Project name: 7ST5

Chain sequence(s)	H: QVQLVQSGAEVKKPGASVKVSCKASGYTFRGYGISWVRQAPGQGLEWMGWISAYGGETNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCAREAGSSWYDFDLWGRGTLVTVSS; L: DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYAASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGASFPITFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:04)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:05)

• Minimal score value: -3.2111
• Maximal score value: 1.0923
• Average score: -0.5808
• Total score value: -131.8386

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.2008
2	V	H	-0.4895
3	Q	H	-0.8643
4	L	H	0.0000
5	V	H	-0.4488
6	Q	H	-0.7719
7	S	H	-0.7112
8	G	H	-0.6070
9	A	H	0.3397
11	E	H	0.2739
12	V	H	1.0923
13	K	H	-0.9317
14	K	H	-2.2177
15	P	H	-2.3962
16	G	H	-1.7627
17	A	H	-1.4149
18	S	H	-1.4298
19	V	H	0.0000
20	K	H	-1.4361
21	V	H	0.0000
22	S	H	-0.5287
23	C	H	0.0000
24	K	H	-1.0154
25	A	H	0.0000
26	S	H	-0.6319
27	G	H	-0.7204
28	Y	H	-0.4615
29	T	H	-0.6170
30	F	H	0.0000
35	R	H	-1.4401
36	G	H	-0.9009
37	Y	H	-0.2773
38	G	H	-0.4046
39	I	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.4964
45	A	H	-0.8838
46	P	H	-0.9113
47	G	H	-1.2439
48	Q	H	-1.7369
49	G	H	-1.1391
50	L	H	0.0000
51	E	H	-0.7894
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	W	H	-0.2915
56	I	H	0.0000
57	S	H	-0.7970
58	A	H	0.0000
59	Y	H	0.0359
62	G	H	-0.8670
63	G	H	-1.2402
64	E	H	-2.0342
65	T	H	-1.1685
66	N	H	-0.7850
67	Y	H	-0.6712
68	A	H	0.0000
69	Q	H	-2.5702
70	K	H	-2.6903
71	L	H	0.0000
72	Q	H	-2.3773
74	G	H	-1.5990
75	R	H	-1.3572
76	V	H	0.0000
77	T	H	-0.5983
78	M	H	0.0000
79	T	H	-0.5093
80	T	H	-0.5066
81	D	H	-0.7360
82	T	H	-0.6063
83	S	H	-0.4243
84	T	H	-0.5324
85	S	H	-0.8860
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.3273
89	M	H	0.0000
90	E	H	-0.9627
91	L	H	0.0000
92	R	H	-1.4930
93	S	H	-1.5062
94	L	H	0.0000
95	R	H	-3.2111
96	S	H	-2.4273
97	D	H	-2.5654
98	D	H	0.0000
99	T	H	-0.7336
100	A	H	0.0000
101	V	H	0.4537
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.2339
107	E	H	0.0000
108	A	H	-0.2996
109	G	H	-0.5342
110	S	H	-0.3635
111	S	H	-0.1581
112	W	H	0.3094
113	Y	H	0.1675
114	D	H	-0.1119
115	F	H	0.0000
116	D	H	-0.6551
117	L	H	-0.5080
118	W	H	0.0000
119	G	H	0.0000
120	R	H	-2.1369
121	G	H	-1.0027
122	T	H	0.0000
123	L	H	0.9517
124	V	H	0.0000
125	T	H	-0.0858
126	V	H	0.0000
127	S	H	-1.2980
128	S	H	-1.0597
1	D	L	-2.1599
2	I	L	-1.5593
3	Q	L	-2.1688
4	M	L	0.0000
5	T	L	-1.3089
6	Q	L	0.0000
7	S	L	-0.7874
8	P	L	-0.5756
9	S	L	-0.7349
10	S	L	-0.8901
11	V	L	-0.4636
12	S	L	-0.6367
13	A	L	0.0000
14	S	L	0.0095
15	V	L	0.9113
16	G	L	-0.3559
17	D	L	-1.3953
18	R	L	-2.1161
19	V	L	0.0000
20	T	L	-0.5687
21	I	L	0.0000
22	T	L	-0.8243
23	C	L	0.0000
24	R	L	-2.7976
25	A	L	0.0000
26	S	L	-1.9913
27	Q	L	-2.2717
28	G	L	-1.4970
29	I	L	0.0000
36	S	L	-0.5498
37	S	L	-0.2078
38	W	L	0.4371
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7766
44	Q	L	0.0000
45	K	L	-1.7319
46	P	L	-1.3029
47	G	L	-1.7254
48	K	L	-2.6999
49	A	L	-1.7655
50	P	L	0.0000
51	K	L	-1.2114
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.0815
56	A	L	0.0144
57	A	L	0.0000
65	S	L	-0.5792
66	N	L	-0.7403
67	L	L	-0.0280
68	Q	L	-0.4558
69	S	L	-0.4965
70	G	L	-0.4817
71	V	L	-0.2615
72	P	L	-0.3196
74	S	L	-0.3897
75	R	L	-0.8128
76	F	L	0.0000
77	S	L	-0.4451
78	G	L	-0.3977
79	S	L	-0.7160
80	G	L	-1.0327
83	S	L	-0.9857
84	G	L	-1.2576
85	T	L	-1.8339
86	D	L	-2.1331
87	F	L	0.0000
88	T	L	-0.7165
89	L	L	0.0000
90	T	L	-0.6142
91	I	L	0.0000
92	S	L	-1.3671
93	S	L	-1.0160
94	L	L	0.0000
95	Q	L	-0.6125
96	P	L	-0.5471
97	E	L	-1.6483
98	D	L	0.0000
99	F	L	-0.3208
100	A	L	0.0000
101	T	L	-0.8318
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	G	L	0.4061
108	A	L	0.1533
109	S	L	0.0681
114	F	L	0.2967
115	P	L	-0.4301
116	I	L	0.0000
117	T	L	-0.5727
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-1.0429
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.4002
124	V	L	0.0000
125	E	L	-0.6773
126	I	L	0.9925
127	K	L	-0.7915