B | -1.4974 | |
461 | P | B | -1.4391 | |
462 | I | B | 0.0000 | |
463 | D | B | -2.0426 | |
464 | E | B | -2.3378 | |
465 | F | B | 0.0000 | |
466 | A | B | -0.5855 | |
467 | Q | B | -0.2946 | |
468 | G | B | 0.0000 | |
469 | W | B | 0.3458 | |
470 | G | B | -0.3560 | |
471 | P | B | -0.4981 | |
472 | I | B | -0.1579 | |
473 | T | B | 0.0080 | |
474 | Y | B | 0.3766 | |
475 | A | B | -1.0978 | |
476 | E | B | -2.4733 | |
477 | G | B | 0.0000 | |
478 | H | B | -2.2805 | |
479 | G | B | -1.7626 | |
480 | S | B | -1.6001 | |
481 | D | B | -1.7139 | |
482 | Q | B | -1.9048 | |
483 | R | B | -1.8268 | |
484 | P | B | -0.6224 | |
485 | Y | B | -0.5196 | |
486 | C | B | 0.0000 | |
487 | W | B | 0.0000 | |
488 | H | B | -0.3237 | |
489 | Y | B | -0.6641 | |
490 | A | B | 0.0000 | |
491 | P | B | 0.0000 | |
492 | R | B | -2.9691 | |
493 | Q | B | -2.5916 | |
494 | C | B | 0.0000 | |
495 | G | B | -1.1083 | |
496 | T | B | -0.3709 | |
497 | I | B | -0.1039 | |
498 | P | B | -0.9987 | |
499 | A | B | 0.0000 | |
500 | S | B | -1.6686 | |
501 | Q | B | -1.4238 | |
502 | V | B | 0.0000 | |
503 | C | B | 0.0000 | |
504 | G | B | 0.0000 | |
505 | P | B | 0.0000 | |
506 | V | B | 0.0000 | |
507 | Y | B | 0.0000 | |
508 | C | B | 0.0000 | |
509 | F | B | 0.0000 | |
510 | T | B | -0.1350 | |
511 | P | B | 0.0000 | |
512 | S | B | -0.5786 | |
513 | P | B | 0.0254 | |
514 | V | B | 0.4701 | |
515 | V | B | 0.4715 | |
516 | V | B | 0.5285 | |
517 | G | B | 0.0000 | |
518 | T | B | 0.0000 | |
519 | T | B | -0.1373 | |
520 | D | B | -0.9046 | |
521 | R | B | -1.0935 | |
522 | F | B | 0.8733 | |
523 | G | B | 0.1157 | |
524 | A | B | -0.0930 | |
525 | P | B | -0.1894 | |
526 | T | B | -0.1562 | |
527 | Y | B | 0.4736 | |
528 | T | B | -0.1298 | |
529 | W | B | -0.1134 | |
530 | G | B | 0.0000 | |
531 | E | B | -2.3930 | |
532 | N | B | -2.4140 | |
533 | E | B | -2.7275 | |
534 | T | B | -1.8207 | |
535 | D | B | 0.0000 | |
536 | V | B | -0.8031 | |
537 | L | B | 0.0000 | |
538 | I | B | 0.1825 | |
539 | L | B | 0.0000 | |
540 | N | B | -1.4985 | |
541 | N | B | -1.1308 | |
542 | T | B | -1.0637 | |
543 | R | B | 0.0000 | |
544 | P | B | 0.0000 | |
545 | P | B | -0.9987 | |
546 | Q | B | -1.5979 | |
547 | G | B | -1.3417 | |
548 | N | B | -1.1825 | |
549 | W | B | -0.5866 | |
550 | F | B | 0.0000 | |
551 | G | B | 0.0000 | |
552 | C | B | 0.0000 | |
553 | T | B | 0.0000 | |
554 | W | B | 0.0000 | |
555 | M | B | 0.0000 | |
556 | N | B | -0.3828 | |
557 | S | B | -0.7182 | |
558 | T | B | -0.2370 | |
559 | G | B | 0.3447 | |
560 | F | B | 1.3631 | |
561 | T | B | 0.3687 | |
562 | K | B | -0.2989 | |
563 | T | B | -0.5418 | |
564 | C | B | 0.0000 | |
565 | G | B | 0.0000 | |
566 | G | B | 0.0000 | |
567 | P | B | -1.1126 | |
568 | P | B | 0.0000 | |
569 | C | B | 0.0000 | |
570 | N | B | -0.4547 | |
571 | I | B | 0.0000 | |
572 | G | B | 0.0335 | |
573 | G | B | 0.2976 | |
574 | V | B | 1.1662 | |
575 | G | B | -0.3671 | |
576 | N | B | -1.2995 | |
577 | N | B | -1.0535 | |
578 | T | B | -0.6550 | |
579 | L | B | 0.0000 | |
580 | T | B | -0.2109 | |
581 | C | B | 0.0000 | |
582 | P | B | 0.0000 | |
583 | T | B | 0.0000 | |
584 | D | B | 0.0000 | |
585 | C | B | 0.0000 | |
586 | F | B | 0.0000 | |
587 | R | B | 0.0000 | |
588 | K | B | 0.0000 | |
589 | H | B | 0.0000 | |
590 | P | B | -0.8650 | |
591 | E | B | -1.8631 | |
592 | A | B | 0.0000 | |
593 | T | B | -0.8403 | |
594 | Y | B | 0.0000 | |
595 | T | B | -0.5482 | |
596 | K | B | -0.7341 | |
597 | C | B | 0.0000 | |
598 | G | B | 0.0000 | |
599 | S | B | 0.0000 | |
600 | G | B | 0.0000 | |
601 | P | B | 0.0000 | |
602 | W | B | 0.0000 | |
603 | L | B | 0.0000 | |
604 | T | B | 0.0000 | |
605 | P | B | 0.0000 | |
606 | R | B | -0.6669 | |
607 | C | B | 0.0000 | |
608 | L | B | 0.0000 | |
609 | V | B | 0.0000 | |
610 | D | B | -0.2743 | |
611 | Y | B | 0.0000 | |
612 | P | B | -0.1736 | |
613 | Y | B | 0.0000 | |
614 | R | B | 0.0000 | |
615 | L | B | 0.2654 | |
616 | W | B | 0.0000 | |
617 | H | B | 0.0000 | |
618 | Y | B | 0.0000 | |
619 | P | B | -0.1147 | |
620 | C | B | -0.2839 | |
621 | T | B | 0.0000 | |
622 | V | B | -0.2159 | |
623 | N | B | -0.8920 | |
624 | F | B | 0.0000 | |
625 | T | B | 0.4641 | |
626 | I | B | 1.2312 | |
627 | F | B | 0.0847 | |
628 | K | B | -1.7378 | |
629 | V | B | 0.0000 | |
630 | R | B | -1.3702 | |
631 | M | B | 0.0000 | |
632 | Y | B | 0.4541 | |
633 | V | B | 0.0000 | |
634 | G | B | -0.3619 | |
635 | G | B | 0.1675 | |
636 | V | B | 1.0142 | |
637 | E | B | -0.3920 | |
638 | H | B | -0.9306 | |
639 | R | B | -2.2789 | |
640 | L | B | 0.0000 | |
641 | N | B | -1.1434 | |
642 | A | B | 0.0000 | |
643 | A | B | 0.0000 | |
644 | C | B | 0.0000 | |
645 | N | B | -1.0207 | |
646 | W | B | -1.1797 | |
647 | T | B | -1.8270 | |
648 | R | B | -2.6262 | |
649 | G | B | -2.2462 | |
650 | E | B | -2.7229 | |
651 | R | B | -3.0101 | |
652 | C | B | -2.1722 | |
653 | D | B | -2.1384 | |
654 | L | B | -0.9487 | |
655 | Q | B | -1.2033 | |
656 | D | B | -1.2912 | |
657 | R | B | 0.0000 | |
658 | D | B | 0.0000 | |
659 | R | B | 0.0000 | |
660 | S | B | 0.0000 | |
661 | E | B | -0.2478 | |
662 | L | B | 0.0000 | |
663 | S | B | -0.0359 | |
664 | P | B | 0.0000 | |
665 | L | B | 0.4051 | |
666 | L | B | 1.2180 | |
667 | L | B | 1.3635 | |
668 | S | B | 0.6137 | |
669 | T | B | 0.2623 | |
670 | T | B | 0.0000 | |
671 | E | B | 0.1261 | |
672 | W | B | 0.0000 | |
673 | Q | B | -0.0051 | |
674 | I | B | 0.0000 | |
675 | L | B | 0.0000 | |
676 | P | B | 0.0000 | |
677 | C | B | 0.0000 | |
678 | S | B | 0.0000 | |
679 | F | B | 0.0000 | |
680 | T | B | 0.0000 | |
681 | T | B | -0.0306 | |
682 | L | B | 0.0000 | |
683 | P | B | 0.2512 | |
684 | A | B | 0.4270 | |
685 | L | B | 1.1825 | |
686 | S | B | 0.7106 | |
687 | T | B | 0.5626 | |
688 | G | B | 0.0000 | |
689 | L | B | 0.0000 | |
690 | I | B | 0.0000 | |
691 | H | B | 0.0284 | |
692 | L | B | -0.0841 | |
693 | H | B | -0.7254 | |
694 | Q | B | -1.7160 | |
695 | N | B | -1.3912 | |
696 | I | B | -0.0025 | |
697 | V | B | -0.5918 | |
698 | D | B | -0.1446 | |
699 | V | B | 0.0000 | |
700 | Q | B | 0.0000 | |
701 | Y | B | 0.0666 | |
702 | L | B | 0.0000 | |
703 | Y | B | 0.4081 | |
704 | G | B | 0.1752 | |
705 | I | B | 0.4300 | |
706 | G | B | 0.0000 | |
707 | S | B | 1.0506 | |
708 | A | B | 1.4469 | |
709 | V | B | 2.2127 | |
710 | V | B | 1.3798 | |
711 | S | B | 1.0758 | |
712 | F | B | 2.0399 | |
713 | A | B | 1.0024 | |
714 | I | B | 0.0000 | |
715 | K | B | -0.9604 | |
716 | W | B | -0.5891 | |
717 | E | B | -0.5217 | |
718 | Y | B | 0.1539 | |
719 | V | B | 0.0000 | |
720 | V | B | 0.0000 | |
721 | L | B | 0.5565 | |
722 | L | B | 0.0000 | |
723 | F | B | 0.0000 | |
724 | L | B | 0.0000 | |
725 | L | B | 0.2775 | |
726 | L | B | 0.0000 | |
727 | A | B | 0.0000 | |
728 | D | B | -0.2999 | |
729 | A | B | 0.0000 | |
730 | R | B | -0.8403 | |
731 | V | B | 1.3105 | |
732 | C | B | 1.1777 | |
733 | A | B | 0.0000 | |
734 | C | B | 1.8662 | |
735 | L | B | 2.0987 | |
736 | W | B | 1.8894 | |
737 | M | B | 2.4414 | |
738 | M | B | 2.7348 | |
739 | L | B | 2.4034 | |
740 | L | B | 2.2667 | |
741 | I | B | 3.1683 | |
742 | V | B | 2.6683 | |
743 | Q | B | 0.5935 |