| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPEKDIIVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEYVHCGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRCGPDGHPLPAAPPPSPLFTPPPPDSPYAVLPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQVCTPATNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:02)
[INFO] Main: Simulation completed successfully. (00:00:08)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9428 | |
| 2 | L | A | 1.9627 | |
| 3 | P | A | 0.8333 | |
| 4 | P | A | 0.3803 | |
| 5 | T | A | 0.1270 | |
| 6 | T | A | 0.1314 | |
| 7 | P | A | 0.1774 | |
| 8 | V | A | 1.2146 | |
| 9 | A | A | 0.0882 | |
| 10 | K | A | -1.0174 | |
| 11 | V | A | -0.1491 | |
| 12 | Q | A | -1.3907 | |
| 13 | S | A | -1.5507 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4328 | |
| 16 | E | A | -2.4438 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4552 | |
| 20 | P | A | 0.1249 | |
| 21 | T | A | 0.1813 | |
| 22 | S | A | -0.0955 | |
| 23 | L | A | 0.1189 | |
| 24 | F | A | -0.0250 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.3017 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8974 | |
| 31 | R | A | -2.6759 | |
| 32 | L | A | -0.7892 | |
| 33 | L | A | 1.1758 | |
| 34 | T | A | 1.3920 | |
| 35 | V | A | 1.8765 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.3222 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -1.2365 | |
| 40 | K | A | -1.8559 | |
| 41 | D | A | -0.5852 | |
| 42 | I | A | 1.4312 | |
| 43 | I | A | 2.5761 | |
| 44 | V | A | 1.7949 | |
| 45 | N | A | -0.4773 | |
| 46 | G | A | -0.2937 | |
| 47 | K | A | -0.0403 | |
| 48 | V | A | 2.1517 | |
| 49 | L | A | 2.6354 | |
| 50 | V | A | 1.5567 | |
| 51 | P | A | 0.3829 | |
| 52 | K | A | -0.7722 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1308 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3900 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2692 | |
| 70 | K | A | -1.7907 | |
| 71 | F | A | -0.6417 | |
| 72 | A | A | -0.5780 | |
| 73 | L | A | -0.8621 | |
| 74 | P | A | -1.2073 | |
| 75 | Q | A | -2.5071 | |
| 76 | K | A | -3.1096 | |
| 77 | D | A | -2.9883 | |
| 78 | F | A | -1.6505 | |
| 79 | Y | A | -1.8863 | |
| 80 | D | A | -2.6925 | |
| 81 | P | A | -2.3619 | |
| 82 | E | A | -3.0548 | |
| 83 | K | A | -3.3974 | |
| 84 | E | A | -2.4629 | |
| 85 | R | A | -1.2992 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6547 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9661 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3475 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6885 | |
| 99 | G | A | -0.5366 | |
| 100 | P | A | -0.3995 | |
| 101 | L | A | 0.0515 | |
| 102 | G | A | -0.1999 | |
| 103 | K | A | -0.5527 | |
| 104 | G | A | -0.3851 | |
| 105 | T | A | -0.3702 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.0695 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4186 | |
| 110 | L | A | 0.3176 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1050 | |
| 113 | K | A | -0.4527 | |
| 114 | L | A | -0.7072 | |
| 115 | G | A | -0.8920 | |
| 116 | D | A | -1.5697 | |
| 117 | T | A | -1.0670 | |
| 118 | E | A | -1.8708 | |
| 119 | N | A | -2.2296 | |
| 120 | P | A | -1.8081 | |
| 121 | T | A | -1.4195 | |
| 122 | E | A | -1.7565 | |
| 123 | Y | A | 0.0603 | |
| 124 | V | A | 0.3472 | |
| 125 | H | A | 0.2526 | |
| 126 | C | A | -0.4015 | |
| 127 | G | A | -1.0682 | |
| 128 | A | A | -1.2262 | |
| 129 | D | A | -2.1890 | |
| 130 | D | A | -1.7097 | |
| 131 | R | A | -1.1228 | |
| 132 | V | A | 0.2355 | |
| 133 | A | A | 0.4615 | |
| 134 | F | A | 0.2906 | |
| 135 | S | A | -0.0375 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5652 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1983 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1686 | |
| 157 | D | A | 0.3331 | |
| 158 | L | A | 0.7990 | |
| 159 | A | A | 0.1901 | |
| 160 | E | A | -1.4476 | |
| 161 | P | A | -0.2003 | |
| 162 | C | A | 0.1925 | |
| 163 | P | A | -0.1611 | |
| 164 | G | A | -0.0609 | |
| 165 | L | A | 0.6185 | |
| 166 | P | A | -0.1014 | |
| 167 | P | A | -0.3341 | |
| 168 | G | A | -0.4194 | |
| 169 | A | A | -0.0222 | |
| 170 | C | A | 0.6615 | |
| 171 | P | A | 0.5345 | |
| 172 | P | A | 0.8757 | |
| 173 | I | A | 2.0565 | |
| 174 | Q | A | 0.8832 | |
| 175 | L | A | 1.5123 | |
| 176 | V | A | 0.8789 | |
| 177 | N | A | -0.2876 | |
| 178 | S | A | 0.0352 | |
| 179 | V | A | 0.4280 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3769 | |
| 182 | D | A | 0.0765 | |
| 183 | G | A | -0.1589 | |
| 184 | D | A | -0.5370 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1515 | |
| 190 | F | A | 0.0685 | |
| 191 | G | A | -0.0979 | |
| 192 | N | A | -0.2576 | |
| 193 | M | A | -0.1130 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4132 | |
| 197 | E | A | -2.6473 | |
| 198 | L | A | -1.2499 | |
| 199 | Q | A | -2.5804 | |
| 200 | Q | A | -3.3309 | |
| 201 | D | A | -3.5901 | |
| 202 | R | A | -3.3517 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | -0.0799 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.4471 | |
| 211 | S | A | -1.9028 | |
| 212 | T | A | -1.4455 | |
| 213 | R | A | -2.0905 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1601 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3560 | |
| 220 | L | A | 0.5771 | |
| 221 | K | A | -1.1691 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8338 | |
| 224 | N | A | -1.5140 | |
| 225 | E | A | -1.2514 | |
| 226 | A | A | -0.5999 | |
| 227 | Y | A | -0.3642 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6896 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0764 | |
| 234 | F | A | 0.2632 | |
| 235 | G | A | -0.8260 | |
| 236 | R | A | -2.6200 | |
| 237 | R | A | -2.9028 | |
| 238 | E | A | -2.1247 | |
| 239 | Q | A | -0.1584 | |
| 240 | V | A | 1.5351 | |
| 241 | Y | A | 1.2721 | |
| 242 | A | A | 0.4056 | |
| 243 | R | A | -0.5899 | |
| 244 | H | A | -0.6958 | |
| 245 | F | A | 0.0423 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.6238 | |
| 249 | C | A | -0.8353 | |
| 250 | G | A | -0.9066 | |
| 251 | P | A | -0.9369 | |
| 252 | D | A | -1.3970 | |
| 253 | G | A | -1.3095 | |
| 254 | H | A | -1.4625 | |
| 255 | P | A | -0.8774 | |
| 256 | L | A | 0.4162 | |
| 257 | P | A | 0.1152 | |
| 258 | A | A | 0.0206 | |
| 259 | A | A | 0.0329 | |
| 260 | P | A | -0.4900 | |
| 261 | P | A | -0.3853 | |
| 262 | P | A | -0.2905 | |
| 263 | S | A | 0.2338 | |
| 264 | P | A | 0.4781 | |
| 265 | L | A | 1.6219 | |
| 266 | F | A | 1.0638 | |
| 267 | T | A | 0.1933 | |
| 268 | P | A | 0.1535 | |
| 269 | P | A | 0.0458 | |
| 270 | P | A | -0.8307 | |
| 271 | P | A | -0.9050 | |
| 272 | D | A | -1.7091 | |
| 273 | S | A | -0.5616 | |
| 274 | P | A | 0.3601 | |
| 275 | Y | A | 1.4422 | |
| 276 | A | A | 0.9046 | |
| 277 | V | A | 2.0877 | |
| 278 | L | A | 1.9308 | |
| 279 | P | A | 0.8293 | |
| 280 | P | A | -0.1349 | |
| 281 | T | A | -0.4966 | |
| 282 | D | A | -1.1614 | |
| 283 | Y | A | 0.6948 | |
| 284 | F | A | 0.6386 | |
| 285 | G | A | 0.3175 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 1.0289 | |
| 291 | L | A | 1.6360 | |
| 292 | V | A | 0.6499 | |
| 293 | S | A | -0.1601 | |
| 294 | S | A | -0.9610 | |
| 295 | D | A | -1.8428 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1237 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6402 | |
| 301 | R | A | -1.8700 | |
| 302 | P | A | -0.9607 | |
| 303 | F | A | -0.1967 | |
| 304 | W | A | -0.5654 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0859 | |
| 307 | R | A | -2.8352 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2543 | |
| 310 | G | A | -1.2230 | |
| 311 | N | A | -1.2717 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7839 | |
| 319 | N | A | -0.9158 | |
| 320 | E | A | -1.0314 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3347 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0728 | |
| 333 | N | A | 0.5910 | |
| 334 | F | A | 1.8338 | |
| 335 | T | A | 0.9765 | |
| 336 | I | A | 0.4832 | |
| 337 | S | A | -0.9853 | |
| 338 | Q | A | -1.7796 | |
| 339 | Q | A | -1.3475 | |
| 340 | V | A | 0.1534 | |
| 341 | C | A | 0.2601 | |
| 342 | T | A | 0.0367 | |
| 343 | P | A | -0.3121 | |
| 344 | A | A | 0.0795 | |
| 345 | T | A | 0.0341 | |
| 346 | N | A | -0.2290 | |
| 347 | V | A | 1.5685 | |
| 348 | Y | A | 1.4694 | |
| 349 | D | A | 0.0334 | |
| 350 | P | A | -0.5557 | |
| 351 | S | A | -0.4574 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.9846 | |
| 354 | K | A | -2.2726 | |
| 355 | N | A | -1.8056 | |
| 356 | Y | A | 0.0598 | |
| 357 | L | A | 0.7440 | |
| 358 | R | A | 1.0003 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4085 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0659 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0148 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6867 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3032 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3122 | |
| 376 | L | A | -1.7058 | |
| 377 | D | A | -1.9864 | |
| 378 | P | A | -1.0361 | |
| 379 | G | A | -1.0130 | |
| 380 | V | A | -0.9302 | |
| 381 | L | A | -0.5282 | |
| 382 | A | A | -0.6543 | |
| 383 | H | A | -0.8023 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4117 | |
| 386 | T | A | -0.5502 | |
| 387 | M | A | -0.2974 | |
| 388 | N | A | -0.8632 | |
| 389 | P | A | -1.2369 | |
| 390 | T | A | -1.4231 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4211 | |
| 393 | E | A | -2.7507 | |
| 394 | N | A | -2.3229 | |
| 395 | W | A | -1.3508 | |
| 396 | N | A | -1.1225 | |
| 397 | L | A | -0.1973 | |
| 398 | G | A | 0.5141 | |
| 399 | F | A | 2.4115 | |
| 400 | V | A | 1.8188 | |
| 401 | P | A | 0.0401 | |
| 402 | P | A | -1.7856 | |
| 403 | K | A | -3.2967 | |
| 404 | E | A | -3.7418 | |
| 405 | R | A | -3.8334 | |
| 406 | E | A | -3.7584 | |
| 407 | D | A | -2.8633 | |
| 408 | P | A | -1.7581 | |
| 409 | Y | A | -0.9889 | |
| 410 | K | A | -2.1182 | |
| 411 | G | A | -0.6327 | |
| 412 | L | A | 0.6775 | |
| 413 | I | A | 1.5930 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3748 | |
| 416 | E | A | -1.6466 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9398 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0601 | |
| 421 | E | A | -2.7945 | |
| 422 | R | A | -2.6644 | |
| 423 | F | A | -1.2960 | |
| 424 | S | A | -1.4711 | |
| 425 | Q | A | -1.8339 | |
| 426 | D | A | -2.8759 | |
| 427 | L | A | -1.9612 | |
| 428 | D | A | -2.7236 | |
| 429 | Q | A | -2.5940 | |
| 430 | F | A | -1.4227 | |
| 431 | A | A | -0.8976 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5893 | |
| 435 | K | A | -0.7128 | |
| 436 | F | A | 0.1475 | |
| 437 | L | A | 1.0303 | |
| 438 | Y | A | 0.8247 | |
| 439 | Q | A | -0.2762 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine